메뉴 건너뛰기




Volumn 10, Issue 6, 2004, Pages 275-282

VEGF: Necessary to prevent motoneuron degeneration, sufficient to treat ALS?

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; COPPER ZINC SUPEROXIDE DISMUTASE; RILUZOLE; VASCULOTROPIN;

EID: 2642585619     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2004.04.004     Document Type: Review
Times cited : (44)

References (66)
  • 1
    • 0027401203 scopus 로고
    • Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
    • Rosen D.R., et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 362:1993;59-62
    • (1993) Nature , vol.362 , pp. 59-62
    • Rosen, D.R.1
  • 2
    • 0028284779 scopus 로고
    • Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
    • Gurney M.E., et al. Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation. Science. 264:1994;1772-1775
    • (1994) Science , vol.264 , pp. 1772-1775
    • Gurney, M.E.1
  • 3
    • 15844393658 scopus 로고    scopus 로고
    • Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury
    • Reaume A.G., et al. Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nat. Genet. 13:1996;43-47
    • (1996) Nat. Genet. , vol.13 , pp. 43-47
    • Reaume, A.G.1
  • 4
    • 0034961104 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis: Pathogenesis
    • Brown R.H. Jr, Robberecht W. Amyotrophic lateral sclerosis: pathogenesis. Semin. Neurol. 21:2001;131-139
    • (2001) Semin. Neurol. , vol.21 , pp. 131-139
    • Brown Jr., R.H.1    Robberecht, W.2
  • 5
    • 0035516124 scopus 로고    scopus 로고
    • From Charcot to Lou Gehrig: Deciphering selective motor neuron death in ALS
    • Cleveland D.W., Rothstein J.D. From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat. Rev. Neurosci. 2:2001;806-819
    • (2001) Nat. Rev. Neurosci. , vol.2 , pp. 806-819
    • Cleveland, D.W.1    Rothstein, J.D.2
  • 6
    • 0035936804 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis. Unfolding the toxicity of the misfolded
    • Julien J.P. Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded. Cell. 104:2001;581-591
    • (2001) Cell , vol.104 , pp. 581-591
    • Julien, J.P.1
  • 8
    • 0042632880 scopus 로고    scopus 로고
    • Genetic epidemiology of amyotrophic lateral sclerosis
    • Majoor-Krakauer D., et al. Genetic epidemiology of amyotrophic lateral sclerosis. Clin. Genet. 63:2003;83-101
    • (2003) Clin. Genet. , vol.63 , pp. 83-101
    • Majoor-Krakauer, D.1
  • 9
    • 0041664059 scopus 로고    scopus 로고
    • Identification of two novel loci for dominantly inherited familial amyotrophic lateral sclerosis
    • Sapp P.C., et al. Identification of two novel loci for dominantly inherited familial amyotrophic lateral sclerosis. Am. J. Hum. Genet. 73:2003;397-403
    • (2003) Am. J. Hum. Genet. , vol.73 , pp. 397-403
    • Sapp, P.C.1
  • 10
    • 0041664055 scopus 로고    scopus 로고
    • Two families with familial amyotrophic lateral sclerosis are linked to a novel locus on chromosome 16q
    • Ruddy D.M., et al. Two families with familial amyotrophic lateral sclerosis are linked to a novel locus on chromosome 16q. Am. J. Hum. Genet. 73:2003;390-396
    • (2003) Am. J. Hum. Genet. , vol.73 , pp. 390-396
    • Ruddy, D.M.1
  • 11
    • 0034517829 scopus 로고    scopus 로고
    • Genetics of amyotrophic lateral sclerosis
    • Robberecht W. Genetics of amyotrophic lateral sclerosis. J. Neurol. 247:2000;2-6
    • (2000) J. Neurol. , vol.247 , pp. 2-6
    • Robberecht, W.1
  • 12
    • 0029977337 scopus 로고    scopus 로고
    • Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis/riluzole study group II
    • Lacomblez L., et al. Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis/riluzole study group II. Lancet. 347:1996;1425-1431
    • (1996) Lancet , vol.347 , pp. 1425-1431
    • Lacomblez, L.1
  • 13
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N., et al. The biology of VEGF and its receptors. Nat. Med. 9:2003;669-676
    • (2003) Nat. Med. , vol.9 , pp. 669-676
    • Ferrara, N.1
  • 14
    • 0343920277 scopus 로고    scopus 로고
    • Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    • Carmeliet P., et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 380:1996;435-439
    • (1996) Nature , vol.380 , pp. 435-439
    • Carmeliet, P.1
  • 15
    • 0030004485 scopus 로고    scopus 로고
    • Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    • Ferrara N., et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature. 380:1996;439-442
    • (1996) Nature , vol.380 , pp. 439-442
    • Ferrara, N.1
  • 16
    • 19244379078 scopus 로고    scopus 로고
    • Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
    • Carmeliet P., et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat. Med. 7:2001;575-583
    • (2001) Nat. Med. , vol.7 , pp. 575-583
    • Carmeliet, P.1
  • 17
    • 0034125067 scopus 로고    scopus 로고
    • Molecular basis of angiogenesis. Role of VEGF and VE-cadherin
    • Carmeliet P., Collen D. Molecular basis of angiogenesis. Role of VEGF and VE-cadherin. Ann. N. Y. Acad. Sci. 902:2000;249-262
    • (2000) Ann. N. Y. Acad. Sci. , vol.902 , pp. 249-262
    • Carmeliet, P.1    Collen, D.2
  • 18
    • 0026593331 scopus 로고
    • Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation
    • Breier G., et al. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development. 114:1992;521-532
    • (1992) Development , vol.114 , pp. 521-532
    • Breier, G.1
  • 19
    • 0029015923 scopus 로고
    • Vascularization of the mouse embryo: A study of flk-1, tek, tie, and vascular endothelial growth factor expression during development
    • Dumont D.J., et al. Vascularization of the mouse embryo: a study of flk-1, tek, tie, and vascular endothelial growth factor expression during development. Dev. Dyn. 203:1995;80-92
    • (1995) Dev. Dyn. , vol.203 , pp. 80-92
    • Dumont, D.J.1
  • 20
    • 0027466849 scopus 로고
    • High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
    • Millauer B., et al. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell. 72:1993;835-846
    • (1993) Cell , vol.72 , pp. 835-846
    • Millauer, B.1
  • 21
    • 0037077134 scopus 로고    scopus 로고
    • Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin
    • Mukouyama Y.S., et al. Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin. Cell. 109:2002;693-705
    • (2002) Cell , vol.109 , pp. 693-705
    • Mukouyama, Y.S.1
  • 22
    • 0141503519 scopus 로고    scopus 로고
    • Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling
    • Haigh J.J., et al. Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling. Dev. Biol. 262:2003;225-241
    • (2003) Dev. Biol. , vol.262 , pp. 225-241
    • Haigh, J.J.1
  • 23
    • 0035873074 scopus 로고    scopus 로고
    • Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor
    • Bagnard D., et al. Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor. J. Neurosci. 21:2001;3332-3341
    • (2001) J. Neurosci. , vol.21 , pp. 3332-3341
    • Bagnard, D.1
  • 24
    • 0041378074 scopus 로고    scopus 로고
    • Blood vessels and nerves: Common signals, pathways and diseases
    • Carmeliet P. Blood vessels and nerves: common signals, pathways and diseases. Nat. Rev. Genet. 4:2003;710-720
    • (2003) Nat. Rev. Genet. , vol.4 , pp. 710-720
    • Carmeliet, P.1
  • 25
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe J.A., et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 16:1996;4604-4613
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1
  • 27
    • 0034978562 scopus 로고    scopus 로고
    • Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
    • Oosthuyse B., et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat. Genet. 28:2001;131-138
    • (2001) Nat. Genet. , vol.28 , pp. 131-138
    • Oosthuyse, B.1
  • 28
    • 0037329890 scopus 로고    scopus 로고
    • VEGF: A modifier of the del22q11 (DiGeorge) syndrome?
    • Stalmans I., et al. VEGF: a modifier of the del22q11 (DiGeorge) syndrome? Nat. Med. 9:2003;173-182
    • (2003) Nat. Med. , vol.9 , pp. 173-182
    • Stalmans, I.1
  • 29
    • 0041903805 scopus 로고    scopus 로고
    • VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
    • Lambrechts D., et al. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat. Genet. 34:2003;383-394
    • (2003) Nat. Genet. , vol.34 , pp. 383-394
    • Lambrechts, D.1
  • 30
    • 0033400238 scopus 로고    scopus 로고
    • Novel polymorphisms in the promoter and 5′ UTR regions of the human vascular endothelial growth factor gene
    • Brogan I.J., et al. Novel polymorphisms in the promoter and 5′ UTR regions of the human vascular endothelial growth factor gene. Hum. Immunol. 60:1999;1245-1249
    • (1999) Hum. Immunol. , vol.60 , pp. 1245-1249
    • Brogan, I.J.1
  • 31
    • 0031869662 scopus 로고    scopus 로고
    • Translation of vascular endothelial growth factor mRNA by internal ribosome entry: Implications for translation under hypoxia
    • Stein I., et al. Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia. Mol. Cell. Biol. 18:1998;3112-3119
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 3112-3119
    • Stein, I.1
  • 32
    • 0032422032 scopus 로고    scopus 로고
    • The vascular endothelial growth factor mRNA contains an internal ribosome entry site
    • Miller D.L., et al. The vascular endothelial growth factor mRNA contains an internal ribosome entry site. FEBS Lett. 434:1998;417-420
    • (1998) FEBS Lett. , vol.434 , pp. 417-420
    • Miller, D.L.1
  • 33
    • 0031741862 scopus 로고    scopus 로고
    • Two independent internal ribosome entry sites are involved in translation initiation of vascular endothelial growth factor mRNA
    • Huez I., et al. Two independent internal ribosome entry sites are involved in translation initiation of vascular endothelial growth factor mRNA. Mol. Cell. Biol. 18:1998;6178-6190
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 6178-6190
    • Huez, I.1
  • 34
    • 0033005239 scopus 로고    scopus 로고
    • The role of the 5′ untranslated region of an mRNA in translation regulation during development
    • van der Velden A.W., Thomas A.A. The role of the 5′ untranslated region of an mRNA in translation regulation during development. Int. J. Biochem. Cell Biol. 31:1999;87-106
    • (1999) Int. J. Biochem. Cell Biol. , vol.31 , pp. 87-106
    • Van Der Velden, A.W.1    Thomas, A.A.2
  • 35
    • 0035208145 scopus 로고    scopus 로고
    • New vascular endothelial growth factor isoform generated by internal ribosome entry site-driven CUG translation initiation
    • Huez I., et al. New vascular endothelial growth factor isoform generated by internal ribosome entry site-driven CUG translation initiation. Mol. Endocrinol. 15:2001;2197-2210
    • (2001) Mol. Endocrinol. , vol.15 , pp. 2197-2210
    • Huez, I.1
  • 36
    • 0034815731 scopus 로고    scopus 로고
    • New isoforms of VEGF are translated from alternative initiation CUG codons located in its 5′UTR
    • Meiron M., et al. New isoforms of VEGF are translated from alternative initiation CUG codons located in its 5′UTR. Biochem. Biophys. Res. Commun. 282:2001;1053-1060
    • (2001) Biochem. Biophys. Res. Commun. , vol.282 , pp. 1053-1060
    • Meiron, M.1
  • 37
    • 0033984420 scopus 로고    scopus 로고
    • Spinal cord ischemia. Development of a model in the mouse
    • Lang-Lazdunski L., et al. Spinal cord ischemia. Development of a model in the mouse. Stroke. 31:2000;208-213
    • (2000) Stroke , vol.31 , pp. 208-213
    • Lang-Lazdunski, L.1
  • 38
    • 0036445830 scopus 로고    scopus 로고
    • Vascular and neuronal effects of VEGF in the nervous system: Implications for neurological disorders
    • Carmeliet P., Storkebaum E. Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders. Semin. Cell Dev. Biol. 13:2002;39-53
    • (2002) Semin. Cell Dev. Biol. , vol.13 , pp. 39-53
    • Carmeliet, P.1    Storkebaum, E.2
  • 39
    • 0026341587 scopus 로고
    • Focal reductions of cerebral blood flow in amyotrophic lateral sclerosis: A [99mTc]-d,l-HMPAO SPECT study
    • Waldemar G., et al. Focal reductions of cerebral blood flow in amyotrophic lateral sclerosis: a [99mTc]-d, l-HMPAO SPECT study. J. Neurol. Sci. 107:1992;19-28
    • (1992) J. Neurol. Sci. , vol.107 , pp. 19-28
    • Waldemar, G.1
  • 40
    • 0030449312 scopus 로고    scopus 로고
    • Local cerebral blood flow in motor neuron disease: Correlation with clinical findings
    • Kobari M., et al. Local cerebral blood flow in motor neuron disease: correlation with clinical findings. J. Neurol. Sci. 144:1996;64-69
    • (1996) J. Neurol. Sci. , vol.144 , pp. 64-69
    • Kobari, M.1
  • 41
    • 0742304302 scopus 로고    scopus 로고
    • VEGF and ALS: The luckiest growth factor?
    • Greenberg D.A., Jin K. VEGF and ALS: the luckiest growth factor? Trends Mol. Med. 10:2004;1-3
    • (2004) Trends Mol. Med. , vol.10 , pp. 1-3
    • Greenberg, D.A.1    Jin, K.2
  • 42
    • 0033565417 scopus 로고    scopus 로고
    • Vascular endothelial growth factor has neurotrophic activity and stimulates axonal outgrowth, enhancing cell survival and Schwann cell proliferation in the peripheral nervous system
    • Sondell M., et al. Vascular endothelial growth factor has neurotrophic activity and stimulates axonal outgrowth, enhancing cell survival and Schwann cell proliferation in the peripheral nervous system. J. Neurosci. 19:1999;5731-5740
    • (1999) J. Neurosci. , vol.19 , pp. 5731-5740
    • Sondell, M.1
  • 43
    • 0035842544 scopus 로고    scopus 로고
    • Caspase-3 and the regulation of hypoxic neuronal death by vascular endothelial growth factor
    • Jin K., et al. Caspase-3 and the regulation of hypoxic neuronal death by vascular endothelial growth factor. Neuroscience. 108:2001;351-358
    • (2001) Neuroscience , vol.108 , pp. 351-358
    • Jin, K.1
  • 44
    • 0346118855 scopus 로고    scopus 로고
    • Neurotrophic effects of vascular endothelial growth factor on organotypic cortical explants and primary cortical neurons
    • Rosenstein J.M., et al. Neurotrophic effects of vascular endothelial growth factor on organotypic cortical explants and primary cortical neurons. J. Neurosci. 23:2003;11036-11044
    • (2003) J. Neurosci. , vol.23 , pp. 11036-11044
    • Rosenstein, J.M.1
  • 45
    • 0036829006 scopus 로고    scopus 로고
    • Neurotrophins: From enthusiastic expectations through sobering experiences to rational therapeutic approaches
    • Thoenen H., Sendtner M. Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches. Nat. Neurosci. 5:(Suppl):2002;1046-1050
    • (2002) Nat. Neurosci. , vol.5 , Issue.SUPPL. , pp. 1046-1050
    • Thoenen, H.1    Sendtner, M.2
  • 46
    • 12144286872 scopus 로고    scopus 로고
    • Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration
    • Sopher B.L., et al. Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration. Neuron. 41:2004;687-699
    • (2004) Neuron , vol.41 , pp. 687-699
    • Sopher, B.L.1
  • 47
    • 0033797255 scopus 로고    scopus 로고
    • VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain
    • Zhang Z.G., et al. VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J. Clin. Invest. 106:2000;829-838
    • (2000) J. Clin. Invest. , vol.106 , pp. 829-838
    • Zhang, Z.G.1
  • 48
    • 0033404669 scopus 로고    scopus 로고
    • VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain
    • van Bruggen N., et al. VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain. J. Clin. Invest. 104:1999;1613-1620
    • (1999) J. Clin. Invest. , vol.104 , pp. 1613-1620
    • Van Bruggen, N.1
  • 49
    • 0041743159 scopus 로고    scopus 로고
    • VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
    • Sun Y., et al. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J. Clin. Invest. 111:2003;1843-1851
    • (2003) J. Clin. Invest. , vol.111 , pp. 1843-1851
    • Sun, Y.1
  • 50
    • 0037266459 scopus 로고    scopus 로고
    • Effects of intraventricular infusion of vascular endothelial growth factor on cerebral blood flow, edema, and infarct volume
    • Harrigan M.R., et al. Effects of intraventricular infusion of vascular endothelial growth factor on cerebral blood flow, edema, and infarct volume. Acta Neurochir. (Wien). 145:2003;49-53
    • (2003) Acta Neurochir. (Wien) , vol.145 , pp. 49-53
    • Harrigan, M.R.1
  • 51
    • 0032910902 scopus 로고    scopus 로고
    • Intraventricular vascular endothelial growth factor antibody increases infarct volume following transient cerebral ischemia
    • Bao W.L., et al. Intraventricular vascular endothelial growth factor antibody increases infarct volume following transient cerebral ischemia. Zhongguo Yao Li Xue Bao. 20:1999;313-318
    • (1999) Zhongguo Yao Li Xue Bao , vol.20 , pp. 313-318
    • Bao, W.L.1
  • 52
    • 0142116387 scopus 로고    scopus 로고
    • VEGF165 therapy exacerbates secondary damage following spinal cord injury
    • Benton R.L., Whittemore S.R. VEGF165 therapy exacerbates secondary damage following spinal cord injury. Neurochem. Res. 28:2003;1693-1703
    • (2003) Neurochem. Res. , vol.28 , pp. 1693-1703
    • Benton, R.L.1    Whittemore, S.R.2
  • 53
    • 0042133340 scopus 로고    scopus 로고
    • Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury
    • Widenfalk J., et al. Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury. Neuroscience. 120:2003;951-960
    • (2003) Neuroscience , vol.120 , pp. 951-960
    • Widenfalk, J.1
  • 54
    • 9044219848 scopus 로고    scopus 로고
    • A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. rhCNTF ALS Study Group
    • Miller R.G., et al. A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. rhCNTF ALS Study Group. Ann. Neurol. 39:1996;256-260
    • (1996) Ann. Neurol. , vol.39 , pp. 256-260
    • Miller, R.G.1
  • 55
    • 0042528664 scopus 로고    scopus 로고
    • Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model
    • Kaspar B.K., et al. Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science. 301:2003;839-842
    • (2003) Science , vol.301 , pp. 839-842
    • Kaspar, B.K.1
  • 56
    • 85047698430 scopus 로고    scopus 로고
    • Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease
    • Wang L., et al. Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease. Gene Ther. 9:2002;381-389
    • (2002) Gene Ther. , vol.9 , pp. 381-389
    • Wang, L.1
  • 57
    • 0034701321 scopus 로고    scopus 로고
    • Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2
    • Azzouz M., et al. Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2. Hum. Mol. Genet. 9:2000;803-811
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 803-811
    • Azzouz, M.1
  • 58
    • 0037221498 scopus 로고    scopus 로고
    • Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport
    • Lu Y.Y., et al. Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport. Neurosci. Res. 45:2003;33-40
    • (2003) Neurosci. Res. , vol.45 , pp. 33-40
    • Lu, Y.Y.1
  • 59
    • 0033761804 scopus 로고    scopus 로고
    • Adeno-associated virus vectors for gene therapy: More pros than cons?
    • Monahan P.E., Samulski R.J. Adeno-associated virus vectors for gene therapy: more pros than cons? Mol. Med. Today. 6:2000;433-440
    • (2000) Mol. Med. Today , vol.6 , pp. 433-440
    • Monahan, P.E.1    Samulski, R.J.2
  • 60
    • 17944378442 scopus 로고    scopus 로고
    • Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes
    • Xu R., et al. Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes. Gene Ther. 8:2001;1323-1332
    • (2001) Gene Ther. , vol.8 , pp. 1323-1332
    • Xu, R.1
  • 61
    • 0032550793 scopus 로고    scopus 로고
    • Selective and rapid uptake of adeno-associated virus type 2 in brain
    • Bartlett J.S., et al. Selective and rapid uptake of adeno-associated virus type 2 in brain. Hum. Gene Ther. 9:1998;1181-1186
    • (1998) Hum. Gene Ther. , vol.9 , pp. 1181-1186
    • Bartlett, J.S.1
  • 62
    • 17144474840 scopus 로고    scopus 로고
    • Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy
    • Schratzberger P., et al. Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy. Nat. Med. 6:2000;405-413
    • (2000) Nat. Med. , vol.6 , pp. 405-413
    • Schratzberger, P.1
  • 63
    • 0034597430 scopus 로고    scopus 로고
    • Vascular niche for adult hippocampal neurogenesis
    • Palmer T.D., et al. Vascular niche for adult hippocampal neurogenesis. J. Comp. Neurol. 425:2000;479-494
    • (2000) J. Comp. Neurol. , vol.425 , pp. 479-494
    • Palmer, T.D.1
  • 64
    • 0037071892 scopus 로고    scopus 로고
    • Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain
    • Louissaint A. Jr, et al. Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain. Neuron. 34:2002;945-960
    • (2002) Neuron , vol.34 , pp. 945-960
    • Louissaint Jr., A.1
  • 66
    • 0032707163 scopus 로고    scopus 로고
    • Population choice in mapping genes for complex diseases
    • Wright A.F., et al. Population choice in mapping genes for complex diseases. Nat. Genet. 23:1999;397-404
    • (1999) Nat. Genet. , vol.23 , pp. 397-404
    • Wright, A.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.