Subcutaneous glucagon-like peptide I combined with insulin normalizes postcibal glycemic excursions in IDDM

Diabetes Care

Volumn 20, Issue 3, 1997, Pages 381-384

  Dupré, John ^a,b   Behme, Margaret T ^a   Hramiak, Irene M ^a   Mcdonald, Thomas J ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1 [7-36] AMIDE; GLUCOSE; INSULIN; PANCREAS POLYPEPTIDE; SODIUM CHLORIDE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NORMAL HUMAN; POSTPRANDIAL STATE; SUBCUTANEOUS DRUG ADMINISTRATION; TEST MEAL; VOLUNTEER;

EID: 0031035778     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.20.3.381     Document Type: Article

References (9)

1. Gutniak M, Orskov C, Holst JJ, Ahren B, Efendic S: Antidiabetogenic effect of glucagon-like peptide-1 (7-36) amide in normal subjects and patients with diabetes mellitus. N Engl J Med 326:1316-1322, 1992
2. Gutniak M, Linde B, Holst JJ, Efendic S: Subcutaneous injection of the incretin hormone glucagon-like peptide 1 abolishes postprandial glycemia in NIDDM. Diabetes Care 17:1039-1044, 1994
3. Willms B, Werner J, Holst JJ, Orskov C, Creutzfeldt W, Nauck MA: Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1-(7-36) amide in type 2 (non-insulin-dependent) diabetic patients. J Clin Endocrinol Metab 81:327-332, 1996
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6. Anvari M, Paterson CA, Daniel EE, McDonald TJ: Effect of GLP-1 on antropyloric motility, transpyloric flow and gastric emptying of non-nutrient liquids in conscious dogs (Abstract). Gastroenterology 108:A563, 1995
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8. Dupré J, Jenner M, Mahon JL, Purdon C, Rodger NW, Stiller CR: Endocrine-metabolic function in remission-phase insulin-dependent diabetes mellitus (IDDM) during administration of cyclosporin. Diabetes 40:598-604, 1991
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