Heritable gene silencing in Drosophila using double-stranded RNA

Nature Biotechnology

Volumn 18, Issue 8, 2000, Pages 896-898

  Kennerdell, J R ^a   Carthew, R W ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA;

ARTICLE; CONTROLLED STUDY; DROSOPHILA; GENE FUNCTION; GENE SILENCING; HEREDITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA DEGRADATION; RNA SYNTHESIS; TRANSGENE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BASE SEQUENCE; DROSOPHILA; GENE SILENCING; LAC OPERON; MICE; RNA, DOUBLE-STRANDED;

EID: 0033883114     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/78531     Document Type: Article

References (19)

1. RNA makes RNA makes no protein
2. RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans
3. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled2 act in the wingless pathway
4. Targeted disruption of gene function in Drosophila by RNA interference (RNA-i): A role for nautilis in embryonic somatic muscle formation
5. Double-stranded RNA injection produces null phenotypes in zebrafish
6. Specific interference with gene function by double-stranded RNA in early mouse development
7. Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes
8. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
9. Transposition of cloned P elements into Drosophila germ line chromosomes
10. Specific genetic interference with behavioural rhythms in Drosophila by expression of inverted repeats
11. The effects of nucleotide sequence changes on DNA secondary structure formation in Escherichia coli are consistent with cruciform extrusion in vivo
12. Current protocols in molecular biology
13. Region-specific recombination and expression are directed by portions of the Drosophila engrailed promoter
14. Cell- and stage-specific splicing events resolved in specialized neurons of the rat cerebellum
15. Quantitation of RNA using the polymerase chain reaction
16. Atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system
17. A cell-autonomous, ubiquitous marker for the analysis of Drosophilaw genetic mosaics
18. Ras1 signaling and transcriptional competence in the R7 cell of Drosophila