Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

Nature Cell Biology

Volumn 1, Issue 5, 1999, Pages 260-266

  Ashcroft, Gillian S ^a,b   Yang, Xiao ^c   Glick, Adam B ^a   Weinstein, Michael ^c   Letterio, John J ^a   Mizel, Diane E ^b   Anzano, Mario ^a   Greenwell Wild, Teresa ^b   Wahl, Sharon M ^b   Deng, Chuxia ^c   Roberts, Anita B ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

DNA BINDING PROTEIN; SMAD3 PROTEIN; SMAD3 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; ARTICLE; BONE MARROW CELL; CELL ADHESION; CELL CULTURE; CELL DIVISION; CHEMOTAXIS; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; INJURY; KERATINOCYTE; MALE; MONOCYTE; MOUSE; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SKIN; WOUND HEALING;

ANIMALS; BONE MARROW CELLS; CELL ADHESION; CELL DIVISION; CELLS, CULTURED; CHEMOTAXIS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; INFLAMMATION; KERATINOCYTES; MALE; MICE; MICE, KNOCKOUT; MONOCYTES; SIGNAL TRANSDUCTION; SKIN; SMAD3 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; WOUND HEALING; WOUNDS AND INJURIES;

EID: 0033195998     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/12971     Document Type: Article

References (33)

1. Massague, J. TGF-beta signal transduction. Annu. Rev. Biochem. 67, 753-791 (1998).
2. Derynck, R., Zhang, Y. & Feng, X. H. Smads: transcriptional activators of TGF-beta responses. Cell 95, 737-740 (1998).
3. Roberts, A. B. Transforming growth factor-β: activity and efficacy in animal models of wound healing. Wound Repair Regen. 3, 408-418 (1995).
4. O'Kane, S. & Ferguson, M. W. J. Transforming growth factor beta s and wound healing. Int. J. Biochem. Cell Biol. 29, 63-78 (1997).
5. Yang, X. et al. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J. 18, 1280-1291 (1999).
6. Datto, M. B. et al. Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. Mol. Cell Biol. 19, 2495-2504 (1999).
7. Zhu, Y., Richardson, J. A., Parada, L. F., & Graff, J. M. Smad3 mutant mice develop metastatic colorectal cancer. Cell 18, 703-714 (1998).
8. Weinstein, M., Yang, X., Li, C., Xu, X., & Deng, C. Failure of extraembryonic membrane formation and mesoderm induction in embryos lacking the tumor suppressor Smad2. Proc. Natl Acad. Sci. USA 95, 9378-9383 (1998).
9. Ashcroft, G. S. et al. Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levels. Nature Med. 3, 1209-1215 (1997).
10. Gross, J. et al. On the mechanism of skin wound "contraction": a granulation tissue "knockout" with a normal phenotype. Proc. Natl Acad. Sci. USA 92, 5982-5986 (1995).
11. Wahl, S. M. et al. Transforming growth factor type beta induces monocyte chemotaxis and growth factor production. Proc. Natl Acad. Sci. USA 84, 5788-5792 (1987).
12. Leibovich, S. J. & Ross, R. The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. Am. J. Pathol. 78, 71-100 (1975).
13. McCartney-Francis, N., & Wahl, S. M. Transforming growth factor beta: a matter of life and death. J. Leuk. Biol. 55, 401-109 (1994).
14. Pierce, G. F. et al. Transforming growth factor beta reverses the glucocorticoid-induced wound-healing deficit in rats: possible regulation in macrophages by platelet-derived growth factor. Proc. Natl Acad. Sci. USA 86, 2229-2233 (1989).
15. Vindevoghel, L. et al. SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta. Proc. Natl Acad. Sci. USA 95, 14769-14774 (1998).
16. Chen, S. J. et al. Stimulation of type I collagen transcription in human skin fibroblasts by TGF-beta: involvement of Smad3. J. Invest. Dermatol. 112, 49-57 (1999).
17. Hocevar, B. A., Brown, T. L. & Howe, P. H. TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMBO J. 18, 1345-1356 (1999).
18. Wiseman, D. M., Polverini, P. J., Kamp, D. W. & Leibovich, S. J. Transforming growth factor-beta (TGF beta) is chemotactic for human monocytes and induces their expression of angiogenic activity. Biochem. Biophys. Res. Commun. 157, 793-800 (1988).
19. Wahl, S. M., Allen, J. B., Weeks, B. S., Wong, H. L. & Klotman, P. E. Transforming growth factor beta enhances integrin expression and type IV collagenase secretion in human monocytes. Proc. Natl Acad. Sci. USA 90, 4577-4581 (1993).
20. Zambruno, G. et al. Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: implications for wound healing. J. Cell Biol 129, 853-865 (1995).
21. Mustoe, T. A., Pierce, G. F., Morishima, C. & Deuel, T. F. Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model. J. Clin. Invest. 87, 694-703 (1991).
22. Hebda, P. A. Stimulatory effects of transforming growth factor-beta and epidermal growth factor on epidermal cell outgrowth from porcine skin explant cultures. J. Invest. Dermatol. 91, 440-445 (1988).
23. Yanagisawa, K. et al. Induction of apoptosis by Smad3 and down-regulation of Smad3 expression in response to TGF-beta in human normal lung epithelial cells. Oncogene 17, 1743-1747 (1998).
24. Dennler, S., Huet, S. & Gauthier, J. M. A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3. Oncogene 18, 1643-1648 (1999).
25. Ulloa, L., Doody, J. & Massague, J. Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. Nature 397, 710-713 (1999).
26. Yanagisawa, J. et al. Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators. Science 283, 1317-1321 (1999).
27. Kurokawa, M. et al. The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3. Nature 2, 92-96 (1998).
28. de Caestecker, M. P. et al. Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases. Genes Dev. 12, 587-592 (1998).
29. Kretzschmar, M. et al. A mechanism of repression of TGFbeta/Smad signaling by oncogenic Ras. Genes Dev. 1, 804-816 (1999).
30. Liu, X. et al. Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc. Natl Acad. Sci. USA 94, 10669-10674 (1997).
31. Feldman, G. et al. STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression. Blood 90, 1768-1776 (1997).
32. Dlugosz, A. A., Glick, A. B., Tennenbaum, T., Weinberg, W. C. & Yuspa, S. H. Isolation and utilization of epidermal keratinocytes for oncogene research. Methods Enzymol. 254, 3-20 (1995).
33. Danielpour, D. et al. Immunodetection and quantitation of the two forms of transforming growth factor-beta (TGF-beta 1 and TGF-beta 2) secreted by cells in culture. J. Cell Physiol. 138, 79-86 (1989).