Identification of glucagon-like peptide-2 (GLP-2)-activated signaling pathways in baby hamster kidney fibroblasts expressing the rat GLP-2 receptor

Journal of Biological Chemistry

Volumn 274, Issue 43, 1999, Pages 30459-30467

  Yusta, Bernardo ^a   Somwar, Romel ^b   Wang, Feng ^a   Munroe, Donald ^c   Grinstein, Sergio ^b   Klip, Amira ^b   Drucker, Daniel J ^a,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c NPS Pharmaceutical Inc   (United States)

^d TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON LIKE PEPTIDE; GLUCAGON RECEPTOR;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL PROLIFERATION; CELLULAR DISTRIBUTION; ENZYME ACTIVATION; FIBROBLAST; GROWTH REGULATION; HAMSTER; MITOGENICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIVISION; CELL LINE; CRICETINAE; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FIBROBLASTS; GASTROINTESTINAL HORMONES; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCAGON-LIKE PEPTIDE 2; KIDNEY; LUCIFERASES; MITOGEN-ACTIVATED PROTEIN KINASES; PEPTIDE FRAGMENTS; PEPTIDES; PHOSPHORYLATION; PROTEIN PRECURSORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTORS, GLUCAGON; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0032718059     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.43.30459     Document Type: Article

References (45)

1. Drucker, D. J. (1998) Diabetes 47, 159-169
2. Jelinek, L. J., Lok, S., Rosenberg, G. B., Smith, R. A., Grant, F. J., Biggs, S., Bensch, P. A., Kuijper, J. L., Sheppard, P. O., Sprecher, C. A., O'Hara, P. J., Foster, D., Walker, K. M., Chen, L. H. J., McKernan, P. A., and Kindsvogel, W. (1993) Science 259, 1614-1616
3. Thorens, B. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 8641-8645
4. Drucker, D. J., Ehrlich, P., Asa, S. L., and Brubaker, P. L. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 7911-7916
5. Tsai, C.-H., Hill, M., Asa, S. L., Brubaker, P. L., and Drucker, D. J. (1997) Am. J. Physiol. 273, E77-E84
6. Scott, R. B., Kirk, D., MacNaughton, W. K., and Meddings, J. B. (1998) Am. J. Physiol. 275, G911-G921
7. Drucker, D. J., Yusta, B., Boushey, R. P., Deforest, L., and Brubaker, P. L. (1999) Am. J. Physiol. 276, G79-G91
8. Wojdemann, M., Wettergren, A., Hartmann, B., and Holst, J. J. (1998) Scand. J. Gastroenterol. 33, 828-832
9. Cheeseman, C. I., and Tsang, R. (1996) Am. J. Physiol. 271, G477-G482
10. Cheeseman, C. I. (1997) Am. J. Physiol. 273, R1965-R1971
11. Munroe, D. G., Gupta, A. K., Kooshesh, P., Rizkalla, G., Wang, H., Demchyshyn, L., Yang, Z.-J., Kamboj, R. K., Chen, H., McCallum, K., Sumner-Smith, M., Drucker, D. J., and Crivici, A. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 1569-1573
12. Galang, C. K., Der, C. J., and Hauser, C. A. (1994) Oncogene 9, 2913-2921
13. Chen, W., Shields, T. S., Stork, P. J., and Cone, R. D. (1995) Anal. Biochem. 226, 349-354
14. Correll, L. A., Woodford, T. A., Corbin, J. D., Mellon, P. L., and McKnight, G. S. (1989) J. Biol. Chem. 264, 16672-16678
15. Wheeler, M. B., Lu, M., Dillon, J. S., Leng, X.-H., Chen, C., and Boyd, A. E., III (1993) Endocrinology 133, 57-62
16. Kaestner, K. H., Katz, J., Liu, Y., Drucker, D. J., and Schutz, G. (1999) Genes Dev. 13, 495-504
17. Jin, T., and Drucker, D. J. (1996) Mol. Cell. Biol. 16, 19-28
18. Chomczynski, P., and Sacchi, N. (1987) Anal. Biochem. 162, 156-159
19. Drucker, D. J., and Brubaker, P. L. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 3953-3957
20. Coppolino, M. G., Woodside, M. J., Demaurex, N., Grinstein, S., St-Arnaud, R., and Dedhar, S. (1997) Nature 386, 843-847
21. Somwar, R., Sweeney, G., Ramlal, T., and Klip, A. (1998) Clin. Ther. 20, 125-140
22. Cowley, S., Paterson, H., Kemp, P., and Marshall, C. J. (1994) Cell 77, 841-852
23. Somwar, R., Sumitani, S., Taha, C., Sweeney, G., and Klip, A. (1998) Am. J. Physiol. 275, E618-E625
24. Drucker, D. J., Shi, Q., Crivici, A., Sumner-Smith, M., Tavares, W., Hill, M., Deforest, L., Cooper, S., and Brubaker, P. L. (1997) Nature Biotechnol. 15, 673-677
25. Susini, S., Roche, E., Prentki, M., and Schlegel, W. (1998) FASEB J. 12, 1173-1182
26. Hansen, L. H., Gromada, J., Bouchelouche, P., Whitmore, T., Jelinek, L., Kindsvogel, W., and Nishimura, E. (1998) Am. J. Physiol. 274, C1552-C1562
27. Landolfi, B., Curci, S., Debellis, L., Pozzan, T., and Hofer, A. M. (1998) J. Cell Biol. 142, 1235-1243
28. Hafner, S., Adler, H. S., Mischak, H., Janosch, P., Heidecker, G., Wolfman, A., Pippig, S., Lohse, M., Ueffing, M., and Kolch, W. (1994) Mol. Cell. Biol. 14, 6696-6703
29. Wakelam, M. J., Murphy, G. J., Hruby, V. J., and Houslay, M. D. (1986) Nature 323, 68-71
30. Pittner, R. A., and Fain, J. N. (1991) Biochem. J. 277, 371-378
31. Tang, E. K., and Houslay, M. D. (1992) Biochem. J. 283, 341-346
32. Widmann, C., Bürki, E., Dolci, W., and Thorens, B. (1994) Mol. Pharmacol. 45, 1029-1035
33. Serre, V., Dolci, W., Scrocchi, L. A., Drucker, D. J., Efrat, S., and Thorens, B. (1998) Endocrinology 139, 4448-4454
34. Yada, T., Itoh, K., and Nakata, M. (1993) Endocrinology 133, 1685-1692
35. Holz, G. G., Leech, C. A., Heller, R. S., Castonguay, M., and Habener, J. F. (1999) J. Biol. Chem. 274, 14147-14156
36. Drucker, D. J. (1999) Trends Endocrinol. Metab. 10, 153-156
37. Todisco, A., Takeuchi, Y., Yamada, J., Stepan, V. M., and Yamada, T. (1997) Am. J. Physiol. 273, G891-G898
38. Edvell, A., and Lindstrom, P. (1999) Endocrinology 140, 778-783
39. Dong, J. M., Leung, T., Manser, E., and Lim, L. (1998) J. Biol. Chem. 273, 22554-22562
40. Schoenwaelder, S. M., and Burridge, K. (1999) Curr. Opin. Cell Biol. 11, 274-286
41. Barrie, A. P., Clohessy, A. M., Buensucesco, C. S., Rogers, M. V., and Allen, J. M. (1997) J. Biol. Chem. 272, 19666-19671
42. Daub, H., Weiss, F. U., Wallasch, C., and Ullrich, A. (1996) Nature 379, 557-560
43. Orskov, C., and Holst, J. J. (1987) Scand. J. Clin. Lab. Invest. 47, 165-174
44. Brubaker, P. L., Crivici, A., Izzo, A., Ehrlich, P., Tsai, C.-H., and Drucker, D. J. (1997) Endocrinology 138, 4837-4843
45. Xiao, Q., Boushey, R. P., Drucker, D. J., and Brubaker, P. L. (1999) Gastroenterology 117, 99-105