Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription

Molecular Endocrinology

Volumn 13, Issue 9, 1999, Pages 1474-1486

  Hill, Mary E ^a   Asa, Sylvia L ^b   Drucker, Daniel J ^a  

^a TORONTO GENERAL HOSPITAL   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCAGON LIKE PEPTIDE 1; INSULIN; PROGLUCAGON;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRAIN BHK; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA;

EID: 0033305721     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.13.9.0340     Document Type: Article

References (36)

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4. β-Cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes
5. Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: Building a functional insulin minienhancer complex
6. The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription
7. Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells
8. Insulin-promoter-factor 1 is required for pancreas development in mice
9. Early-onset type-II diabetes mellitus (MODY4) linked to IPF1
10. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice
11. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells
12. The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas
13. Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas
14. Pax-QNR/Pax-6, a paired box and homeobox-containing gene expressed in neurons, is also expressed in pancreatic endocrine cells
15. Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins
16. The pancreatic islet-specific glucagon G3 transcription factors recognize control elements in the rat somatostatin and insulin-I genes
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18. Multiple functions for Pax6 in mouse eye and nasal development
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20. Mapping enteroendocrine cell populations in transgenic mice reveals an unexpected degree of complexity in cellular differentiation within the gastrointestinal tract
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24. Identification of a transcriptional enhancer important for enteroendocrine and pancreatic islet cell-specific expression of the secretin gene
25. Transcriptional activity of domain A of the rat glucagon G3 element conferred by an islet-specific nuclear protein that also binds to similar pancreatic islet cell-specific enhancer sequences (PISCES)
26. Expression of liver fatty acid-binding protein/human growth hormone fusion genes within the enterocytes and enteroendocrine cell populations of fetal transgenic mice
27. Peptide YY expression is an early event in colonic endocrine cell differentiation: Evidence from normal and transgenic mice
28. Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3
29. The caudal homeobox protein cdx-2/3 activates endogenous proglucagon gene expression in InR1-G9 islet cells
30. Proglucagon gene expression and posttranslational processing in a hamster islet ceil line
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32. The pro-glucagon gene upstream enhancer contains positive and negative domains important for tissue-specific proglucagon gene transcription
33. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction
34. Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine
35. Intestinal growth-promoting properties of glucagon-like peptide 2 in mice
36. Development of coIonic and pancreatic endocrine tumors in mice expressing a glucagon-SV40 T antigen transgene