Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

Nature

Volumn 410, Issue 6832, 2001, Pages 1111-1116

  Johnson, Leisa ^a,b   Mercer, Kim ^a,c   Greenbaum, Doron ^a,d   Bronson, Roderick T ^e   Crowley, Denise ^a,c   Tuveson, David A ^a,c,f   Jacks, Tyler ^a,c  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b ONYX PHARMACEUTICALS   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e TUFTS UNIVERSITY   (United States)

^f DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE ACTIVATION;

CHEMICAL ACTIVATION; CYTOLOGY; MUTAGENESIS; TUMORS;

GENES;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE ACTIVATION; GENE MUTATION; GENE TARGETING; GENETIC RECOMBINATION; IMMUNOHISTOCHEMISTRY; LUNG CANCER; MOUSE; NONHUMAN; ONCOGENE RAS; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

ALLELES; ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GENE TARGETING; GENES, P53; GENES, RAS; HUMANS; LUNG NEOPLASMS; LYMPHOMA; MICE; MICE, INBRED C57BL; MUTATION; PAPILLOMA; RECOMBINATION, GENETIC; SKIN NEOPLASMS; THYMUS NEOPLASMS;

ANIMALIA; MUS MUSCULUS;

EID: 0035953550     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35074129     Document Type: Article

References (30)

1. ras oncogenes in human cancer: A review
2. The Ras signal transduction pathway
3. Prevalence of ras gene mutations in human colorectal cancers
4. Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma
5. K-ras and p53 gene mutations in pancreatic cancer: Ductal and nonductal tumors progress through different genetic lesions
6. Genetic alterations during colorectal-tumor development
7. Transgenic models of tumor development
8. Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells
9. K-ras is an essential gene in the mouse with partial functional overlap with N-ras
10. Somatic and germ-line reverse mutation rates of the retrovirus-induced dilute coat-color mutation of DBA mice
11. Differential distribution and increased levels of ras proteins during lung development
12. Alveolar epithelial hyperplasia and adenocarcinoma of the lung
13. Atypical adenomatous hyperplasia of the lung. Implications for the pathogenesis of peripheral lung adenocarcinoma
14. Expression of surfactant-associated protein in non-small-cell lung cancer: A discriminant between biologic subsets
15. Aberrant crypts: Putative preneoplastic foci in human colonic mucosa
16. The ras gene family and human carcinogenesis
17. Predisposition to neoplastic transformation caused by gene replacement of H-ras1
18. Genetic changes in skin tumor progression: Correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7
19. Alterations of myc, myb, and rasHa proto-oncogenes in cancers are frequent and show clinical correlation
20. Laser capture microdissection: Molecular analysis of tissue
21. Molecular abnormalities in lung cancer
22. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
23. Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1
24. Tumor spectrum analysis in p53-mutant mice
25. Modeling human lung cancer in mice: Similarities and shortcomings
26. Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression?
27. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
28. Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic
29. Inhibitors of prenyl transferases
30. Inhibition of Ras prenylation: A signaling target for novel anti-cancer drug design