Glutamate AMPA receptors change in motor neurons of SOD1G93A transgenic mice and their inhibition by a noncompetitive antagonist ameliorates the progression of amytrophic lateral sclerosis-like disease

Journal of Neuroscience Research

Volumn 83, Issue 1, 2006, Pages 134-146

  Tortarolo, Massimo ^a   Grignaschi, Giuliano ^a   Calvaresi, Novella ^a   Zennaro, Eleonora ^a   Spaltro, Gabriella ^a   Colovic, Milena ^a   Fracasso, Claudia ^a   Guiso, Giovanna ^a   Elger, Bernd ^b   Schneider, Herbert ^b   Seilheimer, Bernd ^b   Caccia, Silvio ^a   Bendotti, Caterina ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b BAYER PHARMA AG   (Germany)

Author keywords

AMPA antagonist; AMPA receptors; Amyotrophic lateral sclerosis; GluR2; SOD1G93A

Indexed keywords

1 (4 AMINOPHENYL) 3,4 DIHYDRO 4 METHYL 3 METHYLCARBAMOYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; BENZODIAZEPINE DERIVATIVE; COPPER ZINC SUPEROXIDE DISMUTASE; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR 2; UNCLASSIFIED DRUG; ZK 187638;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING COMPETITION; CALCIUM TRANSPORT; CELL SURVIVAL; COMPETITIVE INHIBITION; CONTROLLED STUDY; DISEASE COURSE; DISEASE PREDISPOSITION; EXCITOTOXICITY; GENE MUTATION; GENE OVEREXPRESSION; INHIBITION KINETICS; MEMBRANE PERMEABILITY; MOTONEURON; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BEHAVIOR, ANIMAL; BENZODIAZEPINES; BLOTTING, WESTERN; CHOLINE O-ACETYLTRANSFERASE; DIOXOLES; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LOCOMOTION; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUSCULOSKELETAL EQUILIBRIUM; RECEPTORS, AMPA; RNA, MESSENGER; SUPEROXIDE DISMUTASE; SURVIVAL;

EID: 30344437262     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20715     Document Type: Article

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