Biodistribution and hepatic uptake of triplex-forming oligonucleotides against type α1(1) collagen gene promoter in normal and fibrotic rats

Molecular Pharmaceutics

Volumn 2, Issue 3, 2005, Pages 206-217

  Cheng, Kun ^a   Ye, Zhaoyang ^a   Guntaka, Ramareddy V ^a,b   Mahato, Ram I ^a,b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b Feurt 413 ^*  (United States)

Author keywords

Biodistribution; Hepatic stellate cells; Liver fibrosis; Liver perfusion; Nuclear localization; Triplex forming oligonucleotide (TFO)

Indexed keywords

ANTIPARALLEL PHOSPHOROTHIOATE TRIPLEX FORMING OLIGONUCLEOTIDE; COLLAGEN TYPE 1; COLLAGEN TYPE 1ALPHA1; DEXTRAN SULFATE; OLIGONUCLEOTIDE; POLYINOSINIC ACID; SCAVENGER RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG LIVER LEVEL; DRUG STRUCTURE; DRUG UPTAKE; ENDOTHELIUM CELL; EXTRACELLULAR SPACE; GENE EXPRESSION REGULATION; GENE TARGETING; KUPFFER CELL; LIVER FIBROSIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; STELLATE CELL;

ANIMALS; CELL NUCLEUS; COLLAGEN TYPE I; DIMETHYLNITROSAMINE; DNA; DRUG CARRIERS; INJECTIONS, INTRAVENOUS; LIVER CIRRHOSIS; MALE; PROMOTER REGIONS (GENETICS); RATS; RATS, SPRAGUE-DAWLEY; SUBCELLULAR FRACTIONS; THIONUCLEOTIDES;

EID: 21444439431     PISSN: 15438384     EISSN: None     Source Type: Journal    
DOI: 10.1021/mp050012x     Document Type: Article

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