Efficient short interference rna delivery to tumor cells using a combination of octaarginine, gala and tumor-specific, cleavable polyethylene glycol system

Biological and Pharmaceutical Bulletin

Volumn 32, Issue 5, 2009, Pages 928-932

  Sakurai, Yu ^a,c   Hatakeyama, Hiroto ^a,c   Akita, Hidetaka ^b,c   Oishi, Motoi ^a,b,c,d   Nagasaki, Yukio ^b,c   Futaki, Shiro ^d   Harashima, Hideyoshi ^a,c  

^a HOKKAIDO UNIVERSITY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

Cancer gene therapy; Multifunctional envelope type nano device; Non viral delivery system; Ph sensitive furogenic peptide; Stearyl octaarginine

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; MACROGOL; OCTAARGININE; PEPTIDE; PEPTIDE GALA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; NANODEVICE; NONVIRAL GENE DELIVERY SYSTEM; TUMOR CELL;

DRUG DELIVERY SYSTEMS; FATTY ACIDS, MONOUNSATURATED; GENE SILENCING; GENE TRANSFER TECHNIQUES; HELA CELLS; HUMANS; LUCIFERASES; NANOPARTICLES; OLIGOPEPTIDES; PEPTIDES; POLYETHYLENE GLYCOLS; QUATERNARY AMMONIUM COMPOUNDS; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 66749134637     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.32.928     Document Type: Article

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