Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic β-cells

Endocrinology

Volumn 142, Issue 1, 2001, Pages 129-138

  Moritz, Wolfgang ^c   Leech, Colin A ^a   Ferrer, Jorge ^d   Habener, Joel F ^b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; DIAZOXIDE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; POTASSIUM CHANNEL; SULFONYLUREA; SULFONYLUREA RECEPTOR; TOLBUTAMIDE;

5' UNTRANSLATED REGION; ADAPTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GLUCOSE HOMEOSTASIS; INSULIN RELEASE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; STEADY STATE; TRANSCRIPTION REGULATION;

EID: 0035114908     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.1.7885     Document Type: Article

References (47)

1. The ABCs of ATP-sensitive potassium channels: More pieces of the puzzle
2. Cloning of the β cell high-affinity sulfonylurea receptor: A regulator of insulin secretion
3. ATP: An inward rectifier subunit plus the sulfonylurea receptor
4. + channel
5. Octameric stoichiometry of the KATP channel complex
6. The sulfonylurea receptor
7. + channel Kir6.1 expressed in human embryonic kidney cells
8. Adenosine diphosphate as an intracellular regulator of insulin secretion
9. ATP channel subunits
10. + channel
11. An autosomal dominant form of familial persistent hyperinsulinemic hypoglycemia of infancy, not linked to the sulfonylurea receptor locus
12. Congenital hyperinsulinism: Molecular basis of a heterogeneous disease
13. ATP channels induces profound neonatal diabetes
14. Characterization of the mouse sulfonylurea receptor 1 promoter and its regulation
15. Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic β-cells, brain, heart and skeletal muscle
16. + channels
17. Cloning of the promoters for the β-cell ATP-sensitive K-channel subunits Kit6.2 and SUR1
18. An improved method for isolation of mouse pancreatic islets
19. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
20. Preparation and screening of an arrayed human genomic library generated with the P1 cloning system
21. Luciferase reporter gene vectors for analysis of promoters and enhancers
22. MatInd and MatInspector: New fast and versatile tools for detection of consensus matches in nucleotide sequence data
23. Rat inwardly rectifying potassium channel Kir6.2: Cloning electrophysiological characterization, and decreased expression in pancreatic islets of male Zucker diabetic fatty rats
24. Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats
25. Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats
26. Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma βTC-1 cells
27. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in β (INS-1)-cells
28. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells
29. +-channel function in perifused rat pancreatic islets
30. Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the β-cell function
31. Impaired β-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose
32. Chronic hyperglycemia triggers loss of pancreatic β cell differentiation in an animal model of diabetes
33. Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin 1 gene cAMP responsive element
34. Pancreatic β-cell-specific repression of insulin gene transcription by CCAAT/enhancer-binding protein β. Inhibitory interactions with basic helix-loop-helix transcription factor E47
35. Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein β and transactivator islet duodenum homeobox-1 in rat pancreatic β cells during the development of diabetes mellitus
36. Glucagon-like peptide-1 affects gene transcription and messenger ribonucleic acid stability of components of the insulin secretory system in RIN 1046-1038 cells
37. ATP channel-deficient mice
38. ATP channel
39. Sulfonylurea receptor 1 and Kit6.2 expression in the novel human insulin-secreting cell line NES2Y
40. Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians
41. Evidence for linkage of regions on chromosomes 6 and 11 to plasma glucose concentrations in Mexican Americans
42. Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians
43. The 31-cM region of chromosome 11 including the obesity gene tubby and ATP-sensitive potassium channel genes, SUR1 and Kir6.2, does not contain a major susceptibility locus for NIDDM in 127 non-Hispanic white affected sibships
44. Variant in sulfonylurea receptor-1 gene is associated with high insulin concentrations in non-diabetic Mexican Americans: SUR-1 gene variant and hyperinsulinemia
45. + channel gene (KIR6.2/BIR): A meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians
46. Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene
47. Variants in the sulphonylurea receptor gene: Association of the exon 16-3t variant with type II diabetes mellitus in Dutch Caucasians