Glucose and glucoincretin peptides synergize to induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic β(INS-1) cells

FASEB Journal

Volumn 12, Issue 12, 1998, Pages 1173-1182

  Susini, Stefan ^a   Roche, Enrique ^b   Prentki, Marc ^b   Schlegel, Werner ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Glucagon like peptide 1; Immediate early response genes; Intracellular Ca2+; Pituitary adenylate cyclase activating polypeptide; Proto oncogenes

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; CYCLIC AMP; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; MESSENGER RNA; NIFEDIPINE;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; EARLY RESPONSE GENE; GENE EXPRESSION REGULATION; HYPERGLYCEMIA; ONCOGENE C FOS; ONCOGENE C JUN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTO ONCOGENE;

EID: 0031656888     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.12.12.1173     Document Type: Article

References (42)

1. Brun, T., Roche, E., Kim, K. H., and Prentki, M. (1993) Glucose regulates acetyl-CoA carboxylase gene expression in a pancreatic β-cell line (INS-1). J. Biol. Chem. 268, 18905-18911
2. Marie, S., Diaz-Guerra, M. J., Miquerol, L., Kahn, A., and Iynedjian, P. B. (1993) The pyruvate kinase gene as a model for studies of glucose-dependent regulation of gene expression in the endocrine pancreatic β-cell type. J Biol. Chem. 268, 23881-23890
3. Roche, E., Assimacopoulos-Jeannet, F., Witters, L. A., Perruchoud, B., Yaney, G., Corkey, B., Asfari, M., and Prentki, M. (1996) Induction by glucose of genes coding for glycolytic enzymes in a pancreatic β-cell line (INS-1). J. Biol. Chem. 272, 3091-3098
4. m glucose transporter GLUT2 gene and its transcriptional regulation by glucose in a differentiated insulin-secreting cell line. J. Biol. Chem. 269, 26912-26919
5. Bonner-Weir, S., and Smith, F. E. (1994) Islet growth and the growths factors involved. Trends Endocr. Metab. 5, 60-64
6. Holz, G. G., IV, Kühtreiber, W. M., and Habener, J. F. (1993) Pancreatic beta-cells are rendered glucose-competent by the inulinotropic hormone glucagon-like peptide-1 (7-37). Nature (London) 361, 362-365
7. Fehmann, H., Göke, R., and Göke, B. (1995) Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide. Endocr. Rev. 16, 390-410
8. Thorens, B. (1995) Glucagon-like peptide-1 and control of insulin secretion. Diabete Metab. 21, 311-318
9. Fehmann, H. C., and Habener, J. F. (1992) Insulinotropic hormone glucagon-like peptide-1(7-37) stimulation of proinsulin gene epression and proinsulin biosynthesis in insulinoma βTC-1 cells. Endocrinology 130, 159-166
10. Sjöholm, A. (1996) Diabetes mellitus and impaired pancreatic β-cell proliferation. J Int. Med. 239, 211-220
11. Prentki, M. (1996) New insights into pancreatic β-cell metabolic signaling in insulin secretion. Eur. J. Endocrinol. 134, 272-286
12. Frödin, M., Sekine, N., Roche, E., Filloux, C., Prentki, M., Wollheim, C., and Van Obberghen, E. (1995) Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting β-cell line, INS-1. J. Biol. Chem. 270, 7882-7889
13. 2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion. Physiol. Rev. 67, 1185-1248
14. Roche, E., and Prentki, M. (1994) Calcium regulation of immediate-early response genes. Cell Calcium 16, 331-338
15. Gurney, A., Park, A., Giralt, M., Liu, J., and Hanson, R. W. (1992) Opposing action of Fos and Jun transcription of the phosphoenolpyruvate carboxykinase (GTP) gene. J. Biol. Chem. 267, 18133-18139
16. Yoon, J. K., and Lau, L. (1993) Transcriptional activation of the inducible nuclear receptor gene nur-77 by nerve growth factor and membrane depolarization in PC12 cells. J. Biol. Chem. 268, 9148-9155
17. Liu, Z. G., Smith, S. W., McLaughlin, K.A., Schwartz, L. M., and Osborne, B. A. (1994) Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur-77. Nature (London) 367, 281-284
18. McMahon, S. B., and Monroe, J. G. (1992) Role of primary response genes in generating cellular responses to growth factors. FASEB J. 6, 2707-2715
19. Asfari, M., Janjic, D., Meda, P., Li, G., Halban, P., and Wollheim, C. B. (1992) Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130, 167-178
20. Liang, Y., Bai, G., Doliba, N., Buettger, C., Wang, L., Berner, D. K., and Matschinsky, F. M. (1996) Glucose metabolism and insulin release in mouse βHC9 cells, as model for wild-type pancreatic β-cells. Am. J. Physiol. 290, E846-E857
21. Salomom, Y., Londos, C., and Rodbell, M. (1974) A highly sensitive adenylate cyclase assay. Anal. Biochem. 58, 541-548
22. Góke, R., and Conlon, J. M. (1988) Receptors for glucagon-like peptide-1(7-36)amide on rat insulinoma-derived cells. J. Endocrinol. 116, 357-362
23. Yada, T., Sakurada, M., Ihida, K., Nakata, M., Murata, F., Arimura, A., and Kikuchi, M. (1994) Pituitary adenylate cyclase activating polypeptide is an extraordinary potent intra-pancreatic regulator of insulin secretion from islet β-cells. J. Biol. Chem. 269, 1290-1293
24. Widmann, C., Bürki, E., Dolci, W., and Thorens, B. (1994) Signal transduction by the cloned glucagon-like peptide-1 receptor: comparison with signaling by the endogenous receptor of β cell lines. Mol. Pharmacol. 45, 1029-1035
25. Rawlings, S., Piuz, I., Schlegel, W., Bockaert, J., and Journot, L. (1995) Differential expression of pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide receptor subtypes in clonal pituitary somatotrophs and gonadotrophs. Endocrinology 136, 2088-2098
26. Mac Donald, M. J. (1996) Glucose-stimulated expressed sequence tags from rat pancreatic islets. Mol. Cell. Endocrinol. 123, 199-204
27. Blanchard, M. (1992) Le proto-oncogéne c-fos: un 'entremetteur' moléculaire. Médecine/Sciences 8, 455-470
28. Schult, F. C., Kiekens, R., and Pipeleers, D. (1991) Measuring the balance between insulin synthesis and insulin release. Biochem. Biophys. Res. Commun. 178, 1182-1187
29. Alarcon, C., Lincoln, B., and Rhodes, C. J. (1993) The biosynthesis of the subtilisin-related proprotein convertase PC3, but not that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets. J. Biol. Chem. 268, 4276-4280
30. Schuit, F. C., In 'T Veld, P. A., and Pipeleers, D. G. (1988) Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells. Proc. Natl. Acad. Sci. USA 85, 3865-3869
31. Shuppin, G. T., and Rhodes, C. J. (1996) Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproiusulin in insulin-producing (TC3 cells. Biochem. J. 313, 259-268
32. German, M. S., Moss, L. G., andRutter, W. J. (1990) Regulation of insulin gene expression by glucose and calcium in transfected primary islet cultures. J. Biol. Chem. 265, 22063-22066
33. Schuit, F. C., De Vos, A., Farfari, S., Moens, K., Pipeleers, D., Brun, T., and Prentki, M. (1997) Metabolic fate of glucose in purified islet cells. J. Biol. Chem. 272, 18572-18579
34. Gurney, A. L., Park, E. A., Giralt, M., Liu, J., and Hanson, R. W. (1992) Opposing actions of Fos and Jun on transcription of the phosphenolpyruvate carboxykinase (GTP) gene. J. Biol. Chem. 267, 18133-18139
35. Karin, M. (1995) The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270, 16483-16486
36. Coffer, P., de Jonge, M., Mettouchi, A., Binetruy, B., Ghysdael, J., and Kruijer, W. (1994) JunB promoter regulation: Ras mediated transactivation by c-Ets-1 and c-Ets-2. Oncogene 9, 911-921
37. Woronicz, J. D., Lina, A., Calnan, B. J., Szychowsji, S., Cheng, L., and Winoto, A. (1995) Regulation of the Nur77 orphan steroid receptor in activation-induced apoptosis. Mol. Cell. Biol. 15, 6364-6376
38. Angel, P., and Karin, M. (1991) The role of Jun, Fos, and the AP-1 complex in cell proliferation and transformation. Biochim. Biophys. Acta 1072, 129-157
39. Hammonds, P., Schofield, P. N., and Ashcroft, S. J. H. (1987) Glucose regulates preproinsulin messengers RNA levels in a clonal cell line of simian virus 40-transformed B cell. FEBS Lett. 213, 149-154
40. Inagaki N., Maekawa, T., Sudo, T., Ishii, S., Seino, Y., and Imura, H. (1992) c-Jun represses the human insulin promoter activity that depends on multiple cAMP response elements. Proc. Natl. Acad. Sci. USA 89, 1045-1049
41. McKeown-Eyssen, G. (1994) Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk? Cancer Epidemiol. Biomarkers Prev. 3, 687-695
42. Bruce, W. R., and Corpet, D. E. (1996) The colonic protein fermentation and insulin resistance hypotheses for colon cancer etiology: experimental tests using precursor lesions. Eur. J. Cancer Prev. 5, 41-47.