메뉴 건너뛰기




Volumn 53, Issue 5, 2004, Pages 1187-1194

One Week's Treatment with the Long-Acting Glucagon-Like Peptide 1 Derivative Liraglutide (NN2211) Markedly Improves 24-h Glycemia and α- and β-Cell Function and Reduces Endogenous Glucose Release in Patients with Type 2 Diabetes

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; C PEPTIDE; FATTY ACID; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; LIRAGLUTIDE; METFORMIN; PANCREAS HORMONE; PARACETAMOL; PLACEBO; SULFONYLUREA DERIVATIVE; UNCLASSIFIED DRUG;

EID: 2342599057     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.5.1187     Document Type: Article
Times cited : (440)

References (45)
  • 1
    • 0032456709 scopus 로고    scopus 로고
    • Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: Problems and prospects
    • Ferrannini E: Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects. Endocr Rev 19:477-490, 1998
    • (1998) Endocr Rev , vol.19 , pp. 477-490
    • Ferrannini, E.1
  • 2
    • 0024511329 scopus 로고
    • Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM
    • Consoli A, Nuijhan N, Capani F, Gerich J: Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM. Diabetes 38:550-557, 1989
    • (1989) Diabetes , vol.38 , pp. 550-557
    • Consoli, A.1    Nuijhan, N.2    Capani, F.3    Gerich, J.4
  • 3
    • 0026488079 scopus 로고
    • Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study
    • Magnusson I, Rothman DL, Katz LD, Shulman RG, Shulman GI: Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study. J Clin Invest 90:1323-1327, 1992
    • (1992) J Clin Invest , vol.90 , pp. 1323-1327
    • Magnusson, I.1    Rothman, D.L.2    Katz, L.D.3    Shulman, R.G.4    Shulman, G.I.5
  • 4
    • 0034524938 scopus 로고    scopus 로고
    • Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus
    • Shah P, Vella A, Basu A, Basu R, Schwenk WF, Rizza RA: Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab 85:4053-4059, 2000
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4053-4059
    • Shah, P.1    Vella, A.2    Basu, A.3    Basu, R.4    Schwenk, W.F.5    Rizza, R.A.6
  • 5
    • 0023109225 scopus 로고
    • Documentation of hyperglucagonemia throughout the day in nonobese and obese patients with noninsulin-dependent diabetes mellitus
    • Reaven GM, Chen YD, Golay A, Swislocki AL, Jaspan JB: Documentation of hyperglucagonemia throughout the day in nonobese and obese patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 64:106-110, 1987
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 106-110
    • Reaven, G.M.1    Chen, Y.D.2    Golay, A.3    Swislocki, A.L.4    Jaspan, J.B.5
  • 6
    • 0001095690 scopus 로고    scopus 로고
    • Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients
    • Vilsboll T, Krarup T, Deacon CF, Madsbad S, Holst JJ: Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients. Diabetes 50:609-613, 2001
    • (2001) Diabetes , vol.50 , pp. 609-613
    • Vilsboll, T.1    Krarup, T.2    Deacon, C.F.3    Madsbad, S.4    Holst, J.J.5
  • 7
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33): U.K. Prospective Diabetes Study (UKPDS) Group
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33): U.K. Prospective Diabetes Study (UKPDS) Group. Lancet 352:837-853, 1998
    • (1998) Lancet , vol.352 , pp. 837-853
  • 8
    • 0037472879 scopus 로고    scopus 로고
    • Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes
    • Gaede P, Vedel P, Larsen N, Jensen GV, Parving HH, Pedersen O: Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med 348:383-393, 2003
    • (2003) N Engl J Med , vol.348 , pp. 383-393
    • Gaede, P.1    Vedel, P.2    Larsen, N.3    Jensen, G.V.4    Parving, H.H.5    Pedersen, O.6
  • 9
    • 0033028297 scopus 로고    scopus 로고
    • Is glucagon-like peptide 1 an incretin hormone?
    • Nauck MA: Is glucagon-like peptide 1 an incretin hormone? Diabetologia 42:373-379, 1999
    • (1999) Diabetologia , vol.42 , pp. 373-379
    • Nauck, M.A.1
  • 10
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
    • Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF, Egan JM: Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49:741-748, 2000
    • (2000) Diabetes , vol.49 , pp. 741-748
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3    Drucker, D.J.4    Bonner-Weir, S.5    Habener, J.F.6    Egan, J.M.7
  • 11
    • 0032005005 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
    • Flint A, Raben A, Astrup A, Holst JJ: Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J Clin Invest 101:515-520, 1998
    • (1998) J Clin Invest , vol.101 , pp. 515-520
    • Flint, A.1    Raben, A.2    Astrup, A.3    Holst, J.J.4
  • 12
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study
    • Zander M, Madsbad S, Madsen JL, Holst JJ: Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. Lancet 359: 824-830, 2002
    • (2002) Lancet , vol.359 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3    Holst, J.J.4
  • 13
    • 0141669196 scopus 로고    scopus 로고
    • Effects of 3 months of continuous subcutaneous administration of glucagon-like peptide 1 in elderly patients with type 2 diabetes
    • Meneilly GS, Grieg N, Tildesley H, Habener JF, Egan JM, Eliha D: Effects of 3 months of continuous subcutaneous administration of glucagon-like peptide 1 in elderly patients with type 2 diabetes. Diabetes Care 26:2835-2841, 2003
    • (2003) Diabetes Care , vol.26 , pp. 2835-2841
    • Meneilly, G.S.1    Grieg, N.2    Tildesley, H.3    Habener, J.F.4    Egan, J.M.5    Eliha, D.6
  • 15
    • 0036189831 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men
    • Agerso H, Jensen LB, Elbrond B, Rolan P, Zdravkovic M: The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men. Diabetologia 45:195-202, 2002
    • (2002) Diabetologia , vol.45 , pp. 195-202
    • Agerso, H.1    Jensen, L.B.2    Elbrond, B.3    Rolan, P.4    Zdravkovic, M.5
  • 16
    • 0036066641 scopus 로고    scopus 로고
    • Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes
    • Juhl CB, Hollingdal M, Sturis J, Jakobsen G, Agerso H, Veldhuis J, Porksen N, Schmitz O: Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes. Diabetes 51:424-429, 2002
    • (2002) Diabetes , vol.51 , pp. 424-429
    • Juhl, C.B.1    Hollingdal, M.2    Sturis, J.3    Jakobsen, G.4    Agerso, H.5    Veldhuis, J.6    Porksen, N.7    Schmitz, O.8
  • 17
    • 0038527035 scopus 로고    scopus 로고
    • The long-acting GLP-1 derivative, NN2211, a new agent for the treatment of type 2 diabetes
    • Matthews D, Madsbad S, Schmitz O, Lagendorf KW, Jakobsen G: The long-acting GLP-1 derivative, NN2211, a new agent for the treatment of type 2 diabetes (Abstract). Diabetes 51 (Suppl. 2):A84, 2002
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 2
    • Matthews, D.1    Madsbad, S.2    Schmitz, O.3    Lagendorf, K.W.4    Jakobsen, G.5
  • 19
    • 0026493729 scopus 로고
    • Assessment of glucose turnover rates in euglycaemic clamp studies using primed-constant [3-3H]-glucose infusion and labelled or unlabelled glucose infusates
    • Hother-Nielsen O, Mengel A, Moller J, Rasmussen O, Schmitz O, Beck-Nielsen H: Assessment of glucose turnover rates in euglycaemic clamp studies using primed-constant [3-3H]-glucose infusion and labelled or unlabelled glucose infusates. Diabet Med 9:840-849, 1992
    • (1992) Diabet Med , vol.9 , pp. 840-849
    • Hother-Nielsen, O.1    Mengel, A.2    Moller, J.3    Rasmussen, O.4    Schmitz, O.5    Beck-Nielsen, H.6
  • 21
    • 0023245416 scopus 로고
    • Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps: Comparison of unlabeled and labeled exogenous glucose infusates
    • Finegood DT, Bergman RN, Vranic M: Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps: comparison of unlabeled and labeled exogenous glucose infusates. Diabetes 36:914-924, 1987
    • (1987) Diabetes , vol.36 , pp. 914-924
    • Finegood, D.T.1    Bergman, R.N.2    Vranic, M.3
  • 22
    • 0022572232 scopus 로고
    • Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients
    • Polonsky KS, Licinio-Paixao J, Given BD, Pugh W, Rue P, Galloway J, Karrison T, Frank B: Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients. J Clin Invest 77:98-105, 1986
    • (1986) J Clin Invest , vol.77 , pp. 98-105
    • Polonsky, K.S.1    Licinio-Paixao, J.2    Given, B.D.3    Pugh, W.4    Rue, P.5    Galloway, J.6    Karrison, T.7    Frank, B.8
  • 23
    • 0026504160 scopus 로고
    • Estimation of insulin secretion rates from C-peptide levels: Comparison of individual and standard kinetic parameters for C-peptide clearance
    • Van Cauter E, Mestrez F, Sturis J, Polonsky KS: Estimation of insulin secretion rates from C-peptide levels: comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes 41:368-377, 1992
    • (1992) Diabetes , vol.41 , pp. 368-377
    • Van Cauter, E.1    Mestrez, F.2    Sturis, J.3    Polonsky, K.S.4
  • 24
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419, 1985
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 26
    • 23944513384 scopus 로고    scopus 로고
    • Standards of medical care for patients with diabetes mellitus
    • American Diabetes Association: Standards of medical care for patients with diabetes mellitus. Diabetes Care 25 (Suppl. 1):S33-S49, 2002
    • (2002) Diabetes Care , vol.25 , Issue.SUPPL. 1
  • 27
    • 0035432607 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 infusion must be maintained for 24 h/day to obtain acceptable glycemia in type 2 diabetic patients who are poorly controlled on sulphonylurea treatment
    • Larsen J, Hylleberg B, Ng K, Damsbo P: Glucagon-like peptide-1 infusion must be maintained for 24 h/day to obtain acceptable glycemia in type 2 diabetic patients who are poorly controlled on sulphonylurea treatment Diabetes Care 24:1416-1421, 2001
    • (2001) Diabetes Care , vol.24 , pp. 1416-1421
    • Larsen, J.1    Hylleberg, B.2    Ng, K.3    Damsbo, P.4
  • 28
    • 0025966024 scopus 로고
    • Contribution to postprandial hyperglycemia and effect on initial splanchnic glucose clearance of hepatic glucose cycling in glucose-intolerant or NIDDM patients
    • Butler PC, Rizza RA: Contribution to postprandial hyperglycemia and effect on initial splanchnic glucose clearance of hepatic glucose cycling in glucose-intolerant or NIDDM patients. Diabetes 40:73-81, 1991
    • (1991) Diabetes , vol.40 , pp. 73-81
    • Butler, P.C.1    Rizza, R.A.2
  • 30
    • 0034071561 scopus 로고    scopus 로고
    • Gastric emptying: Comparison of scintigraphic, polyethylene glycol dilution, and paracetamol tracer assessment techniques
    • Naslund E, Bogefors J, Gryback P, Jacobsson H, Hellstrom PM: Gastric emptying: comparison of scintigraphic, polyethylene glycol dilution, and paracetamol tracer assessment techniques. Scand J Gastroenterol 35:375-379, 2000
    • (2000) Scand J Gastroenterol , vol.35 , pp. 375-379
    • Naslund, E.1    Bogefors, J.2    Gryback, P.3    Jacobsson, H.4    Hellstrom, P.M.5
  • 33
    • 0028883204 scopus 로고
    • Failure of glucagon suppression contributes to postprandial hyperglycaemia in IDDM
    • Dinneen S, Alzaid A, Turk D, Rizza R: Failure of glucagon suppression contributes to postprandial hyperglycaemia in IDDM. Diabetologia 38:337-343, 1995
    • (1995) Diabetologia , vol.38 , pp. 337-343
    • Dinneen, S.1    Alzaid, A.2    Turk, D.3    Rizza, R.4
  • 34
  • 36
    • 0033126490 scopus 로고    scopus 로고
    • Banting Lecture 1997: Control of glucose uptake and release by the liver in vivo
    • Cherrington AD: Banting Lecture 1997: control of glucose uptake and release by the liver in vivo. Diabetes 48:1198-1214, 1999
    • (1999) Diabetes , vol.48 , pp. 1198-1214
    • Cherrington, A.D.1
  • 37
    • 0028961526 scopus 로고
    • Contribution of hepatic glycogenolysis to glucose production in hurhans in response to a physiological increase in plasma glucagon concentration
    • Magnusson I, Rothman DL, Gerard DP, Katz LD, Shulman GI: Contribution of hepatic glycogenolysis to glucose production in hurhans in response to a physiological increase in plasma glucagon concentration. Diabetes 44: 185-189, 1995
    • (1995) Diabetes , vol.44 , pp. 185-189
    • Magnusson, I.1    Rothman, D.L.2    Gerard, D.P.3    Katz, L.D.4    Shulman, G.I.5
  • 38
    • 0030034518 scopus 로고    scopus 로고
    • United Kingdom Prospective Diabetes Study 17: A 9-year update of a randomized, controlled trial on the effect of improved metabolic control on complications in non-insulin-dependent diabetes mellitus
    • Turner R, Cull C, Holman R: United Kingdom Prospective Diabetes Study 17: a 9-year update of a randomized, controlled trial on the effect of improved metabolic control on complications in non-insulin-dependent diabetes mellitus. Ann Intern Med 124:136-145, 1996
    • (1996) Ann Intern Med , vol.124 , pp. 136-145
    • Turner, R.1    Cull, C.2    Holman, R.3
  • 39
    • 0026110135 scopus 로고
    • Banting Lecture 1990: β-cells in type II diabetes mellitus
    • Porte D Jr: Banting Lecture 1990: β-cells in type II diabetes mellitus. Diabetes 40:166-180, 1991
    • (1991) Diabetes , vol.40 , pp. 166-180
    • Porte Jr., D.1
  • 40
    • 0033323822 scopus 로고    scopus 로고
    • Clinical review 102: Type 2 diabetes mellitus: Update on diagnosis, pathophysiology, and treatment
    • Mahler RJ, Adler ML: Clinical review 102: type 2 diabetes mellitus: update on diagnosis, pathophysiology, and treatment. J Clin Endocrinol Metab 84:1165-1171, 1999
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1165-1171
    • Mahler, R.J.1    Adler, M.L.2
  • 41
    • 0031032244 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 on islet function and insulin sensitivity in noninsulin-dependent diabetes mellitus
    • Ahren B, Larsson H, Holst JJ: Effects of glucagon-like peptide-1 on islet function and insulin sensitivity in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 82:473-478, 1997
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 473-478
    • Ahren, B.1    Larsson, H.2    Holst, J.J.3
  • 42
    • 0032757178 scopus 로고    scopus 로고
    • Twenty-four-hour insulin secretion rates, circulating concentrations of fuel substrates and gut incretin hormones in healthy offspring of type II (non-insulin-dependent) diabetic parents: Evidence of several aberrations
    • Nyholm B, Walker M, Gravholt CH, Shearing PA, Sturis J, Alberti KG, Holst JJ, Schmitz O: Twenty-four-hour insulin secretion rates, circulating concentrations of fuel substrates and gut incretin hormones in healthy offspring of type II (non-insulin-dependent) diabetic parents: evidence of several aberrations. Diabetologia 42:1314-1323, 1999
    • (1999) Diabetologia , vol.42 , pp. 1314-1323
    • Nyholm, B.1    Walker, M.2    Gravholt, C.H.3    Shearing, P.A.4    Sturis, J.5    Alberti, K.G.6    Holst, J.J.7    Schmitz, O.8
  • 43
    • 0030662718 scopus 로고    scopus 로고
    • Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM
    • Kahn SE, Halban PA: Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM. Diabetes 46:1725-1732, 1997
    • (1997) Diabetes , vol.46 , pp. 1725-1732
    • Kahn, S.E.1    Halban, P.A.2
  • 44
    • 0031791047 scopus 로고    scopus 로고
    • Disproportionately elevated proinsulin levels reflect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus
    • Roder ME, Porte D Jr, Schwartz RS, Kahn SE: Disproportionately elevated proinsulin levels reflect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 83:604-608, 1998
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 604-608
    • Roder, M.E.1    Porte Jr., D.2    Schwartz, R.S.3    Kahn, S.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.