Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas

Diabetes

Volumn 49, Issue 5, 2000, Pages 741-748

  Stoffers, Doris A ^a   Kieffer, Timothy J ^g   Hussain, Mehboob A ^b,c   Drucker, Daniel J ^f   Bonner Weir, Susan ^d   Habener, Joel F ^b,c,h   Egan, Josephine M ^e  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d JOSLIN DIABETES CENTER   (United States)

^e NATIONAL INSTITUTE ON AGING   (United States)

^f TORONTO GENERAL HOSPITAL   (Canada)

^g UNIVERSITY OF ALBERTA   (Canada)

^h MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON LIKE PEPTIDE 1 [7-36] AMIDE; GLUCOSE; HOMEODOMAIN PROTEIN; INSULIN; TRANSCRIPTION FACTOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

EID: 0034032317     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.5.741     Document Type: Article

References (45)

1. Slack JMW: Developmental biology of the pancreas. Development 121:1569-1580, 1995
2. Hattersley AT: Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity. Diabet Med 15:15-24, 1998
3. Habener JF, Stoffers DA: A newly discovered role of transcription factors involved in pancreas development and the pathogonesis of diabetes mellitus. Proc Assoc Am Physicians 110:12-21, 1998
4. Stoffers DA, Thomas MK, Habener JF: Homeodomain protein IDX-1: a master regulator of pancreas development and insulin gene expression. Trends Endocrinol Metab 8:145-151, 1997
5. Edlund H: Transcribing pancreas. Diabetes 47:1817-1823, 1998
6. Jonsson J, Carlsson L, Edlund T, Edlund H: Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371:606-609, 1994
7. Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, Habener JF: Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF-1 gene coding sequence. Nat Genet 15:106-110, 1997
8. Dutta S. Bonner-Weir S, Montminy M, Wright C: Regulatory factor linked to late-onset diabetes? Nature 392:560, 1998
9. Stoffers DA, Ferrer J, Clarke WL, Habener JF: Early-onset type-II diabetes mellitus (MODY4) linked to [PF]. Nat Genet 17:138-139, 1997
10. Seufert J, Weir GC, Habener JF: Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein β and transactivator islet duodenum homeobox-1 in rat pancreatic cells during the development of diabetes mellitus. J Clin Invest 101:2528-2539, 1998
11. Jonas J-C, Sharma A, Hasenkamp W, Ilkova H, Patanè G, Laybutt R, Bonner-Weir S, Weir GC: Chronic hyperglycemia triggers loss of pancreatic β-cell differentiation in an animal model of diabetes. J Biol Chem 274:14112-14121, 1999
12. Lu M, Seufert J, Habener JF: Pancreatic beta-cell-specific repression of insulin gene transcription by CCAAT/enhancer-binding protein β: inhibitory interactions with basic helix-loop-helix transcription factor E47. J Biol Chem 272:28349-28359, 1997
13. Sharma A, Olson LK, Robertson RP, Stein R: The reduction of insulin gene transcription in HIT-T15 β cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression. Mol Endocrinol 9:1127-1134, 1995
14. Harmon JS, Tanaka Y, Olson LK, Robertson RP: Reconstitution of glucotoxic HIT-T15 cells with somatostatin transcription factor-1 partially restores insulin promoter activity. Diabetes 47:900-904, 1998
15. Gremlich S, Bonny C, Waeber G, Thorens B: Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin and somatostatin levels. J Biol Chem 272:30261-30269, 1997
16. Habener JF: The incretin notion and its relevance to diabetes. Endocrinol Metab Clin North Am 22:775-794, 1993
17. Drucker DJ: Glucagon-like peptides. Diabetes 47:159-169, 1998
18. Kieffer TJ, Habener JF: The glucagon-like peptides. Endocr Rev 20:870-913, 1999
19. Wang Y, Perfetti R, Greig NH, Holloway HW, De Ore KA, Montrose-Rafiyadeh C, Elahi D, Egan JM: Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats. J Clin Invest 99:2883-2889, 1997
20. Grieg NH, Holloway HW, De Ore KA, Jani D, Wang Y, Zhou J, Garant MJ, Egan JM: Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations. Diabetologia 42:45-50, 1999
21. Stoffers DA, Heller RS, Miller CP, Habener JF: Developmental expression of the homeodomain protein IDX-1 in inice transgenic for an IDX-1 promoter/lacZ transcriptional reporter. Endocrinology 140:5374-5381, 1999
22. Scrocchi LA, Brown TJ, MacLusky N, Brubaker PL, Auerbach AB, Joyner AL, Drucker DJ: Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat Med 2:1254-1258, 1996
23. Stoffers DA, Stanojevic V, Habener JF: Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein. J Clin Incest 102:232-241, 1998
24. Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE: A second pathway for regeneration of adult exocrine and endocrine pancreas: a possible recapitulation of embryonic development. Diabetes 42:1715-1720, 1993
25. Gutniak M, Orskov C, Holst JJ, Ahren B, Efendic S: Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus. N Engl J Med 326:1316-1322, 1992
26. Yang H, Egan JM, Wang Y, Moyes CD, Roth J, Montrose MH, Montrose-Rafizadeh C: GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor. Am J Physiol 275:C675-C683, 1998
27. Montrose-Rafizadeh C, Yang H, Wang Y, Roth J, Montrose MH, Adams LG: Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes. J Cell Physiol 172:275-283, 1997
28. Macfarlane WM, McKinnon CM, Felton-Edkins ZA, Cragg H, James RF, Docherty K: Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic β-cells. J Biol Chem 274:1011-1016, 1999
29. Rafiq I, Kennedy HJ, Rutter GA: Glucose-dependent translocation of insulin promoter factor-1 (IPF-1) between the nuclear periphery and the nucleoplasm of single MIN6 β-cells. J Biol Chem 273:23241-23247, 1998
30. Waguri M. Yamamoto K, Miyagawa JI, Tochino Y, Yamamori K, Kajimoto Y, Nakajima H, Watada H, Yoshiuchi I, Itoh N, Imagawa A, Namba M, Kuwajima M, Yamasaki Y, Hanafusa T, Matsuzawa Y: Demonstration of two different processes of β-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan. Diabetes 46:1281-1290, 1997
31. Sharma A, Zangen DH, Reitz P, Taneja M, Lissauer ME, Miller CP, Weir GC, Habener JK, Bonner-Weir S: The homeodomain protein IDX-1 increases after an early hurst of proliferation during pancreatic regeneration. Diabetes 48:507-513, 1999
32. Wu KL, Gannon M, Peshavaria M, Offield MF, Henderson E, Ray M, Marks A, Gamer LW, Wright CVE, Stein R: Hepatocyte nuclear factor 3β is involved in pancreatic β-cell specific transcription of the pdx-1 gene. Mol Cell Biol 17:6002-6013, 1997
33. Guz Y, Montminy MR, Stein R, Leonard J, Gamer LW, Wright CVE, Teitelman G: Expression of murine STF-1, a putative insulin gene transcription factor, in β cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 121:11-18, 1995
34. Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CM, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JP, Smith DM, Shatei MA, Herbert J, Bloom SR: A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379:69-72, 1996
35. Flint A, Raben A, Astrup A, Holst JJ: Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J Clin Invest 101:515-520, 1998
36. Edvell A, Lindstrom P: Initiation of increased pancreatic islet growth in young normoglycemic mice (Umea +/?). Endocrinology 140:778-783, 1999
37. Buteau J, Roduit R, Susini S, Prentki M: Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in β (INS-1)-cells. Diabetologia 42:856-884, 1999
38. Xu G, Stoffers DA, Habener JF, Bonner-Weir S: Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48:2270-2276, 1999
39. Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CV: PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122:983-995, 1996
40. Hani EH, Stoffers DA, Chèvre J-C, Durand E, Stanojevic V, Dina C, Habener JF, Froguel P: Defective mutations in the insulin promoter factor-1 gene (ipf-1) in late-onset type 2 diabetes mellitus. J Clin Invest 104:R41-R48, 1999
41. Macfarlane WM, Frayling TM, Ellard S, Evans J, Allen LIS, Bulman MP, Ayres S, Shepherd M, Clark P, Millward A, Demaine A, Wilkin T, Docherty K, Hattersley AT: Missense mutations in the insulin promoter factor 1 (IPF-1) gene predispose to type 2 diabetes. J Clin Invest 104:R33-R39, 1999
42. Zangen DH, Bonner-Weir S, Lee CH, Latimer JB, Miller CP, Habener JF, Weir GC: Reduced insulin, GLUT2, and IDX-1 in β-cells after partial pancreatectomy. Diabetes 46:258-264, 1997
43. Montrose-Rafizadeh C, Avdonin P, Garant MJ, Rodgers BD, Kole S, Yang H, Levine MA, Schwindinger W, Bernier M: Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells. Endocrinology 140: 1132-1140, 1999
44. Kawasaki H, Springett GM, Mochizuke N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM: A family of cAMP-binding proteins that directly activate Rap-1. Science 282:2275-2279, 1998
45. Zhou J, Wang X, Pineyro MA, Egan JM: Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing. Diabetes 48:2358-2366, 1999