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Volumn 34, Issue 5, 2006, Pages 1369-1380

In situ fluorescence analysis demonstrates active siRNA exclusion from the nucleus by Exportin 5

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; EXPORTIN 5; MESSENGER RNA; MICRORNA; SMALL INTERFERING RNA; FLUORESCENT DYE; KARYOPHERIN; XPO5 PROTEIN, HUMAN;

EID: 33644992707     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkl001     Document Type: Article
Times cited : (86)

References (53)
  • 1
    • 4644223259 scopus 로고    scopus 로고
    • Mechanisms of gene silencing by double-stranded RNA
    • Meister,G. and Tuschl,T. (2004) Mechanisms of gene silencing by double-stranded RNA. Nature, 431, 343-349.
    • (2004) Nature , vol.431 , pp. 343-349
    • Meister, G.1    Tuschl, T.2
  • 2
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • Ambros,V. (2004) The functions of animal microRNAs. Nature, 431, 350-355.
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 3
    • 3042767202 scopus 로고    scopus 로고
    • MicroRNAs: Small RNAs with a big role in gene regulation
    • He,L. and Hannon,G.J. (2004) MicroRNAs: Small RNAs with a big role in gene regulation. Nature Rev. Genet., 5, 522-531.
    • (2004) Nature Rev. Genet. , vol.5 , pp. 522-531
    • He, L.1    Hannon, G.J.2
  • 4
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire,A., Xu,S., Montgomery,M.K., Kostas,S.A., Driver,S.E. and Mello,C.C. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature, 391, 806-811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 5
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir,S.M., Harborth,J., Lendeckel,W., Yalcin,A., Weber,K. and Tuschl,T. (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature, 411, 494-498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 6
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22-nucleotide RNAs
    • Elbashir,S.M., Lendeckel,W. and Tuschl,T. (2001) RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev., 15, 188-200.
    • (2001) Genes Dev. , vol.15 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 7
    • 0035798415 scopus 로고    scopus 로고
    • ATP requirements and small interfering RNA structure in the RNA interference pathway
    • Nykänen,A., Haley,B. and Zamore,P.D. (2001) ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell, 107, 309-321.
    • (2001) Cell , vol.107 , pp. 309-321
    • Nykänen, A.1    Haley, B.2    Zamore, P.D.3
  • 8
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the ignition step of RNA interference
    • Bernstein,E., Caudy,A.A., Hammond,S.M. and Hannon,G.J. (2001) Role for a bidentate ribonuclease in the ignition step of RNA interference. Nature, 409, 363-366.
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 9
    • 0036074161 scopus 로고    scopus 로고
    • RNA is restricted to the cytoplasm
    • Zeng,Y. and Cullen,B.R. (2002) RNA is restricted to the cytoplasm. RNA, 8, 855-860.
    • (2002) RNA , vol.8 , pp. 855-860
    • Zeng, Y.1    Cullen, B.R.2
  • 10
    • 0035807818 scopus 로고    scopus 로고
    • Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines
    • Billy,E., Brondani,V., Zhang,H., Muller,U. and Filipowicz,W. (2001) Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines. Proc. Natl Acad. Sci. USA, 98, 14428-14433.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 14428-14433
    • Billy, E.1    Brondani, V.2    Zhang, H.3    Muller, U.4    Filipowicz, W.5
  • 11
    • 0036845374 scopus 로고    scopus 로고
    • Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP
    • Zhang,H., Kolb,F.A., Brondani,V., Billy,E. and Filipowicz,W. (2002) Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. EMBO J., 21, 5875-5885.
    • (2002) EMBO J. , vol.21 , pp. 5875-5885
    • Zhang, H.1    Kolb, F.A.2    Brondani, V.3    Billy, E.4    Filipowicz, W.5
  • 13
    • 0034673638 scopus 로고    scopus 로고
    • An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
    • Hammond,S.M., Bernstein,E., Beach,D. and Hannon,G.J. (2000) An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature, 404, 293-296.
    • (2000) Nature , vol.404 , pp. 293-296
    • Hammond, S.M.1    Bernstein, E.2    Beach, D.3    Hannon, G.J.4
  • 14
    • 0035839109 scopus 로고    scopus 로고
    • Argonaute2, a link between genetic and biochemical analyses of RNAi
    • Hammond,S.M., Boettcher,S., Caudy,A.A., Kobayashi,R. and Hannon,G.J. (2001) Argonaute2, a link between genetic and biochemical analyses of RNAi. Science, 293, 1146-1150.
    • (2001) Science , vol.293 , pp. 1146-1150
    • Hammond, S.M.1    Boettcher, S.2    Caudy, A.A.3    Kobayashi, R.4    Hannon, G.J.5
  • 15
    • 0037031576 scopus 로고    scopus 로고
    • Single-stranded antisense siRNAs guide target RNA cleavage in RNAi
    • Martinez,J., Patkaniowska,A., Urlaub,H., Lührmann,R. and Tuschl,T. (2002) Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell, 110, 563-574.
    • (2002) Cell , vol.110 , pp. 563-574
    • Martinez, J.1    Patkaniowska, A.2    Urlaub, H.3    Lührmann, R.4    Tuschl, T.5
  • 18
    • 0035803583 scopus 로고    scopus 로고
    • Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
    • Elbashir,S.M., Martinez,J., Patkaniowska,A., Lendeckel,W. and Tuschl,T. (2001) Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J., 20, 6877-6888.
    • (2001) EMBO J. , vol.20 , pp. 6877-6888
    • Elbashir, S.M.1    Martinez, J.2    Patkaniowska, A.3    Lendeckel, W.4    Tuschl, T.5
  • 19
    • 2442495329 scopus 로고    scopus 로고
    • RISC is a 5′ phosphomonoester-producing RNA endonuclease
    • Martinez,J. and Tuschl,T. (2004) RISC is a 5′ phosphomonoester-producing RNA endonuclease. Genes Dev., 18, 975-980.
    • (2004) Genes Dev. , vol.18 , pp. 975-980
    • Martinez, J.1    Tuschl, T.2
  • 20
    • 0027751663 scopus 로고
    • The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee,R.C., Feinbaum,R.L. and Ambros,V. (1993) The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell, 75, 843-854.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 24
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel,D.P. (2004) MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell, 116, 281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 27
    • 0035800521 scopus 로고    scopus 로고
    • A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    • Hutvagner,G., McLachlan,J., Pasquinelli,A.E., Balint,E., Tuschl,T. and Zamore,P.D. (2001) A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science, 293, 834-838.
    • (2001) Science , vol.293 , pp. 834-838
    • Hutvagner, G.1    McLachlan, J.2    Pasquinelli, A.E.3    Balint, E.4    Tuschl, T.5    Zamore, P.D.6
  • 28
    • 0037009364 scopus 로고    scopus 로고
    • MicroRNA maturation: Stepwise processing and sub-cellular localization
    • Lee,Y., Jeon,K., Lee,J., Kim,S. and Kim,V.N. (2002) MicroRNA maturation: stepwise processing and sub-cellular localization. EMBO J., 21, 4663-4670.
    • (2002) EMBO J. , vol.21 , pp. 4663-4670
    • Lee, Y.1    Jeon, K.2    Lee, J.3    Kim, S.4    Kim, V.N.5
  • 29
    • 0036792769 scopus 로고    scopus 로고
    • Fragile X-related protein and VIG associate with the RNA interference machinery
    • Caudy,A.A., Myers,M., Hannon,G.J. and Hammond,S.M. (2002) Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev., 16, 2491-2496.
    • (2002) Genes Dev. , vol.16 , pp. 2491-2496
    • Caudy, A.A.1    Myers, M.2    Hannon, G.J.3    Hammond, S.M.4
  • 30
    • 3142729150 scopus 로고    scopus 로고
    • Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways
    • Okamura,K., Ishizuka,A., Siomi,H. and Siomi,M.C. (2004) Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev., 18, 1655-1666.
    • (2004) Genes Dev. , vol.18 , pp. 1655-1666
    • Okamura, K.1    Ishizuka, A.2    Siomi, H.3    Siomi, M.C.4
  • 33
    • 0032823599 scopus 로고    scopus 로고
    • An in vitro system using HeLacytoplasmic extracts that reproduces regulated mRNA stability
    • Ford,L.P. and Wilusz,J. (1999) An in vitro system using HeLacytoplasmic extracts that reproduces regulated mRNA stability. Methods, 17, 21-27.
    • (1999) Methods , vol.17 , pp. 21-27
    • Ford, L.P.1    Wilusz, J.2
  • 34
    • 0036752785 scopus 로고    scopus 로고
    • RNAi in human cells: Basic structural and functional features of small interfering RNA
    • Chiu,Y.L. and Rana,T.M. (2002) RNAi in human cells: Basic structural and functional features of small interfering RNA. Mol. Cell, 10, 549-561.
    • (2002) Mol. Cell , vol.10 , pp. 549-561
    • Chiu, Y.L.1    Rana, T.M.2
  • 35
  • 37
    • 0035854822 scopus 로고    scopus 로고
    • Terminal minihelix, a novel RNA motif that directs polymerase III transcripts to the cell cytoplasm. Terminal minihelix and RNA export
    • Gwizdek,C., Bertrand,E., Dargemont,C., Lefebvre,J.C., Blanchard,J.M., Singer,R.H. and Doglio,A. (2001) Terminal minihelix, a novel RNA motif that directs polymerase III transcripts to the cell cytoplasm. Terminal minihelix and RNA export. J. Biol. Chem., 276, 25910-25918.
    • (2001) J. Biol. Chem. , vol.276 , pp. 25910-25918
    • Gwizdek, C.1    Bertrand, E.2    Dargemont, C.3    Lefebvre, J.C.4    Blanchard, J.M.5    Singer, R.H.6    Doglio, A.7
  • 38
    • 4444230672 scopus 로고    scopus 로고
    • Structural requirements for pre-microRNA binding and nuclear export by Exportin 5
    • Zeng,Y. and Cullen,B.R. (2004) Structural requirements for pre-microRNA binding and nuclear export by Exportin 5. Nucleic Acids Res., 32, 4776-4785.
    • (2004) Nucleic Acids Res. , vol.32 , pp. 4776-4785
    • Zeng, Y.1    Cullen, B.R.2
  • 39
    • 0037033792 scopus 로고    scopus 로고
    • Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins
    • Brownawell,A.M. and Macara,I.G. (2002) Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins. J. Cell Biol., 156, 53-64.
    • (2002) J. Cell Biol. , vol.156 , pp. 53-64
    • Brownawell, A.M.1    Macara, I.G.2
  • 40
    • 0347361541 scopus 로고    scopus 로고
    • Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
    • Yi,R., Qin,Y., Macara,I.G. and Cullen,B.R. (2003) Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev., 17, 3011-3016.
    • (2003) Genes Dev. , vol.17 , pp. 3011-3016
    • Yi, R.1    Qin, Y.2    Macara, I.G.3    Cullen, B.R.4
  • 41
    • 4344651353 scopus 로고    scopus 로고
    • Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells
    • Chiu,Y.L., Ali,A., Chu,C.Y., Cao,H. and Rana,T.M. (2004) Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells. Chem. Biol., 11, 1165-1175.
    • (2004) Chem. Biol. , vol.11 , pp. 1165-1175
    • Chiu, Y.L.1    Ali, A.2    Chu, C.Y.3    Cao, H.4    Rana, T.M.5
  • 44
    • 0347093422 scopus 로고    scopus 로고
    • Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3
    • Gwizdek,C., Ossareh-Nazari,B., Brownawell,A.M., Evers,S., Macara,I.G. and Dargemont,C. (2004) Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3. J. Biol. Chem., 279, 884-891.
    • (2004) J. Biol. Chem. , vol.279 , pp. 884-891
    • Gwizdek, C.1    Ossareh-Nazari, B.2    Brownawell, A.M.3    Evers, S.4    Macara, I.G.5    Dargemont, C.6
  • 45
    • 12844285548 scopus 로고    scopus 로고
    • Overexpression of Exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs
    • Yi,R., Doehle,B.P., Qin,Y., Macara,I.G. and Cullen,B.R. (2005) Overexpression of Exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs. RNA, 11, 220-226.
    • (2005) RNA , vol.11 , pp. 220-226
    • Yi, R.1    Doehle, B.P.2    Qin, Y.3    Macara, I.G.4    Cullen, B.R.5
  • 48
    • 18144365478 scopus 로고    scopus 로고
    • MicroRNA biogenesis and cancer
    • Gregory,R.I. and Shiekhattar,R. (2005) MicroRNA biogenesis and cancer. Cancer Res., 65, 3509-3512.
    • (2005) Cancer Res. , vol.65 , pp. 3509-3512
    • Gregory, R.I.1    Shiekhattar, R.2
  • 51
    • 4344705410 scopus 로고    scopus 로고
    • Small interfering RNA-induced transcriptional gene silencing in human cells
    • Morris,K.V., Chan,S.W., L, Jacobsen,S.E. and Looney,D.J. (2004) Small interfering RNA-induced transcriptional gene silencing in human cells. Science, 305, 1289-1292.
    • (2004) Science , vol.305 , pp. 1289-1292
    • Morris, K.V.1    Chan, S.W.L.2    Jacobsen, S.E.3    Looney, D.J.4
  • 52
    • 10644237968 scopus 로고    scopus 로고
    • RNAi-mediated pathways in the nucleus
    • Matzke,M.A. and Birchler,J.A. (2005) RNAi-mediated pathways in the nucleus. Nature Rev. Genet., 6, 24-35.
    • (2005) Nature Rev. Genet. , vol.6 , pp. 24-35
    • Matzke, M.A.1    Birchler, J.A.2
  • 53
    • 0032739015 scopus 로고    scopus 로고
    • Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD
    • Ketting,R.F., Haverkamp,T.H., van Luenen,H.G. and Plasterk,R.H. (1999) Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD. Cell, 99, 133-141.
    • (1999) Cell , vol.99 , pp. 133-141
    • Ketting, R.F.1    Haverkamp, T.H.2    van Luenen, H.G.3    Plasterk, R.H.4


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