Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice

Cancer Research

Volumn 62, Issue 22, 2002, Pages 6362-6366

  Engle, Sandra J ^a,b   Ormsby, Ilona ^a   Pawlowski, Sharon ^a   Boivin, Gregory P ^a   Croft, Joanne ^c   Balish, Edward ^c,d   Doetschman, Tom ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b SANOFI   (France)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COLONIZATION; COLON CANCER; CONTROLLED STUDY; GENE DISRUPTION; GERMFREE ANIMAL; GROWTH INHIBITION; INTESTINE CRYPT; INTESTINE FLORA; MICROSATELLITE INSTABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; ULCERATIVE COLITIS;

ANIMALS; COLITIS, ULCERATIVE; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GERM-FREE LIFE; HUMANS; MALE; MICE; MICE, INBRED C3H; MICE, KNOCKOUT; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 0037112436     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Kim, S. J., Im, Y. H., Markowitz, S. D., and Bang, Y. J. Molecular mechanisms of inactivation of TGF-β receptors during carcinogenesis. Cytokine Growth Factor. Rev., 11: 159-168, 2000
2. Manning, A. M., Williams, A. C., Game, S. M., and Paraskeva, C. Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor β (TGF-β): Conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-β. Oncogene, 6: 1471-1476, 1991
3. Parsons, R., Myeroff, L. L., Liu, B., Willson, J. K., Markowitz, S. D., Kinzler, K. W., and Vogelstein, B. Microsatellite instability and mutations of the transforming growth factor β type II receptor gene in colorectal cancer. Cancer Res., 55: 5548-5550, 1995
4. Jass, J. R., Do, K. A., Simms, L. A., Iino, H., Wynter, C., Pillay, S. P., Searle, J., Radford-Smith, G., Young, J., and Leggett, B. Morphology of sporadic colorectal cancer with DNA replication errors. Gut, 42: 673-679, 1998
5. Markowitz, S., Wang, J., Myeroff, L., Parsons, R., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kinzler, K. W., Vogelstein, B., Brattain, M., and Willson, J. K. V. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science (Wash. DC), 268: 1336-1338, 1995
6. Engle, S. J., Hoying, J. B., Boivin, G. P., Ormsby, I., Gartside, P. S., and Doetschman, T. Transforming growth factor β1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis. Cancer Res., 59: 3379-3386, 1999
7. Boivin, G. P., Ormsby, I., Jones-Carson, J., O’Toole, B. A., and Doetschman, T. Germ-free and barrier-raised TGFβ1-deficient mice have similar inflammatory lesions. Transgenic Res., 6: 197-202, 1997
8. Balish, E., and Filutowicz, H. Serum antibody response of gnotobiotic athymic and euthymic mice following alimentary tract colonization and infection with Candida albicans. Can. J. Microbiol., 37: 204-210, 1991
9. Kennedy, B. P., Payette, P., Mudgett, J., Vadas, P., Pruzanski, W., Kwan, M., Tang. C., Rancourt, D. E., and Cromlish, W. A. A natural disruption of the secretory group II phospholipase A2 gene in inbred mouse strains. J. Biol. Chem., 270: 22378-22385, 1995
10. Dieleman, L. A., Ridwan, B. U., Tennyson, G. S., Beagley, K. W., Bucy, R. P., and Elson, C. O. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology, 107: 1643-1652, 1994
11. Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., and Doetschman, T. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature (Lond.), 359: 693-699, 1992
12. Diebold, R. J., Eis, M. J., Yin, M., Ormsby, I., Boivin, G. P., Darrow, B. J., Saffitz, J. E., and Doetschman, T. Early-onset multifocal inflammation in the transforming growth factor β1-null mouse is lymphocyte mediated. Proc. Natl. Acad. Sci. USA, 92: 12215-12219, 1995
13. Zhu, Y., Richardson, J. A., Parada, L. F., and Graff, J. M. Smad3 mutant mice develop metastatic colorectal cancer. Cell, 94: 703-714, 1998
14. Burich, A., Hershberg, R., Waggie, K., Zeng, W., Brabb, T., Westrich, G., Viney, J. L., and Maggio-Price, L. Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice. Am. J. Physiol., 281: G764-G778, 2001
15. Velcich, A., Yang, W., Heyer, J., Fragale, A., Nicholas, C., Viani, S., Kucherlapati, R., Lipkin, M., Yang, K., and Augenlicht, L. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science (Wash. DC), 295: 1726-1729, 2002
16. Sohn, K. J., Shah, S. A., Reid, S., Choi, M., Carrier, J., Comiskey, M., Terhorst, C., and Kim, Y. I. Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and β (2)-microglobulin-deficient mouse. Cancer Res., 61: 6912-6917, 2001
17. Fedorak, R. N., and Madsen, K. L. Naturally occurring and experimental models of inflammatory bowel disease. In: J. B. Kirsner and R. G. Shorter (eds.), Inflammatory Bowel Disease, 5 Ed., pp. 113-143. Philadelphia: WB Saunders Company, 1999
18. Chawengsaksophak, K., James, R., Hammond, V. E., Kontgen, F., and Beck, F. Homeosis and intestinal tumours in Cdx2 mutant mice. Nature (Lond.), 386: 84-87, 1997
19. Dove, W. F., Clipson, L., Gould, K. A., Luongo, C., Marshall, D. J., Moser, A. R., Newton, M. A., and Jacoby, R. F. Intestinal neoplasia in the ApcMin mouse: Independence from the microbial and natural killer (beige locus) status. Cancer Res., 57: 812-814, 1997
20. Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., and Gordon, J. I. Molecular analysis of commensal host-microbial relationships in the intestine. Science (Wash. DC), 291: 881-884, 2001
21. Grady, W. M., Myeroff, L. L., Swinler, S. E., Rajput, A., Thiagalingam, S., Lutterbaugh, J. D., Neumann, A., Brattain, M. G., Chang, J., Kim, S. J., Kinzler, K. W., Vogelstein, B., Willson, J. K., and Markowitz, S. Mutational inactivation of transforming growth factor β receptor type II in microsatellite stable colon cancers. Cancer Res., 59: 320-324, 1999
22. Rabinovitch, P. S., Dziadon, S., Brentnall, T. A., Emond, M. J., Crispin, D. A., Haggitt, R. C., and Bronner, M. P. Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis. Cancer Res., 59: 5148-5153, 1999