Glucagon-like peptide I receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I

Diabetes

Volumn 45, Issue 6, 1996, Pages 832-835

  Ørskov, Cathrine ^a   Poulsen, Steen S ^a   Møller, Morten ^a   Holst, Jens J ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; HORMONE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA POSTREMA; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; FEMALE; HORMONE RECEPTOR INTERACTION; NONHUMAN; PRIORITY JOURNAL; RAT; SUBFORNICAL ORGAN;

EID: 0029903111     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.45.6.832     Document Type: Article

References (25)

1. Holst JJ, Ørskov C, Schwartz TW: Truncated glucagonlike peptide-1, an insulin-releasing peptide from the distal gut. FEBS Lett 221:169-174, 1987
2. Mojsov S, Weir GC, Habener JF: Insulinotropin: glucagon-like peptide-I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest 79:616-619, 1987
3. Ørskov C, Holst JJ, Poulsen SS, Kirkegaard P: Pancreatic and intestinal processing of proglucagon in man. Diabetologia 30:874-881, 1987
4. Elliott RM, Morgan LM, Tredger JA, Deacon S, Wright J, Marks V: Glucagon-like peptide-1 (7-36) amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h patterns. J Endocrinol 138:159-166, 1993
5. Thorens B: Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide-1. Proc Natl Acad Sci USA 89:8641-8645, 1992
6. Wettergren A, Schjoldager B, Mortensen PE, Myhre J, Christiansen J, Holst JJ: Truncated GLP-1 (proglucagon 78-107 amide) inhibits gastric and pancreatic functions in man. Dig Dis Sci 38:665-673, 1993
7. Wettergren A, Petersen h, Ørskov C, Christiansen J, Sheikh SP, Holst JJ: Glucagon-like peptide-1 7-36 amide and peptide YY from the L-cell of the ileal mucosa are potent inhibitors of vagally induced gastric acid secretion in man. Scand J Gastroenterol 29:501-505, 1994
8. Ørskov C, Wettergren A, Poulsen SS, Holst JJ: Is the effect of glucagon-like peptide-1 on gastric emptying centrally mediated? (Abstract). Diabetologia 38 (Suppl. 1):A39, 1995
9. Schick RR, vorm Walde T, Zimmermann JP, Schusdziarra V, Classen M: Glucagon-like peptide-1: a novel brain peptide involved in feeding regulation. In Obesity in Europe 1993. Ditschuneit H, Gries FA, Hauner H, Schusdziarra V, Wechsler JG, Eds. London, Libbey, 1994, p. 363-367
10. Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CMB, Meeran K, Chol SJ, Taylor GM, Heath MM, Lambert PD, Wilding JPH, Smith DM, Ghatei MA, Herbert J, Bloom SR: A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379:69-72, 1996
11. Tang-Christensen M, Larsen PJ, Göke R, Fink-Jensen A, Jessop D, Møller M, Sheikh SP: Brain GLP-1 7-36 amide receptors play a major role in regulation of food and water intake. Am J Physiol. In press
12. Göke R, Larsen PJ, Mikkelsen JD, Sheikh SP: Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP1 binding sites. Eur J Neurosci 7:2294-2300, 1995
13. Seifert H, Gallwitz B, Schmidt WE, Creutzfeldt W: Mapping of 125I-GLP-1 (7-36)-NH2 binding sites in rat brain (Abstract). Digestion 46 (Suppl. 1):104, 1990
14. Calvo JC, Yusta B, Mora F, Blazquez E: Structural characterization by affinity cross-linking of glucagon-like peptide-1 (7-36) amide receptor in the rat brain. J Neurochem 64:299-306, 1995
15. Wei Y, Mojsov S: Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences. FEBS Lett 358:219-224, 1995
16. Kreymann B, Ghatei MA, Burnet P, Williams G, Kanse S, Diani AR, Bloom SR: Characterization of glucagon-like peptide-1 (7-30) amide in the hypothalamus. Brain Res 502:325-331, 1989
17. Jin SLC, Han VKM, Simmons JG, Towle AC, Lauder JM, Lund PK: Distribution of glucagon-like peptide-1 (GLP-1), glucagon and glicentin in the rat: an immunocytochemical study. Can J Comp Neurol 271:19-532, 1988
18. Duffy KR, Pardridge WM: Blood-brain barrier transcytosis of insulin in developing rats. Brain Res 420:32-38, 1987
19. Krisch B: The functional and structural borders between the CSF- and blood-dominated milieus in the choroid plexuses and the area postrema of the rat. Cell Tissue Res 245:101-115, 1986
20. Ørskov C, Jeppesen J, Madsbad S, Holst JJ: Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine. J Clin Invest 87:415-423, 1991
21. Gross PM: Circumventricular organ capillaries. Prog Brain Res 91:219-233, 1992
22. Oldfield BJ, McKinley MJ: Circumventricular organs. In The Rat Nervous System. Paxinos G, Ed. San Diego, Academic, 1995, p. 391-403
23. Larsen PJ, Mikkelsen JD: Functional identification of central afferent projections conveying information of acute "stress" to the hypothalamic paraventricular nucleus. J Neurosci 15:2609-2627, 1995
24. Contreras RJ, Beckstead RM, Norgren R: The central projections of the trigeminal, facial, glosso-pharyngeal, and vagus nerves: an autoradiographic study. J Auton Nerv Syst 6:303-322, 1982
25. Shapiro RE, Miselis RR: The central neural connections of the area postrema of the rat. J Comp Neurol 234:344-364, 1985