Gut instincts: Thoughts on intestinal epithelial stem cells

Journal of Clinical Investigation

Volumn 105, Issue 11, 2000, Pages 1493-1499

  Booth, Catherine ^a   Potten, Christopher S ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DIFFERENTIATION; CELL DIVISION; COLUMNAR EPITHELIUM; EPITHELIUM CELL; INTESTINE CRYPT; INTESTINE EPITHELIUM; PANETH CELL; PRIORITY JOURNAL; REVIEW; STEM CELL;

EID: 0034080251     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI10229     Document Type: Review

References (20)

1. Potten, C.S. 1995. Structure, function and proliferative organisation of the mammalian gut. In Radiation and gut. C.S. Potten and J.H. Hendry, editors. Elsevier Science. Amsterdam, The Netherlands. 1-31.
2. Kaur, P., and Potten, C.S. 1986. Cell migration velocities in the crypts of the small intestine after cytotoxic insult are not dependent on mitotic activity. Cell Tissue Kinet. 19:601-610.
3. Potten, C.S., and Loeffler, M. 1990. Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development. 110:1001-1020.
4. Potten, C.S., Booth, C., and Pritchard, D.M. 1997. The intestinal epithelial stem cell: the mucosal governor. Int. J. Exp. Pathol. 78:219-243.
5. Hendry, J.H., et al. 1989. The response of the murine intestinal crypts to short range prometheium-147 radiation. Radiat. Res. 118:364-374.
6. Potten, C.S. 1998. Stem cells in gastrointestinal epithelium: numbers, characteristics and death. Philos. Trans. R. Soc. Lond. B Biol. Sci. 353:821-830.
7. Potten, C.S. 1977. Extreme sensitivity of some intestinal crypt cells to X and γ irradiation. Nature. 269:518-521.
8. Merrirt, A.J., et al. 1994. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res. 54:614-617.
9. Loeffler, M., Birke, A., Winton, D., and Potten, C.S. 1993. Somatic mutation monoclonality and stochastic models of stem cell organisation in the intestinal crypt. J. Theor. Biol. 162:471-491.
10. Winton, D.J., Blount, M.A., and Ponder, B.A.J. 1988. A clonal marker induced by mutation in mouse intestinal epithelium. Nature. 33:463-466.
11. Williams, E.D., Lowes, A.P., Williams, D., and Williams, G.T. 1992. A stem cell niche theory of intestinal crypt maintenance based on a study of somatic mutation in colonic mucosa. Am. J. Pathol. 141:773-776.
12. Cairns, J. 1975. Mutation selection and the natural history of cancer. Nature. 15:197-200.
13. Potten, C.S., Hume, W.J., Reid, P., and Cairns, J. 1978. The segregation of DNA in epithelial stem cells. Cell. 15:899-906.
14. Sakakibara, S., and Okano, H. 1997. Expression of neural RNA-binding proteins in the postnatal CNS: implications of their roles in neuronal and glial cell development. J. Neurosci. 17:8300-8312.
15. Merritt, A.J., et al. 1995. Differential expression of bcl-2 in intestinal epithelia-correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia. J. Cell Sci. 108:2261-2271.
16. Martin, K., Kirkwood, T.B., and Potten, C.S. 1998. Age changes in stem cells of marine small intestinal crypts. Exp. Cell Res. 241:316-323.
17. Martin, K., Potten, C.S., Roberts, S.A., and Kirkwood, T.B. 1998. Altered stem cell regeneration in irradiated intestinal crypts of senescent mice. J. Cell Sci. 111:2297-2303.
18. Potten, C.S., Booth, D., and Haley, J.D. 1997. Pretreatment with transforming growth factor beta-3 protects small intestinal stem cells against radiation damage in vivo. Br. J. Cancer. 75:1454-1459.
19. Booth, C., O'Shea, J.A., and Potten, C.S. 1999. Maintenance of functional stem cells in isolated and cultured intestinal epithelium. Exp. Cell Res. 249:359-366.
20. Whitehead, R.H., Demmler, K., Rockman, S.P., and Watson, N.K. 1999. Clonogenic growth of epithelial cells from normal colonic mucosa from both mice and humans. Gastroenterology. 117:858-865.