메뉴 건너뛰기




Volumn 160, Issue 4, 1997, Pages 413-422

Glucagon-like peptide-1 reduces hepatic glucose production indirectly through insulin and glucagon in humans

Author keywords

GLP 1; Glucose metabolic clearance rate; Rate of glucose appearance; Rate of glucose disappearance; Somatostatin

Indexed keywords

GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; SOMATOSTATIN;

EID: 0030798846     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-201X.1997.00161.x     Document Type: Article
Times cited : (119)

References (35)
  • 1
    • 0025728406 scopus 로고
    • Absence of insulinotropic glucagon-like peptide-I (7-37) receptors on isolated rat liver hepatocytes
    • Blackmore, P., Mojsov, S., Exton, J.H. & Habener, J.F. 1991. Absence of insulinotropic glucagon-like peptide-I (7-37) receptors on isolated rat liver hepatocytes. FEBS Lett 283, 7-10.
    • (1991) FEBS Lett , vol.283 , pp. 7-10
    • Blackmore, P.1    Mojsov, S.2    Exton, J.H.3    Habener, J.F.4
  • 2
    • 0028325376 scopus 로고
    • Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse
    • Campos, R.V., Lee, Y.C. & Drucker, D.J. 1994. Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. Endocrinology 134, 2156-2164.
    • (1994) Endocrinology , vol.134 , pp. 2156-2164
    • Campos, R.V.1    Lee, Y.C.2    Drucker, D.J.3
  • 3
    • 0023605138 scopus 로고
    • Glucagon as a regulator of hepatic glucose production in vivo
    • Cherrington, A.D., Stevenson, R.V. & Steiner, K.E. 1987. Glucagon as a regulator of hepatic glucose production in vivo. Biochem Soc Trans 15, 1023-1027.
    • (1987) Biochem Soc Trans , vol.15 , pp. 1023-1027
    • Cherrington, A.D.1    Stevenson, R.V.2    Steiner, K.E.3
  • 4
    • 0028296643 scopus 로고
    • Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal
    • D'Alessio, D.A., Kahn, S.E., Luesner, C.R. & Ensinck, J.W. 1994. Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal. J Clin Invest 93, 2263-2266.
    • (1994) J Clin Invest , vol.93 , pp. 2263-2266
    • D'Alessio, D.A.1    Kahn, S.E.2    Luesner, C.R.3    Ensinck, J.W.4
  • 6
    • 0028077525 scopus 로고
    • Glucagon-like peptide-1 (7-36) amide (GLP-1) enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes: One of several potential extrapancreatic sites of GLP-1 action
    • Egan, J.M., Montrose-Rafizadeh, C., Wang, Y., Bernier, M. & Roth, J. 1994. Glucagon-like peptide-1 (7-36) amide (GLP-1) enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes: one of several potential extrapancreatic sites of GLP-1 action, Endocrinology 135, 2070-2075.
    • (1994) Endocrinology , vol.135 , pp. 2070-2075
    • Egan, J.M.1    Montrose-Rafizadeh, C.2    Wang, Y.3    Bernier, M.4    Roth, J.5
  • 7
    • 0029043139 scopus 로고
    • Cell and molecular biology of the incretin hormones glucagon-like peptide-1 and glucose-dependent insulin releasing polypeptide
    • Fehmann, H.C., Göke, R. & Göke, B. 1995. Cell and molecular biology of the incretin hormones glucagon-like peptide-1 and glucose-dependent insulin releasing polypeptide. Endocr Rev 16, 390-410.
    • (1995) Endocr Rev , vol.16 , pp. 390-410
    • Fehmann, H.C.1    Göke, R.2    Göke, B.3
  • 8
    • 0026080393 scopus 로고
    • (7-36) amide: Influences on basal and stimulated insulin and glucagon secretion in the mouse
    • (7-36) amide: influences on basal and stimulated insulin and glucagon secretion in the mouse. Pancreas 6, 208-215.
    • (1991) Pancreas , vol.6 , pp. 208-215
    • Fridolf, T.1    Böttcher, G.2    Sundler, F.3    Ahrén, B.4
  • 9
    • 0029840172 scopus 로고    scopus 로고
    • Potential therapeutic levels of glucagon-like peptide-1 achieved in humans by a buccal tablet
    • Gutniak, M.K., Larsson, M.K., Heiber, S.J., Juneskans, O.T., Holst, J.J. & Ahrén, B. 1996. Potential therapeutic levels of glucagon-like peptide-1 achieved in humans by a buccal tablet. Diabetes Care 19, 843-848.
    • (1996) Diabetes Care , vol.19 , pp. 843-848
    • Gutniak, M.K.1    Larsson, M.K.2    Heiber, S.J.3    Juneskans, O.T.4    Holst, J.J.5    Ahrén, B.6
  • 10
    • 0026596851 scopus 로고
    • Antidiabetogenic effect of glucagon-like peptide-1 (7-36 amide) in normal subjects and patients with diabetes mellitus
    • Gutniak, M., Orskov, C., Hoist, J.J., Ahrén, B. & Efendic, S. 1992. Antidiabetogenic effect of glucagon-like peptide-1 (7-36 amide) in normal subjects and patients with diabetes mellitus. N Engl J Med 326, 1316-1322.
    • (1992) N Engl J Med , vol.326 , pp. 1316-1322
    • Gutniak, M.1    Orskov, C.2    Hoist, J.J.3    Ahrén, B.4    Efendic, S.5
  • 11
    • 0023104829 scopus 로고
    • Truncated glucagon-like peptide 1, an insulin-releasing hormone from the distal gut
    • Holst, J.J., Orskov, C., Schwartz, T.W. & Nielsen, O.V. 1987. Truncated glucagon-like peptide 1, an insulin-releasing hormone from the distal gut. FEBS Lett 211, 169-174.
    • (1987) FEBS Lett , vol.211 , pp. 169-174
    • Holst, J.J.1    Orskov, C.2    Schwartz, T.W.3    Nielsen, O.V.4
  • 12
    • 0028156856 scopus 로고
    • Effect of glucagon-like peptide-1 (proglucagon 78-107 amide) on hepatic glucose production in healthy man
    • Hvidberg, A., Toft Nielsen, M., Hilsted, J., Orskov, C. & Holst, J.J. 1994. Effect of glucagon-like peptide-1 (proglucagon 78-107 amide) on hepatic glucose production in healthy man. Metabolism 43, 104-108.
    • (1994) Metabolism , vol.43 , pp. 104-108
    • Hvidberg, A.1    Toft Nielsen, M.2    Hilsted, J.3    Orskov, C.4    Holst, J.J.5
  • 13
    • 0028945815 scopus 로고
    • Effects of glucose-dependent insulinotropic polypeptide and glucagon-like-peptide-l-(7-36) on insulin secretion
    • Jia, C., Brown, J.C., Ma, P., Pederson, R.A. & McIntosh, C.H.S. 1995. Effects of glucose-dependent insulinotropic polypeptide and glucagon-like-peptide-l-(7-36) on insulin secretion. Am J Physiol 268, E645-E651.
    • (1995) Am J Physiol , vol.268
    • Jia, C.1    Brown, J.C.2    Ma, P.3    Pederson, R.A.4    McIntosh, C.H.S.5
  • 14
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36: A physiological incretin in man
    • Kreymann, B., Williams, G., Ghatei, M.A. & Bloom, S.R. 1987. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 2, 1300-1303.
    • (1987) Lancet , vol.2 , pp. 1300-1303
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3    Bloom, S.R.4
  • 15
    • 0023008693 scopus 로고
    • Proglucagon gene expression in pancreas and intestine diversifies at the level of posttranslational processing
    • Mojsov, S., Heinrich, G., Wilson, I.B., Ravazzola, M., Orci, L. & Habener, J.F. 1986. Proglucagon gene expression in pancreas and intestine diversifies at the level of posttranslational processing. J Biol Chem 261, 11880-11889.
    • (1986) J Biol Chem , vol.261 , pp. 11880-11889
    • Mojsov, S.1    Heinrich, G.2    Wilson, I.B.3    Ravazzola, M.4    Orci, L.5    Habener, J.F.6
  • 16
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide-1 (7-36 amide) but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • Nauck, M.A., Heimesaat, M.M., Orskov, C., Holst, J.J., Ebert, R. & Creutzfeldt, W. (1993a) Preserved incretin activity of glucagon-like peptide-1 (7-36 amide) but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Intest 91, 301-307.
    • (1993) J Clin Intest , vol.91 , pp. 301-307
    • Nauck, M.A.1    Heimesaat, M.M.2    Orskov, C.3    Holst, J.J.4    Ebert, R.5    Creutzfeldt, W.6
  • 17
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycemia by exogeneous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients
    • Nauck, M.A., Kleine, N., Orskov, C., Holst, J.J., Willms, B. & Creutzfeldt, W. (1993b) Normalization of fasting hyperglycemia by exogeneous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients. Diabetologia 36, 741-744.
    • (1993) Diabetologia , vol.36 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Orskov, C.3    Holst, J.J.4    Willms, B.5    Creutzfeldt, W.6
  • 19
    • 0026659679 scopus 로고
    • Glucagon-like peptide-1, a new hormone of the entero-insular axis
    • Orskov, C. 1992. Glucagon-like peptide-1, a new hormone of the entero-insular axis. Diabetologia 35, 701-711.
    • (1992) Diabetologia , vol.35 , pp. 701-711
    • Orskov, C.1
  • 21
    • 0026063183 scopus 로고
    • Glucagon-like peptide-1-(7-36)-amide receptors only in islets of Langerhans. Autoradiographic survey of extracerebral tissues in rats
    • Orskov, C. & Poulsen, S.S. 1991. Glucagon-like peptide-1-(7-36)-amide receptors only in islets of Langerhans. Autoradiographic survey of extracerebral tissues in rats. Diabetes 40, 1292-1296.
    • (1991) Diabetes , vol.40 , pp. 1292-1296
    • Orskov, C.1    Poulsen, S.S.2
  • 22
    • 0028281773 scopus 로고
    • Production and secretion of amidated and glycine-extended glucagon-like peptide-1 (GLP-1) in man
    • Orskov, C., Rabenhöj, L., Kofod, H., Wettergren, A. & Holst, J.J. 1994. Production and secretion of amidated and glycine-extended glucagon-like peptide-1 (GLP-1) in man. Diabetes 43, 535-539.
    • (1994) Diabetes , vol.43 , pp. 535-539
    • Orskov, C.1    Rabenhöj, L.2    Kofod, H.3    Wettergren, A.4    Holst, J.J.5
  • 24
    • 0028904931 scopus 로고
    • Insulinotropic actions ot intravenous glucagon-like peptide-1 (GLP-1) [7-36 amide] in the tasting state in healthy subjects
    • Qualmann, C., Nauck, M.A., Holst, J.J., Orskov, C. & Creutzfeldt, W. 1995. Insulinotropic actions ot intravenous glucagon-like peptide-1 (GLP-1) [7-36 amide] in the tasting state in healthy subjects. Acta Diabetol 32, 13-16.
    • (1995) Acta Diabetol , vol.32 , pp. 13-16
    • Qualmann, C.1    Nauck, M.A.2    Holst, J.J.3    Orskov, C.4    Creutzfeldt, W.5
  • 25
    • 0029060435 scopus 로고
    • Drugs on the horizon for treatment of type 2 diabetes
    • Rachman, J. & Turner, R.C. 1995. Drugs on the horizon for treatment of type 2 diabetes. Diabetic Med 12, 467-478.
    • (1995) Diabetic Med , vol.12 , pp. 467-478
    • Rachman, J.1    Turner, R.C.2
  • 26
    • 0029074964 scopus 로고
    • Pharmacokinetic, insulinotropic and glucagonostatic properties of GLP-1 (7-36 amide) after subcutaneous injection in healthy volunteers. Dose-response relationships
    • Ritzel, R., Orskov, C., Holst, J.J. & Nauck, M.A. 1995. Pharmacokinetic, insulinotropic and glucagonostatic properties of GLP-1 (7-36 amide) after subcutaneous injection in healthy volunteers. Dose-response relationships. Diabetologia 38, 720-725.
    • (1995) Diabetologia , vol.38 , pp. 720-725
    • Ritzel, R.1    Orskov, C.2    Holst, J.J.3    Nauck, M.A.4
  • 27
    • 0000648085 scopus 로고
    • Influences of glucose loading and of injected insulin on hepatic glucose output
    • Steele, R. 1959. Influences of glucose loading and of injected insulin on hepatic glucose output. Ann NY Acad Sci 82, 420-430.
    • (1959) Ann NY Acad Sci , vol.82 , pp. 420-430
    • Steele, R.1
  • 28
    • 0025637706 scopus 로고
    • Effects of insulin on glucagon-stimulated glucose production in the conscious dog
    • Steiner, K.E., Williams, P.M., Lacy, W.W. & Cherrington, A.D. 1990. Effects of insulin on glucagon-stimulated glucose production in the conscious dog. Metabolism 39, 1325-1333.
    • (1990) Metabolism , vol.39 , pp. 1325-1333
    • Steiner, K.E.1    Williams, P.M.2    Lacy, W.W.3    Cherrington, A.D.4
  • 29
    • 0030010364 scopus 로고    scopus 로고
    • The effect of glucagon-like peptide 1 (GLP-1) on glucose elimination in healthy subjects depends on the pancreatic glucoregulatory hormones
    • Toft-Kielsen, M., Madsbad, S. & Holst, J.J. 1996. The effect of glucagon-like peptide 1 (GLP-1) on glucose elimination in healthy subjects depends on the pancreatic glucoregulatory hormones. Diabetes 45, 552-556.
    • (1996) Diabetes , vol.45 , pp. 552-556
    • Toft-Kielsen, M.1    Madsbad, S.2    Holst, J.J.3
  • 34
    • 0030068620 scopus 로고    scopus 로고
    • Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: Effects of exogeneous glucagon-like peptide-1 (GLP-l)-(7-36) amide in type 2 (noninsulin dependent) diabetic patients
    • Willms, B., Werner, J., Holst, J.J., Orskov, C., Creutzfeldt, W. & Nauck, M.A. 1996. Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: Effects of exogeneous glucagon-like peptide-1 (GLP-l)-(7-36) amide in type 2 (noninsulin dependent) diabetic patients. J Clin Endocrinol Metab 81, 327-332.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 327-332
    • Willms, B.1    Werner, J.2    Holst, J.J.3    Orskov, C.4    Creutzfeldt, W.5    Nauck, M.A.6
  • 35
    • 0003512785 scopus 로고
    • Geneva, World Health Organization, Technical Report Series no. 727
    • World Health Organization. 1985. Diabetes Mellitus: Report of a study group. Geneva, World Health Organization, Technical Report Series no. 727.
    • (1985) Diabetes Mellitus: Report of a Study Group


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.