Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice

Virchows Archiv

Volumn 438, Issue 4, 2001, Pages 382-387

  Ling, Z ^a   Wu, D ^a   Zambre, Y ^a   Flamez, D ^a   Drucker, D J ^b   Pipeleers, D G ^a   Schuit, F C ^a  

^a DIABETES RESEARCH CENTER   (Belgium)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

GLP 1 receptor; Islet; Morphometry

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; HORMONE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL COMPOSITION; CELL VOLUME; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TOPOGRAPHY;

ANIMALS; CELL COUNT; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOENZYME TECHNIQUES; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; PEPTIDE FRAGMENTS; PROTEIN PRECURSORS; SIGNAL TRANSDUCTION; SPECIFIC PATHOGEN-FREE ORGANISMS; TISSUE DISTRIBUTION;

EID: 0035069103     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004280000374     Document Type: Article

References (18)

1. New perspectives on the microvasculature of the islets of Langerhans in the rat
2. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
3. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells
4. Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal
5. Initiation of increased pancreatic islet growth in young normoglycemic mice (Umea +/?)
6. Neural cell adhesion molecule (N-CAM) is required for cell type segregation and normal ultrastructure in pancreatic islets
7. Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene
8. Altered cAMP and Ca2 signaling in mouse pancreatic islets with GLP-1 receptor null phenotype
9. Glucagon-like peptide-1 7-36: A physiological incretin in man
10. Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice
11. Interplay of nutrients and hormones in the regulation of insulin release
12. Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice
13. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene
14. Glucose and glucoincretin peptides synergize to induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic beta (INS-1) cells
15. Beta-cell growth in adolescent and adult rats treated with streptozotocin during the neonatal period
16. Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats
17. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
18. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells