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Volumn 267, Issue 24, 2000, Pages 6982-6988

Targeted mutations of transforming growth factor-β genes reveal important roles in mouse development and adult homeostasis

(2) Dünker, Nicole a Krieglstein, Kerstin a,b

a SAARLAND UNIVERSITY (Germany)

b SAARLAND UNIVERSITY (Germany)

Author keywords

Cytokines; Development; Embryology; Gene targeting; Growth factors; Serine threonine kinase; Smad; TGF

Indexed keywords

SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; UNCLASSIFIED DRUG;

CELL ADHESION; CELL DIFFERENTIATION; CELL PROLIFERATION; ENDOTHELIUM CELL; GASTRULATION; GENE TARGETING; HEMATOPOIESIS; IMMUNOREGULATION; MESODERM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; SIGNAL TRANSDUCTION; WOUND HEALING;

ANIMALS; DNA-BINDING PROTEINS; EMBRYONIC AND FETAL DEVELOPMENT; GENE TARGETING; HOMEOSTASIS; MICE; MUTATION; SMAD2 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034530165 PISSN: 00142956 EISSN: None Source Type: Journal
DOI: 10.1046/j.1432-1327.2000.01825.x Document Type: Short Survey

Times cited : (186)

References (76)

1
- 0000116653
- The transforming growth factors-βs
- Handbook of Experimental Pharmacology (Sporn, M.B. & Roberts, A.B., eds) Springer, Heidelberg, Germany
- (1990) , vol.95 , pp. 419-472
- Roberts, A.B.¹ Sporn, M.B.²

2
- 0025222517
- The transforming growth factor-beta family
- (1990) Annu. Rev. Cell Biol. , vol.6 , pp. 597-641
- Massague, J.¹

3
- 0034533657
- Signaling of transforming growth factor-β family members through smad proteins
- (2000) Eur. J. Biochem. , vol.267 , pp. 6954-6967
- Itoh, S.¹ Itoh, F.² Goumans, M.J.³ Ten Dijke, P.⁴

4
- 0026496172
- TGF beta signals through a heteromeric protein kinase receptor complex
- (1992) Cell , vol.71 , pp. 1003-1014
- Wrana, J.L.¹ Attisano, L.² Carcamo, J.³ Zentella, A.⁴ Doody, J.⁵ Laiho, M.⁶ Wang, X.F.⁷ Massague, J.⁸

5
- 0030775109
- From receptor to nucleus: The Smad pathway
- (1997) Curr. Opin. Genet. Dev. , vol.7 , pp. 467-473
- Baker, J.C.¹ Harland, R.M.²

6
- 0031438047
- TGF-β signaling from cell membrane to nucleus through SMAD proteins
- (1997) Nature , vol.390 , pp. 465-471
- Heldin, C.H.¹ Miyazono, K.² Ten Dijke, P.³

7
- 0034678908
- Transcriptional control by the TGF-beta/Smad signaling system
- (2000) EMBO J. , vol.19 , pp. 1745-1754
- Massague, J.¹ Wotton, D.²

8
- 0028603343
- TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type 1 receptors
- (1994) J. Cell Biol. , vol.127 , pp. 2021-2036
- Miettinen, P.J.¹ Ebner, R.² Lopez, A.R.³ Derynck, R.⁴

9
- 0028171579
- Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
- (1994) Nat. Genet. , vol.8 , pp. 345-351
- McAllister, K.A.¹ Grogg, K.M.² Johnson, D.W.³ Gallione, C.J.⁴ Baldwin, M.A.⁵ Jackson, C.E.⁶ Helmbold, E.A.⁷ Markel, D.S.⁸ McKinnon, W.C.⁹ Murrell, J.¹⁰

10
- 0030050973
- Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2
- (1996) Nat. Genet. , vol.13 , pp. 189-195
- Johnson, D.W.¹ Berg, J.N.² Baldwin, M.A.³ Gallione, C.J.⁴ Marondel, I.⁵ Yoon, S.J.⁶ Stenzel, T.T.⁷ Speer, M.⁸ Pericak-Vance, M.A.⁹ Diamond, A.¹⁰ Guttmacher, A.E.¹¹ Jackson, C.E.¹² Attisano, L.¹³ Kucherlapati, R.¹⁴ Porteous, M.E.¹⁵ Marchuk, D.A.¹⁶

11
- 0034213609
- Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation
- (2000) Dev. Biol. , vol.222 , pp. 1-11
- Lai, Y.T.¹ Beason, K.B.² Brames, G.P.³ Desgrosellier, J.S.⁴ Cleggett, M.C.⁵ Shaw, M.V.⁶ Brown, C.B.⁷ Barnett, J.V.⁸

12
- 0030051749
- Expression, localization, and function of transforming growth factor-beta's in embryonic chick spinal cord, hindbrain, and dorsal root ganglia
- (1996) J. Neurobiol. , vol.29 , pp. 262-276
- Unsicker, K.¹ Meier, C.² Krieglstein, K.³ Sartor, B.M.⁴ Flanders, K.C.⁵

13
- 0027366905
- Effect of TGF-βs and bFGF on astroglial cell growth and gene expression in vitro
- (1993) Mol. Cell Neurosci. , vol.4 , pp. 406-4017
- Flanders, K.C.¹ Lüdecke, G.² Renzig, J.³ Hamm, C.⁴ Cissl, D.S.⁵ Unsicker, K.⁶

14
- 0025800595
- Localization and actions of transforming growth factor beta's in the embryonic nervous system
- (1991) Development , vol.113 , pp. 83-91
- Flanders, K.C.¹ Lüdecke, G.² Engels, S.³ Cissl, D.S.⁴ Roberts, A.B.⁵ Kondaiah, P.⁶ Lafyatis, R.⁷ Sporn, M.B.⁸ Unsicker, K.⁹

15
- 0025977578
- Embryonic gene expression patterns of TGF beta 1, beta 2 and beta 3 suggest different developmental functions in vivo
- (1991) Development , vol.111 , pp. 131-143
- Millan, F.A.¹ Denhez, F.² Kondaiah, P.³ Akhurst, R.J.⁴

16
- 0026326375
- Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: Expression patterns suggest multiple roles during embryonic development
- (1991) J. Cell Biol. , vol.115 , pp. 1091-1105
- Pelton, R.W.¹ Saxena, B.² Jones, M.³ Moses, H.L.⁴ Gold, L.I.⁵

17
- 0026053972
- Differential expression of TGF beta 1, beta 2 and beta 3 genes during mouse embryogenesis
- (1991) Development , vol.111 , pp. 117-130
- Schmid, P.¹ Cox, D.² Bilbe, G.³ Maier, R.⁴ McMaster, G.K.⁵

18
- 0025002055
- Expression of TGF-beta isoforms during first trimester human embryogenesis
- (1990) Development , vol.110 , pp. 445-460
- Gatherer, D.¹ Ten Dijke, P.² Baird, D.T.³ Akhurst, R.J.⁴

19
- 0025132988
- In situ hybridization of TGF beta 3 RNA expression during mouse development: Comparative studies with TGF beta 1 and beta 2
- (1990) Development , vol.110 , pp. 609-620
- Pelton, R.W.¹ Dickinson, M.E.² Moses, H.L.³ Hogan, B.L.⁴

20
- 0023549793
- Role of transforming growth factor-beta in the development of the mouse embryo
- (1987) J. Cell Biol. , vol.105 , pp. 2861-2876
- Heine, U.¹ Munoz, E.F.² Flanders, K.C.³ Ellingsworth, L.R.⁴ Lam, H.Y.⁵ Thompson, N.L.⁶ Roberts, A.B.⁷ Sporn, M.B.⁸

21
- 0023685731
- Embryonic expression pattern of TGF beta type-1 RNA suggests both paracrine and autocrine mechanisms of action
- (1988) Development , vol.104 , pp. 263-273
- Lehnert, S.A.¹ Akhurst, R.J.²

22
- 0029037374
- Neural functions of the transforming growth factor beta
- (1995) Int. J. Dev. Neurosci. , vol.13 , pp. 301-315
- Krieglstein, K.¹ Rufer, M.² Suter-Crazzolara, C.³ Unsicker, K.⁴

23
- 0032403377
- Glia cell line-derived neurotrophic factor requires transforming growth factor-beta for exerting its full neurotrophic potential on peripheral and CNS neurons
- (1998) J. Neurosci. , vol.18 , pp. 9822-9834
- Krieglstein, K.¹ Henheik, P.² Farkas, L.³ Jaszai, J.⁴ Galter, D.⁵ Krohn, K.⁶ Unsicker, K.⁷

24
- 0024555682
- Expression of transforming growth factor-beta 1 in specific cells and tissues of adult and neonatal mice
- (1989) J. Cell Biol. , vol.108 , pp. 661-669
- Thompson, N.L.¹ Flanders, K.C.² Smith, J.M.³ Ellingsworth, L.R.⁴ Roberts, A.B.⁵ Sporn, M.B.⁶

25
- 0025776477
- Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system
- (1991) Neuroscience , vol.44 , pp. 613-625
- Unsicker, K.¹ Flanders, K.C.² Cissl, D.S.³ Lafyatis, R.⁴ Sporn, M.B.⁵

26
- 0034105456
- Co-activation of TGF-β and cytokine signalling pathways are required for neurotrophic functions
- (2000) Cytokine Growth Factor Rev. , vol.11 , pp. 97-102
- Unsicker, K.¹ Krieglstein, K.²

27
- 0033773180
- The TGF-βs: Structure, signaling and roles in nervous system development and functions
- (2000) J. Neurochem. , vol.75 , pp. 2227-2240
- Böttner, M.¹ Krieglstein, K.² Unsicker, K.³

28
- 0026799402
- Target disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
- (1992) Nature , vol.359 , pp. 693-699
- Shull, M.M.¹ Ormsby, I.² Kier, A.B.³ Pawlowsky, S.⁴ Diebold, R.J.⁵ Yin, M.⁶ Allen, R.⁷ Sidman, C.⁸ Preotzel, G.⁹ Calvin, D.¹⁰ Ammunziata, N.¹¹ Doetschman, T.¹²

29
- 0027531528
- Transforming growth factor β1 null mutation in mice causes excessive inflammatory response and early death
- (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 770-774
- Kulkarni, A.B.¹ Huh, C.-G.² Becker, D.³ Geiser, A.⁴ Lyght, M.⁵ Flanders, K.C.⁶ Roberts, A.B.⁷ Sporn, M.B.⁸ Ward, J.M.⁹

30
- 0028859738
- Onset and progression of pathological lesions in transforming growth factor-β1-deficient mice
- (1995) Am. J. Pathol. , vol.146 , pp. 276-288
- Boivin, G.P.¹ O'Toole, B.A.² Ormsby, I.E.³ Diebold, R.J.⁴ Eis, M.J.⁵ Doetschman, T.⁶ Kier, A.B.⁷

31
- 0028982242
- Transforming growth factor-beta 1 null mice. An animal model for inflammatory disorders
- (1995) Am. J. Pathol. , vol.146 , pp. 264-275
- Kulkarni, A.B.¹ Ward, J.M.² Yaswen, L.³ Mackall, C.L.⁴ Bauer, S.R.⁵ Huh, C.G.⁶ Gress, R.E.⁷ Karlsson, S.⁸

32
- 0029995587
- Transforming growth factor-β1-deficient mice: Identification of isoform-specific activities in vivo
- (1996) J. Leukozyte Biol. , vol.50 , pp. 769-774
- Letterio, J.J.¹ Roberts, A.B.²

33
- 0028169444
- Immune dysregulation in TGF-β1 deficient mice
- (1994) J. Immunol. , vol.153 , pp. 1936-1946
- Christ, M.¹ McCartney-Francis, N.² Kulkarni, A.B.³ Ward, J.M.⁴ Mizel, D.E.⁵ Mackall, C.L.⁶ Gress, R.E.⁷ Hines, K.L.⁸ Tian, H.⁹ Karlsson, S.¹⁰ Wahl, S.M.¹¹

34
- 0028070715
- Maternal rescue of Transforming growth factor-β1 null mice
- (1994) Science , vol.264 , pp. 1936-1938
- Letterio, J.J.¹ Geiser, A.G.² Kulkarni, A.B.³ Roche, N.S.⁴ Sporn, M.B.⁵ Roberts, A.B.⁶

35
- 0029618694
- Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated
- (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 12215-12219
- Diebold, R.J.¹ Eis, M.J.² Yin, M.³ Ormsby, I.⁴ Boivin, G.P.⁵ Darrow, B.J.⁶ Saffitz, J.E.⁷ Doetschman, T.⁸

36
- 0032588796
- Strain dependency of TGFbetal function during embryogenesis
- (1999) Mol. Reprod. Dev. , vol.52 , pp. 341-349
- Kallapur, S.¹ Ormsby, I.² Doetschman, T.³

37
- 0006010813
- The liver in transforming growth factor-beta-1 (TGF-β1) null mutant mice
- (1996) Ultrastruct. Pathol. , vol.20 , pp. 477-490
- Williams, A.O.¹ Knapton, A.D.² Geiser, A.³ Letterio, J.J.⁴ Roberts, A.B.⁵

38
- 0029074681
- Defective haematopoiesis and vasculogenesis in transforming growth factor β1 knock out mice
- (1995) Development , vol.121 , pp. 1845-1854
- Dickson, M.C.¹ Martin, J.S.² Cousins, F.M.³ Kulkarni, A.B.⁴ Karlsson, S.⁵ Akhurst, R.J.⁶

39
- 2642614530
- Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency
- (1998) Nat. Med. , vol.4 , pp. 802-807
- Tang, B.¹ Bottinger, E.P.² Jakowlew, S.B.³ Bagnall, K.M.⁴ Mariano, J.⁵ Anver, M.R.⁶ Letterio, J.J.⁷ Wakefield, L.M.⁸

40
- 0033565626
- Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis
- (1999) Cancer Res. , vol.59 , pp. 3379-3386
- Engle, S.J.¹ Hoying, J.B.² Boivin, G.P.³ Ormsby, I.⁴ Gartside, P.S.⁵ Doetschman, T.⁶

41
- 0028171401
- Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma
- (1994) Genes Dev. , vol.8 , pp. 2429-2440
- Glick, A.B.¹ Lee, M.M.² Darwiche, N.³ Kulkarni, A.B.⁴ Karlsson, S.⁵ Yuspa, S.H.⁶

42
- 18344419077
- Control of murine hair follicle regression (catagen) by TGF-beta1 in vivo
- (2000) FASEB J. , vol.14 , pp. 752-760
- Foitzik, K.¹ Lindner, G.² Mueller-Roever, S.³ Maurer, M.⁴ Botchkareva, N.⁵ Botchkarev, V.⁶ Handjiski, B.⁷ Metz, M.⁸ Hibino, T.⁹ Soma, T.¹⁰ Dotto, G.P.¹¹ Paus, R.¹²

43
- 0032145238
- Decreased bone mass and bone elasticity in mice lacking the transforming growth factor-beta1 gene
- (1998) Bone , vol.23 , pp. 87-93
- Geiser, A.G.¹ Zeng, Q.Q.² Sato, M.³ Helvering, L.M.⁴ Hirano, T.⁵ Turner, C.H.⁶

44
- 0031601166
- TGF-beta1 is essential for the homeostasis of the dentin-pulp complex
- (1998) Eur. J. Oral. Sci. , vol.106 , pp. 185-191
- D'Souza, R.N.¹ Cavender, A.² Dickinson, D.³ Roberts, A.⁴

45
- 0030456368
- A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: The skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells
- (1996) J. Exp. Med. , vol.184 , pp. 2417-2422
- Borkowski, T.A.¹ Letterio, J.J.² Farr, A.G.³ Udey, M.C.⁴

46
- 0032720627
- Transforming growth factor beta1 enhances platelet aggregation through a non-transcriptional effect on the fibrinogen receptor
- (2000) J. Biol. Chem. , vol.27 , pp. 31008-31013
- Hoying, J.B.¹ Yin, M.² Diebold, R.³ Ormsby, I.⁴ Becker, A.⁵ Doetschman, T.⁶

47
- 0030609894
- TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes
- (1997) Development , vol.124 , pp. 2659-2670
- Sanford, L.P.¹ Ormsby, I.² Gittenberger-de Groot, A.³ Sariola, H.⁴ Friedman, R.⁵ Boivin, G.P.⁶ Cardell, E.L.⁷ Doetschman, T.⁸

48
- 0033566365
- The TGF-beta2 isoform is both a required and sufficient inducer of murine hair follicle morphogenesis
- (1999) Dev. Biol. , vol.212 , pp. 278-289
- Foitzik, K.¹ Paus, R.² Doetschman, T.³ Dotto, G.P.⁴

49
- 0028972869
- Transforming growth factor-β3 is required for secondary palate fusion
- (1995) Nat. Gen. , vol.11 , pp. 409-414
- Proetzel, G.¹ Pawlowski, S.A.² Wiles, W.V.³ Yin, M.⁴ Boivin, G.P.⁵ Howles, P.N.⁶ Ding, J.⁷ Ferguson, M.W.J.⁸ Doetschman, T.⁹

50
- 0028806184
- Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction
- (1995) Nat. Gen. , vol.11 , pp. 415-421
- Kaartinen, V.¹ Voncken, J.W.² Shuler, C.³ Warburton, D.⁴ Bu, D.⁵ Heisterkamp, N.⁶ Groffen, J.⁷

51
- 0032823873
- Pathogenesis of cleft palate in TGF-beta3 knockout mice
- (1999) Development , vol.126 , pp. 3869-3879
- Taya, Y.¹ O'Kane, S.² Ferguson, M.W.³

52
- 0342635464
- Medial edge epithelial cell fate during palatal fusion
- (2000) Dev. Biol. , vol.220 , pp. 343-357
- Martinez-Alvarez, C.¹ Tudela, C.² Perez-Miguelsanz, J.³ O'Kane, S.⁴ Puerta, J.⁵ Ferguson, M.W.⁶

53
- 0033547875
- TGF-β3, but not TGF-β1, protects keratinocytes against, 12-O-tetradecanoylphorbol-13-acetate-induced cell death in vitro and in vivo
- (2000) J. Biol. Chem. , vol.274 , pp. 4213-4219
- Li, J.¹ Foitzik, K.² Calautti, E.³ Baden, H.⁴ Doetschman, T.⁵ Dotto, G.P.⁶

54
- 0030579203
- TGF-β receptor type II deficiency results in defects of yolk sac haematopoiesis and vasculogenesis
- (1996) Dev. Biol. , vol.179 , pp. 297-302
- Masanobu, O.¹ Oshima, H.² Taketo, M.M.³

55
- 0032549806
- Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of early mouse embryo
- (1998) Cell , vol.92 , pp. 797-808
- Waldrip, W.R.¹ Bikoff, E.K.² Hoodless, P.A.³ Wrana, J.L.⁴ Robertson, E.J.⁵

56
- 0032565859
- Smad2 role in mesoderm formation, left-right patterning and craniofacial development
- (1998) Nature , vol.393 , pp. 786-790
- Nomura, M.¹ Li, E.²

57
- 0032482751
- Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2
- (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9378-9383
- Weinstein, M.¹ Yang, X.² Cuiling, L.³ Xu, X.⁴ Gotay, J.⁵ Deng, C.-X.⁶

58
- 0033607183
- Postgrastrulation smad2-deficient embryos show defects in embryo turning and anterior morphogenesis
- (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 12595-12600
- Heyer, J.¹ Escalante-Alcalde, D.² Lia, E.³ Boettinger, E.⁴ Edelmann, W.⁵ Stewart, C.L.⁶ Kucherlapati, R.⁷

59
- 0032521185
- The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse
- (1998) Genes , vol.12 , pp. 844-857
- Gu, Z.¹ Nomura, M.² Simpson, B.B.³ Lei, H.⁴ Feijen, A.⁵ Van den Eijden-van Raaij, J.⁶ Danahoe, P.K.⁷ Li, E.⁸

60
- 0028180752
- A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse
- (1994) Development , vol.120 , pp. 1919-1928
- Conlon, F.L.¹ Lyons, K.M.² Takaesu, N.³ Barth, K.S.⁴ Kispert, A.⁵ Herrmann, B.⁶ Robertson, E.J.⁷

61
- 16044369574
- MADR2 maps to 18q21 and encodes a TGF-β-regulated MAD-related protein that is functionally mutated in colorectal carcinomas
- (1996) Cell , vol.86 , pp. 543-552
- Eppert, K.¹ Scherer, S.² Ozcelik, H.³ Pirone, R.⁴ Hoodless, P.⁵ Kim, H.⁶ Tsui, L.C.⁷ Gallinger, S.⁸ Thomsen, G.⁹ Wrana, J.¹⁰ Attisano, L.¹¹

62
- 0032934979
- Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction
- (1999) Mol. Cell Biol. , vol.19 , pp. 2495-2504
- Datto, M.B.¹ Frederick, J.P.² Pan, L.³ Borton, A.J.⁴ Zhuang, Y.⁵ Wang, X.F.⁶

63
- 0032544448
- Smad3 mutant mice develop metastatic colorectal cancer
- (1998) Cell , vol.94 , pp. 703-714
- Zhu, Y.¹ Richardson, J.A.² Parada, L.F.³ Graft, J.M.⁴

64
- 0031128153
- The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function
- (1997) Curr. Biol. , vol.7 , pp. 270-274
- Zhang, Y.¹ Musci, T.² Derynck, R.³

65
- 0030886204
- Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cell
- (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10669-10674
- Liu, X.¹ Sun, Y.² Constantinescu, S.N.³ Karam, E.⁴ Weinberg, R.A.⁵ Lodish, H.F.⁶

66
- 0034108424
- Loss of Smad3 modulates wound healing
- (2000) Cyokine Growth Factor Rev. , vol.11 , pp. 125-131
- Ashcroft, G.S.¹ Roberts, A.B.²

67
- 0034065392
- Murine models define the role of TGF-β as a master regulator of immune cell function
- (2000) Cytokine Growth Factor Rev. , vol.11 , pp. 81-87
- Letterio, J.J.¹

68
- 15444348295
- The tumor suppressor gene smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
- (1998) Gen. Dev. , vol.12 , pp. 107-119
- Sirard, C.¹ Dela Pompa, J.L.² Elia, A.³ Itie, A.⁴ Mirtsos, C.⁵ Cheung, A.⁶ Hahn, S.⁷ Wakeham, A.⁸ Schwartz, L.⁹ Kern, S.E.¹⁰ Rossant, J.¹¹ Mak, T.W.¹²

69
- 0033104503
- Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β
- (1999) EMBO J. , vol.18 , pp. 1280-1291
- Yang, X.¹ Letterio, J.J.² Lechleider, R.J.³ Chen, L.⁴ Hayman, R.⁵ Gu, L.⁶ Roberts, A.B.⁷ Deng, C.⁸

70
- 0031739638
- Smad4 (DPC4) - A potent tumour suppressor?
- (1998) Brit. J. Cancer , vol.78 , Issue.12 , pp. 1615-1619
- Duff, E.K.¹ Clarke, A.R.²

71
- 0029868841
- Negative regulation of cell growth by TGF beta
- (1996) Biochem. Biophys. Acta , vol.1242 , pp. 185-199
- Polyak, K.¹

72
- 0034141673
- Reduction of endogenous TGF-beta increases proliferation of developing adrenal chromaffin cells in vivo
- (2000) J. Neurosci. Res. , vol.59 , pp. 379-383
- Combs, S.E.¹ Krieglstein, K.² Unsicker, K.³

73
- 0033381357
- The role for transforming growth factor-β (TGF-β) in human cancer
- (1999) Crit. Rev. Oncogen. , vol.10 , pp. 303-360
- Gold, L.I.¹

74
- 0029066689
- Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability
- (1995) Science , vol.268 , pp. 1336-1338
- Markowitz, S.¹ Wang, J.² Myeroff, L.³ Parsons, R.⁴ Sun, L.⁵ Lutterbaugh, J.⁶ Fan, R.⁷ Zborowska, E.⁸ Kinzler, K.⁹ Vogelstein, B.¹⁰ Brattain, M.¹¹ Willson, J.¹²

75
- 15844390729
- Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers
- (1996) Nat. Genet. , vol.13 , pp. 343-346
- Thiagalingam, S.¹ Lengauer, C.² Leach, F.³ Schutte, M.⁴ Hahn, S.⁵ Overhauser, J.⁶ Willson, J.⁷ Markowitz, S.⁸ Hamilton, S.⁹ Kern, S.¹⁰ Kinzler, K.¹¹ Vogelstein, B.¹²

76
- 0032065913
- HNPCC associated with germline mutation in the TGFβ type II receptor gene
- (1998) Nat. Genet. , vol.19 , pp. 17-18
- Lu, S.¹ Kawabata, M.² Imamura, T.³ Akiyama, Y.⁴ Nomizu, T.⁵ Miyazono, K.⁶ Yuasa, Y.⁷

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.