메뉴 건너뛰기




Volumn 9, Issue 5, 2000, Pages 803-811

Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; GREEN FLUORESCENT PROTEIN; PROTEIN BCL 2;

EID: 0034701321     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/9.5.803     Document Type: Article
Times cited : (122)

References (54)
  • 1
    • 0026099960 scopus 로고
    • Motor neuron disease (amyotrophic lateral sclerosis)
    • Williams, D.B. and Windebank, A.J. (1991) Motor neuron disease (amyotrophic lateral sclerosis). Mayo Clin. Proc., 66, 54-82.
    • (1991) Mayo Clin. Proc. , vol.66 , pp. 54-82
    • Williams, D.B.1    Windebank, A.J.2
  • 4
    • 0029053881 scopus 로고
    • An adverse property of a familial ALS-linked SODI mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
    • Wong, P., Pardo, C., Borchelt, D., Lee, M., Copeland, N., Jenkins, N., Sisodia, S., Cleveland, D. and Price, D. (1995) An adverse property of a familial ALS-linked SODI mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron, 14, 1105-1116.
    • (1995) Neuron , vol.14 , pp. 1105-1116
    • Wong, P.1    Pardo, C.2    Borchelt, D.3    Lee, M.4    Copeland, N.5    Jenkins, N.6    Sisodia, S.7    Cleveland, D.8    Price, D.9
  • 5
    • 0028888945 scopus 로고
    • Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis
    • Ripps, E., Huntley, G.W., Hof, P.R., Morrison, J.H. and Gordon J.W. (1995) Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc. Natl Acad. Sci. USA, 92, 689-693.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 689-693
    • Ripps, E.1    Huntley, G.W.2    Hof, P.R.3    Morrison, J.H.4    Gordon, J.W.5
  • 6
    • 0029584941 scopus 로고
    • Superoxide dismutase in familial amyotrophic sclerosis: Models for gain of function
    • Brown Jr, R.H. (1995) Superoxide dismutase in familial amyotrophic sclerosis: models for gain of function. Curr. Opin. Neurobiol., 5, 841-846.
    • (1995) Curr. Opin. Neurobiol. , vol.5 , pp. 841-846
    • Brown R.H., Jr.1
  • 7
    • 0031672857 scopus 로고    scopus 로고
    • The genetic and molecular mechanisms of motor neuron disease
    • Wong, P.C., Rothstein, J.D. and Price, D.L. (1998) The genetic and molecular mechanisms of motor neuron disease. Curr. Opin. Neurobiol., 8, 791-799.
    • (1998) Curr. Opin. Neurobiol. , vol.8 , pp. 791-799
    • Wong, P.C.1    Rothstein, J.D.2    Price, D.L.3
  • 8
    • 0033366461 scopus 로고    scopus 로고
    • SODI mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter
    • Trotti, D., Rolfs, A., Danbolt, N., Brown, R.H. and Hediger, M.A. (1999) SODI mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter. Nature Neurosci., 2, 427-433.
    • (1999) Nature Neurosci. , vol.2 , pp. 427-433
    • Trotti, D.1    Rolfs, A.2    Danbolt, N.3    Brown, R.H.4    Hediger, M.A.5
  • 9
    • 0028915976 scopus 로고
    • Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: Studies in yeast and neural cells
    • Rabizadeh, S., Gralla, E., Borchelt, D., Gwinn, R., Valentine, J., Sisodia, S., Wong, P., Lee, M., Hann, H. and Bredesen, D. (1995) Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells. Proc. Natl Acad. Sci. USA, 92, 3024-3028.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 3024-3028
    • Rabizadeh, S.1    Gralla, E.2    Borchelt, D.3    Gwinn, R.4    Valentine, J.5    Sisodia, S.6    Wong, P.7    Lee, M.8    Hann, H.9    Bredesen, D.10
  • 10
    • 0030831352 scopus 로고    scopus 로고
    • Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: Molecular mechanisms of neuronal death and protection
    • Ghadge, G.D., Lee, J.P., Bindokas, V.P., Jordan, J., Ma L., Miller, R.J. and Roos, R.P. (1997) Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection. J. Neurosci., 17, 8756-8766.
    • (1997) J. Neurosci. , vol.17 , pp. 8756-8766
    • Ghadge, G.D.1    Lee, J.P.2    Bindokas, V.P.3    Jordan, J.4    Ma, L.5    Miller, R.J.6    Roos, R.P.7
  • 11
    • 0032430185 scopus 로고    scopus 로고
    • Caspase-1 is activated in neuronal cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase
    • Pasinelli, P., Borchelt, D.R., Houseweart, M.K., Cleveland, D.W. and Brown, R.H. (1998) Caspase-1 is activated in neuronal cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase. Proc. Natl Acad. Sci. USA, 95, 15763-15768.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 15763-15768
    • Pasinelli, P.1    Borchelt, D.R.2    Houseweart, M.K.3    Cleveland, D.W.4    Brown, R.H.5
  • 12
    • 0030756459 scopus 로고    scopus 로고
    • Bcl-2: Prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis
    • Kostic, V., Jackson-Lewis, V., de Bilbao, F., Dubois-Dauphin, M. and Przedborski, S. (1997) Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis. Science, 277, 559-562.
    • (1997) Science , vol.277 , pp. 559-562
    • Kostic, V.1    Jackson-Lewis, V.2    De Bilbao, F.3    Dubois-Dauphin, M.4    Przedborski, S.5
  • 14
    • 0032190675 scopus 로고    scopus 로고
    • Adeno-associated virus expression systems for gene transfer
    • Rabinowitz, J.E. and Samulski, J. (1998) Adeno-associated virus expression systems for gene transfer. Curr. Opin. Biotechnol., 9, 470-475.
    • (1998) Curr. Opin. Biotechnol. , vol.9 , pp. 470-475
    • Rabinowitz, J.E.1    Samulski, J.2
  • 15
    • 0141636324 scopus 로고    scopus 로고
    • Adeno-associated viral vectors for gene transfer and gene therapy
    • Büler, H. (1999) Adeno-associated viral vectors for gene transfer and gene therapy. Biol. Chem., 380, 613-622.
    • (1999) Biol. Chem. , vol.380 , pp. 613-622
    • Büler, H.1
  • 16
    • 0031969428 scopus 로고    scopus 로고
    • Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers
    • Jooss, K., Yang, Y., Fisher, K.J. and Wilson, J.M. (1998) Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers. J. Virol. 72., 4212-4213.
    • (1998) J. Virol. , vol.72 , pp. 4212-4213
    • Jooss, K.1    Yang, Y.2    Fisher, K.J.3    Wilson, J.M.4
  • 17
    • 0031456051 scopus 로고    scopus 로고
    • Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rat
    • Mandel, R.J., Spratt, S.K., Snyder, R.O. and Leff, S.E. (1997) Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rat. Proc. Natl Acad. Sci. USA, 94, 14083-14088.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 14083-14088
    • Mandel, R.J.1    Spratt, S.K.2    Snyder, R.O.3    Leff, S.E.4
  • 18
    • 0031875751 scopus 로고    scopus 로고
    • In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector
    • During, M.J., Samulski, R.J., Elsworth, J.D., Kaplitt, M.G., Leone, P., Xiao, X., Li, J., Freese, A., Taylor, J.R., Roth, R.H. et al. (1998) In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector. Gene Ther., 5, 820-827.
    • (1998) Gene Ther. , vol.5 , pp. 820-827
    • During, M.J.1    Samulski, R.J.2    Elsworth, J.D.3    Kaplitt, M.G.4    Leone, P.5    Xiao, X.6    Li, J.7    Freese, A.8    Taylor, J.R.9    Roth, R.H.10
  • 20
    • 0030953519 scopus 로고    scopus 로고
    • Gene therapy of murine motor neuron disease using adenoviral vectors for neurotrophic factors
    • Haase, G., Kennel, P., Pettmann, B., Vigne, E., Akli, S., Revah, F., Schmalbruch, H. and Kahn, A. (1997) Gene therapy of murine motor neuron disease using adenoviral vectors for neurotrophic factors. Nature Med., 3, 429-436.
    • (1997) Nature Med. , vol.3 , pp. 429-436
    • Haase, G.1    Kennel, P.2    Pettmann, B.3    Vigne, E.4    Akli, S.5    Revah, F.6    Schmalbruch, H.7    Kahn, A.8
  • 21
    • 0031014887 scopus 로고    scopus 로고
    • Efficient transduction of green fluorescent protein in spinal cord neurons using adeno-associated virus vectors containing cell type-specific promoters
    • Peel, A.L., Zolotukhin, S., Schrimsher, G.W., Muzyczka, N. and Reier, P.J. (1997) Efficient transduction of green fluorescent protein in spinal cord neurons using adeno-associated virus vectors containing cell type-specific promoters. Gene Ther., 4, 16-24.
    • (1997) Gene Ther. , vol.4 , pp. 16-24
    • Peel, A.L.1    Zolotukhin, S.2    Schrimsher, G.W.3    Muzyczka, N.4    Reier, P.J.5
  • 22
    • 0028169741 scopus 로고
    • Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain
    • Kaplitt, M.G., Leone, P., Samulski, R.J., Xiao, X., Praff, D.W., O'Malley, K.L. and During, M.J. (1994) Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nature Genet., 8, 148-154.
    • (1994) Nature Genet. , vol.8 , pp. 148-154
    • Kaplitt, M.G.1    Leone, P.2    Samulski, R.J.3    Xiao, X.4    Praff, D.W.5    O'Malley, K.L.6    During, M.J.7
  • 23
    • 0029787513 scopus 로고    scopus 로고
    • Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons
    • Mu, X., He, J., Anderson, D.W., Trojanowski, J.Q. and Springer, J.E. (1996) Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons. Ann. Neurol., 40, 379-386.
    • (1996) Ann. Neurol. , vol.40 , pp. 379-386
    • Mu, X.1    He, J.2    Anderson, D.W.3    Trojanowski, J.Q.4    Springer, J.E.5
  • 26
    • 0033258120 scopus 로고    scopus 로고
    • Bcl-2 proteins: Regulators of apoptosis or of mitochondrial homeostasis?
    • Vander Heiden, M.G. and Thompson, C.B. (1999) Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? Nature Cell Biol., 1, E209-E216.
    • (1999) Nature Cell Biol. , vol.1
    • Vander Heiden, M.G.1    Thompson, C.B.2
  • 28
  • 30
  • 33
    • 0031784348 scopus 로고    scopus 로고
    • Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis
    • Andrus, P.K., Fleck, T.J., Gurney, M.E. and Hall, E.D. (1998) Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis. J. Neurochem., 71, 2041-2048.
    • (1998) J. Neurochem. , vol.71 , pp. 2041-2048
    • Andrus, P.K.1    Fleck, T.J.2    Gurney, M.E.3    Hall, E.D.4
  • 34
    • 0028018477 scopus 로고
    • Oxidative stress and mitochondrial dysfunction in neurodegeneration. Biochem
    • Tritschler, H.J., Packer, L. and Medori, R. (1994) Oxidative stress and mitochondrial dysfunction in neurodegeneration. Biochem. Mol. Biol. Int., 34, 169-181.
    • (1994) Mol. Biol. Int. , vol.34 , pp. 169-181
    • Tritschler, H.J.1    Packer, L.2    Medori, R.3
  • 35
    • 0032504622 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in neurodegenerative disorders
    • Schapira, A.H. (1998) Mitochondrial dysfunction in neurodegenerative disorders. Biochem. Biophys. Acta, 1366, 225-233.
    • (1998) Biochem. Biophys. Acta , vol.1366 , pp. 225-233
    • Schapira, A.H.1
  • 36
    • 0030700736 scopus 로고    scopus 로고
    • Changes in mitochondrial membrane potential during oxidative stress-induced apoptosis in PC12 cells
    • Satoh, T., Enokido, Y., Aoshima, H., Uchiyama, Y. and Hatanaka, H. (1997) Changes in mitochondrial membrane potential during oxidative stress-induced apoptosis in PC12 cells. J. Neurosci. Res., 50, 413-420.
    • (1997) J. Neurosci. Res. , vol.50 , pp. 413-420
    • Satoh, T.1    Enokido, Y.2    Aoshima, H.3    Uchiyama, Y.4    Hatanaka, H.5
  • 37
    • 0031962324 scopus 로고    scopus 로고
    • Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid beta- Peptide
    • Bruce-Keller, A.J., Begley, J.G., Fu, W., Butterfield, D.A., Bredesen, D.E., Hutchins, J.B., Hensley, K. and Mattson, M.P. (1998) Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid beta- peptide. J. Neurochem., 70, 31-39.
    • (1998) J. Neurochem. , vol.70 , pp. 31-39
    • Bruce-Keller, A.J.1    Begley, J.G.2    Fu, W.3    Butterfield, D.A.4    Bredesen, D.E.5    Hutchins, J.B.6    Hensley, K.7    Mattson, M.P.8
  • 38
    • 0029890685 scopus 로고    scopus 로고
    • The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease
    • Mourelatos, Z., Gonatas, N.K., Stieber, A., Gurney, M.E. and Dal Canto, M.C. (1996) The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease. Proc. Natl Acad. Sci. USA, 93, 5472-5477.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 5472-5477
    • Mourelatos, Z.1    Gonatas, N.K.2    Stieber, A.3    Gurney, M.E.4    Dal Canto, M.C.5
  • 39
    • 0032079517 scopus 로고    scopus 로고
    • Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SODI
    • Kong, J. and Xu, Z. (1998) Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SODI. J. Neurosci., 18, 3241-3250.
    • (1998) J. Neurosci. , vol.18 , pp. 3241-3250
    • Kong, J.1    Xu, Z.2
  • 41
  • 45
    • 0030050727 scopus 로고    scopus 로고
    • Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis
    • Gurney, M., Cutting, F.B., Zhai, P., Doble, A., Taylor, C., Andrus, P.K. and Hall, E.D. (1996) Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Ann. Neurol., 39, 147-157.
    • (1996) Ann. Neurol. , vol.39 , pp. 147-157
    • Gurney, M.1    Cutting, F.B.2    Zhai, P.3    Doble, A.4    Taylor, C.5    Andrus, P.K.6    Hall, E.D.7
  • 46
    • 0032827346 scopus 로고    scopus 로고
    • Therapeutic benefits of putrescine-modified catalase in a transgenic mouse model of familial amyotrophic lateral sclerosis
    • Reinholz, M.M., Merkle, C.M. and Poduslo, J.F. (1999) Therapeutic benefits of putrescine-modified catalase in a transgenic mouse model of familial amyotrophic lateral sclerosis. Exp. Neurol., 159, 204-216.
    • (1999) Exp. Neurol. , vol.159 , pp. 204-216
    • Reinholz, M.M.1    Merkle, C.M.2    Poduslo, J.F.3
  • 47
    • 0033597218 scopus 로고    scopus 로고
    • Benefit of a combined treatment with trientine and ascorbate in familial amyotrophic lateral sclerosis model mice
    • Nagano, S., Ogawa, Y., Yanagihara, T. and Sakoda, S. (1999) Benefit of a combined treatment with trientine and ascorbate in familial amyotrophic lateral sclerosis model mice. Neurosci. Lett., 265, 159-162.
    • (1999) Neurosci. Lett. , vol.265 , pp. 159-162
    • Nagano, S.1    Ogawa, Y.2    Yanagihara, T.3    Sakoda, S.4
  • 50
    • 0033587480 scopus 로고    scopus 로고
    • Intramuscular grafts of myoblasts genetically modified to secrete glial cell line-derived neurotrophic factor prevent motoneuron loss and disease progression in a mouse model of familial amyotrophic lateral sclerosis
    • Mohajeri, M.H., Figlewicz, D.A. and Bonn, M.C. (1999) Intramuscular grafts of myoblasts genetically modified to secrete glial cell line-derived neurotrophic factor prevent motoneuron loss and disease progression in a mouse model of familial amyotrophic lateral sclerosis. Hum. Gene Ther., 10, 1853-1866.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 1853-1866
    • Mohajeri, M.H.1    Figlewicz, D.A.2    Bonn, M.C.3
  • 51
    • 0024311525 scopus 로고
    • Helper-free stocks of recombinant adeno-associated viruses: Normal integration does not require viral gene expression
    • Samulski, R.J., Chang, L.S. and Shenk, T. (1989) Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression. J. Virol., 63, 3822-3828.
    • (1989) J. Virol. , vol.63 , pp. 3822-3828
    • Samulski, R.J.1    Chang, L.S.2    Shenk, T.3
  • 52
    • 0002988871 scopus 로고    scopus 로고
    • Production of recombinant adeno-associated viral vectors
    • Dracopoli, N.C., Haines, J.L., Korf, B.R., Moir, D.T., Morton, C.C., Seidman, C.E., Seidman, J.G. and Smith D.R. (eds), John Wiley & Sons, USA
    • Snyder, R.O., Xiao, X. and Samulski, R.J. (1997) Production of recombinant adeno-associated viral vectors. In Dracopoli, N.C., Haines, J.L., Korf, B.R., Moir, D.T., Morton, C.C., Seidman, C.E., Seidman, J.G. and Smith D.R. (eds), Current Protocols in Human Genetics. John Wiley & Sons, USA.
    • (1997) Current Protocols in Human Genetics
    • Snyder, R.O.1    Xiao, X.2    Samulski, R.J.3
  • 53
    • 0001153788 scopus 로고
    • Analysis of epitopes on choline acetyltransferase (ChAT) using monoclonal antibodies (Mabs)
    • Cozzari, C., Howard, J. and Hartman, B. (1990) Analysis of epitopes on choline acetyltransferase (ChAT) using monoclonal antibodies (Mabs). Soc. Neurosci. Abstr., 16, 200.
    • (1990) Soc. Neurosci. Abstr. , vol.16 , pp. 200
    • Cozzari, C.1    Howard, J.2    Hartman, B.3
  • 54
    • 0027481440 scopus 로고
    • Diversity among reactive astrocytes: Proximal reactive astrocytes in lacerated spinal cord preferentially react with monoclonal antibody J1-31
    • Malhotra, S.K., Svensson, M., Aldskogius, H., Bhatnagar, R., Das, G.D. and Shnitka, T.K. (1993) Diversity among reactive astrocytes: proximal reactive astrocytes in lacerated spinal cord preferentially react with monoclonal antibody J1-31. Brain Res. Bull., 30, 395-404.
    • (1993) Brain Res. Bull. , vol.30 , pp. 395-404
    • Malhotra, S.K.1    Svensson, M.2    Aldskogius, H.3    Bhatnagar, R.4    Das, G.D.5    Shnitka, T.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.