A folate receptor-targeting nanoparticle minimizes drug resistance in a human cancer model

ACS Nano

Volumn 5, Issue 8, 2011, Pages 6184-6194

  Wang, Xu ^a   Li, Jun ^b   Wang, Yuxiang ^a   Koenig, Lydia ^a   Gjyrezi, Ada ^c   Giannakakou, Paraskevi ^c   Shin, Edwin H ^d   Tighiouart, Mourad ^e   Chen, Zhuo ^a   Nie, Shuming ^b   Shin, Dong M ^a  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d UNIVERSITY OF GEORGIA   (United States)

^e EMORY UNIVERSITY   (United States)

Author keywords

chemotherapy; drug resistance; folate receptor; paclitaxel; targeting nanoparticle

Indexed keywords

ANTI-ANGIOGENIC ACTIVITY; ANTICANCER DRUG; CANCER CELLS; CANCER MODELS; CANCER THERAPY; DRUG RESISTANCE; ENHANCED UPTAKE; FOLATE RECEPTOR; FREEFORMS; HIGHER-DEGREE; HUMAN CANCER; HYDROPHOBIC CORE; IMMUNOHISTOCHEMICAL ANALYSIS; IN-VITRO ANALYSIS; IN-VIVO; INTRACELLULAR RETENTION; MICROTUBULES; MITOTIC ARREST; NON-TARGETED; P-GLYCOPROTEIN; PACLITAXEL; TARGETING NANOPARTICLE; THERAPEUTIC EFFICACY; TUMOR GROWTH; TUMOR TISSUES; UNDERLYING MECHANISM;

BIOLOGICAL MATERIALS; CELL PROLIFERATION; CHEMOTHERAPY; DISEASES; ENZYME INHIBITION; GLYCOPROTEINS; HISTOLOGY; TUMORS;

NANOPARTICLES;

ANGIOGENESIS INHIBITOR; DRUG CARRIER; FOLATE TRANSPORTER; FOLIC ACID; HEPARIN; NANOPARTICLE; PACLITAXEL;

ANIMAL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STRAIN KB; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; DRUG RESISTANCE; DRUG SCREENING; FEMALE; HUMAN; METABOLISM; MICROTUBULE; MOUSE; NEOPLASM; PATHOLOGY; TRANSPORT AT THE CELLULAR LEVEL; VASCULARIZATION;

ANGIOGENESIS INHIBITORS; ANIMALS; APOPTOSIS; BIOLOGICAL TRANSPORT; CELL PROLIFERATION; CELL SURVIVAL; DRUG CARRIERS; DRUG RESISTANCE, NEOPLASM; FEMALE; FOLIC ACID; FOLIC ACID TRANSPORTERS; HEPARIN; HUMANS; KB CELLS; MICE; MICROTUBULES; NANOPARTICLES; NEOPLASMS; PACLITAXEL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80052061132     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn200739q     Document Type: Article

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