Antioxidants, oxidative stress, and degenerative neurological disorders

Proceedings of the Society for Experimental Biology and Medicine

Volumn 222, Issue 3, 1999, Pages 236-245

  Floyd, Robert A ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTIOXIDANT; HYDROGEN PEROXIDE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; N TERT BUTYL ALPHA PHENYLNITRONE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; SYNAPTOPHYSIN;

AGING; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; BRAIN PROTECTION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; HUMAN; HUMAN TISSUE; INFLAMMATION; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RAT;

ANIMALIA;

EID: 0032704101     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1373.1999.d01-140.x     Document Type: Conference Paper

References (44)

1. Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 59:527-605, 1979.
2. Floyd RA, Carney JM. Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann Neurol 32:S22-S27, 1992.
3. Zaleska MM, Floyd RA. Regional lipid peroxidation in rat brain in vitro: Possible role of endogenous iron. Neurochem Res 10:397-410, 1985.
4. Marklund SL, Westman NG, Lundgren E, Roos G. Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues. Cancer Res 42:1955-1961, 1982.
5. Zaleska MM, Nagy K, Floyd RA. Iron-induced lipid peroxidation and inhibition of dopamine synthesis in striatum synaptosomes. Neurochemistry 14:597-605, 1989.
6. Hensley K, Pye QN, Maidt ML, Stewart CA, Robinson KA, Jaffrey F, Floyd RA. Interaction of α-phenyl-N-tert-butyl nitrone and alternative electron acceptors with complex I indicates a substrate reduction site upstream from the rotenone binding site. J Neurochem 71:2549-2557, 1998.
7. Shoulson I, Fahn S, Kieburtz K, Lang A, Langston JW, Olanow CW. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med 328:176-183, 1993.
8. Floyd RA, Watson JJ, Wong PK. Sensitive assay of hydroxyl free radical formation utilizing high-pressure liquid chromatography with electrochemical detection of phenol and salicylate hydroxylation products. J Biochem Biophys Methods 10:221-235, 1984.
9. Floyd RA, Henderson R, Watson JJ, Wong PK. Use of salicylate with high-pressure liquid chromatography and electrochemical detection (LCED) as a sensitive measure of hydroyxl free radicals in adriamycin-treated rats. Free Radic Biol Med 2:13-18, 1986.
10. Cao W, Carney JM, Duchon A, Floyd RA, Chevion M. Oxygen free radical involvement in ischemia and reperfusion injury to brain. Neurosci Lett 88:233-238, 1988.
11. Floyd RA, West MS, Eneff KL, Schneider JE, Wong PK, Tingey DT, Hogsett WE. Conditions influencing yield and analysis of 8-hydroxy-2'-deoxyguanosine in oxidatively damaged DNA. Anal Biochem 188:155-158, 1990.
12. Carney JM, Tatsuno T, Floyd RA. The role of oxygen radicals in ischemic brain damage: Free radical production, protein oxidation, and tissue dysfunction. In: Krieglstein J, Oberpichler-Schwenk H, Eds. Pharmacology of Cerebral Ischemia. Stuttgart, Germany: Wissenschaftliche Verlagsgesellschaft, pp321-331, 1992.
13. Oliver CN, Starke-Reed PE, Stadtman ER, Liu GJ, Carney JM, Floyd RA. Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain. Proc Natl Acad Sci USA 87:5144-5147, 1990.
14. Floyd RA. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J 4:2587-2597, 1990.
15. Phillis JW, Clough-Helfman C. Free radicals and ischaemic brain injury: Protection by the spin trap agent PBN. Med Sci Res 18:403-404, 1990.
16. Phillis JW, Clough-Helfman C. Protection from cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl-α-phenylnitrone (PBN). Neurosci Lett 116:315-319, 1990.
17. Clough-Helfman C, Phillis JW. The free radical trapping agent N-tert-butyl-α-phenylnitrone (PBN) attenuates cerebral ischaemic injury in gerbils. Free Radic Res 15:177-186, 1991.
18. Zhao Q, Pahlmark K, Smith MI, Siesjo BK. Delayed treatment with the spin trap α-phenyl-N-tert-butylnitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats. Acta Physiol Scand 152:349-350, 1994.
19. Carney JM, Starke-Reed PE, Oliver CN, Landrum RW, Chen MS, Wu JF, Floyd RA. Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spacial memory by chronic administration of the spin-trapping compound N-tert-butyl-α-phenylnitrone. Proc Natl Acad Sci USA 88:3633-3636, 1991.
20. Floyd RA, Carney JM. Nitrone radical traps protect in experimental neurodegenerative diseases. In: Chapman CA, Olanow CW, Jenner P, Youssim M, Eds. Neuroprotective Approaches to the Treatment of Parkinson's Disease and Other Neurodegenerative Disorders. London: Academic Press Limited, pp69-90, 1996.
21. Chen G, Bray TM, Janzen EG, McCay PB. Excretion, metabolism, and tissue distribution of a spin trapping agent, α-phenyl-N-tert-butylnitrone (PBN) in rats. Free Radic Res 9:317-323, 1990.
22. Cheng HY, Liu T, Feuerstein G, Barone FC. Distribution of spin-trapping compounds in rat blood and brain: In vivo microdialysis determination. Free Radic Biol Med 14:243-250, 1993.
23. Vatassery GT, Angerhofer CK, Knox CA, Deshmukh DS. Concentrations of vitamin E in various neuroanatomical regions and subcellular fractions, and the uptake of vitamin E by specific areas of rat brain. Biochim Biophys Acta 792:118-122, 1984.
24. Yoshida S, Abe K, Busto R, Watson BD, Kogure K, Ginsberg MD. Influence of transient ischemia on lipid-soluble antioxidants, free fatty acids, and energy metabolites in rat brain. Brain Res 245:307-316, 1982.
25. Janzen EG, West MS, Poyer JL. Comparison of antioxidant activity of PBN with hindered phenols in initiated rat liver microsomal lipid peroxidation. In: Asada K, Yoshikawa T, Eds. Frontiers of Reactive Oxygen Species in Biology and Medicine. New York: Elsevier Science, pp431-446, 1994.
26. Floyd RA. The protective action of nitrone-based free radical traps in neurodegenerative diseases. In: Fiskum G, Ed. Neurodegenerative Diseases '95: Cellular and Molecular Mechanisms and Therapeutic Advances. New York: Plenum Press, pp235-245, 1996.
27. Floyd RA. Protective action of nitrone-based free radical traps against oxidative damage of the central nervous system. In: Sies H, Ed. Advances in Pharmacology. San Diego: Academic Press, pp361-378, 1996.
28. Carney JM, Kindy MS, Smith CD, Wood K, Tatsuno T, Wu JF, Landrum WR, Floyd RA. Gene expression and functional changes after acute ischemia: Age-related differences in outcome and mechanisms. In: Hartmann A, Yatsu F, Kuschinsky W, Eds. Cerebral Ischemia and Basic Mechanisms. Berlin: Springer-Verlag, pp301-311, 1994.
29. Miyajima T, Kotake Y. Spin trapping agent, phenyl N-tert-butylnitrone, inhibits induction of nitric oxide synthase in endotoxin-induced shock in mice. Biochem Biophys Res Commun 215:114-121, 1995.
30. Dawson VL, Dawson TM, London ED, Bred DS, Snyder SH. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci USA 88:6368-6371, 1991.
31. Iadecola C. Bright and dark sides of nitric oxide in ischemic brain injury. Trends Neurosci 20:132-139, 1997.
32. Iadecola C, Zhang F, Xu S, Casey R, Ross ME. Inducible nitric oxide synthase gene expression in brain following cerebral ischemia. J Cereb Blood Flow Metab 15:378-384, 1995.
33. Dawson VL, Dawson TM, Uhl GR, Snyder SH. Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures. Proc Natl Acad Sci USA 90:3256-3259, 1993.
34. Dawson VL, Dawson TM, Bartley DA, Uhl GR, Snyder SH. Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J Neurosci 13:2651-2661, 1993.
35. Floyd RA, Stewart CA, Tabatabaie T, Hensley K, Pye Q, Liu PK. Apoptosis in brain cells: Role in neurodegeneration. In: Christen Y, Doly M, Droy-Lefaix M-T, Eds. Les Seminaires Ophtalmologiques d'IPSEN, "Retine, apoptose et cytokines." Paris: Irvinn, pp17-30, 1997.
36. Hensley K, Maidt ML, Pye QN, Stewart CA, Wack M, Tabatabaie T, Floyd RA. Quantitation of protein-bound 3-nitrotyrosine and 3,4-dihydroxyphenylalanine by high-performance liquid chromatography with electrochemical array detection. Anal Biochem 251:187-195, 1997.
37. Hensley K, Maidt ML, Yu Z, Markesbery WR, Floyd RA. Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation. J Neurosci 18:8126-8132, 1998.
38. Robinson KA, Stewart CA, Pye QN, Nguyen X, Kenney L, Salzman S, Floyd RA, Hensley K. Redox-sensitive protein phosphatase activity regulates the phosphorylation state of p38 protein kinase in primary astrocyte culture. J Neurosci Res 55:724-732, 1999.
39. Hensley K, Floyd RA, Zheng NY, Nael R, Robinson KA, Nguyen X, Pye QN, Stewart CA, Geddes J, Markesbery WR, Patel E, Johnson GV, Bing G. p38 Kinase is activated in the Alzheimer's disease brain. J Neurochem 72:2053-2058, 1999.
40. Sano M, Ernesto MS, Thomas RG, Klauber MR, Schafer K, Grundman M, Woodbury P, Growdon J, Cotman CW, Pfeiffer E, Schneider LS. A controlled trial of selegiline, α-tocopherol, or both as treatment for Alzheimer's disease. N Engl J Med 336:1216-1222, 1997.
41. Kieburtz K, et al. A randomized, double-blind, placebo-controlled trial of deprenyl and thioctic acid in human immunodeficiency virus-associated cognitive impairment. Neurology 50:645-651, 1998.
42. Funahashi T, Floyd RA, Carney JM. Age effect on brain pH during ischemia/reperfusion and pH influence on peroxidation. Neurobiol Aging 15:161-167, 1994.
43. Folbergrova J, Zhao Q, Katsura KI, Siesjo BK. N-tert-butyl-α-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia. Proc Natl Acad Sci USA 92:5057-5061, 1995.
44. Floyd RA, Carney JM. Age influence on oxidative events during brain ischemia/reperfusion. Arch Gerontol Geriatr 12:155-177, 1991.