메뉴 건너뛰기




Volumn 18, Issue 36, 2011, Pages 5655-5665

Amyotrophic lateral sclerosis: From research to therapeutic attempts and therapeutic perspectives

Author keywords

Amyotrophic lateral sclerosis; Animal models; Clinical trials; Excitotoxicity; Gene therapy; Mitochondrial damage; Neuroinflammation; Neurotrophic factors; Oxidative stress; Protein aggregates; Stem cells; Therapy

Indexed keywords

4 PHENYLBUTYRIC ACID; AEOL 10150; ALPHA TOCOPHEROL; ANTIOXIDANT; CELASTROL; CELECOXIB; DEXTROMETHORPHAN; GABAPENTIN; GLATIRAMER; GLUTATHIONE; LAMOTRIGINE; LITHIUM; MINOCYCLINE; NITRIC OXIDE SYNTHASE; RILUZOLE; SELEGILINE; UBIDECARENONE; UNCLASSIFIED DRUG; VALPROIC ACID;

EID: 84055192382     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986711798347289     Document Type: Review
Times cited : (36)

References (227)
  • 1
    • 0020388782 scopus 로고
    • Epidemiology of amyotrophic lateral sclerosis
    • Kurtzke, J.F. Epidemiology of amyotrophic lateral sclerosis. Adv. Neurol., 1982, 36, 281-302.
    • (1982) Adv. Neurol. , vol.36 , pp. 281-302
    • Kurtzke, J.F.1
  • 4
    • 15044342282 scopus 로고    scopus 로고
    • Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players
    • DOI 10.1093/brain/awh373
    • Chio, A.; Benzi, G.; Dossena, M.; Mutani, R.; Mora, G. Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players. Brain, 2005, 128, 472-6. (Pubitemid 40380183)
    • (2005) Brain , vol.128 , Issue.3 , pp. 472-476
    • Chio, A.1    Benzi, G.2    Dossena, M.3    Mutani, R.4    Mora, G.5
  • 5
    • 67649391011 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis
    • Eisen, A.A. and Shaw, P.J. (Eds.) Elsevier, Edinburgh
    • Leigh, P.N. Amyotrophic lateral sclerosis. In: Eisen, A.A. and Shaw, P.J. (Eds.) , Motor Neuron Disorders and Related Diseases. Elsevier, Edinburgh, 2007, pp. 249-78.
    • (2007) Motor Neuron Disorders and Related Diseases , pp. 249-278
    • Leigh, P.N.1
  • 6
    • 22244479388 scopus 로고    scopus 로고
    • Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis
    • DOI 10.1146/annurev.biochem.72.121801.161647
    • Selverstone, V.J.; Doucette, P.A.; Zittin, P.S. Copper-Zinc superoxide dismutase and amyotrophic lateral sclerosis. Annu. Rev. Biochem., 2005, 74, 563-93. (Pubitemid 40995518)
    • (2005) Annual Review of Biochemistry , vol.74 , pp. 563-593
    • Valentine, J.S.1    Doucette, P.A.2    Potter, S.Z.3
  • 7
    • 34248541568 scopus 로고    scopus 로고
    • Familial amyotrophic lateral sclerosis and related motor neuron disorders
    • Emery, A.E.H. (Ed.), John Wiley & Sons, Chichester
    • Al-Chalabi, A.; Leigh, P.N. Familial amyotrophic lateral sclerosis and related motor neuron disorders. In: Emery, A.E.H. (Ed.), Neuromuscular Disorders: Clinical and Molecular Genetics, John Wiley & Sons, Chichester, 2006, pp. 433-67.
    • (2006) Neuromuscular Disorders: Clinical and Molecular Genetics , pp. 433-467
    • Al-Chalabi, A.1    Leigh, P.N.2
  • 9
    • 4043075622 scopus 로고    scopus 로고
    • Lessons from models of SOD1-linked familial ALS
    • DOI 10.1016/j.molmed.2004.06.009, PII S1471491404001595
    • Bendotti, C.; Carri, M.T. Lessons from models of SOD1-linked familial ALS. Trends Mol. Med., 2004, 10, 393-400. (Pubitemid 39061141)
    • (2004) Trends in Molecular Medicine , vol.10 , Issue.8 , pp. 393-400
    • Bendotti, C.1    Carri, M.T.2
  • 10
    • 22244479388 scopus 로고    scopus 로고
    • Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis
    • Valentine, J.S.; Doucette, P.A.; Zittin Potter, S. Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis.Annu. Rev. Biochem., 2005, 74, 563-98.
    • (2005) Annu. Rev. Biochem. , vol.74 , pp. 563-598
    • Valentine, J.S.1    Doucette, P.A.2    Zittin Potter, S.3
  • 11
  • 13
    • 0032704101 scopus 로고    scopus 로고
    • Antioxidants, oxidative stress, and degenerative neurological disorders (44448)
    • Floyd, R.A. Antioxidants, oxidative stress and degenerative neurological disorders. Proc. Soc. Exp. Biol. Med., 1999, 333, 236-45. (Pubitemid 129708638)
    • (1999) Experimental Biology and Medicine , vol.222 , Issue.3 , pp. 236-245
    • Floyd, R.A.1
  • 14
    • 0035749743 scopus 로고    scopus 로고
    • Oxidative stress in neurodegeneration: Mechanisms and therapeutic perspectives
    • Contestabile, A. Oxidative stress in neurodegeneration: mechanisms and therapeutic perspectives. Curr. Topics Med. Chem., 2001, 1, 553-68.
    • (2001) Curr. Topics Med. Chem. , vol.1 , pp. 553-568
    • Contestabile, A.1
  • 16
    • 0036396282 scopus 로고    scopus 로고
    • Reciprocal interactions between microglia and neurons: From survival to neuropathology
    • Polazzi, E.; Contestabile, A. Reciprocal interactions between microglia and neurons: from serviva to neuropathology. Rev. Neurosci., 2002, 13, 221-42. (Pubitemid 35178154)
    • (2002) Reviews in the Neurosciences , vol.13 , Issue.3 , pp. 221-242
    • Polazzi, E.1    Contestabile, A.2
  • 17
    • 0141761414 scopus 로고    scopus 로고
    • Brain nitric oxide and its dual role in neurodegeneration/ neuroprotection: Understanding molecular mechanisms to devise drug approaches
    • DOI 10.2174/0929867033456792
    • Contestabile, A.; Monti, B.; Contestabile, A.; Ciani, E. Brain nitric oxide and its dual role in neurodegeneration/neuroprotection: understanding molecular mechanisms to devise drug approaches. Curr. Med. Chem., 2003, 10, 2147-74. (Pubitemid 37139068)
    • (2003) Current Medicinal Chemistry , vol.10 , Issue.20 , pp. 2147-2174
    • Contestabile, A.1    Monti, B.2    Contestabile, A.3    Ciani, E.4
  • 18
    • 0029805172 scopus 로고    scopus 로고
    • Nitric oxide, superoxide and peroxinitrite: The good, the bad and the ugly
    • Beckman, J.S.; Koppenol, W.H. Nitric oxide, superoxide and peroxinitrite: the good, the bad and the ugly. Am. J. Physiol., 1996, 271, C1424-37.
    • (1996) Am. J. Physiol. , vol.271
    • Beckman, J.S.1    Koppenol, W.H.2
  • 19
    • 0034031598 scopus 로고    scopus 로고
    • Molecular factors underlying selective vulnerability of motor neurons to neurodegeneration in amyotrophic lateral sclerosis
    • Shaw, P.J.; Egget, C.J. Molecular factors underlying selective vulnerability of motor neurons to neurodegeneration in amyotrophic lateral sclerosis. J: Neurol., 2000, 247, 17-27. (Pubitemid 30182083)
    • (2000) Journal of Neurology, Supplement , vol.247 , Issue.1 , pp. 17-27
    • Shaw, P.J.1    Eggett, C.J.2
  • 20
    • 33751003518 scopus 로고    scopus 로고
    • Oxidative stress in ALS: A mechanism of neurodegeneration and a therapeutic target
    • DOI 10.1016/j.bbadis.2006.03.008, PII S0925443906000524
    • Barber, S.C.; Mead, R.J.; Shaw, P.J. Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target. Biochim. Biophys. Acta, 2006, 1762, 1051-67. (Pubitemid 44750575)
    • (2006) Biochimica et Biophysica Acta - Molecular Basis of Disease , vol.1762 , Issue.11-12 , pp. 1051-1067
    • Barber, S.C.1    Mead, R.J.2    Shaw, P.J.3
  • 22
    • 0030825472 scopus 로고    scopus 로고
    • Therapeutic advances in amyotrophic lateral sclerosis
    • DOI 10.1016/S0165-6147(97)01062-6
    • Louvel, E.; Hugon, J.; Doble, A. Therapeutic advances in amyotrophic lateral sclerosis. Trends Pharmacol. Sci., 1997, 18, 196-203. (Pubitemid 27283649)
    • (1997) Trends in Pharmacological Sciences , vol.18 , Issue.6 , pp. 196-203
    • Louvel, E.1    Hugon, J.2    Doble, A.3
  • 24
    • 0034601439 scopus 로고    scopus 로고
    • N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis
    • Andreassen, O. A.; Dedeoglu, A.; Klivenyi, P.; Beal, M. F.; Bush, A. I. Nacetyl-Lcysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis. Neuroreport. 2000, 11, 2491-3. (Pubitemid 30622295)
    • (2000) NeuroReport , vol.11 , Issue.11 , pp. 2491-2493
    • Andreassen, O.A.1    Dedeoglu, A.2    Klivenyi, P.3    Beal, M.F.4    Bush, A.I.5
  • 25
    • 0029040463 scopus 로고
    • Randomized CNTFdouble-blind, controlled trial of acetylcysteine in amyotrophiclateral sclerosis
    • Louwerse, E. S.; Weverling, G. J.; Bossuyt, P. M.; Meyjes, F. E.; de Jong, J. M. Randomized, CNTFdouble-blind, controlled trial of acetylcysteine in amyotrophiclateral sclerosis. Arch. Neurol., 1995, 52, 559-64.
    • (1995) Arch. Neurol. , vol.52 , pp. 559-564
    • Louwerse, E.S.1    Weverling, G.J.2    Bossuyt, P.M.3    Meyjes, F.E.4    De Jong, J.M.5
  • 26
    • 27644448810 scopus 로고    scopus 로고
    • Mitochondrial uncoupling proteins in the CNS: In support of function and survival
    • DOI 10.1038/nrn1767, PII N1767
    • Andrews, Z.B.; Diano, S.; Horvath, T.L. Mitochondrial uncoupling proteins inthe CNS: in support of function and survival. Nat. Rev. Neurosci., 2005, 6, 829-40. (Pubitemid 41568725)
    • (2005) Nature Reviews Neuroscience , vol.6 , Issue.11 , pp. 829-840
    • Andrews, Z.B.1    Diano, S.2    Horvath, T.L.3
  • 27
    • 0028364948 scopus 로고
    • Relations between tocopherol depletion and coenzyme Q during lipid peroxidation in rat liver mitochondria
    • Noack, H.; Kube, U.; Augustin, W. Relations between tocopherol depletion and coenzyme Q during lipid peroxidation in rat liver mitochondria. Free Rad. Res., 1994, 20, 375-86. (Pubitemid 24170147)
    • (1994) Free Radical Research , vol.20 , Issue.6 , pp. 375-386
    • Noack, H.1    Kube, U.2    Augustin, W.3
  • 28
    • 0036525567 scopus 로고    scopus 로고
    • 10 as a possible treatment for neurodegenerative diseases
    • DOI 10.1080/10715760290021315
    • Beal, M.F. Coenzyme Q10 as a possible treatment for neurodegenerative diseases. Free Rad. Res., 2002, 36, 455-60. (Pubitemid 35154095)
    • (2002) Free Radical Research , vol.36 , Issue.4 , pp. 455-460
    • Beal, M.F.1
  • 29
    • 0032555066 scopus 로고    scopus 로고
    • Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects
    • Matthews, R.T.; Yang, L.; Browne, S.; Baik, M.; Beal, M.F. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects, Proc. Natl. Acad. Sci. U. S. A., 1998, 95, 8892-7.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 8892-8897
    • Matthews, R.T.1    Yang, L.2    Browne, S.3    Baik, M.4    Beal, M.F.5
  • 33
    • 24044449234 scopus 로고    scopus 로고
    • Alpha-tocopherol: Roles in prevention and therapy of human disease
    • DOI 10.1016/j.biopha.2005.06.005, PII S0753332205001368
    • Tucker, J.M.; Townsend, D.M. Alpha-tocopherol: roles in prevention and therapy of human disease, Biomed. Pharmacother., 2005, 59, 380-7. (Pubitemid 41219652)
    • (2005) Biomedicine and Pharmacotherapy , vol.59 , Issue.7 , pp. 380-387
    • Tucker, J.M.1    Townsend, D.M.2
  • 34
    • 0035007860 scopus 로고    scopus 로고
    • A double-blind, placeho-controlled randomized clinical trial of α-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis
    • DOI 10.1080/146608201300079364
    • Desnuelle, C.; Dib, M.; Garrel, C.; Favier, A. A double-blind, placebocontrolled randomized clinical trial of alpha-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis. ALS riluzole-tocopherol study group. Amyotroph. Lateral Scler. Other Motor Neuron Disord., 2001, 2, 9-18. (Pubitemid 32472143)
    • (2001) Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders , vol.2 , Issue.1 , pp. 9-18
    • Desnuelle, C.1    Dib, M.2    Garrel, C.3    Favier, A.4
  • 35
    • 17844387640 scopus 로고    scopus 로고
    • High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: Results of a placebo-controlled double-blind study
    • DOI 10.1007/s00702-004-0220-1
    • Graf, M.; Ecker, D.; Horowski, R.; Kramer, B.; Riederer, P.; Gerlach, M.; Hager, C.; Ludolph, A.C. et al. High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study, J. Neur. Transm., 2005, 112, 649-60. (Pubitemid 40591197)
    • (2005) Journal of Neural Transmission , vol.112 , Issue.5 , pp. 649-660
    • Graf, M.1    Ecker, D.2    Horowski, R.3    Kramer, B.4    Riederer, P.5    Gerlach, M.6    Hager, C.7    Ludolph, A.C.8
  • 36
    • 0041196069 scopus 로고    scopus 로고
    • Metalloporphyrin class of therapeutic catalytic antioxidants
    • DOI 10.1016/S0165-6147(99)01336-X, PII S016561479901336X
    • Patel, M.; Day, B.J. Metalloporphyrin class of therapeutic catalytic antioxidants. Trends Pharmacol. Sci., 1999, 20, :359-64. (Pubitemid 29421616)
    • (1999) Trends in Pharmacological Sciences , vol.20 , Issue.9 , pp. 359-364
    • Patel, M.1    Day, B.J.2
  • 37
    • 23244439603 scopus 로고    scopus 로고
    • Manganese porphyrin given at symptom onset markedly extends survival of ALS mice
    • DOI 10.1002/ana.20552
    • Crow, J.P.; Calingasan, N.Y.; Chen, J.; Hill, J.L.; Beal, M.F. Manganese porphyrin given at symptom onset markedly extends survival of ALS mice. Ann. Neurol., 2005, 258-65. (Pubitemid 41098883)
    • (2005) Annals of Neurology , vol.58 , Issue.2 , pp. 258-265
    • Crow, J.P.1    Calingasan, N.Y.2    Chen, J.3    Hill, J.L.4    Beal, M.F.5
  • 38
    • 0031886591 scopus 로고    scopus 로고
    • Selegiline is ineffective in a collaborative double-blind, placebo- controlled trial for treatment of amyotrophic lateral sclerosis
    • DOI 10.1001/archneur.55.1.93
    • Lange, D.J.; Murphy, P.L.; Diamond, B.; Appel, V.; Lai, E.C.; Younger, D.S.; Appel, S.H. Selegiline is ineffective in a collaborative double-blind, placebo-controlled trial for treatment of amyotrophic lateral sclerosis. Arch. Neurol., 1998, 55, 93-6. (Pubitemid 28139110)
    • (1998) Archives of Neurology , vol.55 , Issue.1 , pp. 93-96
    • Lange, D.J.1    Murphy, P.L.2    Diamond, B.3    Appel, V.4    Lai, E.C.5    Younger, D.S.6    Appel, S.H.7
  • 39
    • 0028347114 scopus 로고
    • An open-randomized clinical trial of selegiline in amyotrophic lateral sclerosis
    • Mazzini, L.; Testa, D.; Balzarini, C.; Mora, G. An open randomized clinical trial off selegeline in amyotrophic lateral sclerosis. J. Neurol., 1994, 241, 223-7. (Pubitemid 24072934)
    • (1994) Journal of Neurology , vol.241 , Issue.4 , pp. 223-227
    • Mazzini, L.1    Testa, D.2    Balzarini, C.3    Mora, G.4
  • 40
    • 0036482282 scopus 로고    scopus 로고
    • Chemical and physical properties and potential mechanisms: Melatonin as a broad spectrum antioxidant and free radical scavenger
    • Tan, D.X.; Reiter, R.J.; Manchester, L.C.; Yan, M.T.; El-Sawi, M.; Sainz, R.M.; Mayo, J.C.; Kohen, R. et al. Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger. Curr. Top. Med. Chem., 2002, 2, 181-97.
    • (2002) Curr. Top. Med. Chem. , vol.2 , pp. 181-197
    • Tan, D.X.1    Reiter, R.J.2    Manchester, L.C.3    Yan, M.T.4    El-Sawi, M.5    Sainz, R.M.6    Mayo, J.C.7    Kohen, R.8
  • 41
    • 0031845040 scopus 로고    scopus 로고
    • Oxidative damage in the central nervous system: Protection by melatonin
    • DOI 10.1016/S0301-0082(98)00052-5, PII S0301008298000525
    • Reiter, R.J. Oxidative damage in the central nervous system: protection by melatonin. Prog. Neurobiol., 1998, 56, 359-84. (Pubitemid 28389724)
    • (1998) Progress in Neurobiology , vol.56 , Issue.3 , pp. 359-384
    • Reiter, R.J.1
  • 46
    • 0021024932 scopus 로고
    • Carnitine-metabolism and functions
    • Bremer, J. Carnitine-metabolism and functions. Physiol Rev., 1983, 63,1420-80.
    • (1983) Physiol Rev. , vol.63 , pp. 1420-1480
    • Bremer, J.1
  • 48
    • 32644466209 scopus 로고    scopus 로고
    • L-Carnitine suppresses the onset of neuromuscular degeneration and increases the life span of mice with familial amyotrophic lateral sclerosis
    • DOI 10.1016/j.brainres.2005.11.052, PII S0006899305016483
    • Kira, Y.; Nishikawa, M.; Ochi,, A.; Sato, E.; Inoue, M. L-carnitine suppresses the onset of neuromuscular degeneration and increases the life span of mice with familial amyotrophic lateral sclerosis. Brain Res., 2006, 1070, 206-14. (Pubitemid 43247760)
    • (2006) Brain Research , vol.1070 , Issue.1 , pp. 206-214
    • Kira, Y.1    Nishikawa, M.2    Ochi, A.3    Sato, E.4    Inoue, M.5
  • 49
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and diseases of the nervous system
    • Choi, D. Glutamate neurotoxicity and diseases of the nervous system, Neuron, 1988, 1, 623-34.
    • (1988) Neuron , vol.1 , pp. 623-634
    • Choi, D.1
  • 50
    • 0035693680 scopus 로고    scopus 로고
    • Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death
    • DOI 10.1385/MN:24:1-3:107
    • Sattler, R.; Tymianski, M. Molecular mechanisms of glutamate receptor mediated excitotoxic neuronal cell death, Mol. Neurobiol., 2001, 24, 107-29. (Pubitemid 34066681)
    • (2001) Molecular Neurobiology , vol.24 , Issue.1-3 , pp. 107-129
    • Sattler, R.1    Tymianski, M.2
  • 51
    • 0025343142 scopus 로고
    • 2-Amino-3-(methylamino)-propanoic acid (BMAA) in cycad flour: An unlikely cause of amyotrophic lateral sclerosis and parkinsonism-dementia of Guam
    • Duncan, M. W.; Steele, J. C.; Kopin, I. J.; Markey, S. P. 2-Amino-(methylamino)-propanoic acid in cycad flour: an unlikely cause of amyotrophic lateral sclerosis and parkinsonism-dementia. Neurology, 1990, 40, 767-72. (Pubitemid 20159611)
    • (1990) Neurology , vol.40 , Issue.5 , pp. 767-772
    • Duncan, M.W.1    Steele, J.C.2    Kopin, I.J.3    Markey, S.P.4
  • 52
    • 0022973208 scopus 로고
    • Lathyrism: Evidence for role of the neuroexcitatory aminoacid BOAA
    • Spencer, P. S.; Roy, D.N.; Ludolph, A.; Hugon, J.; Dwivedi, M.P.; Schaumburg, H.H. Lathyrism: evidence for the role of the excitatory aminoacid BOAA. Lancet, 1986, 8506, 1066-7. (Pubitemid 17173955)
    • (1986) Lancet , vol.2 , Issue.8515 , pp. 1066-1067
    • Spencer, P.S.1    Roy, D.N.2    Ludolph, A.3
  • 53
    • 0025298782 scopus 로고
    • Glutamate dysfunction and selective motor neuron degeneration in amyotrophic lateral sclerosis: A hypothesis
    • DOI 10.1002/ana.410280103
    • Plaitakis, A. Glutamate dysfunction and selective motor neuron degeneration in amyotrophic lateral sclerosis: a hypothesis. Ann. Neurol., 1990, 28, 3-8 (Pubitemid 20222144)
    • (1990) Annals of Neurology , vol.28 , Issue.1 , pp. 3-8
    • Plaitakis, A.1
  • 54
    • 0029067210 scopus 로고
    • CSF and plasma amino acid levels in motor neuron disease: Elevation of CSF glutamate in a subset of patients
    • Shaw, P.J.; Forrest, V.; Ince, P.G.; Richardson, J.P.; Wastell, H.J. CSF and plasma amino acid levels in motor neuron disease: elevation of CSF glutamate in a subset of patients. Neurodegeneration, 1995,4, 209-16..
    • (1995) Neurodegeneration , vol.4 , pp. 209-216
    • Shaw, P.J.1    Forrest, V.2    Ince, P.G.3    Richardson, J.P.4    Wastell, H.J.5
  • 55
    • 0037081113 scopus 로고    scopus 로고
    • Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: A reappraisal using a new HPLC method with coulometric detection in a large cohort of patients
    • DOI 10.1016/S0022-510X(01)00661-X, PII S0022510X0100661X
    • Spreux-Varoquaux, O.; Bensimon, G.; Lacomblez, L.; Salachas, F.; Pradat, P.F.; Le Forestier, N.; Marouan, A.; Dib, M.; Meininger, V. Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: a reappraisal using a new HPLC method with coulometric detection in a large cohort of patients. J. Neurol. Sci. 2002, 193, 73-8. (Pubitemid 34098937)
    • (2002) Journal of the Neurological Sciences , vol.193 , Issue.2 , pp. 73-78
    • Spreux-Varoquaux, O.1    Bensimon, G.2    Lacomblez, L.3    Salachas, F.4    Pradat, P.F.5    Le Forestier, N.6    Marouan, A.7    Dib, M.8    Meininger, V.9
  • 56
    • 0029030610 scopus 로고
    • Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
    • Rothstein, J.D.; Van Kammen, M.; Levey, A.I.; Martin, L.J.; Kuncl, R.W. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann. Neurol., 1995, 38, 73-84.
    • (1995) Ann. Neurol. , vol.38 , pp. 73-84
    • Rothstein, J.D.1    Van Kammen, M.2    Levey, A.I.3    Martin, L.J.4    Kuncl, R.W.5
  • 57
    • 0027989815 scopus 로고
    • 3H]kainate
    • DOI 10.1016/0006-8993(94)91613-6
    • Shaw, P.J.; Chinnery, R.M.; Ince, P.G. Non-NMDA receptors in motor neuron disease (MND): a quantitative autoradiographic study in spinal cord and motor cortex using [3H]CNQX and [3H] kainate. Brain Res., 1994, 655, 186-94. (Pubitemid 24263008)
    • (1994) Brain Research , vol.655 , Issue.1-2 , pp. 186-194
    • Shaw, P.J.1    Chinnery, R.M.2    Ince, P.G.3
  • 58
    • 0030927075 scopus 로고    scopus 로고
    • Glutamate, excitotoxicity and amyotrophic lateral sclerosis
    • Shaw, P.J.; Ince, P.G. Glutamate, excitotoxicity and amyotrophic lateral sclerosis. J. Neurol., 1997, 244 (Suppl.), S3-S14. (Pubitemid 27208005)
    • (1997) Journal of Neurology, Supplement , vol.244 , Issue.2
    • Shaw, P.J.1
  • 59
    • 0026565639 scopus 로고
    • The quantitative autoradiographic distribution of [3H]MK-801 binding sites in the normal human brainstem in relation to motor neuron disease
    • Shaw, P.J.; Ince, P.G.; Johnson, M.; Perry, E.K.; Candy, J.M. The quantitative autoradiographic distribution of [3H]MK-801 binding sites in the normal human brainstem in relation to motor neuron disease. Brain Res., 1991, 572, 276-80
    • (1991) Brain Res. , vol.572 , pp. 276-280
    • Shaw, P.J.1    Ince, P.G.2    Johnson, M.3    Perry, E.K.4    Candy, J.M.5
  • 60
    • 0027976187 scopus 로고
    • 3H]MK-801
    • Shaw, P.J.; Ince, P.G.; Matthews, J.N.S.; Johnson, M.; Candy, J.M. Nmethyl-D-aspartate (NMDA) receptors in the spinal cord and motor cortex in motor neurone disease: a quantitative autoradiographic study using [3H]MK-801. Brain Res., 1994, 637, 297-302. (Pubitemid 24061063)
    • (1994) Brain Research , vol.637 , Issue.1-2 , pp. 297-302
    • Shaw, P.J.1    Ince, P.G.2    Matthews, J.N.S.3    Johnson, M.4    Candy, J.M.5
  • 62
    • 0026634153 scopus 로고
    • High sensitivity of glutamate uptake to extracellular free arachidonic acid levels in rat cortical synaptosomes and astrocytes
    • Volterra, A.; Trott, D.; Cassutti, P.; Tromba, C.; Salvaggio, A.; Melcangi, R.C.; Racagni, G. High sensitivity of glutamate uptake to extracellular free arachidonic acid levels in rat cortical synaptosomes and astrocytes. J. Neurochem. 1992, 59, 600-6.
    • (1992) J. Neurochem. , vol.59 , pp. 600-606
    • Volterra, A.1    Trott, D.2    Cassutti, P.3    Tromba, C.4    Salvaggio, A.5    Melcangi, R.C.6    Racagni, G.7
  • 63
    • 0032579962 scopus 로고    scopus 로고
    • Glutamate uptake is decreased tardively in the spinal cord of FALS mice
    • Canton, T.; Pratt, J.; Stutzmann, J.M.; Imperato, A.; Boireau, A. Glutamate uptake is decreased tardively in the spinal cord of FALS mice. NeuroReport, 1998, 9, 775-8. (Pubitemid 28179273)
    • (1998) NeuroReport , vol.9 , Issue.5 , pp. 775-778
    • Canton, T.1    Pratt, J.2    Stutzmann, J.-M.3    Imperato, A.4    Boireau, A.5
  • 64
    • 0031879593 scopus 로고    scopus 로고
    • The expression of the glial glutamate transporter protein EAAT2 in motor neuron disease: An immunohistochemical study
    • DOI 10.1046/j.1460-9568.1998.00273.x
    • Fray, A.E.; Banner. S.J.; Ince, P.G.; Milton, I.D.; Usher, P.A.; Shaw, P.J. Expression of the glial glutamate transporter EAAT2 in motor neurone disease: an immunocytochemical study. Eur. J. Neurosci., 1998, 10, 2481-9 (Pubitemid 28362556)
    • (1998) European Journal of Neuroscience , vol.10 , Issue.8 , pp. 2481-2489
    • Fray, A.E.1    Ince, P.G.2    Banner, S.J.3    Milton, I.D.4    Usher, P.A.5    Cookson, M.R.6    Shaw, P.J.7
  • 65
    • 77953503937 scopus 로고    scopus 로고
    • Riluzole neuroprotection and amyotrophic lateral sclerosis
    • Cheah, B.C.; Vucic, S.; Krishnan, A.V.; Kiernan, M.C. Riluzole, neuroprotection and amyotrophic lateral sclerosis. Curr. Med. Chem., 2010, 17, 1942-9.
    • (2010) Curr. Med. Chem. , vol.17 , pp. 1942-1949
    • Cheah, B.C.1    Vucic, S.2    Krishnan, A.V.3    Kiernan, M.C.4
  • 66
    • 0030050727 scopus 로고    scopus 로고
    • Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis
    • DOI 10.1002/ana.410390203
    • Gurney, M.E.; Cutting, F.B.; Zhai, P.; Doble, A.; Taylor, C.P.; Andrus, P.K.; Hall, E.D. Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Ann. Neurol., 1996, 39, 147-57. (Pubitemid 26071564)
    • (1996) Annals of Neurology , vol.39 , Issue.2 , pp. 147-157
    • Gurney, M.E.1    Cutting, F.B.2    Zhai, P.3    Doble, A.4    Taylor, C.P.5    Andrus, P.K.6    Hall, E.D.7
  • 67
    • 0028097839 scopus 로고
    • A controlled trial of riluzole in amyotrophic lateral sclerosis
    • DOI 10.1056/NEJM199403033300901
    • Bensimon, G.; Lacomblez, L.; Meininger, V. A controlled trial of riluzole in amyotrophic lateral sclerosis. The ALS/Riluzole Study Group.New. Engl. J. Med., 1994, 330, 585-91. (Pubitemid 24065791)
    • (1994) New England Journal of Medicine , vol.330 , Issue.9 , pp. 585-591
    • Bensimon, G.1    Lacomblez, L.2    Meininger, V.3
  • 68
    • 0029977337 scopus 로고    scopus 로고
    • Dose-ranging study of riluzole in amyotrophic lateral sclerosis
    • Lecomblez, L.; Bensimon, G.; Leigh, P.N.; Guillet, P.; Meininger, V. and the Amyotrophic Lateral Sclerosis/Riluzole Study Group II. Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Lancet, 1996, 347, 1425-31. (Pubitemid 26161204)
    • (1996) Lancet , vol.347 , Issue.9013 , pp. 1425-1431
    • Lacomblez, L.1    Bensimon, G.2    Leigh, P.N.3    Guillet, P.4    Meininger, V.5
  • 69
    • 0036257090 scopus 로고    scopus 로고
    • A study of riluzole in the treatment of advanced stage or elderly patients with amyotrophic lateral sclerosis
    • DOI 10.1007/s004150200071
    • Bensimon, G.; Lacomblez, L.; Delumeau, J.C.; Bejuit, R.; Truffinet, P.; Meininger, V. A study of riluzole in the treatment of advanced stage or elderly patients with amyotrophic lateral sclerosis. J. Neurol., 2002, 249, 609-15. (Pubitemid 34516368)
    • (2002) Journal of Neurology , vol.249 , Issue.5 , pp. 609-615
    • Bensimon, G.1    Lacomblez, L.2    Delumeau, J.C.3    Bejuit, R.4    Truffinet, P.5    Meininger, V.6
  • 70
    • 34250208597 scopus 로고    scopus 로고
    • Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)
    • doi:10.1002/14651858.CD001447 pub2
    • Miller, R.G.; Mitchell, J.D.; Lyon, M.; Moore, D.H. Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). Cochrane Database Syst Rev, 2007, CD001447, doi:10.1002/14651858.CD001447. pub2.
    • (2007) Cochrane Database Syst Rev
    • Miller, R.G.1    Mitchell, J.D.2    Lyon, M.3    Moore, D.H.4
  • 72
    • 0037986558 scopus 로고    scopus 로고
    • The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis
    • DOI 10.1016/S0304-3940(03)00314-8
    • Van Damme, P.; Leyssen, M.; Gallewaert, G.; Robberecht, W.; Van Den Bosch, L. The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis. Neurosci. Lett., 2003, 343, 81-4. (Pubitemid 36577521)
    • (2003) Neuroscience Letters , vol.343 , Issue.2 , pp. 81-84
    • Van Damme, P.1    Leyssen, M.2    Callewaert, G.3    Robberecht, W.4    Van Den Bosch, L.5
  • 73
    • 7044231698 scopus 로고    scopus 로고
    • Dementia of Alzheimer's disease and other neurodegenerative disorders - Memantine, a new hope
    • DOI 10.1016/j.phrs.2004.05.005, PII S1043661804001379
    • Sonkusare, S.K.; Kaul, C.L.; Ramarao, P. Dementia of Alzheimer's disease and other neurodegenerative disorders-memantine, a new hope. Pharmacol. Rev., 2005, 51, 1-17. (Pubitemid 39425068)
    • (2005) Pharmacological Research , vol.51 , Issue.1 , pp. 1-17
    • Sonkusare, S.K.1    Kaul, C.L.2    Ramarao, P.3
  • 74
    • 27844479654 scopus 로고    scopus 로고
    • Memantine prolongs survival in an amyotrophic lateral sclerosis mouse model
    • Wang, R.; Zhang, D. Memantine prolongs survival in an amyotrophic lateral sclerosis mouse model. Eur. J. Neurosci., 2006, 22, 2376-80.
    • (2006) Eur. J. Neurosci. , vol.22 , pp. 2376-2380
    • Wang, R.1    Zhang, D.2
  • 75
    • 70449703412 scopus 로고    scopus 로고
    • Oral administration of memantine prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis
    • Joo. I.S.; Hwang, D.H.; Seok, J.I.; Shin, S.K.; Kim, S.U. Oral administration of memantine prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis. J. Clin. Neurol., 2007, 3, 181-6.
    • (2007) J. Clin. Neurol. , vol.3 , pp. 181-186
    • Joo, I.S.1    Hwang, D.H.2    Seok, J.I.3    Shin, S.K.4    Kim, S.U.5
  • 76
    • 77956627546 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of memantine for functional disability in amyotrophic lateral sclerosis
    • de Carvalho, M.; Pinto, S.; Cota, J.; Evangelista, T.; Ohana, B.; Pinto, A. A randomized, placebo-controlled trial of memantine for functional disability in amyotrophic lateral sclerosis. Amyotroph. Lat. Scler., 2010, 11, 456.60.
    • (2010) Amyotroph. Lat. Scler. , vol.11 , pp. 45660
    • De Carvalho, M.1    Pinto, S.2    Cota, J.3    Evangelista, T.4    Ohana, B.5    Pinto, A.6
  • 80
    • 0026605961 scopus 로고
    • Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue
    • Kawamata. T.; Akiyama, H.; Yamada, T.; McGeer, P.L. Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. Am. J. Pathol.. 1992, 140, 691-707.
    • (1992) Am. J. Pathol.. , vol.140 , pp. 691-707
    • Kawamata, T.1    Akiyama, H.2    Yamada, T.3    McGeer, P.L.4
  • 81
    • 0025185079 scopus 로고
    • Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis
    • Troost. D.; Van den Oord. J.J.; Vianney de Jong, J.M.B. Immunohistochemical characteristics of the inflammatory infiltration in amyotrophic lateral sclerosis. Neuropathol. Appl. Neurobiol., 1990, 16, 401-10. (Pubitemid 20334861)
    • (1990) Neuropathology and Applied Neurobiology , vol.16 , Issue.5 , pp. 401-410
    • Troost, D.1    Van Den Oord, J.J.2    Vianney De Jong, J.M.B.3
  • 82
    • 0002913749 scopus 로고
    • Microglia and the process of phagocytosis in gliomas
    • Penfield, W. Microglia and the process of phagocytosis in gliomas. Am. J. Pathol., 1925, 1, 77-89.
    • (1925) Am. J. Pathol. , vol.1 , pp. 77-89
    • Penfield, W.1
  • 83
    • 0023757471 scopus 로고
    • Immune system associated antigens expressed by cells of the human central nervous system
    • Luber-Narod, J.; Rogers, J. Immune system associated antigens expressed by cells of the human central nervous system. Neurosci. Lett., 1988, 94, 265-73.
    • (1988) Neurosci. Lett. , vol.94 , pp. 265-273
    • Luber-Narod, J.1    Rogers, J.2
  • 84
    • 0023782375 scopus 로고
    • Expression of the histocompatibility glycoprotein HLA-DR in neurological disease
    • McGeer, P.L.; Itagaki, S.; McGeer, E.G. Expression of the histocompatibility glycoprotein HLA-DR in neurological disease. Acta Neuropathol., 1988, 76, 550-7.
    • (1988) Acta Neuropathol. , vol.76 , pp. 550-557
    • McGeer, P.L.1    Itagaki, S.2    McGeer, E.G.3
  • 85
    • 0026605961 scopus 로고
    • Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue
    • Kawamata, T.; Akiyama, H.; Yamada, T.; McGeer, P.L. Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. Am. J. Pathol. 1992, 140, 691-707.
    • (1992) Am. J. Pathol. , vol.140 , pp. 691-707
    • Kawamata, T.1    Akiyama, H.2    Yamada, T.3    McGeer, P.L.4
  • 86
    • 41149088328 scopus 로고    scopus 로고
    • T cells in amyotrophic lateral sclerosis
    • DOI 10.1111/j.1468-1331.2008.02065.x
    • Holmoy, T. T cells in amyotrophic lateral sclerosis. Eur. J. Neurol., 2008, 15, 360-6. (Pubitemid 351424091)
    • (2008) European Journal of Neurology , vol.15 , Issue.4 , pp. 360-366
    • Holmoy, T.1
  • 87
    • 33847297129 scopus 로고    scopus 로고
    • Strategies for axonal repair in central nervous system diseases
    • Kerschensteiner, M. Strategies for axonal repair in central nervous system diseases. J. Neurol., 2007, 254, 29-32.
    • (2007) J. Neurol. , vol.254 , pp. 29-32
    • Kerschensteiner, M.1
  • 88
    • 37849004434 scopus 로고    scopus 로고
    • Neurotrophic cross-talk between the nervous and immune systems: Relevance for repair strategies in multiple sclerosis?
    • Hohlfeld, R. Neurotrophic cross-talk between the nervous and immune systems: relevance for repair strategies in multiple sclerosis? J. Neurol. Sci., 2008, 265, 93-6.
    • (2008) J. Neurol. Sci. , vol.265 , pp. 93-96
    • Hohlfeld, R.1
  • 89
    • 77956537707 scopus 로고    scopus 로고
    • Microglia and neuroprotection: From in vitro studies to therapeutic applications
    • Polazzi, E.; Monti, B. Microglia and neuroprotection: from in vitro studies to therapeutic applications. Prog. Neurobiol., 2010, 92, 293-315.
    • (2010) Prog. Neurobiol. , vol.92 , pp. 293-315
    • Polazzi, E.1    Monti, B.2
  • 90
    • 0034176591 scopus 로고    scopus 로고
    • A new concept in neurodegeneration: TNFα is a silencer of survival signals
    • DOI 10.1016/S0166-2236(99)01533-7, PII S0166223699015337
    • Venters, H.D.; Dantzer, R.; Kelley, K.W. A new concept in neurodegeneration: TNFalpha is a silencer of survival signals. Trends Neurosci . 2000, 23, 175-80. (Pubitemid 30151214)
    • (2000) Trends in Neurosciences , vol.23 , Issue.4 , pp. 175-180
    • Venters, H.D.1    Dantzer, R.2    Kelley, K.W.3
  • 91
    • 0034733968 scopus 로고    scopus 로고
    • Circulating levels of tumour necrosis factor-α and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis
    • DOI 10.1016/S0304-3940(00)01177-0, PII S0304394000011770
    • Poloni, M.; Facchetti, D.; Mai, R.; Micheli, A.; Agnoletti, L.; Francolini, G.; Mora, G.; Camana, C. et al. Circulating levels of tumour necrosis factoralpha and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis. Neurosci. Lett. 2000, 287, 211-4. (Pubitemid 30339386)
    • (2000) Neuroscience Letters , vol.287 , Issue.3 , pp. 211-214
    • Poloni, M.1    Facchetti, D.2    Mai, R.3    Micheli, A.4    Agnoletti, L.5    Francolini, G.6    Mora, G.7    Camana, C.8    Mazzini, L.9    Bachetti, T.10
  • 92
    • 0036269810 scopus 로고    scopus 로고
    • Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis
    • DOI 10.1046/j.0022-3042.2001.00683.x
    • Yoshihara, T.; Ishigaki, S.; Yamamoto, M.; Liang, Y.; Niwa, J.; Takeuchi, H.; Doyu, M.; Sobue, G. Differential expression of inflammation-and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis. J. Neurochem., 2002, 80, 158-67. (Pubitemid 34614588)
    • (2002) Journal of Neurochemistry , vol.80 , Issue.1 , pp. 158-167
    • Yoshihara, T.1    Ishigaki, S.2    Yamamoto, M.3    Liang, Y.4    Niwa, J.-I.5    Takeuchi, H.6    Doyu, M.7    Sobue, G.8
  • 94
    • 0035949799 scopus 로고    scopus 로고
    • Marked increase in cyclooxygenase-2 in ALS spinal cord: Implications for therapy
    • Yasojima, K.; Tourtellotte, W.W.; McGeer, E.G.; McGeer, P.L. Marked increase in cyclooxygenase-2 in ALS spinal cord. Neurology, 2001, 57, 952-6. (Pubitemid 32880185)
    • (2001) Neurology , vol.57 , Issue.6 , pp. 952-956
    • Yasojima, K.1    Tourtellotte, W.W.2    McGeer, E.G.3    McGeer, P.L.4
  • 95
    • 0036787810 scopus 로고    scopus 로고
    • Inflammatory processes in amyotrophic lateral sclerosis
    • McGeer, P.L.; McGeer, E.G. Inflammatory processes in amyotrophic lateral sclerosis. Muscle Nerve, 2002, 26, 459-70.
    • (2002) Muscle Nerve , vol.26 , pp. 459-470
    • McGeer, P.L.1    McGeer, E.G.2
  • 98
    • 0033539522 scopus 로고    scopus 로고
    • A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
    • Yrjanheikki, J.; Tikka, T.; Keinanen, R.; Goldsteins, G.; Chan, P.H.; Koistinaho, J. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc. Natl. Acad. Sci. USA, 1999, 96, 13496-500.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 13496-13500
    • Yrjanheikki, J.1    Tikka, T.2    Keinanen, R.3    Goldsteins, G.4    Chan, P.H.5    Koistinaho, J.6
  • 100
    • 0034998271 scopus 로고    scopus 로고
    • Minocycline reduces traumatic brain injury-mediated caspase-1 activation tissue damage and neurological dysfunction
    • Sanchez Mejia, R.O.; Ona, V.O.; Li, M.; Friedlander, R.M. Minocycline reduces traumatic brain injury-mediated caspase-1 activation tissue damage and neurological dysfunction. Neurosurgery, 2001, 48, 1393-99.
    • (2001) Neurosurgery , vol.48 , pp. 1393-1399
    • Sanchez Mejia, R.O.1    Ona, V.O.2    Li, M.3    Friedlander, R.M.4
  • 101
    • 0036406903 scopus 로고    scopus 로고
    • Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis
    • DOI 10.1006/nbdi.2002.0487
    • Kriz, J.; Nguyen, M.D.; Julien J.P. Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis. Neurobiol. Dis., 2002, 10, 268-78. (Pubitemid 35217580)
    • (2002) Neurobiology of Disease , vol.10 , Issue.3 , pp. 268-278
    • Kriz, J.1    Nguyen, M.D.2    Julien, J.-P.3
  • 103
    • 0037067009 scopus 로고    scopus 로고
    • Minocycline delays disease onset and mortality in a transgenic model of ALS
    • Van Den, B.L.; Tilkin, P.; Lemmens, G.; Robberecht, W. Minocycline delays disease onset and mortality in a transgenic model of ALS. Neuroreport, 2002, 13, 1067-70. (Pubitemid 34587742)
    • (2002) NeuroReport , vol.13 , Issue.8 , pp. 1067-1070
    • Van Den Bosch, L.1    Tilkin, P.2    Lemmens, G.3    Robberecht, W.4
  • 104
    • 0037310563 scopus 로고    scopus 로고
    • Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS
    • DOI 10.1002/ana.10476
    • Zhang, W.; Narayanan, M.; Friedlander, R.M. Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS. Ann. Neurol., 2003, 53, 267-70. (Pubitemid 36164012)
    • (2003) Annals of Neurology , vol.53 , Issue.2 , pp. 267-270
    • Zhang, W.1    Narayanan, M.2    Friedlander, R.M.3
  • 105
    • 79953309859 scopus 로고    scopus 로고
    • Treatment with minocycline after disease onset alters astrocyte reactivity and increases microgliosis in SOD1 mutant mice
    • Epub ahead of print
    • Keller, A.F.; Gravel, M.; Kriz, J. Treatment with minocycline after disease onset alters astrocyte reactivity and increases microgliosis in SOD1 mutant mice. Exp. Neurol., 2010, Epub ahead of print.
    • (2010) Exp. Neurol.
    • Keller, A.F.1    Gravel, M.2    Kriz, J.3
  • 111
    • 33744486642 scopus 로고    scopus 로고
    • Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis
    • DOI 10.1159/000090364
    • Kiaei, M.; Kipiani, K.; Petri, S.; Chen, J.; Calingasan, N.Y.; Beal, M.F. Celastrol blocks neuronal cell death and extends life in transgenic mouse model off amyotrophic lateral sclerosis. Neurodegener. Dis., 2005, 2, 246-54. (Pubitemid 43805908)
    • (2005) Neurodegenerative Diseases , vol.2 , Issue.5 , pp. 246-254
    • Kiaei, M.1    Kipiani, K.2    Petri, S.3    Chen, J.4    Calingasan, N.Y.5    Beal, M.F.6
  • 112
    • 0037389393 scopus 로고    scopus 로고
    • A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis
    • Pompl, P.N.; Ho, L.; Bianchi, M.; McManus, T.; Qin, W.; Pasinetti, G.M. A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis. FASEB J., 2003, 17, 725-27.
    • (2003) FASEB J. , vol.17 , pp. 725-727
    • Pompl, P.N.1    Ho, L.2    Bianchi, M.3    McManus, T.4    Qin, W.5    Pasinetti, G.M.6
  • 113
    • 0942287666 scopus 로고    scopus 로고
    • Additive neuroprotective effects of creatine and cyclooxygenase 2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis
    • DOI 10.1046/j.1471-4159.2003.02160.x
    • Klivenyi, P.; Klael, M.; Gardian, G.; Callingsan, N.Y.; Beal, M.F. Additive neuroprotective effects of creatine and cyclooxygenase 2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis. J. Neurochem., 2004, 88, 576-82. (Pubitemid 38140202)
    • (2004) Journal of Neurochemistry , vol.88 , Issue.3 , pp. 576-582
    • Klivenyi, P.1    Kiaei, M.2    Gardian, G.3    Calingasan, N.Y.4    Beal, M.F.5
  • 115
    • 6044274282 scopus 로고    scopus 로고
    • Coxibs and cardiovascular disease
    • FitzGerald, G.A. Coxibs and cardiovascular disease. N. Engl. J. Med., 2004, 351, 1709-11.
    • (2004) N. Engl. J. Med. , vol.351 , pp. 1709-1711
    • Fitzgerald, G.A.1
  • 118
    • 34447632205 scopus 로고    scopus 로고
    • Limited effects of glatiramer acetate in the high-copy number hSOD1-G93A mouse model of ALS
    • DOI 10.1016/j.expneurol.2007.05.007, PII S0014488607002026
    • Habish, H.J.; Schwalenstocker, B.; Danzeisen, R.; Neuhaus, O.; Hartung, H.P.; Ludolph, A. Limited effects of glatiramer acetate in the high copy number hSOD1-G93A mouse model of ALS. Exp. Neurol. ,2007, 206, 288-95. (Pubitemid 47094773)
    • (2007) Experimental Neurology , vol.206 , Issue.2 , pp. 288-295
    • Habisch, H.-J.1    Schwalenstocker, B.2    Danzeisen, R.3    Neuhaus, O.4    Hartung, H.-P.5    Ludolph, A.6
  • 119
    • 33947216452 scopus 로고    scopus 로고
    • Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS
    • DOI 10.1016/j.nbd.2006.12.013, PII S0969996106003184
    • Haenggel, C.; Julien, J.P.; Mosley, R.L.; Perez, N.; Dhar, A.; Gendelman, H.E.; Rothstein, J.D. Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS. Neurobiol Dis., 2007, 26, 146-52. (Pubitemid 46436494)
    • (2007) Neurobiology of Disease , vol.26 , Issue.1 , pp. 146-152
    • Haenggeli, C.1    Julien, J.-P.2    Lee Mosley, R.3    Perez, N.4    Dhar, A.5    Gendelman, H.E.6    Rothstein, J.D.7
  • 121
    • 70449697216 scopus 로고    scopus 로고
    • Glatiramer acetate has no impact on disease progression in ALS at 40 mg/day: A double blind, randomized, multicentre, placebo-controlled trial
    • Meininger V.; Drory, V.E.; Leigh, P.N.; Ludolph, A.; Robberecht, W.; Silani, V. Glatiramer acetate has no impact on disease progression in ALS at 40 mg/day: a double blind, randomized, multicentre, placebo-controlled trial. Amyotroph. Lateral Scler., 2009, 10, 378-83.
    • (2009) Amyotroph. Lateral Scler. , vol.10 , pp. 378-383
    • Meininger, V.1    Drory, V.E.2    Leigh, P.N.3    Ludolph, A.4    Robberecht, W.5    Silani, V.6
  • 122
    • 59149100311 scopus 로고    scopus 로고
    • Neurotrophic modulation of motor neuron development
    • Gould, T.W.; Enomoto, H. Neurotrophic modulation of motor neuron development. Neuroscientist, 2009, 15, 105-16.
    • (2009) Neuroscientist , vol.15 , pp. 105-116
    • Gould, T.W.1    Enomoto, H.2
  • 123
    • 41249086987 scopus 로고    scopus 로고
    • Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis
    • Suzuki, M.; Svendsen, C.N. Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis. Trends Neurosci., 2008, 31, 192-8.
    • (2008) Trends Neurosci. , vol.31 , pp. 192-198
    • Suzuki, M.1    Svendsen, C.N.2
  • 124
    • 0035123371 scopus 로고    scopus 로고
    • Trophic dependencies of rodent corticospinal neurons
    • Giehl, K.M. Trophic dependencies of rodent cortico-spinal neurons. Rev. Neurosci,, 2001, 12, 79-94. (Pubitemid 32182774)
    • (2001) Reviews in the Neurosciences , vol.12 , Issue.1 , pp. 79-94
    • Giehl, K.M.1
  • 125
    • 32644443605 scopus 로고    scopus 로고
    • Relevance of motoneuron specification and programmed cell death in embryos to therapy of ALS
    • DOI 10.1002/bdrc.20051
    • Banks, G.B.; Chamberlain, J.S. Relevance of motoneuron specification and programmed cell death in embryos tp therapy of ALS. Birth Defects Res. C. Embryo Today, 2005, 75, 294-304. (Pubitemid 43244618)
    • (2005) Birth Defects Research Part C - Embryo Today: Reviews , vol.75 , Issue.4 , pp. 294-304
    • Banks, G.B.1    Chamberlain, J.S.2
  • 126
    • 0026749255 scopus 로고
    • Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy
    • Sendtner, M.; Schmalbruch, H.; Stockli, K.A.; Carrol, P.I.; Kreutzberg, G.W.; Thoenen, H. Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy. Nature, 1992, 358, 502-4.
    • (1992) Nature , vol.358 , pp. 502-504
    • Sendtner, M.1    Schmalbruch, H.2    Stockli, K.A.3    Carrol, P.I.4    Kreutzberg, G.W.5    Thoenen, H.6
  • 127
    • 0028027060 scopus 로고
    • Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF
    • Mitsumoto, H.; Ikeda, K.; Klinkosz, B.; Cedarbaum, J.M.; Wong, V.; Lindsay, R.M. Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF. Science, 1994, 265, 1107-10. (Pubitemid 24293081)
    • (1994) Science , vol.265 , Issue.5175 , pp. 1107-1110
    • Mitsumoto, H.1    Ikeda, K.2    Klinkosz, B.3    Cedarbaum, J.M.4    Wong, V.5    Lindsay, R.M.6
  • 128
    • 0141922963 scopus 로고    scopus 로고
    • Increased serum CNTF level in patients with amyotrophic lateral sclerosis
    • Ilzecka, J. Increased serum CNTF level in patients with amyotrophic lateral sclerosis. Eur. Cytokine Netw., 2003, 14, 192-4. (Pubitemid 37249241)
    • (2003) European Cytokine Network , vol.14 , Issue.3 , pp. 192-194
    • Ilzecka, J.1
  • 129
    • 41049090255 scopus 로고    scopus 로고
    • Serum level of CNTF is elevated in patients with amyotrophic lateral sclerosis and correlates with site of disease onset
    • DOI 10.1111/j.1468-1331.2008.02080.x
    • Laaksovirta, H.; Soinila, S.; Hukkanen, V.; Roytta, M.; Soilu-Hanninen, M. Serum level of CNTF is elevated in patients with amyotrophic lateral sclerosis and correlates with site of disease onset. Eur. J. Neurol., 2008, 15, 355-9. (Pubitemid 351422390)
    • (2008) European Journal of Neurology , vol.15 , Issue.4 , pp. 355-359
    • Laaksovirta, H.1    Soinila, S.2    Hukkanen, V.3    Roytta, M.4    Soilu-Hanninen, M.5
  • 130
    • 2442646665 scopus 로고    scopus 로고
    • A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rhCNTF) in amyotrophic lateral sclerosis
    • ALS CNTF Treatment Study Group
    • ALS CNTF Treatment Study Group. A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rhCNTF) in amyotrophic lateral sclerosis. Neurology, 1996, 46, 1244-9.
    • (1996) Neurology , vol.46 , pp. 1244-1249
  • 132
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • DOI 10.1038/nm0603-669
    • Ferrara, N.; Gerber, H.P.; LeCouter, J. The biology of VEGF and its receptors. Nat. Med., 2003, 9, 669-76. (Pubitemid 36749215)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.-P.2    LeCouter, J.3
  • 133
    • 2642585619 scopus 로고    scopus 로고
    • VEGF: Necessary to prevent motoneuron degeneration, sufficient to treat ALS?
    • DOI 10.1016/j.molmed.2004.04.004, PII S1471491404001017
    • Lambrechts, D.; Storkebaum, E.; Carmeliet, P. VEGF: necessary to prevent motoneuron degeneration, sufficient to treat ALS? Trends Mol. Med., 2004, 10, 275-82. (Pubitemid 38725895)
    • (2004) Trends in Molecular Medicine , vol.10 , Issue.6 , pp. 275-282
    • Lambrechts, D.1    Storkebaum, E.2    Carmeliet, P.3
  • 136
  • 138
    • 62549084794 scopus 로고    scopus 로고
    • Insulin-like growth factor-I for the treatment of amyotrophic lateral sclerosis
    • Sakowski, S.A.; Schuyler, A.D.; Feldman, E.L. Insulin-like growth factor-I for the treatment of amyotrophic lateral sclerosis. Amyotroph. Lateral Scler., 2009, 10, 62-73.
    • (2009) Amyotroph. Lateral Scler. , vol.10 , pp. 62-73
    • Sakowski, S.A.1    Schuyler, A.D.2    Feldman, E.L.3
  • 139
    • 0042528664 scopus 로고    scopus 로고
    • Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model
    • DOI 10.1126/science.1086137
    • Kaspar, B.K.; Llado, J.; Sherkat, N.; Rothstein, J.D.; Gage, F.H. Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science, 2003, 301, 839-42. (Pubitemid 36962626)
    • (2003) Science , vol.301 , Issue.5634 , pp. 839-842
    • Kaspar, B.K.1    Llado, J.2    Sherkat, N.3    Rothstein, J.D.4    Gage, F.H.5
  • 142
    • 44949221309 scopus 로고    scopus 로고
    • Recombinant human insulin-like growth factor I (rhIGF-I) for amyotrophic lateral sclerosis/motor neuron disease
    • DOI 10.1002/14651858.CD002064.pub2
    • Mitchell, J.D.; Wokke, J.H.J.; Borasio, G.D. Recombinant human insulinlike growth factor I (rhIGF-I) for amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database Syst Rev, 2007, CD002064, doi: 10.1002/14651858.CD002064.pub2. (Pubitemid 351805357)
    • (2007) Cochrane Database of Systematic Reviews , Issue.4
    • Mitchell, J.D.1    Wokke, J.H.J.2    Borasio, G.D.3
  • 144
    • 0344076149 scopus 로고    scopus 로고
    • A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF study group (Phase III)
    • A controlled trial of recombinant methionyl human BDNF in ALS: the BDNF study group (Phase III). Neurology, 1999, 52, 1427-33.
    • (1999) Neurology , vol.52 , pp. 1427-1433
  • 146
    • 0038147334 scopus 로고    scopus 로고
    • A prospective, randomized, placebo-controlled evaluation of corticoneuronal response to intrathecal BDNF therapy in ALS using magnetic resonance spectroscopy: Feasibility and results
    • DOI 10.1080/14660820301179
    • Kaira, S.; Genge, A.; Arnold, D.L. A prospective randomized placebocontrolled evaluation of corticoneural response to intrathecal BDNF therapy in ALS using magnetic resonance spectroscopy: feasibility and results. Amyotroph. Lateral Scler. OtherMotor Neuron Disord., 2003, 4, 22-6. (Pubitemid 36636909)
    • (2003) Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders , vol.4 , Issue.1 , pp. 22-26
    • Kalra, S.1    Genge, A.2    Arnold, D.L.3
  • 147
    • 33845353404 scopus 로고    scopus 로고
    • Mitochondriopathy in Parkinson disease and amyotrophic lateral sclerosis
    • DOI 10.1097/01.jnen.0000248541.05552.c4, PII 0000507220061200000001
    • Martin, L.J. Mitochondriopathy in Parkinson disease and amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol., 2006, 65, 1103-10. (Pubitemid 44885934)
    • (2006) Journal of Neuropathology and Experimental Neurology , vol.65 , Issue.12 , pp. 1103-1110
    • Martin, L.J.1
  • 149
    • 0033546228 scopus 로고    scopus 로고
    • Ultrastructural change of synapses of Betz cells in patients with amyotrophic lateral sclerosis
    • DOI 10.1016/S0304-3940(99)00374-2, PII S0304394099003742
    • Sasaki, S.; Iwata, M. Ultrastructural changes of synapses of Betz cell in patients with amyotrophic lateral sclerosis. Neurosci. Lett., 268, 1999, 29-32. (Pubitemid 29292537)
    • (1999) Neuroscience Letters , vol.268 , Issue.1 , pp. 29-32
    • Sasaki, S.1    Iwata, M.2
  • 150
    • 0036176613 scopus 로고    scopus 로고
    • Mitochondrial involvement in amyotrophic lateral sclerosis
    • DOI 10.1016/S0197-0186(01)00125-5, PII S0197018601001255
    • Menzies, F.M.; Ince, P.G.; Shaw, P.J. Mitochondrial involvement in amyotrophic lateral sclerosis. Neurochem. Int., 2002, 40, 543-51. (Pubitemid 34159155)
    • (2002) Neurochemistry International , vol.40 , Issue.6 , pp. 543-551
    • Menzies, F.M.1    Ince, P.G.2    Shaw, P.J.3
  • 151
    • 0029053881 scopus 로고
    • An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
    • Wong, P.C.; Pardo, C.A.; Borchelt, D.R.; Lee, M.K.; Copeland, N.G.; Jenkins, N.A.; Sisodia, S.S.; Cleveland, D.W.; Price, D.L. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron, 1995, 14, 1105-16.
    • (1995) Neuron , vol.14 , pp. 1105-1116
    • Wong, P.C.1    Pardo, C.A.2    Borchelt, D.R.3    Lee, M.K.4    Copeland, N.G.5    Jenkins, N.A.6    Sisodia, S.S.7    Cleveland, D.W.8    Price, D.L.9
  • 152
    • 0032079517 scopus 로고    scopus 로고
    • Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1
    • Kong, J.; Xu, Z. Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1. J. Neurosci., 1998, 18, 3241-50. (Pubitemid 28186017)
    • (1998) Journal of Neuroscience , vol.18 , Issue.9 , pp. 3241-3250
    • Kong, J.1    Xu, Z.2
  • 153
    • 33845361630 scopus 로고    scopus 로고
    • Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: Mechanisms of mitochondriopathy and cell death
    • DOI 10.1002/cne.21160
    • Martin, L.J.; Liu, Z.; Chen, K.; Price, A.C.; Pan, Y.; Swaby, J.A.; Golden, W.C. Motor neuron degeneration in amyotrophoc lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death. J. Comp. Neurol., 2007, 500, 20-46. (Pubitemid 44904300)
    • (2007) Journal of Comparative Neurology , vol.500 , Issue.1 , pp. 20-46
    • Martin, L.J.1    Liu, Z.2    Chen, K.3    Price, A.C.4    Yan, P.5    Swaby, J.A.6    Golden, W.C.7
  • 154
    • 0029939471 scopus 로고    scopus 로고
    • A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn- superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in K(m) for hydrogen peroxide
    • DOI 10.1073/pnas.93.12.5709
    • Yim, M.B.; Kang, J-H.; Yim, H-S.; Kwak, H-S.; Chock, P.B.; Stadtman, E.R. A gain-of function of an amyotrophic lateral sclerosis-associated Cu, Zn-superoxide dismutase mutant: an enhancement of free radical formation due to a decrease in Km for hydrogen peroxide. Proc. Natl. Acad. Sci. USA, 1996, 93, 5709-14. (Pubitemid 26190744)
    • (1996) Proceedings of the National Academy of Sciences of the United States of America , vol.93 , Issue.12 , pp. 5709-5714
    • Moon Bin Yim1    Kang, J.-H.2    Yim, H.-S.3    Kwak, H.-S.4    Chock, P.B.5    Stadtman, E.R.6
  • 155
    • 34250177650 scopus 로고    scopus 로고
    • Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation
    • DOI 10.1111/j.1471-4159.2007.04531.x
    • Ezzi, S.A.; Urushitani, M.; Julien, J-P. Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation. J. Neurochem., 2007, 102, 170-8. (Pubitemid 46906269)
    • (2007) Journal of Neurochemistry , vol.102 , Issue.1 , pp. 170-178
    • Ezzi, S.A.1    Urushitani, M.2    Julien, J.-P.3
  • 158
    • 71849092300 scopus 로고
    • The mitochondrial permeability transtion pore: A molecular target for amyotrophic lateral sclerosis therapy
    • Martin, L.J. The mitochondrial permeability transtion pore: a molecular target for amyotrophic lateral sclerosis therapy. Biochim. Biophys. Acta, 2010, 1802, 186-97.
    • (1802) Biochim. Biophys. Acta , vol.2010 , pp. 186-197
    • Martin, L.J.1
  • 159
    • 0036569407 scopus 로고    scopus 로고
    • Reduced creatine kinase activity in transgenic amyotrophic lateral sclerosis mice
    • DOI 10.1016/S0891-5849(02)00784-0, PII S0891584902007840
    • Wendt, S.; Dedeoglu, A.; Speer, O.; Wallimann, T.; Beal, M.F.; Andreassen, O.A. reduced creatine kinase activity in transgenic amyotrophic lateral sclerosis mice. Free Rad. Biol. Med., 2002, 32, 920-6. (Pubitemid 34439263)
    • (2002) Free Radical Biology and Medicine , vol.32 , Issue.9 , pp. 920-926
    • Wendt, S.1    Dedeoglu, A.2    Speer, O.3    Wallimann, T.4    Beal M.Flint5    Andreassen, O.A.6
  • 161
    • 0037507201 scopus 로고    scopus 로고
    • Creatine supplementation and riluzole treatment provide similar beneficial effects in copper, zinc superoxide dismutase (G93A) transgenic mice
    • DOI 10.1016/S0306-4522(03)00212-4
    • Snow, R.J.; Turnbull, J.; da Silva, S.; Jiang, F.; Tarnopolsky, M.A. Creatine supplementation and riluzole treatment provide similar effects in copper, zinc superoxide dismutase (G93A) transgenic mice. Neuroscience, 2003, 119, 661-7. (Pubitemid 36694794)
    • (2003) Neuroscience , vol.119 , Issue.3 , pp. 661-667
    • Snow, R.J.1    Turnbull, J.2    Da Silva, S.3    Jiang, F.4    Tarnopolsky, M.A.5
  • 162
    • 26244434540 scopus 로고    scopus 로고
    • Neurochemical correlates of differential neuroprotection by long-term dietary creatine supplementation
    • DOI 10.1016/j.brainres.2005.07.011, PII S0006899305010504
    • Pena-Altamira, E.; Crochemore, C.; Virgili, M.; Contestabile, A. Neurochemical correlates off differential neuroprotecdtion by long-term dietary creatine supplementation. Brain Res., 2005, 1058, 183-8. (Pubitemid 41416813)
    • (2005) Brain Research , vol.1058 , Issue.1-2 , pp. 183-188
    • Pena-Altamira, E.1    Crochemore, C.2    Virgili, M.3    Contestabile, A.4
  • 163
    • 71249123229 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy of regional brain metabolite markers in FALS mice and the effects of dietary creatine supplementation
    • Choi, J.K.; Kustermann, E.; Dedeoglu, A.; Jenkins, B.G. Magnetic resonance spectroscopy of regional brain metabolite markers in FALS mice and the effects of dietary creatine supplementation. Eur: J. Neurosci,, 2009, 30, 2143-50.
    • (2009) Eur: J. Neurosci , vol.30 , pp. 2143-2150
    • Choi, J.K.1    Kustermann, E.2    Dedeoglu, A.3    Jenkins, B.G.4
  • 165
    • 0033606410 scopus 로고    scopus 로고
    • No benefit of dietary restriction on disease onset or progression in amyotrophic lateral sclerosis Cu/Zn-superoxide dismutase mutant mice
    • DOI 10.1016/S0006-8993(99)01471-7, PII S0006899399014717
    • Pedersen, W.A.; Mattson, M.P. No benefit of dietary restriction on disease onset or progression in amyotrophic lateral sclerosis Cu/Znsuperoxide dismutase mutant mice. Brain Res., 1999, 833, 117-20. (Pubitemid 29336153)
    • (1999) Brain Research , vol.833 , Issue.1 , pp. 117-120
    • Pedersen, W.A.1    Mattson, M.P.2
  • 166
    • 61949103873 scopus 로고    scopus 로고
    • Benefits of caloric restriction on brain aging and related pathological states: Understanding mechanisms to devise novel therapies
    • Contestabile, A. Benefits of caloric restriction on brain aging and related pathological states: understanding mechanisms to devise novel therapies. Curr. Med. Chem., 2009, 16, 350-61.
    • (2009) Curr. Med. Chem. , vol.16 , pp. 350-361
    • Contestabile, A.1
  • 168
    • 0027453352 scopus 로고
    • Antibody to an abnormal protein in amyotrophic lateral sclerosis identifies Lewy body-like inclusions in ALS and Lewy bodies in Parkinson's disease
    • DOI 10.1016/0304-3940(93)90905-Z
    • Mather, K.; Watts, F.Z.; Carroll, M.; Whitehead, P.; Swash, M.; Cairn, N.; Burke, J. Antibody to an abnormal protein in amyotrophic lateral sclerosis identifies Lewy body-like inclusions in ALS and Lewy bodies in Parkinson's disease. Neurosci. Lett., 1993, 160, 13-16. (Pubitemid 23287590)
    • (1993) Neuroscience Letters , vol.160 , Issue.1 , pp. 13-16
    • Mather, K.1    Watts, F.Z.2    Carroll, M.3    Whitehead, P.4    Swash, M.5    Cairn, N.6    Burke, J.7
  • 169
    • 0032544674 scopus 로고    scopus 로고
    • Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1
    • DOI 10.1126/science.281.5384.1851
    • Bruijn, L.J.; Houseweart,M.K.; Kato, S.; Anderson, K.L.; Anderson, S.D.; Ohama, E.; Reaume, A.G.; Scott,R.W.; Cleveland, D.W. Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1. Science, 1998, 281, 1851-4. (Pubitemid 28450505)
    • (1998) Science , vol.281 , Issue.5384 , pp. 1851-1854
    • Bruijn, L.I.1    Houseweart, M.K.2    Kato, S.3    Anderson, K.L.4    Anderson, S.D.5    Ohama, E.6    Reaume, A.G.7    Scott, R.W.8    Cleveland, D.W.9
  • 170
    • 3242703300 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria
    • DOI 10.1016/j.neuron.2004.06.021, PII S0896627304003915
    • Pasinelli, P.; Belford, M.; Lennon, N.; Bacskai, B.; Hyman, B.; Trotti, D.; Brown, R.J. Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria. Neuron, 2004, 43, 19-30. (Pubitemid 38952816)
    • (2004) Neuron , vol.43 , Issue.1 , pp. 19-30
    • Pasinelli, P.1    Belford, M.E.2    Lennon, N.3    Bacskai, B.J.4    Hyman, B.T.5    Trotti, D.6    Brown Jr., R.H.7
  • 171
    • 0035664213 scopus 로고    scopus 로고
    • Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues
    • DOI 10.1006/nbdi.2001.0443
    • Watanabe, M.; Dykes-Hoberg, M.; Culotta,V.C.; Price, D.L.; Wong, P.C.; Rothstein, J.D. Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues. Neurobiol. Dis., 2001, 8, 933-41. (Pubitemid 34017087)
    • (2001) Neurobiology of Disease , vol.8 , Issue.6 , pp. 933-941
    • Watanabe, M.1    Dykes-Hoberg, M.2    Cizewski Culotta, V.3    Price, D.L.4    Wong, P.C.5    Rothstein, J.D.6
  • 172
    • 33645751494 scopus 로고    scopus 로고
    • Determinants of rapid disease progression in ALS
    • DOI 10.1212/01.wnl.0000192717.25980.b5, PII 0000611420051227000006
    • Yamanaka, K.; Cleveland, D.W. Determinants of rapid disease progression in ALS. Neurology , 2005, 65, 1859-60. (Pubitemid 43970102)
    • (2005) Neurology , vol.65 , Issue.12 , pp. 1859-1860
    • Yamanaka, K.1    Cleveland, D.W.2
  • 175
    • 17044403380 scopus 로고    scopus 로고
    • Hsp27 and Hsp70 administered in combination have a potent protective effect against FALS-associated SOD1-mutant-induced cell death in mammalian neuronal cells
    • Patel, Y.J.; Payne Smith, M.D.; de Belleroche, J.; Latchman, D.S. Hsp27 and Hsp70 administered in combination have a potent protective effect against FALS-associated SOD1-mutant-induced cell death in mammalian neuronal cells. Mol. Brain Res., 2005, 134, 256-74.
    • (2005) Mol. Brain Res. , vol.134 , pp. 256-274
    • Patel, Y.J.1    Payne Smith, M.D.2    De Belleroche, J.3    Latchman, D.S.4
  • 176
    • 1942486792 scopus 로고    scopus 로고
    • Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice
    • DOI 10.1038/nm1021
    • Kieran, D.; Kalmar, B.; Dick, J.R.; Riddoch-Contreras, J.; Burnstock, G.; Greensmith, L.; Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice Nat. Med., 2004, 10, 402-5. (Pubitemid 38508519)
    • (2004) Nature Medicine , vol.10 , Issue.4 , pp. 402-405
    • Kieran, D.1    Kalmar, B.2    Dick, J.R.T.3    Riddoch-Contreras, J.4    Burnstock, G.5    Greensmith, L.6
  • 177
    • 53149114499 scopus 로고    scopus 로고
    • Late stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1 mouse model of ALS
    • Kalmar, B.; Novoselov, S.; Gray, A.; Cheetham, M.E.; Margulis, B.; Greensmith, L. Late stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1 mouse model of ALS. J. Neurochem., 2008, 107, 339-50.
    • (2008) J. Neurochem. , vol.107 , pp. 339-350
    • Kalmar, B.1    Novoselov, S.2    Gray, A.3    Cheetham, M.E.4    Margulis, B.5    Greensmith, L.6
  • 179
    • 77954106884 scopus 로고    scopus 로고
    • Arimoclomol a coinducer of heath shock proteins for the potential treatment of amyotrophic lateral sclerosis
    • Phukan, J. Arimoclomol, a coinducer of heath shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs, 2010, 13, 482-96.
    • (2010) IDrugs , vol.13 , pp. 482-496
    • Phukan, J.1
  • 180
    • 1842430715 scopus 로고    scopus 로고
    • A novel action of histone deacetylase inhibitors in a protein aggresome disease model
    • DOI 10.1016/j.cub.2004.03.003, PII S0960982204001721
    • Corcoran, L.J.; Mitchison, T.J.; Liu, Q. A novel action of histone deacetylase inhibitors in a protein aggregosome disease model. Curr. Biol., 2004, 14, 488-92. (Pubitemid 38431283)
    • (2004) Current Biology , vol.14 , Issue.6 , pp. 488-492
    • Corcoran, L.J.1    Mitchison, T.J.2    Liu, Q.3
  • 181
    • 70349096650 scopus 로고    scopus 로고
    • Biochemical molecular and epigenetic mechanisms of valproic acid neuroprotection
    • Monti, B.; Polazzi, E.; Contestabile, A. Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection. Curr. Mol. Pharmacol., 2009, 2, 95-109.
    • (2009) Curr. Mol. Pharmacol. , vol.2 , pp. 95-109
    • Monti, B.1    Polazzi, E.2    Contestabile, A.3
  • 183
    • 34250612194 scopus 로고    scopus 로고
    • Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse model
    • DOI 10.1523/JNEUROSCI.1139-07.2007
    • Rouaux, C.; Panteleeva, I.; René., F.; Gonzalez de Aguilar, J.L.; Dupuis, L.; Menger, Y.; Boutillier, A.L.; Loeffler, J.P. Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse model. J. Neurosci., 2007, 27, 5535-45. (Pubitemid 350021087)
    • (2007) Journal of Neuroscience , vol.27 , Issue.21 , pp. 5535-5545
    • Rouaux, C.1    Panteleeva, I.2    Rene, F.3    De Aguilar, J.-L.G.4    Echaniz-Laguna, A.5    Dupuis, L.6    Menger, Y.7    Boutillier, A.-L.8    Loeffler, J.-P.9
  • 184
    • 65649146078 scopus 로고    scopus 로고
    • Long-term dietary administration of valproic acid does not affect while retinoic acid decreases, the lifespan of G93A mice, a model for amyotrophic lateral sclerosis
    • Crochemore, C.; Virgili, M.; Bonamassa, B.; Canistro, D.; Pena-Altamira, E.; Paolini, M.; Contestabile, A. Long-term dietary administration of valproic acid does not affect while retinoic acid decreases, the lifespan of G93A mice, a model for amyotrophic lateral sclerosis. Muscle Nerve, 2009, 39, 548-52.
    • (2009) Muscle Nerve , vol.39 , pp. 548-552
    • Crochemore, C.1    Virgili, M.2    Bonamassa, B.3    Canistro, D.4    Pena-Altamira, E.5    Paolini, M.6    Contestabile, A.7
  • 186
    • 49249136687 scopus 로고    scopus 로고
    • Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in amyotrophic lateral sclerosis mouse model
    • Feng, H.L.; Leng, Y.; Ma, C.H.; Zhang, J.; Ren, M.; Chuang, D.M. Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in amyotrophic lateral sclerosis mouse model. Neuroscience, 2008, 155, 567-72.
    • (2008) Neuroscience , vol.155 , pp. 567-572
    • Feng, H.L.1    Leng, Y.2    Ma, C.H.3    Zhang, J.4    Ren, M.5    Chuang, D.M.6
  • 187
    • 68149100027 scopus 로고    scopus 로고
    • Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice
    • Pizzasegola, C.; Caron, I.; Baleno, C.; Ronchi, A.; Minola, C.; Carrì, M.T.; Bendotti, C. Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice. Amyotroph. Lateral Scler., 2009, 10, 221-8.
    • (2009) Amyotroph. Lateral Scler. , vol.10 , pp. 221-228
    • Pizzasegola, C.1    Caron, I.2    Baleno, C.3    Ronchi, A.4    Minola, C.5    Carrì, M.T.6    Bendotti, C.7
  • 188
    • 77955873988 scopus 로고    scopus 로고
    • Lithium carbonate in amyotrophic lateral sclerosis: Lack off efficacy in a dose-finding trial
    • Chiò, A.; Borghero, G.; Calvo, A.; Capasso, M.; Caponnetto, C., Corbo, M.; Giannini, F. Lithium carbonate in amyotrophic lateral sclerosis: lack off efficacy in a dose-finding trial. Neurology, 2010, 75, 619-25.
    • (2010) Neurology , vol.75 , pp. 619-625
    • Chiò, A.1    Borghero, G.2    Calvo, A.3    Capasso, M.4    Caponnetto, C.5    Corbo, M.6    Giannini, F.7
  • 193
    • 0028823728 scopus 로고
    • Potential treatment of amyotrophic lateral sclerosis with gabapentin: A hypothesis
    • Welty, D.F.; Schielke, G.P.; Rothstein, J.D. Potential treatment of amyotrophic lateral sclerosis with gabapentin: a hypothesis. Ann. Pharmacother., 1995, 29, 1164-7.
    • (1995) Ann. Pharmacother. , vol.29 , pp. 1164-1167
    • Welty, D.F.1    Schielke, G.P.2    Rothstein, J.D.3
  • 196
    • 0035836669 scopus 로고    scopus 로고
    • ALS defeats gabapentin: Reflections on another failed treatment
    • McDermott, M.P.; Rowland, L.P. ALS defeats gabapentin: reflections on another failed treatment. Neurology, 2001, 56, 826-7. (Pubitemid 32290796)
    • (2001) Neurology , vol.56 , Issue.7 , pp. 826-827
    • McDermott, M.P.1    Rowland, L.P.2
  • 197
    • 33644513130 scopus 로고    scopus 로고
    • Gene-based treatment of motor neuron diseases
    • Federici, T.; Boulis, N.M. Gene-based treatment of motor neuron diseases. Muscle Nerve, 2006, 33, 302-23.
    • (2006) Muscle Nerve , vol.33 , pp. 302-323
    • Federici, T.1    Boulis, N.M.2
  • 198
    • 33750972592 scopus 로고    scopus 로고
    • Gene Therapy for ALS: Progress and prospects
    • DOI 10.1016/j.bbadis.2006.05.003, PII S0925443906000834
    • Azzouz, M. Gene therapy for ALS: progress and prospects. Biochim. Biophys. Acta, 2006, 1762, 1122-7. (Pubitemid 44750578)
    • (2006) Biochimica et Biophysica Acta - Molecular Basis of Disease , vol.1762 , Issue.11-12 , pp. 1122-1127
    • Azzouz, M.1
  • 199
    • 73449091512 scopus 로고    scopus 로고
    • AAV as a gene transfer vector for the treatment of neurological disorders: Novel treatment thoughts for ALS
    • Hester, M.E.; Foust, K.D.; Kaspar, R.W.; Kaspar, B.K. AAV as a gene transfer vector for the treatment of neurological disorders: novel treatment thoughts for ALS. Curr. Gene Ther., 2009, 9, 428-33.
    • (2009) Curr. Gene Ther. , vol.9 , pp. 428-433
    • Hester, M.E.1    Foust, K.D.2    Kaspar, R.W.3    Kaspar, B.K.4
  • 200
    • 21244490473 scopus 로고    scopus 로고
    • Adeno-associated virus (AAV) vectors in the CNS
    • DOI 10.2174/1566523054064995
    • McCown, T. J. Adeno-associated virus (AAV) vectors in the CNS. Curr. Gene Ther. 2005, 5, 333-8. (Pubitemid 40895017)
    • (2005) Current Gene Therapy , vol.5 , Issue.3 , pp. 333-338
    • McCown, T.J.1
  • 201
    • 30844443267 scopus 로고    scopus 로고
    • Lentivirus-mediated gene transfer to the central nervous system: Therapeutic and research applications
    • DOI 10.1089/hum.2006.17.1
    • Wong, L. F.; Goodhead, L.; Prat, C.; Mitrophanous, K. A.; Kingsman, S.M.; Mazarakis, N.D. Lentivirus-mediated gene transfer to the central nervous system: Therapeutic and research applications. Hum. Gene Ther., 2006, 17, 1-9. (Pubitemid 43102718)
    • (2006) Human Gene Therapy , vol.17 , Issue.1 , pp. 1-9
    • Wong, L.-F.1    Goodhead, L.2    Prat, C.3    Mitrophanous, K.A.4    Kingsman, S.M.5    Mazarakis, N.D.6
  • 203
    • 0034701321 scopus 로고    scopus 로고
    • Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2
    • Azzouz, M.; Hottinger, A.; Paterna, J.C.; Zurn, A.D.; Aebischer, P.; Bueler, H. Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2. Hum. Mol. Genet., 2000, 9, 803-11. (Pubitemid 30162765)
    • (2000) Human Molecular Genetics , vol.9 , Issue.5 , pp. 803-811
    • Azzouz, M.1    Hottinger, A.2    Paterna, J.-C.3    Zurn, A.D.4    Aebischer, P.5    Bueler, H.6
  • 204
    • 0037119253 scopus 로고    scopus 로고
    • Effect on motor neuron survival in mutant SOD1 (G93A) transgenic mice by Bcl-2 expression using retrograde axonal transport of adenoviral vectors
    • DOI 10.1016/S0304-3940(02)00454-8, PII S0304394002004548
    • Yamashita, S.; Mita, S.; Kato, S.; Okado, H.; Ohama, E.; Uchino, M. Effect on motor neuron survival in mutant SOD1 (G93A) transgenic mice by Bcl-2 expression using retrograde axonal transport of adenoviral vectors. Neurosci. Lett., 2002, 328, 289-93. (Pubitemid 34876668)
    • (2002) Neuroscience Letters , vol.328 , Issue.3 , pp. 289-293
    • Yamashita, S.1    Mita, S.2    Kato, S.3    Okado, H.4    Ohama, E.5    Uchino, M.6
  • 205
    • 4444378185 scopus 로고    scopus 로고
    • Gene therapy progress and prospects. Downregulating gene expression: The impact of RNA interference
    • DOI 10.1038/sj.gt.3302324
    • Caplen, N.J.; Gene therapy progress and prospects. Downregulating gene expression: the impact of RNA interference. Gene Ther. 2004, 11, 1241-8. (Pubitemid 39173430)
    • (2004) Gene Therapy , vol.11 , Issue.16 , pp. 1241-1248
    • Caplen, N.J.1
  • 206
    • 5444234179 scopus 로고    scopus 로고
    • RNA interference: From model organisms towards therapy for neural and neuromuscular disorders
    • DOI 10.1093/hmg/ddh224
    • Buckingham, S. D.; Esmaeili, B.; Wood, M.,; Sattelle, D. B.; RNA interference: From model organisms towards therapy for neural and neuromuscular disorders. Hum. Mol. Genet., 2004, 13, R275-R288. (Pubitemid 39359913)
    • (2004) Human Molecular Genetics , vol.13 , Issue.REV. ISS. 2
    • Buckingham, S.D.1    Esmaeili, B.2    Wood, M.3    Sattelle, D.B.4
  • 207
    • 33646715590 scopus 로고    scopus 로고
    • Improved targeting of miRNA with antisense oligonucleotides
    • DOI 10.1093/nar/gkl183
    • Davis S.; Lollo, B.; Freier, S.; Esau, C.; Improved targeting of miRNA with antisense oligonucleotides. Nucleic Acids Res., 2006, 34, 2294-304. (Pubitemid 43985667)
    • (2006) Nucleic Acids Research , vol.34 , Issue.8 , pp. 2294-2304
    • Davis, S.1    Lollo, B.2    Freier, S.3    Esau, C.4
  • 210
    • 17644383664 scopus 로고    scopus 로고
    • Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS
    • DOI 10.1038/nm1207
    • Raoul, C.; Abbas-Terki, T.; Bensadoun, J.C.; Guillot, S.; Haase, G.; Szulc, J.; Henderson, C.E.; Aebischer, P. Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS. Nat. Med., 2005, 11, 423-8. (Pubitemid 40562333)
    • (2005) Nature Medicine , vol.11 , Issue.4 , pp. 423-428
    • Raoul, C.1    Abbas-Terki, T.2    Bensadoun, J.-C.3    Guillot, S.4    Haase, G.5    Szulc, J.6    Henderson, C.E.7    Aebischer, P.8
  • 211
    • 47049099443 scopus 로고    scopus 로고
    • Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression
    • Wang, H.; Ghosh, A.; Baigude, H.; Yang, C.S.; Qiu, L.; Xia, X.; Zhou, H.; Rana, T.M.; Xu, Z. Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression. J. Biol. Chem., 2008, 283, 15845-52.
    • (2008) J. Biol. Chem. , vol.283 , pp. 15845-15852
    • Wang, H.1    Ghosh, A.2    Baigude, H.3    Yang, C.S.4    Qiu, L.5    Xia, X.6    Zhou, H.7    Rana, T.M.8    Xu, Z.9
  • 212
    • 34848923327 scopus 로고    scopus 로고
    • Cell therapy and stem cells in animal models of motor neuron disorders
    • DOI 10.1111/j.1460-9568.2007.05780.x
    • Hedlund, E.; Hefferan, M.P.; Marsala, M.; Isacson, O. Cell therapy and stem cells in animal models of motor neuron disorders. Eur. J. Neurosci., 2007, 26, 1721-37. (Pubitemid 47493182)
    • (2007) European Journal of Neuroscience , vol.26 , Issue.7 , pp. 1721-1737
    • Hedlund, E.1    Hefferan, M.P.2    Marsala, M.3    Isacson, O.4
  • 213
    • 41249086987 scopus 로고    scopus 로고
    • Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis
    • Suzuki, M.; Svendsen, C.N. Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis. Trends Neurosci., 2008, 31, 192-8.
    • (2008) Trends Neurosci. , vol.31 , pp. 192-198
    • Suzuki, M.1    Svendsen, C.N.2
  • 214
    • 70449643154 scopus 로고    scopus 로고
    • Advances in cell research for amyotrophic lateral sclerosis
    • Papadeas, S.T.; Maragakis, N.J. Advances in cell research for amyotrophic lateral sclerosis. Curr. Opin. Biotechnol., 2009, 20, 545-51.
    • (2009) Curr. Opin. Biotechnol. , vol.20 , pp. 545-551
    • Papadeas, S.T.1    Maragakis, N.J.2
  • 215
    • 77954333231 scopus 로고    scopus 로고
    • Stem cells in amyotrophic lateral sclerosis: Motor neuron protection or repolacement?
    • Dilani, V.; Calzarossa, C.; Cova, L.; Ticozzi, N. Stem cells in amyotrophic lateral sclerosis: motor neuron protection or repolacement? CNS Neurol. Disord. Drug Targets, 2010, 9, 314-24.
    • (2010) CNS Neurol. Disord. Drug Targets , vol.9 , pp. 314-324
    • Dilani, V.1    Calzarossa, C.2    Cova, L.3    Ticozzi, N.4
  • 216
    • 33947323759 scopus 로고    scopus 로고
    • Lost in translation: Treatment trials in the SOD1 mouse and in human ALS
    • DOI 10.1016/j.nbd.2006.12.015, PII S0969996106003287
    • Benatar, M. Lost in translation: treatment trials in the SOD1 mouse and in human ALS. Neurobiol Dis., 2007, 26, 1-13. (Pubitemid 46437445)
    • (2007) Neurobiology of Disease , vol.26 , Issue.1 , pp. 1-13
    • Benatar, M.1
  • 217
    • 79954608945 scopus 로고    scopus 로고
    • Emerging targets and treatments in amyotrophic lateral sclerosis
    • Zinman, L.; Cudkowicz, M. Emerging targets and treatments in amyotrophic lateral sclerosis. Lancet Neurol., 2011, 10, 481-90.
    • (2011) Lancet Neurol. , vol.10 , pp. 481-490
    • Zinman, L.1    Cudkowicz, M.2
  • 221
    • 80051563478 scopus 로고    scopus 로고
    • Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations
    • Deng, H.X.; Bigio, E.H.; Zhai, H.; Fecto, F.; Ajroud, K.; Shi, Y.; Yan, J.; Mishra, M. et al. Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations. Arch. Neurol., 2011, 68, 1057-61.
    • (2011) Arch. Neurol. , vol.68 , pp. 1057-1061
    • Deng, H.X.1    Bigio, E.H.2    Zhai, H.3    Fecto, F.4    Ajroud, K.5    Shi, Y.6    Yan, J.7    Mishra, M.8
  • 222
    • 79954594082 scopus 로고    scopus 로고
    • Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders
    • Hortobagyi, T.; Troakes, C.; Nishimura, A.L.; Vance, C.; van Swieten, J.C.; Seelaar, H.; Al-Sarrai, S. et al Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders. Acta Neuropathol., 2011, 121, 519-27.S
    • (2011) Acta Neuropathol. , vol.121
    • Hortobagyi, T.1    Troakes, C.2    Nishimura, A.L.3    Vance, C.4    Van Swieten, J.C.5    Seelaar, H.6    Al-Sarrai, S.7
  • 225
    • 79953743204 scopus 로고    scopus 로고
    • FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration
    • Huang, C.; Zhou, H.; Tong, J.; Chen, H.; Liu, Y.J.; Wang, D.; Wei, X.; Xia, X.G. FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. PLoS Genet., 2011, 7: e1002011.
    • (2011) PLoS Genet. , vol.7
    • Huang, C.1    Zhou, H.2    Tong, J.3    Chen, H.4    Liu, Y.J.5    Wang, D.6    Wei, X.7    Xia, X.G.8
  • 227
    • 79957562827 scopus 로고    scopus 로고
    • Ubiquitinated p62 immunopositive cerebellar cortical neuronal inclusions are evident across the spectrum of TDP-43 proteinopathies but are only rarely additionally immunopositivefor phosphorylation-dependent TDP-43
    • King, A.; Maekawa, S.; Bodi, I.; Troakes, C.; Al-Sarrai, S. Ubiquitinated, p62 immunopositive cerebellar cortical neuronal inclusions are evident across the spectrum of TDP-43 proteinopathies but are only rarely additionally immunopositivefor phosphorylation-dependent TDP-43. Neuropathology, 2011, 31, 239-49.
    • (2011) Neuropathology , vol.31 , pp. 239-249
    • King, A.1    Maekawa, S.2    Bodi, I.3    Troakes, C.4    Al-Sarrai, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.