Glucagonlike peptide-2 enhances small intestinal absorptive function and mucosal mass in vivo

Journal of Pediatric Surgery

Volumn 34, Issue 1, 1999, Pages 18-21

  Kato, Yoshifumi ^b   Yu, Dahong ^b   Schwartz, Marshall Z ^a  

^a NEMOURS ALFRED I DUPONT HOSPITAL FOR CHILDREN   (United States)

^b NONE

Author keywords

Glucagonlike peptide 2; Growth factor; Intestinal function; Intestinal proliferation; Small intestine

Indexed keywords

GLUCAGON LIKE PEPTIDE; GLUCAGON LIKE PEPTIDE 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CARBOHYDRATE ABSORPTION; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; DNA CONTENT; DOSE RESPONSE; INTESTINE ABSORPTION; INTESTINE FUNCTION; INTESTINE MUCOSA; MALE; NONHUMAN; OSMOTIC PUMP; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; SMALL INTESTINE;

EID: 0032906822     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-3468(99)90221-X     Document Type: Conference Paper

References (25)

1. Bell GI, Sanchez-Pescador R, Laybourn PJ, et al: Exon duplication and divergence in the human preproglucagon gene. Nature 304:368-371, 1983
2. Heinrich G, Gros P, Habener JF: Glucagon gene sequence: Four of six exons encode separate functional domains of rat pre-proglucagon. J Biol Chem 259:14082-14087, 1984
3. Brubaker PL, Crivici A, Izzo A, et al: Circulating and tissue forms of the intestinal growth factor, glucagon-like peptide-2. Endocrinology 138:4837-4843, 1997
4. Larsson LI, Holst J, Hakanson R, et al: Distribution and properties of glucagon immunoreactivity in the digestive tract of various mammals: An immunohistochemical and immunochemical study. Histochemistry 44:281-290, 1975
5. Varndell IM, Bishop AE, Sikri KL, et al: Localization of glucagon-like peptide-1 (GLP) immunoreactants in human gut and pancreas using light and electron microscopic immunocytochemistry. J Histochem Cytochem 33:1080-1086, 1985
6. Moody AJ: Gut glucagon-like immunoreactivity. Clin Gastroenterol 9:699-709, 1980
7. Eissele R, Goke R, Willemer S, et al: Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man. Eur J Clin Invest 22:283-291, 1991
8. Chance WT, Foley-Nelson T, Thomas I, et al: Prevention of parenteral nutrition-induced gut hypoplasia by coinfusion of glucagon-like peptide-2. Am J Physiol 273:G559-563, 1997
9. Tsai CH, Hill M, Drucker DJ: Biological determinants of intestinotrophic properties of GLP-2 in vivo. Am J Physiol 272:G662-668, 1997
10. Tsai CH, Hill M, Asa SL, et al: Intestinal growth-promoting properties of glucagon-like peptide-2 in mice. Am J Physiol 273:E77-84, 1997
11. Dunphy JL, Fuller PJ: At the cutting edge: Enteroglucagon, bowel growth and GLP-2. Mol Cell Endocrinol 132:7-11, 1997
12. Drucker DJ, Ehrlich P, Asa SL, et al: Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc Natl Acad Sci U S A 93: 7911-7916, 1996
13. Schwartz MZ, Storozuk RB: Can Gastrointestinal Hormones Enhance Intestinal Absorption? Surgery 98:430-435, 1985
14. Burton K: A study of the conditions and mechanisms of the diphenylamine reaction for the colormetric estimation of deoxyribonucleic acid. Biochem J 62:315-323, 1956
15. Giles KW, Myers A: An improved diphenylamine method for the estimation of deoxyribonucleic acid. Nature 206:93, 1965
16. Lowry OH, Rosebrough NJ, Farr AL, et al: Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275, 1951
17. Eissele R, Goke R, Willemer S, et al: Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man. Eur J Clin Invest 22:283-291, 1992
18. Dhanvantari S, Seidah NG, Brubaker PL: Role of prohormone convertases in the tissue-specific processing of proglucagon. Mol Endocrinol 10:342-355, 1996
19. Gleeson MH, Bloom SR, Polak JM, et al: Endocrine tumor in kidney affecting small bowel structure, motility, and absorptive function. Gut 12:773-782, 1971
20. Bloom SR, Polak JM: The hormonal pattern of intestinal adaptation: A major role for enteroglucagon. Scand J Gastroenterol 17:93-103, 1982 (suppl 74)
21. Taylor RG, Verity K, Fuller PJ: Heal glucagon gene expression: Ontogeny and response to massive small bowel resection. Gastroenterology 99:724-729, 1990
22. Schwartz MZ, Storozuk RB: Enhancement of small intestine function by gastrin. J Surg Res 38:613-617, 1985
23. Schwartz MZ, Storozuk RB: Influence of epidermal growth factor on intestinal function in the rat: Comparison of systemic infusion versus luminal perfusion. Am J Surg 155:18-22, 1988
24. Kato Y, Yu D, Lukish JR, et al: Luminal administration of hepatocyte growth factor can enhance intestinal function and mucosal mass in vivo. J Surg Res 71:49-53, 1997
25. Kato Y, Yu D, Schwartz MZ: Hepatocyte growth factor up-regulates SGLT1 and GLUT5 gene expression after massive small bowel resection. J Pediatr Surg 33:13-15, 1998