Linking colorectal cancer to Wnt signaling

Cell

Volumn 103, Issue 2, 2000, Pages 311-320

  Bienz, Mariann ^a   Clevers, Hans ^b  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GROWTH; CARCINOGENESIS; CELL ADHESION; CELL PROLIFERATION; COLORECTAL CARCINOMA; MUTATION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0034644526     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)00122-7     Document Type: Review

References (109)

1. β-catenin is a target for the ubiquitin-proteasome pathway
2. Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development
3. Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways
4. NH2-terminal deletion of β-catenin results in stable colocalization of mutant β-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion
5. Functional interaction of β-catenin with the transcription factor LEF-1
6. Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β
7. Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancer
8. A new member of the frizzled family from Drosophila functions as a Wingless receptor
9. APC: The plot thickens
10. Cadherin expression in carcinomas: Role in the formation of cell junctions and the prevention of invasiveness
11. Signaling specificity by Frizzled receptors in Drosophila
12. Nuclear overexpression of the oncoprotein β-catenin in colorectal cancer is localized predominantly at the invasion front
13. β-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer
14. XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development
15. Pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila
16. Wnt signalling: A common theme in animal development
17. The hLEF/TCF-1 alpha HMG protein contains a context-dependent transcriptional activation domain that induces the TCRα enhancer in T cells
18. Drosophila Tcf and Groucho interact to repress Wingless signalling activity
19. The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors
20. Binding to cadherins antagonizes the signaling activity of β-catenin during axis formation in Xenopus
21. Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin
22. Domains of axin involved in protein-protein interactions, wnt pathway inhibition, and intracellular localization
23. Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification
24. Somatic mutations of the APC gene in primary breast cancers
25. De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated β-catenin in skin
26. LEF-1 contains an activation domain that stimulates transcription only in a specific context of factor-binding sites
27. Mutation of the type II transforming growth factor-β receptor is coincident with the transformation of human colon adenomas to malignant carcinomas
28. Identification and characterization of the familial adenomatous polyposis coli gene
29. Tumorigenesis in the multiple intestinal neoplasia mouse: Redundancy of negative regulators and specificity of modifiers
30. Identification and characterization of E-APC, a novel Drosophila homologue of the tumor suppressor APC
31. Intestinal polyposis in mice with a dominant stable mutation of the β-catenin gene
32. Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β
33. A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates β-catanin but its zygotic expression is not essential for the regulation of Armadillo
34. Identification of c-MYC as a target of the APC pathway
35. PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs
36. The p300/CBP acetyltransferases function as transcriptional coactivators of β-catenin in vertebrates
37. Nuclear-cytoplasmic shuttling of APC regulates β-catenin subcellular localisation and turnover
38. Tumor-suppressor gene products in cell contacts: The Cadherin-APC-armadillo connection
39. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3β and β-catenin and promotes GSK-3β-dependent phosphorylation of β-catenin
40. Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
41. Asef, a link between the tumor suppressor APC and G-protein signaling
42. Lessons from hereditary colorectal cancer
43. Identification of FAP locus genes from chromosome 5q21
44. DIX domains of dvl and axin are necessary for protein interactions and their ability to regulate β-catenin stability
45. Axin prevents Wnt-3a-induced accumulation of β-catenin
46. g-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of β-catenin
47. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/- colon carcinoma
48. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
49. Distinct β-catenins mediate adhesion and signalling functions in C. elegans
50. Familial adenomatous polyposis
51. APC mutations are sufficient for the growth of early colorectal adenomas
52. Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin-Tcf signaling
53. β-TrCP is a negative regulator of Wnt/β-catenin signaling pathway and dorsal axis formation in Xenopus embryos
54. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability
55. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein
56. Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis
57. + from all tumor lineages
58. Signal transduction through β-catenin and specification of cell fate during embryogenesis
59. Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells
60. XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos
61. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
62. Cancer gets Mad: DPC4 and other TGFβ pathway genes in human cancer
63. Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
64. Mutations of the APC (Adenomatous polyposis coli) gene
65. Identification of a brain-specific APC homologue APCL, and its interaction with β-catenin
66. The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration
67. Dishevelled and armadillo act in the wingless signalling pathway in Drosophila
68. An in vivo structure-function study of armadillo, the β-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling
69. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene
70. Morphological and molecular processes of polyp formation in Apc(Δ716) knockout mice
71. Wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo
72. The genetic basis of patterned baldness in Drosophila
73. Wnt signaling and cancer
74. Negative regulation of cell growth by TGFβ
75. Stem cells: Attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt
76. LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic
77. Mad-related genes in the human
78. Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos
79. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
80. Synergy between tumor suppressor APC and the β-catenin-Tcf4 target Tcf1
81. The APC tumor suppressor has a nuclear export function
82. Association of the APC gene product with β-catenin
83. Stabilization of β-catenin by genetic defects in melanoma cell lines
84. β-catenin mutations arc more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas
85. Uncoupling cadherin-based adhesion from wingless signalling in Drosophila
86. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
87. Wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate
88. Components of wingless signalling in Drosophila
89. Interaction of axin and dvl-2 proteins regulates dvl-2-stimulated TCF-dependent transcription
90. Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc(1638N), a mouse model for Apc-driven carcinogenesis
91. Apc(1638T): A mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development
92. Association between wild type and mutant APC gene products
93. Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes
94. The transcriptional coactivator CBP interacts with β-catenin to activate gene expression
95. β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
96. Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm
97. Actin-dependent membrane association of an epithelial APC and its effect on junctional Armadillo
98. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
99. Identification of APC2, a homologue of the adenomatous polyposis coli tumor suppressor
100. Hot spots in β-catenin for interactions with LEF-1, conductin and APC
101. Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling
102. Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin
103. Dig protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia
104. β-catenin can be transported into the nucleus in a Ran-unassisted manner
105. GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis
106. Ubiquitous expression of a Drosophila Adenomatous polyposis coli homolog and its localisation in cortical actin caps
107. Decapentaplegic, a target gene of the wingless signalling pathway in the Drosophila midgut
108. A new Drosophila APC homologue associated with adhesive zones of epithelial cells
109. The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation