Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats

Journal of Clinical Investigation

Volumn 99, Issue 12, 1997, Pages 2883-2889

  Wang, Yihong ^a   Perfetti, Riccardo ^a   Greig, Nigel H ^a   Holloway, Harold W ^a   DeOre, Kimberly A ^a   Montrose Rafizadeh, Chahrzad ^a   Elahi, Dariush ^a   Egan, Josephine M ^a,b  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b NIA/GRC/LPC   (United States)

Author keywords

Aging; Beta cell; Glucagon; Glucose; Insulin

Indexed keywords

EXENDIN[9-39]; GLUCAGON LIKE PEPTIDE 1; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER; HORMONE ANTAGONIST; INSULIN; MESSENGER RNA; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ADOLESCENT; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; INSULIN RELEASE; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030913210     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119482     Document Type: Article

References (37)

1. Thorens, B., and G. Waeber. 1993. Glucagon-like peptide-1 and the control of insulin secretion in the normal state and in NIDDM. Diabetes. 42:1219-1225.
2. Orskov, C. 1992. Glucagon-like peptide-1, a new hormone of the enteroinsular axis. Diabetologia. 35:701-711.
3. Drucker, C.J., J. Philippe, S. Mosjov, W.L. Chick, and J.F. Habener. 1987. Glucagon-like peptide 1 stimulates insulin gene expression and increases cyclic AMP in a rat islet cell line. Proc. Natl. Acad. Sci. USA. 84:3434-3438.
4. Fehmann, H.C. and J.F. Habener. 1992. Insulinotropic hormone glucagon-like peptide-1 (7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma βTC-1 cells. Endocrinology. 130:159-166.
5. Wang, Y., J.M. Egan, M. Raygada, O. Nadiv, J. Roth, and C. Montrose-Rafizadeh. 1995. Glucagon-like peptide-1 affects gene transcription and messenger ribonucleic acid stability of components of the insulin secretory system in RIN 1046-38 cells. Endocrinology. 136:4910-4917.
6. Wang, Y., C. Montrose-Rafizadeh, L. Adams, M. Raygada, O. Nadiv, and J.M. Egan. 1996. GIP regulates glucose transporters, hexokinases, and glucose-induced insulin secretion in RIN 1046-38 cells. Mol Cell. Endocrinol. 116:81-87.
7. Nauck, M.A, M.M. Heimesaat, C. Orskov, J.J. Holst, R. Ebert, and W. Creutzfeldt. 1993. Preserved incretin activity of glucagon-like peptide 1 (7-36) amide but not of synthetic human gastric inhibitory polypeptide in patients with Type-2 diabetes mellitus. J. Clin. Invest. 91:301-307.
8. Nauck, M.A., N. Kleine, C. Orskov, J.J. Holst, B. Willms, and W. Creutzfeldt. 1993. Normalization of fasting hyperglycemia by exogenous glucagon-like peptide 1 (7-36) amide in Type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 36:741-744.
9. th, G.G., W.M. Kuhtreiber, and J.F. Habener. 1993. Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1 (7-37). Nature (Lond.). 361:362-365.
10. Widmann, C., W. Dolci, and B. Thorens. 1996. Desensitization and phosphorylation of the glucagon-like peptide-1 (GLP-1) receptor by GLP-1 and4-phorbol 12-myristate 13-acetate. Mol. Endocrinol. 10:62-75.
11. Nadiv, O., O. Cohen, and Y. Zick. 1992. Defects in insulin's signal transduction in old rat livers. Endocrinology. 130:1515-1524.
12. Elahi, D., D.C. Muller, D.K. Andersen J.D. Tobin, and R.A. Andres. 1985. The effect of age and glucose concentration on insulin secretion by the isolated perfused pancreas. Endocrinology. 116:11-16.
13. Porte, D., Jr. 1991. β-cells in Type II diabetes mellitus. Diabetes. 40:166-180.
14. Leahy, J.L. 1990. Natural history of B-cell dysfunction in NIDDM. Diabetes Care. 13:992-1010.
15. Perfetti, R., C. Montrose-Rafizadeh, A.S. Liotta, and J.M. Egan. 1995. Age-dependent reduction in insulin secretion and insulin mRNA in isolated islets from rats. Am. J. Physiol. 269:E983-E990.
16. Wang, Z., R.M. Wang, A.A. Owji, D.M. Smith, M.A. Ghatei, and S.R. Bloom. 1995. Glucagon-like peptide-1 is a physiological incretin in rat. J. Clin. Invest. 95:417-421.
17. Egan, J.M., C.M. Asplin, M.A. Drumheller, J.R. Kerrigan, J. Scott, P.M. Martha, Jr., and W.S. Evans. 1991. Glucose stimulated insulin release by individual beta cells: potentiation by glyburide. J. Exp. Med. Biol. 196:203-210.
18. Nathan, D.M., E. Schreiber, H. Fogel S. Mosjov, and J.F. Habener. 1992. Insulinotropic action of glucagonlike peptide-1-(7-37) in diabetic and nondiabetic subjects. Diabetes Care. 15:270-276.
19. Glisin, V., R. Crkvenjakov, and C. Byrus. 1974. Ribonucleic acid isolated by cesium chloride centrifugation. Biochemistry. 13:2633-2637.
20. Chigwin, J.M., A.E. Przybyla, R.J. MacDonald, and W.J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 18:5294-5299.
21. Matschinsky, F. 1990. Glucokinase as glucose sensor and metabolic signal generator in pancreatic β-cells. Diabetes. 39:647-652.
22. Mueckler, M. 1990. Family of glucose-transporter genes. Implications for glucose homeostasis and diabetes. Diabetes. 39:6-11.
23. Gutniak, M., C. Orskov, J.J. Holst, B. Ahren, and S. Efendic. 1992. Antidiabetogenic effect of glucagon-like peptide-1 (7-36) amide in normal subjects and patients with diabetes mellitus. N. Engl. J. Med. 326:1316-1322.
24. Wang, S. Y., P. A. Halban, and J.W. Rowe. 1988. Effects of aging on insulin synthesis and secretion. Differential effects on proinsulin messenger messenger mRNA levels, proinsulin biosynthesis, and secretion of newly made and preformed insulin in the rat. J. Clin. Invest. 81:176-184.
25. Arver, P., T. Pollare, and H. Lilhell. 1991. Different aetiologies of type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects. Diabetologia. 34:483-487.
26. Elahi, D., M. McAloon-Dyke, N.K. Fukagawa, G.S. Meneilly, A.L. Sclater, K.L. Minaker, J.F. Habener, and D.K. Andersen. 1994. The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects. Regul. Peptides. 51:63-74.
27. Perfetti, R., Y. Wang, S.R. Shuldiner, and J.M. Egan. 1996. Investigation of age-related changes in mouse endocrine pancreas. J. Gerontol. 51:B331-B336.
28. Unger, R.H. 1990. Diabetic hyperglycemia: link to impaired glucose transport in pancreatic β cells. Science (Wash. DC). 251:1200-1205.
29. Thorens, B., Y.-J. Wu, J.L. Leahy, and G.C. Weir. 1992. The loss of GLUT2 expression by glucose-unresponsive β cells of db/db mice is reversible and is induced by the diabetic environment. J. Clin. Invest. 90:77-85.
30. Valera, A., G. Solanes, J. Fernandez-Alverez, A. Pujol, J, Asins, R. Gomis, and F. Bosch. 1994. Expression of GLUT-2 antisense RNA in β cells of transgenic mice leads to diabetes. J. Biol. Chem. 269:28543-28546.
31. Pilkis, S.J., I.T. Weber, R.W. Harrison, and G.I. Bell. 1994. Giucokinase: structure analysis of a protein involved in susceptibility to diabetes. J. Biol. Chem. 269:21925-21928.
32. Ferber, S., H. BeltrandelRio, and J.H. Johnson. 1994. GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. J. Biol. Chem. 269:11523-11529.
33. Hosokawa, Y.A., H. Hosokawa, C. Chen, and J.L. Leahy. 1996. Mechanism of impaired glucose-potentiated insulin secretion in diabetic 90% pancreatectomy rats. Study using glucagonlike peptide-1 (7-37). J. Clin. Invest. 97:180-186.
34. Wang, S.Y., and J.W. Rowe. 1988. Age-related impairment in the short term regulation of insulin biosynthesis by glucose in rat pancreatic islets. Endocrinology. 123:1008-1013.
35. Montrose-Rafizadeh. C., J.M. Egan, and J. Roth. 1994. Incretin hormones regulate glucose-dependent insulin secretion in RIN 1046-38 cells: mechanism of action. Endocrinology. 135:589-594.
36. Waeber, G., N. Thompson, P. Nicod, and C. Bonny. 1996. Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox domain. Mol. Endocrinol. 10:1327-1334.
37. Stoffers, D., R.S. Heller, C.P. Miller, and J.F. Habener. 1996. Expression of homeodomain factor IDX-1 in pancreas and duodenum: discordance among expression of an IDX-1 β-galactosidase transcriptional reporter, IDX-1 mRNA and protein. Tenth International Congress of Endocrinology: P2-35 (Abstr.).