Intestinal growth is associated with elevated levels of glucagon-like peptide 2 in diabetic rats

American Journal of Physiology - Endocrinology and Metabolism

Volumn 273, Issue 4 36-4, 1997, Pages

  Fischer, Kirk D ^a   Dhanvantari, Savita ^a   Drucker, Daniel J ^a   Brubaker, Patricia L ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Adaptation; Small intestine

Indexed keywords

GLUCAGON LIKE PEPTIDE 1;

ADAPTATION; ANIMAL TISSUE; ARTICLE; BODY GROWTH; CRYPT CELL; DNA SYNTHESIS INHIBITION; INSULIN RELEASE; INTESTINE EPITHELIUM; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; RAT; STARVATION; STREPTOZOCIN DIABETES; TISSUE SPECIFICITY;

EID: 0030667820     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1997.273.4.e815     Document Type: Article

References (21)

1. Binz, K., J. Zapf, and E. R. Froesch. The role of insulin-like growth factor-1 in growth of diabetic rats. Acta Endocrinol. (Copenhagen) 121: 628-632, 1989.
2. Bloom, S. R., and J. M. Polak. The hormonal pattern of intestinal adaptation: a major role for enteroglucagon. Scand. J. Gastroenterol. 17, Suppl. 74: 93-103, 1982.
3. Brubaker, P. L., A. Crivici, A. Izzo, P. Ehrlich, C.-H. Tsai, and D. J. Drucker. Circulating and tissue forms of the intestinal growth factor, glucagon-like peptide-2. Endocrinology In press.
4. Brubaker, P. L., D. C. Y. So, and D. J. Drucker. Tissue-specific differences in the levels of proglucagon-derived peptides in streptozotocin-induced diabetes. Endocrinology 124: 3003-3009, 1989.
5. Brubaker, P. L., and M. Vranic. Fetal rat intestinal cells in monolayer culture: a new in vitro system to study the glucagon-related peptides. Endocrinology 120: 1976-1985, 1987.
6. D'Alessio, D., R. Thirlby, E. Laschansky, H. Zebroski, and J. Ensinck. Response of tGLP-1 to nutrients in humans. Digestion 54: 377-379, 1993.
7. Dhanvantari, S., N. G. Seidah, and P. L. Brubaker. Role of prohormone convertases in the tissue-specific processing of proglucagon. Mol. Endocrinol. 10: 342-355, 1996.
8. Drucker, D. J., P. Ehrlich, S. L. Asa, and P. L. Brubaker. Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc. Natl. Acad. Sci. USA 93: 7911-7916, 1996.
9. Ekundayo, A. A., C. Y. Lee, and R. A. Goodlad. Gastrin and the growth of the gastrointestinal tract. Gut 36: 203-208, 1995.
10. Folch, J., M. Lees, and G. H. Sloane-Stanley. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226: 497-509, 1957.
11. Gleeson, M. H., S. R. Bloom, J. M. Polak, K. Henry, and R. H. Dowling. Endocrine tumour in kidney affecting small bowel structure, motility, and absorptive function. Gut 12: 773-782, 1971.
12. Granneman, J. G., and E. M. Stricker. Food intake and gastric emptying in rats with streptozotocin-induced diabetes. Am. J. Physiol. 247 (Regulatory Integrative Comp. Physiol. 16): R1054-R1061, 1984.
13. Jervis, E. L., and R. J. Levin. Anatomic adaptation of the alimentary tract of the rat to the hyperphagia of chronic alloxandiabetes. Mitare 210: 391-393, 1966.
14. Kreymann, B., Y. Yiangou, S. Kanse, G. Williams, M. A. Ghatei, and S. R. Bloom. Isolation and characterisation of GLP-1 7-36 amide from rat intestine. Elevated levels in diabetic rats. FEBS Lett. 242: 167-170, 1988.
15. Larsson, L.-I., J. Holst, R. Hakanson, and F. Sundler. Distribution and properties of glucagon immunoreactivity in the digestive tract of various mammals: an immunohistochemical and immunochemical study. Histochemistry 44: 281-290, 1975.
16. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275, 1951.
17. Matsuyama, T., W. H. Hoffman, J. C. Dunbar, N. L. Foa, and P. P. Foa. Glucose, insulin, pancreatic glucagon and glucagon-like immunoreactive materials in the plasma of normal and diabetic children. Effect of the initial insulin treatment. Harm. Metab. Res. 7: 452-456, 1975.
18. Mayhew, T. M., and F. L. Carson. Mechanisms of adaptation in rat small intestine: regional differences in quantitative morphology during normal growth and experimental hypertrophy. J. Anat. 164: 189-200, 1989.
19. Miller, D. L., W. Hanson, H. P. Schedl, and J. W. Osborne. Proliferation rate and transit time of mucosal cells in small intestine of diabetic rat. Gastroenterology 73: 1326-1332, 1977.
20. Mojsov, S., G. Heinrich, I. B. Wilson, M. Ravazzola, L. Orci, and J. F. Habener. Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J. Biol. Chem. 261: 11880-11889, 1986.
21. Orskov, C. Glucagon-like peptide-1, a new hormone of the entero-insular axis. Diabetologia 35: 701-711, 1992.