Hedgehog signal transduction: Recent findings

Current Opinion in Genetics and Development

Volumn 12, Issue 5, 2002, Pages 503-511

  Nybakken, Kent ^a   Perrimon, Norbert ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; KINESIN; PALMITIC ACID; PHOSPHOTRANSFERASE; PROTEIN; PROTEIN COSTAL2; PROTEIN CUBITUS INTERRUPTUS; PROTEIN FUSED; SUPPRESSOR OF FUSED PROTEIN; UNCLASSIFIED DRUG;

BINDING SITE; CYTOPLASM; ENZYME ANALYSIS; GENE INTERACTION; HEDGEHOG; MUTATION; ONCOGENE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; REVIEW; SIGNAL TRANSDUCTION;

ERINACEIDAE;

EID: 0036778132     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(02)00333-7     Document Type: Review

References (57)

1. Hedgehog signaling in animal development: Paradigms and principles
2. The developmental roles and clinical significance of Hedghog signaling
3. Sonic Hedgehog as a mediator of long-range signaling
4. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells
5. Cholesterol modification of hedgehog signaling proteins in animal development
6. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1
7. A freely diffusible form of Sonic hedgehog mediates long-range signalling
8. Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
9. Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite
10. The growth suppressing gas1 product is a GPI-linked protein
11. Gas1-induced growth suppression requires a transactivation-independent p53 function
12. Structure, function, and chromosome mapping of the growth-suppressing human homologue of the murine gas1 gene
13. The growth arrest-specific gene, gas1, is involved in growth suppression
14. Megalin and cubilin: Multifunctional endocytic receptors
15. Megalin functions as an endocytic sonic hedgehog receptor
16. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
17. Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal
18. Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein
19. An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development
20. Distinct roles of Central missing and Dispatched in sending the Hedgehog signal
21. Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling
22. Enhanced potency of human Sonic hedgehog by hydrophobic modification
23. Posttranscriptional regulation of smoothened is part of a self- correcting mechanism in the Hedgehog signaling system
24. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
25. Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein
26. The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane
27. Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos
28. Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
29. Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1
30. Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway
31. Patched overexpression alters wing disc size and pattern: Transcriptional and post-transcriptional effects on hedgehog targets
32. In vivo functions of the patched protein: Requirement of the C terminus for target gene inactivation but not Hedgehog sequestration
33. Mutational analysis of the yeast a-factor transporter STE6, a member of the ATP binding cassette (ABC) protein superfamily
34. In vivo expression of the lacY gene in two segments leads to functional lac permease
35. Reconstitution of an active lactose carrier in vivo by simultaneous synthesis of two complementary protein fragments
36. The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking
37. Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation
38. Distinct consequences of sterol sensor mutations in Drosophila and mouse patched homologs
39. Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan
40. Cerebellar proteoglycans regulate sonic hedgehog responses during development
41. The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling
42. Hedgehog stimulated phosphorylation of the kinesin-related protein costal2 is mediated by the serine/threonine kinase fused
43. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2
44. The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells
45. Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression
46. Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A
47. Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus
48. Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1
49. Shaggy/GSK3 antagonizes hedgehog signalling by regulating Cubitus interruptus
50. Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator
51. Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway
52. Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus
53. Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus
54. Modulation of Hedgehog target gene expression by the Fused serine- threonine kinase in wing imaginal discs
55. Vertebrate homologs of Drosophila suppressor of fused interact with the gli family of transcriptional regulators
56. Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex
57. Hedgehog signal transduction proteins: Contacts of the Fused kinase and Ci transcription factor with the Kinesin-related protein Costal2