Insulinotropic glucagon-like peptide I receptor expression in glucagon- producing α-cells of the rat endocrine pancreas

Diabetes

Volumn 46, Issue 5, 1997, Pages 785-791

  Heller, R Scott ^a   Kieffer, Timothy J ^a   Habener, Joel F ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCAGON LIKE PEPTIDE 1; HORMONE RECEPTOR;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; FEMALE; GLUCAGON RELEASE; IMMUNOFLUORESCENCE TEST; MALE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0030975613     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.46.5.785     Document Type: Article

References (39)

1. Mojsov S, Heinrich G, Wilson IB, Ravazzola M, Orci L, Habener JF: Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem 261:11880-11889, 1986
2. Drucker DJ, Asa S: Glucagon gene expression in vertebrate brain. J Biol Chem 263:13475-13478, 1988
3. Elliott RM, Morgan LM, Tredger JA, Deacon S, Wright J, Marks V: Glucagon-like peptide-1 (7-36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns. J Endocrinology 138:159-166, 1993
4. Mojsov S, Weir GC, Habener JF: Insulinotropin: glucagon-like peptide 1 (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin secretion in the perfused rat pancreas. J Clin Invest 79:616-619, 1987
5. D'Alessio D, Fujimoto WY, Ensinick JW: Effects of glucagon-like peptide 1 (7-36) on release of insulin, glucagon, and somatostatin by rat pancreatic islet cell monolayer cultures. Diabetes 38:1534-1538, 1989
6. Heller RS, Aponte GW: Intra-islet regulation of hormone secretion by glucagon-like peptide-1-(7-36) amide. Am J Physiol 269:G852-G860, 1995
7. Kawai K, Suzuki S, Ohashi S, Mukai H, Ohmori H, Murayama Y, Yamshita K: Comparison of the effects of glucagon-like peptide-1-(1-37) and -(7-37) and glucagon on islet hormone release from isolated perfused canine and rat pancreas. Endocrinology 124:1768-1773, 1989
8. Schmid R, Schusdziarra V, Aulehner R, Weigert N, Classen M: Comparison of GLP-1 (7-36amide) and GIP on release of somatostatin-like immunoreactivity and insulin from the isolated rat pancreas. Z Gastroenterol 28:280-284, 1990
9. Komatsu R, Matsuyama T, Namba M, Watanabe N, Itoh H, Kono N, Tarui S: Glucagonostatic and insulinotropic action of Glucagon-like peptide (7-36) amide. Diabetes 38:902-905, 1989
10. Weir GC, Mojsov S, Hendrick G, Habener JF: Glucagon-like-peptide 1 (7-37) actions on endocrine pancreas. Diabetes 38:338-342, 1989
11. Dobbs R, Sakurai H, Saski H, Faloona G, Valverde I, Baetens D, Orci L, Unger R: Glucagon: role in the hyperglycemia of diabetes mellitus. Science 187:544-547, 1975
12. Göke R, Conlon JM: Receptors for glucagon-like peptide-1 (7-36) amide on rat insulinoma-derived cells. J Endocrinology 116:357-362, 1988
13. Fehmann H-C, Habener JF: Homologous desensitization of the insulinotropic glucagon-like peptide-1 (7-37) receptor on insulinoma (HIT-T15) cells. Endocrinology 128:2880-2888, 1991
14. Fehmann H-C, Habener JF: Functional receptors for insulinotropic hormone glucagon-like peptide-1 (7-37) on a somatostatin secreting cell line. FEBS Lett 279:335-340, 1991
15. Moens K, Heimberg H, Flamez D, Huypens P, Quartier E, Ling Z, Pipeleers D, Gremlich S, Thorens B, Schult F: Expression and functional activity of glucagon, glucagon-like peptide I, and glucose-dependent Insulinotropic peptide receptors in rat pancreatic islet cells. Diabetes 45:257-261, 1996
16. Lacy PE, Kostianovsky M: Method for the isolation of intact pancreatic islets from the rat pancreas. Diabetes 16:35-39, 1967
17. Heller RS, Kieffer TJ, Habener JF: Point mutations in the first and third intracellular loops of the glucagon-like peptide-1 receptor alter intracellular signaling. Biochem Biophys Res Comm 223:624-632, 1996
18. Aponte GW, Gross D, Yamada T: Capillary orientation of rat pancreatic D-cell processes: evidence for endocrine release of somatostatin. Am J Physiol 249:G599-G606, 1985
19. Philippe J, Chick WL, Habener JF: Multipotential phenotypic expression of genes encoding peptide hormones in rat insulinoma cell lines. J Clin Invest 79:351-358, 1987
20. Powers AC, Efrat S, Mojsov S, Spector D, Habener JF, Hanahan D: Proglucagon processing similar to normal islets in pancreatic α-like cell line derived from transgenic mouse tumor. Diabetes 39:406-414, 1990
21. Bullock B, Heller RS, Habener JF: Tissue distribution of messenger RNA encoding the rat glucagon-like peptide-1 receptor. Endocrinology 137:2968-2978, 1996
22. Harbeck MC, Louie DC, Howland J, Wolf BA, Rothenberg PL: Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet β-cells. Diabetes 45:711-717, 1996
23. Habener JF: The incretin notion and its relevance to diabetes. Endocrinol Metab Clin North Am 22:775-794, 1993
24. Creutzfeldt WOC, Kleine N, Willms B, Orskov C, Holst JJ, Nauck MA: Glucagonstatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide 1 (7-36) amide in type I diabetic patients. Diabetes Care 19:580-586, 1996
25. Maruyama H, Tominga M, Bolli G, Orci L, Unger RH: The alpha cell response to glucose change during perfusion of anti-insulin serum in pancreas isolated from normal rats. Diabetologia 28:836-840, 1985
26. Koerker DJ, Ruch W, Chideckel E, Palmer J, Goodner CJ, Ensinck J, Gale CC: Somatostatin: hypothalamic inhibitor of the endocrine pancreas. Science 184:482-484, 1974
27. Orskov C, Poulsen SS: Glucagon-like peptide-1 (7-36) amide receptors only in islets of Langerhans. Diabetes 40:1292-1296, 1991
28. Jensen J, Serup P, Karlsen C, Nielsen TF, Madsen OD: mRNA profiling of rat islet tumors reveals Nkx 6.1 as a β-cell specific homeodomain transcription factor. J Biol Chem 271:18749-18758, 1996
29. Fehmann HC, Janssen M, Goke B: Interaction of glucagon-like peptide-I (GLP-I) and galanin in insulin (beta TC-1) and somatostatin (RIN T3)-secreting cells and evidence that both peptides have no receptors on glucagon (INR1G9)-secreting cells. Acta Diabetologica 32:176-181, 1995
30. Gros L, Thorens B, Bataille D, Kervran A: Glucagon-like peptide-1 (7-36) amide, oxytomodulin, and glucagon interact with a common receptor in a somatostatin-secreting cell line. Endocrinology 133:631-638, 1993
31. Mojsov S, Kopczynski MG, Habener JF: Both amidated and nonamidated forms of glucagon-like-peptide-1 are synthesized in the rat intestine and pancreas. J Biol Chem 265:8001-8008, 1990
32. Shima K, Hirota M, Ohboshi C, Sato M, Nishino T: Release of glucagon-like peptide-1 immunoreactivity from the perfused rat pancreas. Acta Endocrinol 114:531-536, 1987
33. Fehmann H-C, Göke R, Göke B: Cell and molecular biology of the incretin hormones glucagon-like peptide-1 and glucose-dependent insulin releasing polypeptide. Endocrine Rev 16:390-410, 1995
34. Drucker DJ, Philippe J, Mojsov S, Chick WL, Habener JF: Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc Natl Acad Sci USA 84:3434-3438, 1987
35. Reichlin S: Secretion of somatostatin and its physiologic functions. J Lab Clin Med 190:320-326, 1987
36. Fehmann H-C, Göke B, Göke R, Trautmann ME, Arnold R: Synergistic stimulatory effect of glucagon-like peptide-1 (7-36) amide and glucose-dependent insulin-releasing polypeptide on the endocrine rat pancreas. FEBS Lett 252:109-112, 1989
37. Orskov C, Jeppesen J, Madsbad S, Holst JJ: Proglucagon products in plasma of noninsulin-dependent and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine. J Clin Invest 87:415-423, 1991
38. Drucker DJ, Campos R, Stobie KR, Brubaker PL: The rat glucagon gene is regulated by a protein kinase A pathway in pancreatic islets Endocrinology 128:394-400, 1991
39. Miller CP, Lin JC, Habener JF: Transcription of the rat glucagon gene by the cyclic AMP response element-binding protein CREB is modulated by adjacent CREB-associated proteins. Mol Cell Biol 13:7080-7090, 1993