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Volumn 18, Issue 4, 2004, Pages 531-554

Glucagon-like peptide-1 and glucagon-like peptide-2

Author keywords

Apoptosis; Cell proliferation; Diabetes; food intake; Insulin secretion; Intestinal disease; Obesity

Indexed keywords

6 [[2 [[2 (2 CYANO 1 PYRROLIDINYL) 2 OXOETHYL]AMINO]ETHYL]AMINO]NICOTINONITRILE; ANTIDIABETIC AGENT; DEXTRAN SULFATE; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; ENZYME INHIBITOR; EXENDIN 4; EXENDIN[9-39]; FLUOROURACIL; GLICENTIN; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR BLOCKING AGENT; GLUCAGON LIKE PEPTIDE 1 RECEPTOR STIMULATING AGENT; GLUCAGON LIKE PEPTIDE 2; GLUCOSE; HORMONE RECEPTOR BLOCKING AGENT; HORMONE RECEPTOR STIMULATING AGENT; INDOMETACIN; INSULIN; IRINOTECAN; LIRAGLUTIDE; METFORMIN; NONSTEROID ANTIINFLAMMATORY AGENT; OXYNTOMODULIN; STREPTOZOCIN; SULFONYLUREA; UNCLASSIFIED DRUG; UNINDEXED DRUG; VILDAGLIPTIN; PEPTIDE; PEPTIDE FRAGMENT; PROTEIN PRECURSOR;

EID: 8344287000     PISSN: 1521690X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.beem.2004.08.001     Document Type: Review
Times cited : (65)

References (210)
  • 1
    • 0036158954 scopus 로고    scopus 로고
    • Biological actions and therapeutic potential of the glucagon-like peptides
    • D.J. Drucker Biological actions and therapeutic potential of the glucagon-like peptides Gastroenterology 122 2002 531-544
    • (2002) Gastroenterology , vol.122 , pp. 531-544
    • Drucker, D.J.1
  • 2
    • 2542479899 scopus 로고    scopus 로고
    • Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system
    • P.L. Brubaker & D.J. Drucker Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system Endocrinology 145 2004 2653-2659
    • (2004) Endocrinology , vol.145 , pp. 2653-2659
    • Brubaker, P.L.1    Drucker, D.J.2
  • 3
    • 0242492635 scopus 로고    scopus 로고
    • Dual regulation of cell proliferation and survival via activation of glucagon-like peptide-2 receptor signaling
    • J.L. Estall & D.J. Drucker Dual regulation of cell proliferation and survival via activation of glucagon-like peptide-2 receptor signaling J Nutr 133 2003 3708-3711
    • (2003) J. Nutr. , vol.133 , pp. 3708-3711
    • Estall, J.L.1    Drucker, D.J.2
  • 4
    • 0030187992 scopus 로고    scopus 로고
    • Distribution of GLP-1 and PACAP receptors in human tissues
    • Y. Wei & S. Mojsov Distribution of GLP-1 and PACAP receptors in human tissues Acta Physiol Scand 157 1996 355-357
    • (1996) Acta Physiol. Scand. , vol.157 , pp. 355-357
    • Wei, Y.1    Mojsov, S.2
  • 5
    • 0033545166 scopus 로고    scopus 로고
    • Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system
    • I. Merchenthaler M. Lane & P. Shughrue Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system J Comp Neurol 403 1999 261-280
    • (1999) J. Comp. Neurol. , vol.403 , pp. 261-280
    • Merchenthaler, I.1    Lane, M.2    Shughrue, P.3
  • 6
    • 0034456578 scopus 로고    scopus 로고
    • Characterization of human and rat glucagon-like peptide-1 receptors in the neurointermediate lobe: Lack of coupling to either stimulation or inhibition of adenylyl cyclase
    • F. Satoh S.A. Beak C.J. Small et al. Characterization of human and rat glucagon-like peptide-1 receptors in the neurointermediate lobe: Lack of coupling to either stimulation or inhibition of adenylyl cyclase Endocrinology 141 2000 1301-1309
    • (2000) Endocrinology , vol.141 , pp. 1301-1309
    • Satoh, F.1    Beak, S.A.2    Small, C.J.3
  • 7
    • 0023787950 scopus 로고
    • Glucagon gene expression in vertebrate brain
    • D.J. Drucker & S. Asa Glucagon gene expression in vertebrate brain J Biol Chem 263 1988 13475-13478
    • (1988) J. Biol. Chem. , vol.263 , pp. 13475-13478
    • Drucker, D.J.1    Asa, S.2
  • 8
    • 0023161473 scopus 로고
    • Identical mRNA for preproglucagon in pancreas and gut
    • U. Novak A. Wilks G. Buell et al. Identical mRNA for preproglucagon in pancreas and gut Eur J Biochem 164 1987 553-558
    • (1987) Eur. J. Biochem. , vol.164 , pp. 553-558
    • Novak, U.1    Wilks, A.2    Buell, G.3
  • 9
    • 0024442006 scopus 로고
    • Oxyntomodulin from distal gut. Role in regulation of gastric and pancreatic functions
    • B. Schjoldager P.E. Mortensen J. Myhre et al. Oxyntomodulin from distal gut. Role in regulation of gastric and pancreatic functions Dig Dis Sci 34 1989 1411-1419
    • (1989) Dig. Dis. Sci. , vol.34 , pp. 1411-1419
    • Schjoldager, B.1    Mortensen, P.E.2    Myhre, J.3
  • 10
    • 0242288734 scopus 로고    scopus 로고
    • Oxyntomodulin suppresses appetite and reduces food intake in humans
    • M.A. Cohen S.M. Ellis C.W. Le Roux et al. Oxyntomodulin suppresses appetite and reduces food intake in humans J Clin Endocrinol Metab 88 2003 4696-4701
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 4696-4701
    • Cohen, M.A.1    Ellis, S.M.2    Le Roux, C.W.3
  • 11
    • 0034807498 scopus 로고    scopus 로고
    • Oxyntomodulin inhibits food intake in the rat
    • C.L. Dakin I. Gunn C.J. Small et al. Oxyntomodulin inhibits food intake in the rat Endocrinology 142 2001 4244-4250
    • (2001) Endocrinology , vol.142 , pp. 4244-4250
    • Dakin, C.L.1    Gunn, I.2    Small, C.J.3
  • 12
    • 0033452452 scopus 로고    scopus 로고
    • Proprotein and prohormone convertases: A family of subtilases generating diverse bioactive polypeptides
    • N.G. Seidah & M. Chretien Proprotein and prohormone convertases: A family of subtilases generating diverse bioactive polypeptides Brain Res 848 1999 45-62
    • (1999) Brain Res. , vol.848 , pp. 45-62
    • Seidah, N.G.1    Chretien, M.2
  • 13
    • 0030012124 scopus 로고    scopus 로고
    • Role of prohormone convertases in the tissue-specific processing of proglucagon
    • S. Dhanvantari N.G. Seidah & P.L. Brubaker Role of prohormone convertases in the tissue-specific processing of proglucagon Mol Endocrinol 10 1996 342-355
    • (1996) Mol. Endocrinol. , vol.10 , pp. 342-355
    • Dhanvantari, S.1    Seidah, N.G.2    Brubaker, P.L.3
  • 14
    • 12644253798 scopus 로고    scopus 로고
    • Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2
    • M. Furuta H. Yano A. Zhou et al. Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2 Proc Natl Acad Sci USA 94 1999 6646-6651
    • (1999) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 6646-6651
    • Furuta, M.1    Yano, H.2    Zhou, A.3
  • 15
    • 0022971804 scopus 로고
    • Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas
    • C. Orskov J.J. Holst S. Knuhtsen et al. Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas Endocrinology 119 1986 1467-1475
    • (1986) Endocrinology , vol.119 , pp. 1467-1475
    • Orskov, C.1    Holst, J.J.2    Knuhtsen, S.3
  • 16
    • 0020501561 scopus 로고
    • Endocrine cells in human intestine: An immunocytochemical study
    • K. Sjolund G. Sanden R. Hakanson et al. Endocrine cells in human intestine: An immunocytochemical study Gastroenterology 85 1983 1120-1130
    • (1983) Gastroenterology , vol.85 , pp. 1120-1130
    • Sjolund, K.1    Sanden, G.2    Hakanson, R.3
  • 17
    • 0347990354 scopus 로고    scopus 로고
    • Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2
    • P.L. Brubaker & Y. Anini Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2 Can J Physiol Pharmacol 81 2003 1005-1012
    • (2003) Can. J. Physiol. Pharmacol. , vol.81 , pp. 1005-1012
    • Brubaker, P.L.1    Anini, Y.2
  • 18
    • 0033028489 scopus 로고    scopus 로고
    • Secretion of the intestinotropic hormone glucagon-like peptide 2 is differentially regulated by nutrients in humans
    • Q. Xiao R.P. Boushey D.J. Drucker et al. Secretion of the intestinotropic hormone glucagon-like peptide 2 is differentially regulated by nutrients in humans Gastroenterology 117 1999 99-105
    • (1999) Gastroenterology , vol.117 , pp. 99-105
    • Xiao, Q.1    Boushey, R.P.2    Drucker, D.J.3
  • 19
    • 0001095690 scopus 로고    scopus 로고
    • Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients
    • T. Vilsboll T. Krarup C.F. Deacon et al. Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients Diabetes 50 2001 609-613
    • (2001) Diabetes , vol.50 , pp. 609-613
    • Vilsboll, T.1    Krarup, T.2    Deacon, C.F.3
  • 20
    • 0028838030 scopus 로고
    • Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients
    • C. Hermann R. Goke G. Richter et al. Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients Digestion 56 1995 117-126
    • (1995) Digestion , vol.56 , pp. 117-126
    • Hermann, C.1    Goke, R.2    Richter, G.3
  • 21
    • 0025777064 scopus 로고
    • Secretion of proglucagon-derived peptides in response to intestinal luminal nutrients
    • J.N. Roberge & P.L. Brubaker Secretion of proglucagon-derived peptides in response to intestinal luminal nutrients Endocrinology 128 1991 3169-3174
    • (1991) Endocrinology , vol.128 , pp. 3169-3174
    • Roberge, J.N.1    Brubaker, P.L.2
  • 22
    • 0029118049 scopus 로고
    • Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
    • T.J. Kieffer C.H.S. McIntosh & R.A. Pederson Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV Endocrinology 136 1995 3585-3596
    • (1995) Endocrinology , vol.136 , pp. 3585-3596
    • Kieffer, T.J.1    McIntosh, C.H.S.2    Pederson, R.A.3
  • 23
    • 0033970249 scopus 로고    scopus 로고
    • Enzymatic and renal-dependent catabolism of the intestinotropic hormone glucagon-like peptide-2 in the rat
    • W. Tavares D.J. Drucker & P.L. Brubaker Enzymatic and renal-dependent catabolism of the intestinotropic hormone glucagon-like peptide-2 in the rat Am J Physiol 278 1999 E134-E139
    • (1999) Am. J. Physiol. , vol.278
    • Tavares, W.1    Drucker, D.J.2    Brubaker, P.L.3
  • 24
    • 0034457973 scopus 로고    scopus 로고
    • In vivo and in vitro degradation of glucagon-like peptide-2 in humans
    • B. Hartmann M.B. Harr P.B. Jeppesen et al. In vivo and in vitro degradation of glucagon-like peptide-2 in humans J Clin Endocrinol Metab 85 2000 2884-2888
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 2884-2888
    • Hartmann, B.1    Harr, M.B.2    Jeppesen, P.B.3
  • 25
    • 0033619675 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides
    • R. Mentlein Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides Regul Pept 85 1999 9-24
    • (1999) Regul. Pept. , vol.85 , pp. 9-24
    • Mentlein, R.1
  • 26
    • 0033303516 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine
    • L. Hansen C.F. Deacon C. Orskov et al. Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine Endocrinology 140 1999 5356-5363
    • (1999) Endocrinology , vol.140 , pp. 5356-5363
    • Hansen, L.1    Deacon, C.F.2    Orskov, C.3
  • 28
    • 0026561865 scopus 로고
    • All products of proglucagon are elevated in plasma from uremic patients
    • C. Orskov J. Andreasen & J.J. Holst All products of proglucagon are elevated in plasma from uremic patients J Clin Endocrinol Metab 74 1992 379-384
    • (1992) J. Clin. Endocrinol. Metab. , vol.74 , pp. 379-384
    • Orskov, C.1    Andreasen, J.2    Holst, J.J.3
  • 29
    • 1442350411 scopus 로고    scopus 로고
    • Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects
    • J.J. Meier M.A. Nauck D. Kranz et al. Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects Diabetes 53 2004 654-662
    • (2004) Diabetes , vol.53 , pp. 654-662
    • Meier, J.J.1    Nauck, M.A.2    Kranz, D.3
  • 30
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36: A physiological incretin in man
    • B. Kreymann G. Williams M.A. Ghatei et al. Glucagon-like peptide-1 7-36: a physiological incretin in man Lancet 2 1987 1300-1304
    • (1987) Lancet , vol.2 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3
  • 31
    • 0023107555 scopus 로고
    • Insulinotropin: Glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas
    • S. Mojsov G.C. Weir & J.F. Habener Insulinotropin: Glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas J Clin Invest 79 1987 616-619
    • (1987) J. Clin. Invest. , vol.79 , pp. 616-619
    • Mojsov, S.1    Weir, G.C.2    Habener, J.F.3
  • 32
    • 0023104829 scopus 로고
    • Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut
    • J.J. Holst C. Orskov O.V. Nielsen et al. Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut FEBS Lett 211 1987 169-174
    • (1987) FEBS Lett. , vol.211 , pp. 169-174
    • Holst, J.J.1    Orskov, C.2    Nielsen, O.V.3
  • 33
    • 0031965604 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 (7-36) amide stimulates exocytosis in human pancreatic beta-cells by both proximal and distal regulatory steps in stimulus-secretion coupling
    • J. Gromada K. Bokvist W.G. Ding et al. Glucagon-like peptide 1 (7-36) amide stimulates exocytosis in human pancreatic beta-cells by both proximal and distal regulatory steps in stimulus-secretion coupling Diabetes 47 1998 57-65
    • (1998) Diabetes , vol.47 , pp. 57-65
    • Gromada, J.1    Bokvist, K.2    Ding, W.G.3
  • 34
    • 0346732301 scopus 로고    scopus 로고
    • Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways
    • P.E. MacDonald X. Wang F. Xia et al. Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways J Biol Chem 278 2003 52446-52453
    • (2003) J. Biol. Chem. , vol.278 , pp. 52446-52453
    • MacDonald, P.E.1    Wang, X.2    Xia, F.3
  • 35
    • 0031910187 scopus 로고    scopus 로고
    • Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1
    • J. Gromada J.J. Holst & P. Rorsman Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1 Pflugers Arch 435 1998 583-594
    • (1998) Pflugers Arch. , vol.435 , pp. 583-594
    • Gromada, J.1    Holst, J.J.2    Rorsman, P.3
  • 36
    • 0037424363 scopus 로고    scopus 로고
    • Epac-selective cAMP analog 8-pCPT-2′-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells
    • G. Kang J.W. Joseph O.G. Chepurny et al. Epac-selective cAMP analog 8-pCPT-2′-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells J Biol Chem 278 2003 8279-8285
    • (2003) J. Biol. Chem. , vol.278 , pp. 8279-8285
    • Kang, G.1    Joseph, J.W.2    Chepurny, O.G.3
  • 37
    • 0344357096 scopus 로고
    • Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line
    • D.J. Drucker J. Philippe S. Mojsov et al. Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line Proc Natl Acad Sci USA 84 1987 3434-3438
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 3434-3438
    • Drucker, D.J.1    Philippe, J.2    Mojsov, S.3
  • 38
    • 0026535588 scopus 로고
    • Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma βTC-1 cells
    • H-C. Fehmann & J.F. Habener Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma βTC-1 cells Endocrinology 130 1992 159-166
    • (1992) Endocrinology , vol.130 , pp. 159-166
    • Fehmann, H-C.1    Habener, J.F.2
  • 39
    • 0029797540 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig
    • C.F. Deacon L. Pridal L. Klarskov et al. Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig Am J Physiol 271 1996 E458-E464
    • (1996) Am. J. Physiol. , vol.271
    • Deacon, C.F.1    Pridal, L.2    Klarskov, L.3
  • 40
    • 0033696456 scopus 로고    scopus 로고
    • Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms
    • B. Balkan & X. Li Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms Am J Physiol Regul Integr Comp Physiol 279 2000 R1449-R1454
    • (2000) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.279
    • Balkan, B.1    Li, X.2
  • 41
    • 0942287326 scopus 로고    scopus 로고
    • Sensory nerves contribute to insulin secretion by glucagon-like peptide-1 in mice
    • B. Ahren Sensory nerves contribute to insulin secretion by glucagon-like peptide-1 in mice Am J Physiol Regul Integr Comp Physiol 286 2004 R269-R272
    • (2004) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.286
    • Ahren, B.1
  • 42
    • 0035114908 scopus 로고    scopus 로고
    • Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells
    • W. Moritz C.A. Leech J. Ferrer et al. Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells Endocrinology 142 2001 129-138
    • (2001) Endocrinology , vol.142 , pp. 129-138
    • Moritz, W.1    Leech, C.A.2    Ferrer, J.3
  • 43
    • 0027473729 scopus 로고
    • Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37)
    • G.G. Holz W.M. Kuhtreiber & J.F. Habener Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37) Nature 361 1993 362-365
    • (1993) Nature , vol.361 , pp. 362-365
    • Holz, G.G.1    Kuhtreiber, W.M.2    Habener, J.F.3
  • 44
    • 0031820844 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 improves the ability of the beta-cell to sense and respond to glucose in subjects with impaired glucose tolerance
    • M.M. Byrne K. Gliem U. Wank et al. Glucagon-like peptide-1 improves the ability of the beta-cell to sense and respond to glucose in subjects with impaired glucose tolerance Diabetes 47 1998 1259-1265
    • (1998) Diabetes , vol.47 , pp. 1259-1265
    • Byrne, M.M.1    Gliem, K.2    Wank, U.3
  • 45
    • 0030913210 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats
    • Y. Wang R. Perfetti N.H. Greig et al. Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats J Clin Invest 99 1997 2883-2889
    • (1997) J. Clin. Invest. , vol.99 , pp. 2883-2889
    • Wang, Y.1    Perfetti, R.2    Greig, N.H.3
  • 46
    • 0028885121 scopus 로고
    • Glucagon-like peptide-1 affects gene transcription and messenger ribonucleic acid stability of components of the insulin secretory system in RIN 1046-38 cells
    • Y. Wang J.M. Egan M. Raygada et al. Glucagon-like peptide-1 affects gene transcription and messenger ribonucleic acid stability of components of the insulin secretory system in RIN 1046-38 cells Endocrinology 136 1995 4910-4917
    • (1995) Endocrinology , vol.136 , pp. 4910-4917
    • Wang, Y.1    Egan, J.M.2    Raygada, M.3
  • 47
    • 0023781471 scopus 로고
    • Glucagon-like peptide-1 (7-36) amide: A potent glucagonostatic and insulinotropic hormone
    • T. Matsuyama R. Komatsu M. Namba et al. Glucagon-like peptide-1 (7-36) amide: A potent glucagonostatic and insulinotropic hormone Diabetes Res Clin Pract 5 1988 281-284
    • (1988) Diabetes Res. Clin. Pract. , vol.5 , pp. 281-284
    • Matsuyama, T.1    Komatsu, R.2    Namba, M.3
  • 48
    • 0030975613 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing alpha-cells of the rat endocrine pancreas
    • R.S. Heller T.J. Kieffer & J.F. Habener Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing alpha-cells of the rat endocrine pancreas Diabetes 46 1997 785-791
    • (1997) Diabetes , vol.46 , pp. 785-791
    • Heller, R.S.1    Kieffer, T.J.2    Habener, J.F.3
  • 50
    • 0027772404 scopus 로고
    • Effect of GLP-1 on gastric motility and gastric and pancreatic secretion in man
    • A. Wettergren B. Schjoldager P.E. Mortensen et al. Effect of GLP-1 on gastric motility and gastric and pancreatic secretion in man Digestion 54 1993 384-385
    • (1993) Digestion , vol.54 , pp. 384-385
    • Wettergren, A.1    Schjoldager, B.2    Mortensen, P.E.3
  • 51
    • 0031790968 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 retards gastric emptying and small bowel transit in the rat: Effect mediated through central or enteric nervous mechanisms
    • T. Tolessa M. Gutniak J.J. Holst et al. Glucagon-like peptide-1 retards gastric emptying and small bowel transit in the rat: Effect mediated through central or enteric nervous mechanisms Dig Dis Sci 43 1998 2284-2290
    • (1998) Dig. Dis. Sci. , vol.43 , pp. 2284-2290
    • Tolessa, T.1    Gutniak, M.2    Holst, J.J.3
  • 52
    • 0030853076 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms
    • N. Imeryuz B.C. Yegen A. Bozkurt et al. Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms Am J Physiol 273 1997 G920-G927
    • (1997) Am. J. Physiol. , vol.273
    • Imeryuz, N.1    Yegen, B.C.2    Bozkurt, A.3
  • 53
    • 1842329143 scopus 로고    scopus 로고
    • Preserved GLP-I effects on glycogen synthase a activity and glucose metabolism in isolated hepatocytes and skeletal muscle from diabetic rats
    • M. Morales M.I. Lopez-Delgado A. Alcantara et al. Preserved GLP-I effects on glycogen synthase a activity and glucose metabolism in isolated hepatocytes and skeletal muscle from diabetic rats Diabetes 46 1997 1264-1269
    • (1997) Diabetes , vol.46 , pp. 1264-1269
    • Morales, M.1    Lopez-Delgado, M.I.2    Alcantara, A.3
  • 54
    • 0028077525 scopus 로고
    • Glucagon-like peptide-1(7-36) amide (GLP-1) enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes: One of several potential extrapancreatic sites of GLP-1 action
    • J.M. Egan C. Montrose-Rafizadeh Y. Wang et al. Glucagon-like peptide-1(7-36) amide (GLP-1) enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes: One of several potential extrapancreatic sites of GLP-1 action Endocrinology 135 1994 2070-2075
    • (1994) Endocrinology , vol.135 , pp. 2070-2075
    • Egan, J.M.1    Montrose-Rafizadeh, C.2    Wang, Y.3
  • 55
    • 0030582130 scopus 로고    scopus 로고
    • Glucagon-like peptide-1(7-36)amide enhances insulin-stimulated glucose uptake and decreases intracellular cAMP content in isolated rat adipocytes
    • H. Miki M. Namba T. Nishimura et al. Glucagon-like peptide-1(7-36)amide enhances insulin-stimulated glucose uptake and decreases intracellular cAMP content in isolated rat adipocytes Biochim Biophys Acta 1312 1996 132-136
    • (1996) Biochim. Biophys. Acta , vol.1312 , pp. 132-136
    • Miki, H.1    Namba, M.2    Nishimura, T.3
  • 56
    • 0029039537 scopus 로고
    • Failure of GLP-1 (7-36) amide to affect glycogenesis in rat skeletal muscle
    • C. Furnsinn K. Ebner & W. Waldhausl Failure of GLP-1 (7-36) amide to affect glycogenesis in rat skeletal muscle Diabetologia 38 1995 864-867
    • (1995) Diabetologia , vol.38 , pp. 864-867
    • Furnsinn, C.1    Ebner, K.2    Waldhausl, W.3
  • 57
    • 0029760133 scopus 로고    scopus 로고
    • Glucagon-like peptide-1(7-36)amide and glycogen synthesis in the liver
    • Y. Nakagawa K. Kawai H. Suzuki et al. Glucagon-like peptide-1(7-36)amide and glycogen synthesis in the liver Diabetologia 39 1996 1241-1242
    • (1996) Diabetologia , vol.39 , pp. 1241-1242
    • Nakagawa, Y.1    Kawai, K.2    Suzuki, H.3
  • 58
    • 0028296643 scopus 로고
    • Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal
    • D.A. D'alessio S.E. Kahn C.R. Leusner et al. Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal J Clin Invest 93 1994 2263-2266
    • (1994) J. Clin. Invest. , vol.93 , pp. 2263-2266
    • D'alessio, D.A.1    Kahn, S.E.2    Leusner, C.R.3
  • 59
    • 0035514550 scopus 로고    scopus 로고
    • Effect of glucagon-like peptide 1 on non-insulin-mediated glucose uptake in the elderly patient with diabetes
    • G.S. Meneilly C.H. McIntosh R.A. Pederson et al. Effect of glucagon-like peptide 1 on non-insulin-mediated glucose uptake in the elderly patient with diabetes Diabetes Care 24 2001 1951-1956
    • (2001) Diabetes Care , vol.24 , pp. 1951-1956
    • Meneilly, G.S.1    McIntosh, C.H.2    Pederson, R.A.3
  • 60
    • 0036342717 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 augments insulin-mediated glucose uptake in the obese state
    • J.M. Egan G.S. Meneilly J.F. Habener et al. Glucagon-like peptide-1 augments insulin-mediated glucose uptake in the obese state J Clin Endocrinol Metab 87 2002 3768-3773
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 3768-3773
    • Egan, J.M.1    Meneilly, G.S.2    Habener, J.F.3
  • 61
    • 0029745122 scopus 로고    scopus 로고
    • GLP-1 does not not acutely affect insulin sensitivity in healthy man
    • L. Orskov J.J. Holst J. Moller et al. GLP-1 does not not acutely affect insulin sensitivity in healthy man Diabetologia 39 1996 1227-1232
    • (1996) Diabetologia , vol.39 , pp. 1227-1232
    • Orskov, L.1    Holst, J.J.2    Moller, J.3
  • 62
    • 0030010364 scopus 로고    scopus 로고
    • The effect of glucagon-like peptide 1 (GLP-1) on glucose elimination in healthy subjects depends on the pancreatic glucoregulatory hormones
    • M. Toft-Nielsen S. Madsbad & J.J. Holst The effect of glucagon-like peptide 1 (GLP-1) on glucose elimination in healthy subjects depends on the pancreatic glucoregulatory hormones Diabetes 45 1996 552-556
    • (1996) Diabetes , vol.45 , pp. 552-556
    • Toft-Nielsen, M.1    Madsbad, S.2    Holst, J.J.3
  • 63
    • 0030798846 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 reduces hepatic glucose production indirectly through insulin and glucagon in humans
    • H. Larsson J.J. Holst & B. Ahren Glucagon-like peptide-1 reduces hepatic glucose production indirectly through insulin and glucagon in humans Acta Physiol Scand 160 1997 413-422
    • (1997) Acta Physiol. Scand. , vol.160 , pp. 413-422
    • Larsson, H.1    Holst, J.J.2    Ahren, B.3
  • 64
    • 0031756220 scopus 로고    scopus 로고
    • Insulinotropic hormone glucagon-like peptide-1-(7-37) appears not to augment insulin-mediated glucose uptake in young men during euglycemia
    • A.S. Ryan J.M. Egan J.F. Habener et al. Insulinotropic hormone glucagon-like peptide-1-(7-37) appears not to augment insulin-mediated glucose uptake in young men during euglycemia J Clin Endocrinol Metab 83 1998 2399-2404
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 2399-2404
    • Ryan, A.S.1    Egan, J.M.2    Habener, J.F.3
  • 65
    • 0036035521 scopus 로고    scopus 로고
    • Lack of effect of exendin-4 and glucagon-like peptide-1-(7,36)-amide on insulin action in non-diabetic humans
    • A. Vella P. Shah A.S. Reed et al. Lack of effect of exendin-4 and glucagon-like peptide-1-(7,36)-amide on insulin action in non-diabetic humans Diabetologia 45 2002 1410-1415
    • (2002) Diabetologia , vol.45 , pp. 1410-1415
    • Vella, A.1    Shah, P.2    Reed, A.S.3
  • 66
    • 0141615898 scopus 로고    scopus 로고
    • Suppression of glucose production by GLP-1 independent of islet hormones: A novel extrapancreatic effect
    • R.L. Prigeon S. Quddusi B. Paty et al. Suppression of glucose production by GLP-1 independent of islet hormones: A novel extrapancreatic effect Am J Physiol Endocrinol Metab 285 2003 E701-E707
    • (2003) Am. J. Physiol. Endocrinol. Metab. , vol.285
    • Prigeon, R.L.1    Quddusi, S.2    Paty, B.3
  • 67
    • 0030013475 scopus 로고    scopus 로고
    • Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor
    • B.P. Bullock R.S. Heller & J.F. Habener Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor Endocrinology 137 1996 2968-2978
    • (1996) Endocrinology , vol.137 , pp. 2968-2978
    • Bullock, B.P.1    Heller, R.S.2    Habener, J.F.3
  • 68
    • 0028325376 scopus 로고
    • Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse
    • R.V. Campos Y.C. Lee & D.J. Drucker Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse Endocrinology 134 1994 2156-2164
    • (1994) Endocrinology , vol.134 , pp. 2156-2164
    • Campos, R.V.1    Lee, Y.C.2    Drucker, D.J.3
  • 69
    • 0025728406 scopus 로고
    • Absence of insulinotropic glucagon-like peptide-I(7-37) receptors on isolated rat liver hepatocytes
    • P.F. Blackmore S. Mojsov J.H. Exton et al. Absence of insulinotropic glucagon-like peptide-I(7-37) receptors on isolated rat liver hepatocytes FEBS Lett 283 1991 7-10
    • (1991) FEBS Lett , vol.283 , pp. 7-10
    • Blackmore, P.F.1    Mojsov, S.2    Exton, J.H.3
  • 70
    • 0027397282 scopus 로고
    • Presence and characterization of glucagon-like peptide-1(7-36) amide receptors in solubilized membranes of rat adipose tissue
    • I. Valverde E. Merida E. Delgado Presence and characterization of glucagon-like peptide-1(7-36) amide receptors in solubilized membranes of rat adipose tissue Endocrinology 132 1993 75-79
    • (1993) Endocrinology , vol.132 , pp. 75-79
    • Valverde, I.1    Merida, E.2    Delgado, E.3
  • 71
    • 0027164996 scopus 로고
    • Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C
    • M.B. Wheeler M. Lu J.S. Dillon et al. Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C Endocrinology 133 1993 57-62
    • (1993) Endocrinology , vol.133 , pp. 57-62
    • Wheeler, M.B.1    Lu, M.2    Dillon, J.S.3
  • 72
    • 0030884317 scopus 로고    scopus 로고
    • Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes
    • C. Montrose-Rafizadeh H. Yang Y. Wang et al. Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes J Cell Physiol 172 1997 275-283
    • (1997) J. Cell Physiol. , vol.172 , pp. 275-283
    • Montrose-Rafizadeh, C.1    Yang, H.2    Wang, Y.3
  • 73
    • 0031668166 scopus 로고    scopus 로고
    • GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor
    • H. Yang J.M. Egan Y. Wang et al. GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor Am J Physiol 275 1998 C675-C683
    • (1998) Am. J. Physiol. , vol.275
    • Yang, H.1    Egan, J.M.2    Wang, Y.3
  • 75
    • 0036496551 scopus 로고    scopus 로고
    • Exendin-4 increases insulin sensitivity via a PI-3-kinase-dependent mechanism: Contrasting effects of GLP-1
    • I. Idris D. Patiag S. Gray et al. Exendin-4 increases insulin sensitivity via a PI-3-kinase-dependent mechanism: Contrasting effects of GLP-1 Biochem Pharmacol 63 2002 993-996
    • (2002) Biochem. Pharmacol. , vol.63 , pp. 993-996
    • Idris, I.1    Patiag, D.2    Gray, S.3
  • 76
    • 0036305993 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) and glucose metabolism in human myocytes
    • M.A. Luque N. Gonzalez L. Marquez et al. Glucagon-like peptide-1 (GLP-1) and glucose metabolism in human myocytes J Endocrinol 173 2002 465-473
    • (2002) J. Endocrinol. , vol.173 , pp. 465-473
    • Luque, M.A.1    Gonzalez, N.2    Marquez, L.3
  • 77
    • 0030034912 scopus 로고    scopus 로고
    • Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboons
    • D.A. D'alessio R. Vogel R. Prigeon et al. Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboons J Clin Invest 97 1996 133-138
    • (1996) J. Clin. Invest. , vol.97 , pp. 133-138
    • D'alessio, D.A.1    Vogel, R.2    Prigeon, R.3
  • 78
    • 0032960834 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: Studies with the antagonist exendin 9-39
    • C.M. Edwards J.F. Todd M. Mahmoudi et al. Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: studies with the antagonist exendin 9-39 Diabetes 48 1999 86-93
    • (1999) Diabetes , vol.48 , pp. 86-93
    • Edwards, C.M.1    Todd, J.F.2    Mahmoudi, M.3
  • 79
    • 0028821658 scopus 로고
    • Glucagon-like peptide-1 is a physiological incretin in rat
    • Z. Wang R.M. Wang A.A. Owji et al. Glucagon-like peptide-1 is a physiological incretin in rat J Clin Invest 95 1995 417-421
    • (1995) J. Clin. Invest. , vol.95 , pp. 417-421
    • Wang, Z.1    Wang, R.M.2    Owji, A.A.3
  • 80
    • 0029958404 scopus 로고    scopus 로고
    • Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene
    • L.A. Scrocchi T.J. Brown N. MaClusky et al. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene Nat Med 2 1996 1254-1258
    • (1996) Nat. Med. , vol.2 , pp. 1254-1258
    • Scrocchi, L.A.1    Brown, T.J.2    MaClusky, N.3
  • 81
    • 0000385121 scopus 로고    scopus 로고
    • Exendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans
    • J. Schirra K. Sturm P. Leicht et al. Exendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans J Clin Invest 101 1998 1421-1430
    • (1998) J. Clin. Invest. , vol.101 , pp. 1421-1430
    • Schirra, J.1    Sturm, K.2    Leicht, P.3
  • 82
    • 0031656888 scopus 로고    scopus 로고
    • Glucose and glucoincretin peptides synergize to induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic beta(INS-1) cells
    • S. Susini E. Roche M. Prentki et al. Glucose and glucoincretin peptides synergize to induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic beta(INS-1) cells Faseb J 12 1998 1173-1182
    • (1998) Faseb J. , vol.12 , pp. 1173-1182
    • Susini, S.1    Roche, E.2    Prentki, M.3
  • 83
    • 0032768616 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells
    • J. Buteau R. Roduit S. Susini et al. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells Diabetologia 42 1999 856-864
    • (1999) Diabetologia , vol.42 , pp. 856-864
    • Buteau, J.1    Roduit, R.2    Susini, S.3
  • 84
    • 0033512486 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells
    • J. Zhou X. Wang M.A. Pineyro et al. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells Diabetes 48 1999 2358-2366
    • (1999) Diabetes , vol.48 , pp. 2358-2366
    • Zhou, J.1    Wang, X.2    Pineyro, M.A.3
  • 85
    • 0035084164 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells
    • H. Hui C. Wright & R. Perfetti Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells Diabetes 50 2001 785-796
    • (2001) Diabetes , vol.50 , pp. 785-796
    • Hui, H.1    Wright, C.2    Perfetti, R.3
  • 86
    • 0036326210 scopus 로고    scopus 로고
    • Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: Involvement of PDX-1 and HNF3beta transcription factors
    • J. Zhou M.A. Pineyro X. Wang et al. Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: Involvement of PDX-1 and HNF3beta transcription factors J Cell Physiol 192 2002 304-314
    • (2002) J. Cell Physiol. , vol.192 , pp. 304-314
    • Zhou, J.1    Pineyro, M.A.2    Wang, X.3
  • 87
    • 0036775170 scopus 로고    scopus 로고
    • Exendin 4 up-regulates expression of PDX 1 and hastens differentiation and maturation of human fetal pancreatic cells
    • J. Movassat G.M. Beattie A.D. Lopez et al. Exendin 4 up-regulates expression of PDX 1 and hastens differentiation and maturation of human fetal pancreatic cells J Clin Endocrinol Metab 87 2002 4775-4781
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 4775-4781
    • Movassat, J.1    Beattie, G.M.2    Lopez, A.D.3
  • 88
    • 0036721411 scopus 로고    scopus 로고
    • Functional maturation of fetal porcine beta-cells by glucagon-like peptide 1 and cholecystokinin
    • A.A. Hardikar X.Y. Wang L.J. Williams et al. Functional maturation of fetal porcine beta-cells by glucagon-like peptide 1 and cholecystokinin Endocrinology 143 2002 3505-3514
    • (2002) Endocrinology , vol.143 , pp. 3505-3514
    • Hardikar, A.A.1    Wang, X.Y.2    Williams, L.J.3
  • 89
    • 0032908809 scopus 로고    scopus 로고
    • Initiation of increased pancreatic islet growth in young normoglycemic mice (Umea+/?)
    • A. Edvell & P. Lindstrom Initiation of increased pancreatic islet growth in young normoglycemic mice (Umea+/?) Endocrinology 140 1999 778-783
    • (1999) Endocrinology , vol.140 , pp. 778-783
    • Edvell, A.1    Lindstrom, P.2
  • 90
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
    • G. Xu D.A. Stoffers J.F. Habener et al. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats Diabetes 48 1999 2270-2276
    • (1999) Diabetes , vol.48 , pp. 2270-2276
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3
  • 91
    • 0034522773 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
    • R. Perfetti J. Zhou M.E. Doyle et al. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats Endocrinology 141 2000 4600-4605
    • (2000) Endocrinology , vol.141 , pp. 4600-4605
    • Perfetti, R.1    Zhou, J.2    Doyle, M.E.3
  • 92
    • 0036381989 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice
    • Q. Wang & P.L. Brubaker Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice Diabetologia 45 2002 1263-1273
    • (2002) Diabetologia , vol.45 , pp. 1263-1273
    • Wang, Q.1    Brubaker, P.L.2
  • 93
    • 0036312680 scopus 로고    scopus 로고
    • Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4
    • C. Tourrel D. Bailbe M. Lacorne et al. Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4 Diabetes 51 2002 1443-1452
    • (2002) Diabetes , vol.51 , pp. 1443-1452
    • Tourrel, C.1    Bailbe, D.2    Lacorne, M.3
  • 94
    • 0037341252 scopus 로고    scopus 로고
    • Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat
    • D.A. Stoffers B.M. Desai D.D. DeLeon et al. Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat Diabetes 52 2003 734-740
    • (2003) Diabetes , vol.52 , pp. 734-740
    • Stoffers, D.A.1    Desai, B.M.2    DeLeon, D.D.3
  • 95
    • 0037386156 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5′-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway
    • H. Hui A. Nourparvar X. Zhao et al. Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5′-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway Endocrinology 144 2003 1444-1455
    • (2003) Endocrinology , vol.144 , pp. 1444-1455
    • Hui, H.1    Nourparvar, A.2    Zhao, X.3
  • 96
    • 0037414781 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis
    • Y. Li T. Hansotia B. Yusta et al. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis J Biol Chem 278 2003 471-478
    • (2003) J. Biol. Chem. , vol.278 , pp. 471-478
    • Li, Y.1    Hansotia, T.2    Yusta, B.3
  • 97
    • 0345374580 scopus 로고    scopus 로고
    • GLP-1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets
    • L. Farilla A. Bulotta B. Hirshberg et al. GLP-1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets Endocrinology 144 2003 5149-5158
    • (2003) Endocrinology , vol.144 , pp. 5149-5158
    • Farilla, L.1    Bulotta, A.2    Hirshberg, B.3
  • 98
    • 2942568445 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 prevents beta cell glucolipotoxicity
    • J. Buteau W. El-Assaad C.J. Rhodes et al. Glucagon-like peptide-1 prevents beta cell glucolipotoxicity Diabetologia 47 2004 806-815
    • (2004) Diabetologia , vol.47 , pp. 806-815
    • Buteau, J.1    El-Assaad, W.2    Rhodes, C.J.3
  • 99
    • 0036828227 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats
    • L. Farilla H. Hui C. Bertolotto et al. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats Endocrinology 143 2002 4397-4408
    • (2002) Endocrinology , vol.143 , pp. 4397-4408
    • Farilla, L.1    Hui, H.2    Bertolotto, C.3
  • 100
    • 0035069103 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice
    • Z. Ling D. Wu Y. Zambre et al. Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice Virchows Arch 438 2001 382-387
    • (2001) Virchows Arch. , vol.438 , pp. 382-387
    • Ling, Z.1    Wu, D.2    Zambre, Y.3
  • 101
    • 0037312829 scopus 로고    scopus 로고
    • Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy
    • D.D. De Leon S. Deng R. Madani et al. Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy Diabetes 52 2003 365-371
    • (2003) Diabetes , vol.52 , pp. 365-371
    • De Leon, D.D.1    Deng, S.2    Madani, R.3
  • 102
    • 0037221488 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor
    • J. Buteau S. Foisy E. Joly et al. Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor Diabetes 52 2003 124-132
    • (2003) Diabetes , vol.52 , pp. 124-132
    • Buteau, J.1    Foisy, S.2    Joly, E.3
  • 103
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
    • D.A. Stoffers T.J. Kieffer M.A. Hussain et al. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas Diabetes 49 2000 741-748
    • (2000) Diabetes , vol.49 , pp. 741-748
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3
  • 104
    • 0034522773 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
    • R. Perfetti J. Zhou M.E. Doyle & 3 J.M. Egan Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats Endocrinology 141 2000 4600-4605
    • (2000) Endocrinology , vol.141 , pp. 4600-4605
    • Perfetti, R.1    Zhou, J.2    Doyle, M.E.3    Egan, J.M.4
  • 105
    • 0037414781 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor signaling modulates B cell apoptosis
    • Y. Li T. Hansotia B. Yusta et al. Glucagon-like peptide-1 receptor signaling modulates B cell apoptosis J Biol Chem 278 2003 471-478
    • (2003) J. Biol. Chem. , vol.278 , pp. 471-478
    • Li, Y.1    Hansotia, T.2    Yusta, B.3
  • 106
    • 1542365269 scopus 로고    scopus 로고
    • cAMP dose-dependently prevents palmitate-induced apoptosis by both protein kinase A- and cAMP-guanine nucleotide exchange factor-dependent pathways in beta-cells
    • G. Kwon K.L. Pappan C.A. Marshall et al. cAMP dose-dependently prevents palmitate-induced apoptosis by both protein kinase A- and cAMP-guanine nucleotide exchange factor-dependent pathways in beta-cells J Biol Chem 279 2004 8938-8945
    • (2004) J. Biol. Chem. , vol.279 , pp. 8938-8945
    • Kwon, G.1    Pappan, K.L.2    Marshall, C.A.3
  • 107
    • 0038339191 scopus 로고    scopus 로고
    • cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2
    • U.S. Jhala G. Canettieri R.A. Screaton et al. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2 Genes Dev 17 2003 1575-1580
    • (2003) Genes Dev. , vol.17 , pp. 1575-1580
    • Jhala, U.S.1    Canettieri, G.2    Screaton, R.A.3
  • 108
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • A.E. Butler J. Janson S. Bonner-Weir et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes Diabetes 52 2003 102-110
    • (2003) Diabetes , vol.52 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3
  • 109
    • 13344282056 scopus 로고    scopus 로고
    • A role for glucagon-like peptide-1 in the central regulation of feeding
    • M.D. Turton D. O'Shea I. Gunn et al. A role for glucagon-like peptide-1 in the central regulation of feeding Nature 379 1996 69-72
    • (1996) Nature , vol.379 , pp. 69-72
    • Turton, M.D.1    O'Shea, D.2    Gunn, I.3
  • 110
    • 0032940582 scopus 로고    scopus 로고
    • Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat
    • K. Meeran D. O'Shea C.M. Edwards et al. Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat Endocrinology 140 1999 244-250
    • (1999) Endocrinology , vol.140 , pp. 244-250
    • Meeran, K.1    O'Shea, D.2    Edwards, C.M.3
  • 111
    • 0034085701 scopus 로고    scopus 로고
    • Peripheral versus central effects of glucagon-like peptide-1 receptor agonists on satiety and body weight loss in Zucker obese rats
    • F. Rodriquez de Fonseca M. Navarro & E. Alvarez Peripheral versus central effects of glucagon-like peptide-1 receptor agonists on satiety and body weight loss in Zucker obese rats Metabolism 49 2000 709-717
    • (2000) Metabolism , vol.49 , pp. 709-717
    • Rodriquez de Fonseca, F.1    Navarro, M.2    Alvarez, E.3
  • 112
    • 0032005005 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
    • A. Flint A. Raben A. Astrup et al. Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans J Clin Invest 101 1998 515-520
    • (1998) J. Clin. Invest. , vol.101 , pp. 515-520
    • Flint, A.1    Raben, A.2    Astrup, A.3
  • 113
    • 0033021677 scopus 로고    scopus 로고
    • Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men
    • E. Naslund B. Barkeling N. King et al. Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men Int J Obes Relat Metab Disord 23 1999 304-311
    • (1999) Int. J. Obes. Relat. Metab. Disord. , vol.23 , pp. 304-311
    • Naslund, E.1    Barkeling, B.2    King, N.3
  • 114
    • 0032966882 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2
    • J.P. Gutzwiller J. Drewe B. Goke et al. Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2 Am J Physiol 276 1999 R1541-R1544
    • (1999) Am. J. Physiol. , vol.276
    • Gutzwiller, J.P.1    Drewe, J.2    Goke, B.3
  • 115
    • 0030967436 scopus 로고    scopus 로고
    • Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat
    • P.J. Larsen M. Tang-Christensen & D.S. Jessop Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat Endocrinology 138 1997 4445-4455
    • (1997) Endocrinology , vol.138 , pp. 4445-4455
    • Larsen, P.J.1    Tang-Christensen, M.2    Jessop, D.S.3
  • 116
    • 0032830989 scopus 로고    scopus 로고
    • Interoceptive stress activates glucagon-like peptide-1 neurons that project to the hypothalamus
    • L. Rinaman Interoceptive stress activates glucagon-like peptide-1 neurons that project to the hypothalamus Am J Physiol 277 1999 R582-R590
    • (1999) Am. J. Physiol. , vol.277
    • Rinaman, L.1
  • 117
    • 0032763050 scopus 로고    scopus 로고
    • A functional role for central glucagon-like peptide-1 receptors in lithium chloride-induced anorexia
    • L. Rinaman A functional role for central glucagon-like peptide-1 receptors in lithium chloride-induced anorexia Am J Physiol 277 1999 R1537-R1540
    • (1999) Am. J. Physiol. , vol.277
    • Rinaman, L.1
  • 118
    • 0034652302 scopus 로고    scopus 로고
    • The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride
    • R.J. Seeley K. Blake P.A. Rushing et al. The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride J Neurosci 20 2000 1616-1621
    • (2000) J. Neurosci. , vol.20 , pp. 1616-1621
    • Seeley, R.J.1    Blake, K.2    Rushing, P.A.3
  • 119
    • 0028867442 scopus 로고
    • Distribution of GLP-1 binding sites in the rat brain: Evidence that exendin-4 is a ligand of brain GLP-1 binding sites
    • R. Goke P.J. Larsen J.D. Mikkelsen et al. Distribution of GLP-1 binding sites in the rat brain: Evidence that exendin-4 is a ligand of brain GLP-1 binding sites Eur J Neurosci 7 1995 2294-2300
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 2294-2300
    • Goke, R.1    Larsen, P.J.2    Mikkelsen, J.D.3
  • 120
    • 0028814666 scopus 로고
    • Structural characterization by affinity cross-linking of glucagon-like peptide-1(7-36)amide receptor in rat brain
    • J.C. Calvo B. Yusta F. Mora et al. Structural characterization by affinity cross-linking of glucagon-like peptide-1(7-36)amide receptor in rat brain J Neurochem 64 1995 299-306
    • (1995) J. Neurochem. , vol.64 , pp. 299-306
    • Calvo, J.C.1    Yusta, B.2    Mora, F.3
  • 121
    • 0037066595 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 as a regulator of food intake and body weight: Therapeutic perspectives
    • J.J. Meier B. Gallwitz W.E. Schmidt et al. Glucagon-like peptide 1 as a regulator of food intake and body weight: Therapeutic perspectives Eur J Pharmacol 440 2002 269-279
    • (2002) Eur. J. Pharmacol. , vol.440 , pp. 269-279
    • Meier, J.J.1    Gallwitz, B.2    Schmidt, W.E.3
  • 122
    • 0029903111 scopus 로고    scopus 로고
    • Glucagon-like peptide I receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I
    • C. Orskov S.S. Poulsen M. Moller et al. Glucagon-like peptide I receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I Diabetes 45 1996 832-835
    • (1996) Diabetes , vol.45 , pp. 832-835
    • Orskov, C.1    Poulsen, S.S.2    Moller, M.3
  • 123
    • 0030836364 scopus 로고    scopus 로고
    • Cardiovascular and pancreatic endocrine responses to glucagon-like peptide-1(7-36) amide in the conscious calf
    • C.M. Edwards A.V. Edwards & S.R. Bloom Cardiovascular and pancreatic endocrine responses to glucagon-like peptide-1(7-36) amide in the conscious calf Exp Physiol 82 1997 709-716
    • (1997) Exp. Physiol. , vol.82 , pp. 709-716
    • Edwards, C.M.1    Edwards, A.V.2    Bloom, S.R.3
  • 124
    • 0032714917 scopus 로고    scopus 로고
    • Neural contribution to the effect of glucagon-like peptide-1-(7-36) amide on arterial blood pressure in rats
    • J.M. Barragan J. Eng R. Rodriguez et al. Neural contribution to the effect of glucagon-like peptide-1-(7-36) amide on arterial blood pressure in rats Am J Physiol 277 1999 E784-E791
    • (1999) Am. J. Physiol. , vol.277
    • Barragan, J.M.1    Eng, J.2    Rodriguez, R.3
  • 125
    • 0023209346 scopus 로고
    • Central representation of visceral function
    • D.F. Cechetto Central representation of visceral function Fed Proc 46 1987 17-23
    • (1987) Fed. Proc. , vol.46 , pp. 17-23
    • Cechetto, D.F.1
  • 126
    • 0026005086 scopus 로고
    • The area postrema: A cardiovascular control centre at the blood-brain interface?
    • A.V. Ferguson The area postrema: A cardiovascular control centre at the blood-brain interface? Can J Physiol Pharmacol 69 1991 1026-1034
    • (1991) Can. J. Physiol. Pharmacol. , vol.69 , pp. 1026-1034
    • Ferguson, A.V.1
  • 127
    • 0028900758 scopus 로고
    • Tissue-specific expression of the human receptor for glucagon-like peptide 1: Brain, heart and pancreatic forms have the same deduced amino acid sequences
    • Y. Wei & S. Mojsov Tissue-specific expression of the human receptor for glucagon-like peptide 1: Brain, heart and pancreatic forms have the same deduced amino acid sequences FEBS Lett 358 1995 219-224
    • (1995) FEBS Lett , vol.358 , pp. 219-224
    • Wei, Y.1    Mojsov, S.2
  • 128
    • 0036307872 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
    • H. Yamamoto C.E. Lee J.N. Marcus et al. Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons J Clin Invest 110 2002 43-52
    • (2002) J. Clin. Invest. , vol.110 , pp. 43-52
    • Yamamoto, H.1    Lee, C.E.2    Marcus, J.N.3
  • 129
    • 0038577144 scopus 로고    scopus 로고
    • Cardiac function in mice lacking the glucagon-like peptide-1 receptor
    • R. Gros X. You L.L. Baggio et al. Cardiac function in mice lacking the glucagon-like peptide-1 receptor Endocrinology 144 2003 2242-2252
    • (2003) Endocrinology , vol.144 , pp. 2242-2252
    • Gros, R.1    You, X.2    Baggio, L.L.3
  • 130
    • 0032976939 scopus 로고    scopus 로고
    • Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients
    • M.B. Toft-Nielsen S. Madsbad & J.J. Holst Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients Diabetes Care 22 1999 1137-1143
    • (1999) Diabetes Care , vol.22 , pp. 1137-1143
    • Toft-Nielsen, M.B.1    Madsbad, S.2    Holst, J.J.3
  • 131
    • 0034814047 scopus 로고    scopus 로고
    • Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers
    • C.M. Edwards S.A. Stanley R. Davis et al. Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers Am J Physiol Endocrinol Metab 281 2001 E155-E161
    • (2001) Am. J. Physiol. Endocrinol. Metab. , vol.281
    • Edwards, C.M.1    Stanley, S.A.2    Davis, R.3
  • 132
    • 0037850667 scopus 로고    scopus 로고
    • Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes
    • M.S. Fineman T.A. Bicsak L.Z. Shen et al. Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes Diabetes Care 26 2003 2370-2377
    • (2003) Diabetes Care , vol.26 , pp. 2370-2377
    • Fineman, M.S.1    Bicsak, T.A.2    Shen, L.Z.3
  • 133
    • 0038202937 scopus 로고    scopus 로고
    • Antihypertensive effect of glucagon-like peptide 1 in Dahl salt-sensitive rats
    • M. Yu C. Moreno & K.M. Hoagland Antihypertensive effect of glucagon-like peptide 1 in Dahl salt-sensitive rats J Hypertens 21 2003 1125-1135
    • (2003) J. Hypertens , vol.21 , pp. 1125-1135
    • Yu, M.1    Moreno, C.2    Hoagland, K.M.3
  • 134
    • 2942668372 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 induces natriuresis in healthy subjects and in insulin-resistant obese men
    • J.P. Gutzwiller S. Tschopp A. Bock et al. Glucagon-like peptide 1 induces natriuresis in healthy subjects and in insulin-resistant obese men J Clin Endocrinol Metab 89 2004 3055-3061
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 3055-3061
    • Gutzwiller, J.P.1    Tschopp, S.2    Bock, A.3
  • 135
    • 1442311383 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion
    • L.A. Nikolaidis S. Mankad G.G. Sokos et al. Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion Circulation 109 2004 962-965
    • (2004) Circulation , vol.109 , pp. 962-965
    • Nikolaidis, L.A.1    Mankad, S.2    Sokos, G.G.3
  • 136
    • 0036182251 scopus 로고    scopus 로고
    • A novel neurotrophic property of glucagon-like peptide 1: A promoter of nerve growth factor-mediated differentiation in PC12 cells
    • T. Perry D.K. Lahiri D. Chen et al. A novel neurotrophic property of glucagon-like peptide 1: A promoter of nerve growth factor-mediated differentiation in PC12 cells J Pharmacol Exp Ther 300 2002 958-966
    • (2002) J. Pharmacol. Exp. Ther. , vol.300 , pp. 958-966
    • Perry, T.1    Lahiri, D.K.2    Chen, D.3
  • 137
    • 0036721026 scopus 로고    scopus 로고
    • Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4
    • T. Perry N.J. Haughey M.P. Mattson et al. Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4 J Pharmacol Exp Ther 302 2002 881-888
    • (2002) J. Pharmacol. Exp. Ther. , vol.302 , pp. 881-888
    • Perry, T.1    Haughey, N.J.2    Mattson, M.P.3
  • 138
    • 0141461415 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
    • M.J. During L. Cao D.S. Zuzga et al. Glucagon-like peptide-1 receptor is involved in learning and neuroprotection Nat Med 9 2003 1173-1179
    • (2003) Nat. Med. , vol.9 , pp. 1173-1179
    • During, M.J.1    Cao, L.2    Zuzga, D.S.3
  • 139
    • 0041733259 scopus 로고    scopus 로고
    • The glucagon-like peptides: A double-edged therapeutic sword?
    • T. Perry & N.H. Greig The glucagon-like peptides: A double-edged therapeutic sword? Trends Pharmacol Sci 24 2003 377-383
    • (2003) Trends Pharmacol. Sci. , vol.24 , pp. 377-383
    • Perry, T.1    Greig, N.H.2
  • 140
    • 0034730477 scopus 로고    scopus 로고
    • Endogenous GLP-1 is involved in beta-amyloid protein-induced memory impairment and hippocampal neuronal death in rats
    • J. Oka E. Suzuki & Y. Kondo Endogenous GLP-1 is involved in beta-amyloid protein-induced memory impairment and hippocampal neuronal death in rats Brain Res 878 2000 194-198
    • (2000) Brain Res. , vol.878 , pp. 194-198
    • Oka, J.1    Suzuki, E.2    Kondo, Y.3
  • 141
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study
    • M. Zander S. Madsbad J.L. Madsen et al. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study Lancet 359 2002 824-830
    • (2002) Lancet , vol.359 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3
  • 142
    • 0029954211 scopus 로고    scopus 로고
    • Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients
    • W.O. Creutzfeld N. Kleine B. Willms et al. Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients Diabetes Care 19 1996 580-586
    • (1996) Diabetes Care , vol.19 , pp. 580-586
    • Creutzfeld, W.O.1    Kleine, N.2    Willms, B.3
  • 143
    • 0029033945 scopus 로고
    • Glucagon-like peptide I reduces postprandial glycemic excursions in IDDM
    • J. Dupre M.T. Behme I.M. Hramiak et al. Glucagon-like peptide I reduces postprandial glycemic excursions in IDDM Diabetes 44 1995 626-630
    • (1995) Diabetes , vol.44 , pp. 626-630
    • Dupre, J.1    Behme, M.T.2    Hramiak, I.M.3
  • 144
    • 0031035778 scopus 로고    scopus 로고
    • Subcutaneous glucagon-like peptide I combined with insulin normalizes postcibal glycemic excursions in IDDM
    • J. Dupre M.T. Behme I.M. Hramiak et al. Subcutaneous glucagon-like peptide I combined with insulin normalizes postcibal glycemic excursions in IDDM Diabetes Care 20 1997 381-384
    • (1997) Diabetes Care , vol.20 , pp. 381-384
    • Dupre, J.1    Behme, M.T.2    Hramiak, I.M.3
  • 145
    • 0024515406 scopus 로고
    • Glucagonlike peptide I (7-37) actions on endocrine pancreas
    • G.C. Weir S. Mojsov G.K. Hendrick et al. Glucagonlike peptide I (7-37) actions on endocrine pancreas Diabetes 38 1989 338-342
    • (1989) Diabetes , vol.38 , pp. 338-342
    • Weir, G.C.1    Mojsov, S.2    Hendrick, G.K.3
  • 146
    • 0027523613 scopus 로고
    • Glucose-dependency of the insulin stimulatory effect of glucagon-like peptide-1 (7-36) amide on the rat pancreas
    • R. Goke B. Wagner H.C. Fehmann et al. Glucose-dependency of the insulin stimulatory effect of glucagon-like peptide-1 (7-36) amide on the rat pancreas Res Exp Med 193 1993 97-103
    • (1993) Res. Exp. Med. , vol.193 , pp. 97-103
    • Goke, R.1    Wagner, B.2    Fehmann, H.C.3
  • 147
    • 0036959991 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers
    • M.A. Nauck M.M. Heimesaat K. Behle et al. Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers J Clin Endocrinol Metab 87 2002 1239-1246
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 1239-1246
    • Nauck, M.A.1    Heimesaat, M.M.2    Behle, K.3
  • 148
    • 0029856880 scopus 로고    scopus 로고
    • Gut incretin hormones in identical twins discordant for non-insulin-dependent diabetes mellitus (NIDDM)-evidence for decreased glucagon-like peptide 1 secretion during oral glucose ingestion in NIDDM twins
    • A.A. Vaag J.J. Holst A. Volund et al. Gut incretin hormones in identical twins discordant for non-insulin-dependent diabetes mellitus (NIDDM)-evidence for decreased glucagon-like peptide 1 secretion during oral glucose ingestion in NIDDM twins Eur J Endocrinol 135 1996 425-432
    • (1996) Eur. J. Endocrinol. , vol.135 , pp. 425-432
    • Vaag, A.A.1    Holst, J.J.2    Volund, A.3
  • 149
    • 0026648961 scopus 로고
    • Isolation and characterization of exendin 4, an exendin 3 analogue from Heloderma suspectum venom
    • J. Eng W.A. Kleinman L. Singh et al. Isolation and characterization of exendin 4, an exendin 3 analogue from Heloderma suspectum venom J Biol Chem 267 1992 7402-7405
    • (1992) J. Biol. Chem. , vol.267 , pp. 7402-7405
    • Eng, J.1    Kleinman, W.A.2    Singh, L.3
  • 150
    • 0038497464 scopus 로고    scopus 로고
    • Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes
    • O.G. Kolterman J.B. Buse M.S. Fineman et al. Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes J Clin Endocrinol Metab 88 2003 3082-3089
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 3082-3089
    • Kolterman, O.G.1    Buse, J.B.2    Fineman, M.S.3
  • 151
    • 0038178058 scopus 로고    scopus 로고
    • Effects of 1-mo bolus subcutaneous administration of exendin-4 in type 2 diabetes
    • J.M. Egan G.S. Meneilly & D. Elahi Effects of 1-mo bolus subcutaneous administration of exendin-4 in type 2 diabetes Am J Physiol Endocrinol Metab 284 2003 E1072-E1079
    • (2003) Am. J. Physiol. Endocrinol. Metab. , vol.284
    • Egan, J.M.1    Meneilly, G.S.2    Elahi, D.3
  • 152
    • 0036066641 scopus 로고    scopus 로고
    • Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes
    • C.B. Juhl M. Hollingdal J. Sturis et al. Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes Diabetes 51 2002 424-429
    • (2002) Diabetes , vol.51 , pp. 424-429
    • Juhl, C.B.1    Hollingdal, M.2    Sturis, J.3
  • 153
    • 2342599057 scopus 로고    scopus 로고
    • One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes
    • K.B. Degn C.B. Juhl J. Sturis et al. One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes Diabetes 53 2004 1187-1194
    • (2004) Diabetes , vol.53 , pp. 1187-1194
    • Degn, K.B.1    Juhl, C.B.2    Sturis, J.3
  • 154
    • 2542451393 scopus 로고    scopus 로고
    • Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog Liraglutide (NN2211): A 12-week, double-blind, randomized, controlled trial
    • S. Madsbad O. Schmitz J. Ranstam et al. Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog Liraglutide (NN2211): A 12-week, double-blind, randomized, controlled trial Diabetes Care 27 2004 1335-1342
    • (2004) Diabetes Care , vol.27 , pp. 1335-1342
    • Madsbad, S.1    Schmitz, O.2    Ranstam, J.3
  • 155
    • 0037339649 scopus 로고    scopus 로고
    • Development and characterization of a glucagon-like peptide 1-albumin conjugate: The ability to activate the glucagon-like peptide 1 receptor in vivo
    • J.G. Kim L.L. Baggio D.P. Bridon et al. Development and characterization of a glucagon-like peptide 1-albumin conjugate: The ability to activate the glucagon-like peptide 1 receptor in vivo Diabetes 52 2003 751-759
    • (2003) Diabetes , vol.52 , pp. 751-759
    • Kim, J.G.1    Baggio, L.L.2    Bridon, D.P.3
  • 156
    • 0034612348 scopus 로고    scopus 로고
    • Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26
    • D. Marguet L. Baggio & T. Kobayashi Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26 Proc Natl Acad Sci USA 97 2000 6874-6879
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 6874-6879
    • Marguet, D.1    Baggio, L.2    Kobayashi, T.3
  • 157
    • 0037974604 scopus 로고    scopus 로고
    • Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance
    • S.L. Conarello Z. Li J. Ronan et al. Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance Proc Natl Acad Sci USA 100 2003 6825-6830
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 6825-6830
    • Conarello, S.L.1    Li, Z.2    Ronan, J.3
  • 158
    • 0034666562 scopus 로고    scopus 로고
    • Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice
    • B. Ahren J.J. Holst H. Martensson et al. Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice Eur J Pharmacol 404 2000 239-245
    • (2000) Eur. J. Pharmacol. , vol.404 , pp. 239-245
    • Ahren, B.1    Holst, J.J.2    Martensson, H.3
  • 159
    • 0031870418 scopus 로고    scopus 로고
    • Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide
    • R.A. Pederson H.A. White D. Schlenzig et al. Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide Diabetes 47 1998 1253-1258
    • (1998) Diabetes , vol.47 , pp. 1253-1258
    • Pederson, R.A.1    White, H.A.2    Schlenzig, D.3
  • 160
    • 0031916924 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig
    • C.F. Deacon T.E. Hughes & J.J. Holst Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig Diabetes 47 1998 764-769
    • (1998) Diabetes , vol.47 , pp. 764-769
    • Deacon, C.F.1    Hughes, T.E.2    Holst, J.J.3
  • 161
    • 0000135759 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats
    • B. Balkan L. Kwasnik R. Miserendino et al. Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats Diabetologia 42 1999 1324-1331
    • (1999) Diabetologia , vol.42 , pp. 1324-1331
    • Balkan, B.1    Kwasnik, L.2    Miserendino, R.3
  • 162
    • 0032969356 scopus 로고    scopus 로고
    • Improved glucose tolerance in rats treated with the dipeptidyl peptidase IV (CD26) inhibitor Ile-thiazolidide
    • R.P. Pauly H.U. Demuth F. Rosche et al. Improved glucose tolerance in rats treated with the dipeptidyl peptidase IV (CD26) inhibitor Ile-thiazolidide Metabolism 48 1999 385-389
    • (1999) Metabolism , vol.48 , pp. 385-389
    • Pauly, R.P.1    Demuth, H.U.2    Rosche, F.3
  • 163
    • 0037342614 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats
    • J.A. Pospisilik J. Martin T. Doty et al. Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats Diabetes 52 2003 741-750
    • (2003) Diabetes , vol.52 , pp. 741-750
    • Pospisilik, J.A.1    Martin, J.2    Doty, T.3
  • 164
    • 0036228243 scopus 로고    scopus 로고
    • Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats
    • J.A. Pospisilik S.G. Stafford H.U. Demuth et al. Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats Diabetes 51 2002 943-950
    • (2002) Diabetes , vol.51 , pp. 943-950
    • Pospisilik, J.A.1    Stafford, S.G.2    Demuth, H.U.3
  • 165
    • 0036724721 scopus 로고    scopus 로고
    • Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: A euglycemic-hyperinsulinemic clamp study
    • J.A. Pospisilik S.G. Stafford H.U. Demuth et al. Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: A euglycemic-hyperinsulinemic clamp study Diabetes 51 2002 2677-2683
    • (2002) Diabetes , vol.51 , pp. 2677-2683
    • Pospisilik, J.A.1    Stafford, S.G.2    Demuth, H.U.3
  • 167
    • 0036583164 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes
    • B. Ahren E. Simonsson H. Larsson et al. Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes Diabetes Care 25 2002 869-875
    • (2002) Diabetes Care , vol.25 , pp. 869-875
    • Ahren, B.1    Simonsson, E.2    Larsson, H.3
  • 168
    • 2442482515 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes
    • B. Ahren M. Landin-Olsson & P.A. Jansson Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes J Clin Endocrinol Metab 89 2004 2078-2084
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 2078-2084
    • Ahren, B.1    Landin-Olsson, M.2    Jansson, P.A.3
  • 169
    • 0028323205 scopus 로고
    • CD26: A surface protease involved in T-cell activation
    • B. Fleischer CD26: A surface protease involved in T-cell activation Immunol Today 15 1994 180-184
    • (1994) Immunol. Today , vol.15 , pp. 180-184
    • Fleischer, B.1
  • 170
    • 0015139020 scopus 로고
    • Endocrine tumour in kidney affecting small bowel structure, motility, and absorptive function
    • M.H. Gleeson S.R. Bloom J.M. Polak et al. Endocrine tumour in kidney affecting small bowel structure, motility, and absorptive function Gut 12 1971 773-782
    • (1971) Gut , vol.12 , pp. 773-782
    • Gleeson, M.H.1    Bloom, S.R.2    Polak, J.M.3
  • 171
    • 0029795016 scopus 로고    scopus 로고
    • Induction of intestinal epithelial proliferation by glucagon-like peptide 2
    • D.J. Drucker P. Ehrlich & S.L. Asa Induction of intestinal epithelial proliferation by glucagon-like peptide 2 Proc Natl Acad Sci USA 93 1996 7911-7916
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 7911-7916
    • Drucker, D.J.1    Ehrlich, P.2    Asa, S.L.3
  • 172
    • 8344262014 scopus 로고
    • Effect of monoclonal antibodies to enteroglucagon on ileal adaptation after proximal small bowel resection
    • M. Gregor H. Menge R. Stosselet al. Effect of monoclonal antibodies to
    • (1993) Exp. Clin. Endocrinol. , vol.101 , pp. 297-302
    • Gregor, M.1    Menge, H.2    Stossel, R.3
  • 173
    • 0035795227 scopus 로고    scopus 로고
    • Molecular evolution of proglucagon
    • D.M. Irwin Molecular evolution of proglucagon Regul Pept 98 2001 1-12
    • (2001) Regul. Pept. , vol.98 , pp. 1-12
    • Irwin, D.M.1
  • 174
    • 0031417543 scopus 로고    scopus 로고
    • Intestinal response to growth factors administered alone or in combination with h[Gly2]-glucagon-like peptide 2
    • D.J. Drucker L. Deforest & P.L. Brubaker Intestinal response to growth factors administered alone or in combination with h[Gly2]-glucagon-like peptide 2 Am J Physiol 273 1997 G1252-G1262
    • (1997) Am. J. Physiol. , vol.273
    • Drucker, D.J.1    Deforest, L.2    Brubaker, P.L.3
  • 175
    • 0030860751 scopus 로고    scopus 로고
    • Regulation of the biological activity of glucagon-like peptide 2 in vivo by dipeptidyl peptidase IV
    • D.J. Drucker Q. Shi & A. Crivici Regulation of the biological activity of glucagon-like peptide 2 in vivo by dipeptidyl peptidase IV Nat Biotechnol 15 1997 673-677
    • (1997) Nat. Biotechnol. , vol.15 , pp. 673-677
    • Drucker, D.J.1    Shi, Q.2    Crivici, A.3
  • 176
    • 0032906822 scopus 로고    scopus 로고
    • Glucagonlike peptide-2 enhances small intestinal absorptive function and mucosal mass in vivo
    • Y. Kato D. Yu & M.Z. Schwartz Glucagonlike peptide-2 enhances small intestinal absorptive function and mucosal mass in vivo J Pediatr Surg 34 1999 18-20
    • (1999) J. Pediatr. Surg. , vol.34 , pp. 18-20
    • Kato, Y.1    Yu, D.2    Schwartz, M.Z.3
  • 177
    • 0029118049 scopus 로고
    • Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
    • T.J. Kieffer C.H. McIntosh & R.A. Pederson Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV Endocrinology 136 1995 3585-3596
    • (1995) Endocrinology , vol.136 , pp. 3585-3596
    • Kieffer, T.J.1    McIntosh, C.H.2    Pederson, R.A.3
  • 178
    • 0033680541 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition enhances the intestinotrophic effect of glucagon-like peptide-2 in rats and mice
    • B. Hartmann J. Thulesen H. Kissow et al. Dipeptidyl peptidase IV inhibition enhances the intestinotrophic effect of glucagon-like peptide-2 in rats and mice Endocrinology 141 2000 4013-4020
    • (2000) Endocrinology , vol.141 , pp. 4013-4020
    • Hartmann, B.1    Thulesen, J.2    Kissow, H.3
  • 179
    • 0030759264 scopus 로고    scopus 로고
    • Intestinal growth-promoting properties of glucagon-like peptide-2 in mice
    • C.H. Tsai M. Hill S.L. Asa et al. Intestinal growth-promoting properties of glucagon-like peptide-2 in mice Am J Physiol 273 1997 E77-E84
    • (1997) Am. J. Physiol. , vol.273
    • Tsai, C.H.1    Hill, M.2    Asa, S.L.3
  • 180
    • 0030977884 scopus 로고    scopus 로고
    • Biological determinants of intestinotrophic properties of GLP-2 in vivo
    • C.H. Tsai M. Hill & D.J. Drucker Biological determinants of intestinotrophic properties of GLP-2 in vivo Am J Physiol 272 1997 G662-G668
    • (1997) Am. J. Physiol. , vol.272
    • Tsai, C.H.1    Hill, M.2    Drucker, D.J.3
  • 181
    • 0030805335 scopus 로고    scopus 로고
    • Prevention of parenteral nutrition-induced gut hypoplasia by coinfusion of glucagon-like peptide-2
    • W.T. Chance T. Foley-Nelson I. Thomas et al. Prevention of parenteral nutrition-induced gut hypoplasia by coinfusion of glucagon-like peptide-2 Am J Physiol 273 1997 G559-G563
    • (1997) Am. J. Physiol. , vol.273
    • Chance, W.T.1    Foley-Nelson, T.2    Thomas, I.3
  • 182
    • 12944333189 scopus 로고    scopus 로고
    • Glucagon-like peptide-2 increases sucrase-isomaltase but not caudal-related homeobox protein-2 gene expression
    • P.A. Kitchen A.J. Fitzgerald R.A. Goodlad et al. Glucagon-like peptide-2 increases sucrase-isomaltase but not caudal-related homeobox protein-2 gene expression Am J Physiol Gastrointest Liver Physiol 278 2000 G425-G428
    • (2000) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.278
    • Kitchen, P.A.1    Fitzgerald, A.J.2    Goodlad, R.A.3
  • 183
    • 0034995864 scopus 로고    scopus 로고
    • Proglucagon-derived peptides in intestinal epithelial proliferation: Glucagon-like peptide-2 is a major mediator of intestinal epithelial proliferation in rats
    • M.A. Ghatei R.A. Goodlad S. Taheri et al. Proglucagon-derived peptides in intestinal epithelial proliferation: Glucagon-like peptide-2 is a major mediator of intestinal epithelial proliferation in rats Dig Dis Sci 46 2001 1255-1263
    • (2001) Dig. Dis. Sci. , vol.46 , pp. 1255-1263
    • Ghatei, M.A.1    Goodlad, R.A.2    Taheri, S.3
  • 184
    • 0033639262 scopus 로고    scopus 로고
    • Maintaining gut integrity during parenteral nutrition of tumor-bearing rats: Effects of glucagon-like peptide 2
    • W.T. Chance S. Sheriff T. Foley-Nelson et al. Maintaining gut integrity during parenteral nutrition of tumor-bearing rats: Effects of glucagon-like peptide 2 Nutr Cancer 37 2000 215-222
    • (2000) Nutr. Cancer , vol.37 , pp. 215-222
    • Chance, W.T.1    Sheriff, S.2    Foley-Nelson, T.3
  • 185
    • 0030667820 scopus 로고    scopus 로고
    • Intestinal growth is associated with elevated levels of glucagon-like peptide-2 in diabetic rats
    • K.D. Fischer S. Dhanvantari D.J. Drucker et al. Intestinal growth is associated with elevated levels of glucagon-like peptide-2 in diabetic rats Am J Physiol 273 1997 E815-E820
    • (1997) Am. J. Physiol. , vol.273
    • Fischer, K.D.1    Dhanvantari, S.2    Drucker, D.J.3
  • 186
    • 0037198482 scopus 로고    scopus 로고
    • Immunoneutralization of endogenous glucagon-like peptide-2 reduces adaptive intestinal growth in diabetic rats
    • B. Hartmann J. Thulesen K.J. Hare et al. Immunoneutralization of endogenous glucagon-like peptide-2 reduces adaptive intestinal growth in diabetic rats Regul Pept 105 2002 173-179
    • (2002) Regul. Pept. , vol.105 , pp. 173-179
    • Hartmann, B.1    Thulesen, J.2    Hare, K.J.3
  • 187
    • 0033305721 scopus 로고    scopus 로고
    • Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription
    • M.E. Hill S.L. Asa & D.J. Drucker Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription Mol Endocrinol 13 1999 1474-1486
    • (1999) Mol. Endocrinol. , vol.13 , pp. 1474-1486
    • Hill, M.E.1    Asa, S.L.2    Drucker, D.J.3
  • 189
    • 0033695821 scopus 로고    scopus 로고
    • Ontogeny of the glucagon-like peptide-2 receptor axis in the developing rat intestine
    • J. Lovshin B. Yusta I. Iliopoulos et al. Ontogeny of the glucagon-like peptide-2 receptor axis in the developing rat intestine Endocrinology 141 2000 4194-4201
    • (2000) Endocrinology , vol.141 , pp. 4194-4201
    • Lovshin, J.1    Yusta, B.2    Iliopoulos, I.3
  • 190
    • 0032714919 scopus 로고    scopus 로고
    • Glucagon-like peptide 2 decreases mortality and reduces the severity of indomethacin-induced murine enteritis
    • R.P. Boushey B. Yusta & D.J. Drucker Glucagon-like peptide 2 decreases mortality and reduces the severity of indomethacin-induced murine enteritis Am J Physiol 277 1999 E937-E947
    • (1999) Am J Physiol , vol.277
    • Boushey, R.P.1    Yusta, B.2    Drucker, D.J.3
  • 191
    • 0034113232 scopus 로고    scopus 로고
    • Treatment of inflammatory bowel disease in a rodent model with the intestinal growth factor glucagon-like peptide-2
    • K. Alavi M.Z. Schwartz J.P. Palazzo et al. Treatment of inflammatory bowel disease in a rodent model with the intestinal growth factor glucagon-like peptide-2 J Pediatr Surg 35 2000 847-851
    • (2000) J. Pediatr. Surg. , vol.35 , pp. 847-851
    • Alavi, K.1    Schwartz, M.Z.2    Palazzo, J.P.3
  • 193
    • 0037378334 scopus 로고    scopus 로고
    • Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid-small bowel resection
    • E.M. Dahly M.B. Gillingham Z. Guo et al. Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid-small bowel resection Am J Physiol Gastrointest Liver Physiol 284 2003 G670-G682
    • (2003) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.284
    • Dahly, E.M.1    Gillingham, M.B.2    Guo, Z.3
  • 194
    • 0031735064 scopus 로고    scopus 로고
    • GLP-2 augments the adaptive response to massive intestinal resection in rat
    • R.B. Scott D. Kirk W.K. MacNaughton et al. GLP-2 augments the adaptive response to massive intestinal resection in rat Am J Physiol 275 1998 G911-G921
    • (1998) Am. J. Physiol. , vol.275
    • Scott, R.B.1    Kirk, D.2    MacNaughton, W.K.3
  • 195
    • 0035072462 scopus 로고    scopus 로고
    • Glucagon-like peptide-2 stimulates gut mucosal growth and immune response in burned rats
    • W.T. Chance S. Sheriff F. McCarter et al. Glucagon-like peptide-2 stimulates gut mucosal growth and immune response in burned rats J Burn Care Rehabil 22 2001 136-143
    • (2001) J. Burn Care Rehabil. , vol.22 , pp. 136-143
    • Chance, W.T.1    Sheriff, S.2    McCarter, F.3
  • 196
    • 0033964619 scopus 로고    scopus 로고
    • Glucagonlike peptide-2 analogue enhances intestinal mucosal mass after ischemia and reperfusion
    • R. Prasad K. Alavi & M.Z. Schwartz Glucagonlike peptide-2 analogue enhances intestinal mucosal mass after ischemia and reperfusion J Pediatr Surg 35 2000 357-359
    • (2000) J. Pediatr. Surg. , vol.35 , pp. 357-359
    • Prasad, R.1    Alavi, K.2    Schwartz, M.Z.3
  • 197
    • 0034744761 scopus 로고    scopus 로고
    • GLP-2alpha accelerates recovery of mucosal absorptive function after intestinal ischemia/reperfusion
    • R. Prasad K. Alavi & M.Z. Schwartz GLP-2alpha accelerates recovery of mucosal absorptive function after intestinal ischemia/reperfusion J Pediatr Surg 36 2001 570-572
    • (2001) J. Pediatr. Surg. , vol.36 , pp. 570-572
    • Prasad, R.1    Alavi, K.2    Schwartz, M.Z.3
  • 198
    • 0002679769 scopus 로고    scopus 로고
    • Glucagonlike peptide 2 (glp-2) promotes intestinal recovery following chemotherapy-induced enteritis
    • A. Tavakkolizadeh R. Shen P. Abraham et al. Glucagonlike peptide 2 (glp-2) promotes intestinal recovery following chemotherapy-induced enteritis Curr Surg 57 2000 502
    • (2000) Curr. Surg. , vol.57 , pp. 502
    • Tavakkolizadeh, A.1    Shen, R.2    Abraham, P.3
  • 199
    • 0035863327 scopus 로고    scopus 로고
    • Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor
    • R.P. Boushey B. Yusta & D.J. Drucker Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor Cancer Res 61 2001 687-693
    • (2001) Cancer Res. , vol.61 , pp. 687-693
    • Boushey, R.P.1    Yusta, B.2    Drucker, D.J.3
  • 200
    • 0032621235 scopus 로고    scopus 로고
    • Human [Gly2]GLP-2 reduces the severity of colonic injury in a murine model of experimental colitis
    • D.J. Drucker B. Yusta R.P. Boushey et al. Human [Gly2]GLP-2 reduces the severity of colonic injury in a murine model of experimental colitis Am J Physiol 276 1999 G79-G91
    • (1999) Am. J. Physiol. , vol.276
    • Drucker, D.J.1    Yusta, B.2    Boushey, R.P.3
  • 201
    • 13044286018 scopus 로고    scopus 로고
    • Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2
    • D.G. Munroe A.K. Gupta F. Kooshesh et al. Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2 Proc Natl Acad Sci USA 96 1999 1569-1573
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 1569-1573
    • Munroe, D.G.1    Gupta, A.K.2    Kooshesh, F.3
  • 202
    • 0037373183 scopus 로고    scopus 로고
    • International union of pharmacology. XXXV. The glucagon receptor family
    • K.E. Mayo L.J. Miller D. Bataille et al. International union of pharmacology. XXXV. The glucagon receptor family Pharmacol Rev 55 2003 167-194
    • (2003) Pharmacol. Rev. , vol.55 , pp. 167-194
    • Mayo, K.E.1    Miller, L.J.2    Bataille, D.3
  • 203
    • 0032718059 scopus 로고    scopus 로고
    • Identification of glucagon-like peptide-2 (GLP-2)-activated signaling pathways in baby hamster kidney fibroblasts expressing the rat GLP-2 receptor
    • B. Yusta R. Somwar F. Wang et al. Identification of glucagon-like peptide-2 (GLP-2)-activated signaling pathways in baby hamster kidney fibroblasts expressing the rat GLP-2 receptor J Biol Chem 274 1999 30459-30467
    • (1999) J. Biol. Chem. , vol.274 , pp. 30459-30467
    • Yusta, B.1    Somwar, R.2    Wang, F.3
  • 204
    • 19244378320 scopus 로고    scopus 로고
    • Glucagon-like peptide-2 stimulates the proliferation of cultured rat astrocytes
    • E. Velazquez J.M. Ruiz-Albusac & E. Blazquez Glucagon-like peptide-2 stimulates the proliferation of cultured rat astrocytes Eur J Biochem 270 2003 3001-3009
    • (2003) Eur. J. Biochem. , vol.270 , pp. 3001-3009
    • Velazquez, E.1    Ruiz-Albusac, J.M.2    Blazquez, E.3
  • 205
    • 0033858090 scopus 로고    scopus 로고
    • Enteroendocrine localization of GLP-2 receptor expression in humans and rodents
    • B. Yusta L. Huang D. Munroe et al. Enteroendocrine localization of GLP-2 receptor expression in humans and rodents Gastroenterology 119 2000 744-755
    • (2000) Gastroenterology , vol.119 , pp. 744-755
    • Yusta, B.1    Huang, L.2    Munroe, D.3
  • 206
    • 0035940435 scopus 로고    scopus 로고
    • Modulation of specific intestinal epithelial progenitors by enteric neurons
    • M. Bjerknes & H. Cheng Modulation of specific intestinal epithelial progenitors by enteric neurons Proc Natl Acad Sci USA 98 2001 12497-12502
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12497-12502
    • Bjerknes, M.1    Cheng, H.2
  • 207
    • 0033638570 scopus 로고    scopus 로고
    • GLP-2 stimulates intestinal growth in premature TPN-fed pigs by suppressing proteolysis and apoptosis
    • D.G. Burrin B. Stoll R. Jiang et al. GLP-2 stimulates intestinal growth in premature TPN-fed pigs by suppressing proteolysis and apoptosis Am J Physiol Gastrointest Liver Physiol 279 2000 G1249-G1256
    • (2000) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.279
    • Burrin, D.G.1    Stoll, B.2    Jiang, R.3
  • 208
    • 0034634637 scopus 로고    scopus 로고
    • The glucagon-like peptide-2 receptor mediates direct inhibition of cellular apoptosis via a cAMP-dependent protein kinase-independent pathway
    • B. Yusta R.P. Boushey & D.J. Drucker The glucagon-like peptide-2 receptor mediates direct inhibition of cellular apoptosis via a cAMP-dependent protein kinase-independent pathway J Biol Chem 275 2000 35345-35352
    • (2000) J. Biol. Chem. , vol.275 , pp. 35345-35352
    • Yusta, B.1    Boushey, R.P.2    Drucker, D.J.3
  • 209
    • 0037067677 scopus 로고    scopus 로고
    • GLP-2 receptor activation engages Bad and glycogen synthase kinase 3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of phosphatidylinositol 3-kinase
    • B. Yusta J. Estall & D.J. Drucker GLP-2 receptor activation engages Bad and glycogen synthase kinase 3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of phosphatidylinositol 3-kinase J Biol Chem 277 2002 24896-24906
    • (2002) J. Biol. Chem. , vol.277 , pp. 24896-24906
    • Yusta, B.1    Estall, J.2    Drucker, D.J.3
  • 210
    • 0035123108 scopus 로고    scopus 로고
    • Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon
    • P.B. Jeppesen B. Hartmann J. Thulesen et al. Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon Gastroenterology 120 2001 806-815
    • (2001) Gastroenterology , vol.120 , pp. 806-815
    • Jeppesen, P.B.1    Hartmann, B.2    Thulesen, J.3


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