Triplex forming oligonucleotides against type α1(I) collagen attenuates liver fibrosis induced by bile duct ligation

Biochemical Pharmacology

Volumn 80, Issue 11, 2010, Pages 1718-1726

  Panakanti, Ravikiran ^a   Pratap, Akshay ^b   Yang, Ningning ^a   Jackson, John S ^a   Mahato, Ram I ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b METHODIST UNIVERSITY HOSPITAL   (United States)

Author keywords

SMA; Common bile duct ligation; Liver fibrosis; TGF 1; Triplex forming oligonucleotide; Type 1(I) collagen

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; ASPARTATE AMINOTRANSFERASE; COLLAGEN TYPE 1; CYTOKERATIN 19; CYTOKINE; HYDROXYPROLINE; MYELOPEROXIDASE; OLIGONUCLEOTIDE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1; TRIPLEX FORMING OLIGONUCLEOTIDE; UNCLASSIFIED DRUG; DNA; TRIPLEX DNA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE DUCT LIGATION; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; DRUG EFFECT; GENE OVEREXPRESSION; LIVER FIBROSIS; LIVER FUNCTION; MALE; MYOFIBROBLAST; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMISTRY; CHOLESTASIS, EXTRAHEPATIC; COMMON BILE DUCT; COMPARATIVE STUDY; CONFORMATION; GENETICS; LIGATION; LIVER CIRRHOSIS; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; TRANSFORMED CELL LINE;

ANIMALS; CELL LINE, TRANSFORMED; CHOLESTASIS, EXTRAHEPATIC; COLLAGEN TYPE I; COMMON BILE DUCT; DNA; LIGATION; LIVER CIRRHOSIS; MALE; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77957897062     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.08.020     Document Type: Article

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