Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 13, 1997, Pages 6646-6651

  Furuta, Machi ^a   Yano, Hideki ^a,e   Zhou, An ^a   Rouillé, Yves ^a,b   Holst, Jens J ^c   Carroll, Raymond ^a   Ravazzola, Mariella ^d   Orci, Lelio ^d   Furuta, Hiroto ^a   Steiner, Donald F ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b INSTITUT PASTEUR DE LILLE   (France)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF GENEVA   (Switzerland)

^e SUZUKA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

Gene disruption; Neuroendocrine precursor; Proprotein convertase

Indexed keywords

DNA; GLUCAGON; GLUCOSE; HORMONE PRECURSOR; INSULIN; MESSENGER RNA; NEOMYCIN; NEUROPEPTIDE; PEPTIDE HORMONE; PROGLUCAGON; PROINSULIN; PROTEIN; SERINE PROTEINASE INHIBITOR;

AGAR GEL ELECTROPHORESIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; GENE; GENE DISRUPTION; GENE INSERTION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MORPHOLOGY; MOUSE; MUTANT; NONHUMAN; PANCREAS ISLET; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SOUTHERN BLOTTING;

ANIMALS; GENE DELETION; GENE EXPRESSION REGULATION; GLUCAGON; ISLETS OF LANGERHANS; MICE; MICE, MUTANT STRAINS; PROGLUCAGON; PROINSULIN; PROPROTEIN CONVERTASE 2; PROTEIN PRECURSORS; SOMATOSTATIN; SUBTILISINS;

ANIMALIA;

EID: 12644253798     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.13.6646     Document Type: Article

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