GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor

American Journal of Physiology - Cell Physiology

Volumn 275, Issue 3 44-3, 1998, Pages

  Yang, H ^a   Egan, J M ^a   Wang, Y ^a   Moyes, C D ^b   Roth, J ^c   Montrose, M H ^c   Montrose Rafizadeh, C ^a,d  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c QUEEN S UNIVERSITY   (Canada)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

Glucagon like peptide; Glycogen synthesis; Glycolysis; Muscle; Transfection

Indexed keywords

GLYCOPROTEIN IB;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; GENETIC TRANSFECTION; GLUCOSE OXIDATION; GLYCOGEN SYNTHESIS; GLYCOLYSIS; HORMONE ACTION; HORMONE RELEASE; INSULIN LIKE ACTIVITY; MYOTUBE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION;

EID: 0031668166     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1998.275.3.c675     Document Type: Article

References (26)

1. Beak, S. A., C. J. Small, I. Ilovaiskaia, J. D. Hurley, M. A. Ghatei, S. R. Bloom, and D. M. Smith. Glucagon-like peptide-1 (GLP-1) releases thyrotropin (TSH): characterization of binding sites for GLP-1 on α-TSH cells. Endocrinology 137: 4130-4138, 1996.
2. Beguinot, F., C. R. Kahn, A. C. Moses, and R. J. Smith. The development of insulin receptors and responsiveness is an early marker of differentiation in the muscle cell line L6. Endocrinology 18: 446-455, 1986.
3. D'Alessio, D. A., R. L. Prigeon, and J. W. Ensinck. Enteral enhancement of glucose disposition by both insulin-dependent and insulin-independent processes. A physiological role of glucagon-like peptide I. Diabetes 44: 1433-1437, 1995.
4. Delgado, E., M. A. Luque, A. Alcantara, M. A. Trapote, F. Clemente, C. Galera, I. Valverde, and M. L. Villanueva-Penacarrillo. Glucagon-like peptide-I binding to rat skeletal muscle. Peptides 16: 225-229, 1995.
5. Egan, J. M., C. Montrose-Rafizadeh, Y. Wang, M. Bernier, and J. Roth. Glucagon-like peptide-1 (7-36) amide (GLP-1) enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes: one of several potential extrapancreatic sites of GLP-1 action. Endocrinology 135: 2070-2075, 1994.
6. Fehmann, H.-C., R. Goke, and B. Goke. Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide. Endocr. Rev. 16: 390-410, 1995.
7. Furnsinn, C., K. Ebner, and W. Waldhausl. Failure of GLP-1 (7-36) amide to affect glycogenesis in rat skeletal muscle. Diabetologia 38: 864-867, 1995.
8. Galera, C., F. Clemente, A. Alcantara, M. A. Trapote, A. Perea, M. I. Lopez-Delgado, M. L. Villanueva-Penacarrillo, and I. Valverde. Inositolphosphoglycans and diacylglycerol are possible mediators in the glycogenic effect of GLP-1 (7-36) amide in BC3H-1 myocytes. Cell Biochem. Funct. 14: 43-48, 1996.
9. Garcia de Frutos, P., and I. V. Baanante. The muscle isoform of 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase of the teleost Sparas aurata: relationship with the liver isoform. Arch. Biochem. Biophys. 321: 297-302, 1995.
10. Goke, R., H.-C. Fehmann, T. Linn, H. Schmidt, M. Krause, J. Eng, and G. Burkhard. Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells. J. Biol. Chem. 268: 19650-19655, 1993.
11. Gutniak, M., C. Orskov, J. J. Holst, B. Ahren, and S. Efendic. Antidiabetogenic effect of glucagon-like peptide-1 (7-36) amide in normal subjects and patients with diabetes mellitus. N. Engl. J. Med. 326: 1316-1322, 1992.
12. Klip, A., G. Li, and D. Walker. Insulin binding to differentiating muscle cells in culture. Can. J. Biochem. Cell Biol. 61: 644-649, 1983.
13. Larsen, P. J., M. Tang-Christensen, and D. S. Jessop. Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat. Endocrinology 138: 4445-4455, 1997.
14. Montrose-Rafizadeh, C., J. M. Egan, and J. Roth. Incretin hormones regulate glucose-dependent insulin secretion in RIN 1046-38 cells: mechanism of action. Endocrinology 135: 589-594, 1994.
15. Montrose-Rafizadeh, C., H. Yang, Y. Wang, J. Roth, M. H. Montrose, and L. G. Adams. Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes. J. Cell. Physiol. 172: 275-283, 1997.
16. Moyes, C. D., P. M. Schulte, and P. W. Hochachka. Recovery metabolism of trout white muscle: role of mitochondria. Am. J. Physiol. 262 (Regulatory Integrative Comp. Physiol. 31): R295-R304, 1992.
17. Myers, M. G., Jr., J. M. Backer, K. Siddle, and M. F. White. The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus. J. Biol. Chem. 266: 10616-10623, 1991.
18. Pilkis, S. J., D. M. Regen, B. H. Stewart, T. Chrisman, J. Pilkis, P. Kountz, T. Pate, M. McGrane, M. R. El-Maghrabi, and T. H. Claus. Rat liver 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase: a unique bifunctional enzyme regulated by cyclic AMP-dependent phosphorylation. In: Enzyme Regulation by Reversible Phosphorylation: Further Advances, edited by P. Cohen. Amsterdam: Elsevier Science, 1984, p. 95-122.
19. Sargeant, R., Y. Mitsumoto, V. Sarabia, G. Shillabeer, and A. Klip. Hormonal regulation of glucose transporters in muscle cells in culture. J. Endocrinol. Invest. 16: 147-162, 1993.
20. Scrocchi, L. A., T. J. Brown, N. MacLusky, P. L. Brubaker, A. B. Auberbach, A. L. Joyner, and D. J. Drucker. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat. Med. 2: 1254-1258, 1996.
21. Scrocchi, L. A., B. A. Marshall, S. M. Cook, P. L. Brubaker, and D. J. Drucker. Identification of glucagon-like peptide 1 (GLP-1) actions essential for glucose homeostasis in mice with disruption of GLP-1 receptor signaling. Diabetes 47: 632-639 1998.
22. Thorens, B. Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide I. Proc. Natl. Acad. Sci. USA 89: 8641-8645, 1992.
23. Trapote, M. A., F. Clemente, C. Galera, M. Morales, A. I. Alcantara, M. I. Lopez-Delgado, M. L. Villanueva-Penacarrillo, and L Valverde. Inositolphosphoglycans are possible mediators of the glucagon-like peptide I (7-36) amide action in the liver. J. Endocrinol. Invest. 19: 114-118, 1996.
24. Valverde, I., M. Morales, C. Felipe, M. I. Lopez-Delgado, E. Delgado, A. Perea, and M. L. Vlllanueva-Penacarrillo. Glucagon-like peptide-I: a potent glycogenic hormone. FEBS Lett. 349: 313-316, 1994.
25. Villanueva-Penacarrillo, M. L., A. I. Alcantara, F. Clemente, E. Delgado, and I. Valverde. Potent glycogenic eflect of GLP-1 (7-36) amide in rat skeletal muscle. Diabetologia 37: 1163-1166, 1994.
26. Wheeler, M. B., M. Lu, J. S. Dillon, X.-H. Leng, C. Chen, and A. E. Boyd III. Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C. Endocrinology 133: 57-62, 1993.