Subcellular fate and off-target effects of siRNA, shRNA, and miRNA

Pharmaceutical Research

Volumn 28, Issue 12, 2011, Pages 2996-3015

  Singh, Saurabh ^a   Narang, Ajit S ^b   Mahato, Ram I ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

cellular uptake; intracellular trafficking; miRNA; RNA interference; shRNA; siRNA

Indexed keywords

ADENOVIRUS VECTOR; ARGINYLGLYCYLASPARTIC ACID; CELL PENETRATING PEPTIDE; CHITOSAN; CYCLODEXTRIN; DICER; DIOLEOYLPHOSPHATIDYLETHANOLAMINE; ENDONUCLEASE; ENHANCED GREEN FLUORESCENT PROTEIN; FOLIC ACID; IMMUNOLIPOSOME; LENTIVIRUS VECTOR; LIPOFECTAMINE; LIPOSOME; MACROGOL; MICRORNA; NANOCARRIER; PENETRATIN; PLASMA PROTEIN; POLYETHYLENEIMINE; RNA INDUCED SILENCING COMPLEX; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; TRANSACTIVATOR PROTEIN; TRANSPORTAN; UNCLASSIFIED DRUG;

BREAST CANCER; CELL FATE; CHEMICAL MODIFICATION; CLINICAL TRIAL (TOPIC); COMPLEX FORMATION; DRUG CONJUGATION; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG FORMULATION; DRUG STABILITY; DRUG TARGETING; DRUG TRANSPORT; ENCAPSULATION; ENDOSOME; GENE EXPRESSION REGULATION; GENE SILENCING; GLOMERULUS FILTRATION; HUMAN; IMMUNOSTIMULATION; INHIBITION KINETICS; INTRACELLULAR TRANSPORT; LIVER CANCER; LUNG METASTASIS; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PANCREAS CANCER; PHAGOCYTOSIS; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; PROTEIN AGGREGATION; RETINA MACULA AGE RELATED DEGENERATION; REVIEW; RNA DEGRADATION; RNA INTERFERENCE; RNA PROCESSING; RNA STRUCTURE; RNA TRANSLATION; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; BIOLOGICAL TRANSPORT; HUMANS; MICRORNAS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SUBCELLULAR FRACTIONS;

EID: 83555166124     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0608-1     Document Type: Review

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