Sensory nerves contribute to insulin secretion by glucagon-like peptide-1 in mice

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 286, Issue 2 55-2, 2004, Pages

  Ahrén, Bo ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b NONE   (Sweden)

Author keywords

Capsaicin; Glucose elimination

Indexed keywords

CAPSAICIN; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENERVATION; FEMALE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; HYPOTHESIS; IN VIVO STUDY; INSULIN RELEASE; INSULIN RESPONSE; MOUSE; NEWBORN; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SENSORY NERVE;

EID: 0942287326     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00423.2003     Document Type: Article

References (21)

1. Ahrén B. Insulinotropic action of truncated glucagon-like peptide-1 in mice. Endocrine 3: 367-369, 1995.
2. Ahrén B. Glucagon-like peptide 1 (GLP-1) - a gut hormone of potential interest in the treatment of diabetes. Bioessays 20: 642-651, 1998.
3. Ahrén B. Autonomic regulation of islet hormone secretion - implications for health and disease. Diabetologia 43: 393-410, 2000.
4. Ahrén B and Holst JJ. The cephalic insulin response to meal ingestion in humans is dependent both on cholinergic and non-cholinergic mechanisms and is important for postprandial glycemia. Diabetes 50: 1030-1038, 2001.
5. Ahrén B and Pacini G. Dose-related effects of GLP-1 on insulin secretion, insulin sensitivity, and glucose effectiveness in mice. Am J Physiol Endocrinol Metab 277: E996-E1004, 1999.
6. Balkan B and Li X. Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms. Am J Physiol Regul Integr Comp Physiol 279: R1449-R1454, 2000.
7. Drucker DJ. Biological actions and therapeutic potential of the glucagon-like peptides. Gastroenterology 122: 531-544, 2002.
8. Drucker DJ. Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis. Mol Endocrinol 17: 161-171, 2003.
9. Fehmann HC, Göke R, and Göke B. Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulinotropic polypeptide. Endocr Rev 16: 390-410, 1995.
10. Fridolf T and Ahrén B. GLP-1(7-36)amide stimulates insulin secretion in rat islets: studies on the mode of action. Diabetes Res 16: 185-191, 1991.
11. 7-36 amide: influences on basal and stimulated insulin and glucagon secretion in the mouse. Pancreas 6: 208-215, 1991.
12. Holst JJ. Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1. Diabetes Metab Res Rev 18: 430-441, 2002.
13. Holst JJ and Orskov C. Incretin hormones-an update. Scand J Clin Lab Invest Suppl 61: 75-85, 2001.
14. Holzer P. Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol Rev 43: 143-201, 1991.
15. Karlsson S, Scheurink AJW, Steffens AB, and Ahrén B. Involvement of capsaicin-sensitive nerves in regulation of insulin secretion and glucose tolerance in conscious mice. Am J Physiol Regul Integr Comp Physiol 267: R1071-R1077, 1994.
16. Karlsson S, Sundler F, and Ahrén B. Neonatal capsaicin-treatment in mice: effects on pancreatic peptidergic nerves and 2-deoxy-D-glucose-induced insulin and glucagon secretion. J Auton Nerv Syst 39: 51-60, 1992.
17. Koopmans SJ, Leighton B, and DeFronzo RA. Neonatal deafferentation of capsaicin-sensitivity sensory nerves increases in vivo insulin sensitivity in conscious adult rats. Diabetologia 41: 813-820, 1998.
18. Nakabayashi H, Nishizawa M, Nakagawa A, Takeda R, and Niijima A. Vagal hepatopancreatic reflex effect evoked by intraportal appearance of tGLP-1. Am J Physiol Endocrinol Metab 271: E808-E813, 1996.
19. Scadding JW. The permanent anatomical effects of neonatal capsaicin on somatosensory nerves. J Anat 131: 473-484, 1980.
20. Thorens B. Expression cloning of the pancreatic β-cell receptor for the glucoincretin hormone glucagon-like peptide 1. Proc Natl Acad Sci USA 89: 8641-8645, 1992.
21. Watt PC, Livingstone EH, DeGiorgia R, Sternini C, Zinner MJ, and Brunicardi FC. Afferent sensory denervation alters first phase insulin secretion in isolated perfused rat pancreas. Gastroenterology 100, Suppl: A303, 1991.