메뉴 건너뛰기




Volumn 7, Issue 8, 2011, Pages 989-1007

Bioactivation of herbal constituents: Simple alerts in the complex system

Author keywords

bioactivation; herbal medicines; herbal toxicity; herbdrug interactions

Indexed keywords

ALLICIN; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE; BERGAMOTTIN; CYTOCHROME P450; CYTOCHROME P450 2A6; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; DAURICINE; DRUG METABOLIZING ENZYME; ESTRAGOLE; EVODIAMINE; FLAVONOID; FUROSEMIDE; GLABRIDIN; HERBACEOUS AGENT; KAVA; LIMONIN; MENTHOFURAN; METHOXSALEN; METHYLEUGENOL; NOSCAPINE; PYRROLIZIDINE ALKALOID; RESVERATROL; RUTAECARPINE; SAFROLE; SILIBININ; UNINDEXED DRUG; WARFARIN;

EID: 79960526327     PISSN: 17425255     EISSN: 17447607     Source Type: Journal    
DOI: 10.1517/17425255.2011.586335     Document Type: Review
Times cited : (42)

References (140)
  • 1
    • 0347510705 scopus 로고    scopus 로고
    • Drug interactions between herbal and prescription medicines
    • DOI 10.2165/00002018-200326150-00002
    • Williamson E. Drug interactions between herbal and prescription medicines. Drug Saf 2003;26:1075-92 (Pubitemid 38021390)
    • (2003) Drug Safety , vol.26 , Issue.15 , pp. 1075-1092
    • Williamson, E.M.1
  • 3
    • 26444508950 scopus 로고    scopus 로고
    • The severity of toxic reactions to ephedra: Comparisons to other botanical products and national trends from 1993-2002
    • DOI 10.1081/CLT-200066075
    • Woolf AD, Watson WA, Smolinske S, et al. The severity of toxic reactions to Ephedra: Comparisons to other botanical products and national trends from 1993-2002. Clin Toxicol 2003;43:347-55 (Pubitemid 41428767)
    • (2005) Clinical Toxicology , vol.43 , Issue.5 , pp. 347-355
    • Woolf, A.D.1    Watson, W.A.2    Smolinske, S.3    Litovitz, T.4
  • 4
    • 3042615390 scopus 로고    scopus 로고
    • Health risks of herbal remedies
    • De Smet PAGM. Health risks of herbal remedies. Clin Pharmacol Ther 2004;76:1-17
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 1-17
    • De Smet, P.A.G.M.1
  • 5
    • 34547733497 scopus 로고    scopus 로고
    • Identification of drugs that interact with herbs in drug development
    • Zhou SF, Zhou ZW, Li CG, et al. Identification of drugs that interact with herbs in drug development. Drug Discov Today 2007;12:664-73
    • (2007) Drug Discov Today , vol.12 , pp. 664-73
    • Zhou, S.F.1    Zhou, Z.W.2    Li, C.G.3
  • 6
    • 33645050104 scopus 로고    scopus 로고
    • Cytochrome P450s and other enzymes in drug metabolism and toxicity
    • Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. AAPS J 2006;8:E101-11
    • (2006) AAPS J , vol.8
    • Guengerich, F.P.1
  • 7
    • 33749009806 scopus 로고    scopus 로고
    • Detecting and characterizing reactive metabolites by liquid chromatography/tandem mass spectrometry
    • DOI 10.1002/jms.1098
    • Ma S, Subramanian R. Detecting and characterizing reactive metabolites by liquid chromatography/tandem mass spectrometry. J Mass Spectrom 2006;41:1121-39 (Pubitemid 44454166)
    • (2006) Journal of Mass Spectrometry , vol.41 , Issue.9 , pp. 1121-1139
    • Ma, S.1    Subramanian, R.2
  • 8
    • 0346220388 scopus 로고    scopus 로고
    • Herbal bioactivation: The good, the bad and the ugly
    • Zhou SF, Koh HL, Gao YH, et al. Herbal bioactivation: the good, the bad and the ugly. Life Sci 2004;74:935-68
    • (2004) Life Sci , vol.74 , pp. 935-68
    • Zhou, S.F.1    Koh, H.L.2    Gao, Y.H.3
  • 9
    • 34547677792 scopus 로고    scopus 로고
    • Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: An update
    • DOI 10.2174/138920007781368863
    • Zhou SF, Xue CC, Yu XQ, et al. Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update. Curr Drug Metab 2007;8:526-53 (Pubitemid 47209094)
    • (2007) Current Drug Metabolism , vol.8 , Issue.6 , pp. 526-553
    • Zhou, S.-F.1    Xue, C.C.2    Yu, X.-Q.3    Wang, G.4
  • 11
    • 0037325276 scopus 로고    scopus 로고
    • In vitro metabolism of tolcapone to reactive intermediates: Relevance to tolcapone liver toxicity
    • Smith KS, Smith PL, Heady TN, et al. In vitro metabolism of tolcapone to reactive intermediates: relevance to tolcapone liver toxicity. Chem Res Toxicol 2003;16:123-8
    • (2003) Chem Res Toxicol , vol.16 , pp. 123-8
    • Smith, K.S.1    Smith, P.L.2    Heady, T.N.3
  • 12
    • 0030812882 scopus 로고    scopus 로고
    • In vitro comparison of cytochrome P450-mediated metabolic activities in human, dog, cat and horse
    • Chauret N, Gauthier A, Martin J, et al. In vitro comparison of cytochrome P450-mediated metabolic activities in human, dog, cat and horse. Drug Metab Dispos 1997;25:1130-6
    • (1997) Drug Metab Dispos , vol.25 , pp. 1130-6
    • Chauret, N.1    Gauthier, A.2    Martin, J.3
  • 14
    • 0034751383 scopus 로고    scopus 로고
    • Is ?Chinese Herbs Nephropathy? a prejudical term?
    • Solez K, Daugirdes J, Gregory MC, et al. Is ?Chinese Herbs Nephropathy? a prejudical term? Am J Kidney Dis 2001;38:1141-2
    • (2001) Am J Kidney Dis , vol.38 , pp. 1141-2
    • Solez, K.1    Daugirdes, J.2    Gregory, M.C.3
  • 15
    • 0034861029 scopus 로고    scopus 로고
    • Human enzymes involved in the metabolic activation of carcinogenic aristolochic acids: Evidence for reductive activation by cytochromes P450 1A1 and 1A2
    • DOI 10.1021/tx010059z
    • Stiborova M, Frei E, Wiessler M, et al. Human enzymes involved in the metabolic activation of carcinogenic aristolochic acids: evidence for reductive activation by cytochromes P450 1A1 and 1A2. Chem Res Toxicol 2001;14:1128-37 (Pubitemid 32800169)
    • (2001) Chemical Research in Toxicology , vol.14 , Issue.8 , pp. 1128-1137
    • Stiborova, M.1    Frei, E.2    Wiessler, M.3    Schmeiser, H.H.4
  • 16
    • 0036257348 scopus 로고    scopus 로고
    • Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy
    • Stiborova M, Frei E, Sopko B, et al. Carcinogenic aristolochic acids upon activation by DT-diaphorase from adducts found in DNA of patients with Chinese herbs nephropathy. Carcinogenesis 2002;23:617-25 (Pubitemid 34498500)
    • (2002) Carcinogenesis , vol.23 , Issue.4 , pp. 617-625
    • Stiborova, M.1    Frei, E.2    Sopko, B.3    Wiessler, M.4    Schmeiser, H.H.5
  • 17
    • 0025181829 scopus 로고
    • Aristolochic acid binds covalently to the exocyclic amino group of purine nucleotides in DNA
    • Pfau W, Schmeiser HH, Wiessler M. Aristolochic acid binds covalently to the exocyclic amino group of purine nucleotides in DNA. Carcinogenesis 1990;11:313-19 (Pubitemid 20072170)
    • (1990) Carcinogenesis , vol.11 , Issue.2 , pp. 313-319
    • Pfau, W.1    Schmeiser, H.H.2    Wiessler, M.3
  • 18
    • 0029983768 scopus 로고    scopus 로고
    • Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy
    • Schmeiser HH, Bieler CA, Wiessler M, et al. Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy. Cancer Res 1996;56:2025-8 (Pubitemid 26119902)
    • (1996) Cancer Research , vol.56 , Issue.9 , pp. 2025-2028
    • Schmeiser, H.H.1    Bieler, C.A.2    Wiessler, M.3    Van Ypersele De Strihou, C.4    Cosyns, J.-P.5
  • 20
    • 0025916249 scopus 로고
    • Activating mutations at codon 61 of the c-Ha-ras gene in thin-tissue sections of tumors induced by aristolochic acid in rats and mice
    • Schmeiser HH, Scherf HR, Wiessler M, et al. Activating mutations at codon 61 of the c-Ha-ras gene in thin-tissue sections of tumors induced by aristolochic acid in rats and mice. Cancer Res 1991;59:139-43
    • (1991) Cancer Res , vol.59 , pp. 139-43
    • Schmeiser, H.H.1    Scherf, H.R.2    Wiessler, M.3
  • 21
    • 0036020624 scopus 로고    scopus 로고
    • Aristolochic acid as a probable human cancer hazard in herbal remedies: A review
    • Arlt VM, Stiborova M, Schmeiser HH. Aristolochic acid as a probable human cancer hazard in herbal remedies: a review. Mutagenesis 2002;17:265-77 (Pubitemid 34814645)
    • (2002) Mutagenesis , vol.17 , Issue.4 , pp. 265-277
    • Arlt, V.M.1    Stiborova, M.2    Schmeiser, H.H.3
  • 22
    • 0034232506 scopus 로고    scopus 로고
    • Mechanisms of inhibitory and regulatory effects of methylenedioxyphenyl compounds on cytochrome P450-dependent drug oxidation
    • Murray M. Mechanisms of inhibitory and regulatory effects of methylenedioxyphenyl compounds on cytochrome P450-dependent drug oxidation. Curr Drug Metab 2000;1:67-84
    • (2000) Curr Drug Metab , vol.1 , pp. 67-84
    • Murray, M.1
  • 23
    • 0031685498 scopus 로고    scopus 로고
    • In vitro toxicity of zamifenacin (UK-76,654) and metabolites in primary hepatocyte cultures
    • DOI 10.1080/004982598239137
    • Amacher DE, Fasulo LM, Charuel C, et al. In vitro toxicity of zamifenacin (UK-76654) and metabolites in primary hepatocyte cultures. Xenobiotica 1998;28:895-908 (Pubitemid 28446365)
    • (1998) Xenobiotica , vol.28 , Issue.9 , pp. 895-908
    • Amacher, D.E.1    Fasulo, L.M.2    Charuel, C.3    Comby, P.4    Beaumont, K.5
  • 25
    • 0017405097 scopus 로고
    • Carcinogenic and mutagenic activities of safrole, 1'-hydroxysafrole, and some known or possible metabolites
    • Wislocki PG, Miller EC, Killer JA, et al. Carcinogenic and mutagenic activities of safrole, 1′-hydroxysafrole, and some known or possible metabolites. Cancer Res 1977;37:1883-91 (Pubitemid 8095207)
    • (1977) Cancer Research , vol.37 , Issue.6 , pp. 1883-1891
    • Wislocki, P.G.1    Miller, E.C.2    Miller, J.A.3
  • 27
    • 4243125326 scopus 로고    scopus 로고
    • Identification of the main human cytochrome P450 enzymes involved in safrole 1′hydroxylation
    • Ueng YF, Hsieh CH, Don MJ, et al. Identification of the main human cytochrome P450 enzymes involved in safrole 1′hydroxylation. Chem Res Toxicol 2004;17:1151-6
    • (2004) Chem Res Toxicol , vol.17 , pp. 1151-6
    • Ueng, Y.F.1    Hsieh, C.H.2    Don, M.J.3
  • 28
    • 0028285123 scopus 로고
    • Evidence that 4-allyl-o-quinones spontaneously rearrange to their more electrophilic quinone methides: Potential bioactivation mechanism for the hepatocarcinogen safrole
    • Bolton JL, Acay NM, Vukomanovic V. Evidence that 4-Allyl-o-quinones spontaneously rearrange to their more electrophilic quinone methides: potential bioactivation mechanism for the hepatocarcinogen safrole. Chem Res Toxicol 1994;7:443-50 (Pubitemid 24150107)
    • (1994) Chemical Research in Toxicology , vol.7 , Issue.3 , pp. 443-450
    • Bolton, J.L.1    Acay, N.M.2    Vukomanovic, V.3
  • 30
    • 33746309901 scopus 로고    scopus 로고
    • Abuse of nutmeg (Myristica fragrans Houtt.): Studies on the metabolism and the toxicologic detection of its ingredients elemicin, myristicin, and safrole in rat and human urine using gas chromatography/mass spectrometry
    • DOI 10.1097/00007691-200608000-00013, PII 0000769120060800000013
    • Beyer J, Ehlers D, Maurer HH. Abuse of nutmeg (Myristica fragrans Houtt.): studies on the metabolism and the toxicologic detection of its ingredients elemicin, myristicin and safrole in rat and human urine using gas chromatography/mass spectrometry. Ther Drug Monit 2006;28:568-75 (Pubitemid 44181492)
    • (2006) Therapeutic Drug Monitoring , vol.28 , Issue.4 , pp. 568-575
    • Beyer, J.1    Ehlers, D.2    Maurer, H.H.3
  • 31
    • 0018574846 scopus 로고
    • Comparison of the antitussive effects of codeine phosphate 20 mg, dextromethorphan 30 mg and noscapine 30 mg using citric acid-induced cough in normal subjects
    • DOI 10.1007/BF00568199
    • Empey DW, Laitinen LA, Young GA, et al. Comparison of the antitussive effects of codeine phosphate 20 mg, dextromethorphan 30 mg and noscapine 30 mg using citric acid-induced cough in normal subjects. Eur J Clin Pharmacol 1979;16:393-7 (Pubitemid 10173750)
    • (1979) European Journal of Clinical Pharmacology , vol.16 , Issue.6 , pp. 393-397
    • Empey, D.W.1    Laitinen, L.A.2    Young, G.A.3
  • 33
    • 75149152466 scopus 로고    scopus 로고
    • Time-dependent inhibition (TDI) of CYP3A4 and CYP2C9 by noscapine potentially explains clinical noscapine-warfarin interaction
    • Fang ZZ, Zhang YY, Ge GB, et al. Time-dependent inhibition (TDI) of CYP3A4 and CYP2C9 by noscapine potentially explains clinical noscapine-warfarin interaction. Br J Clin Pharmacol 2010;69:193-9
    • (2010) Br J Clin Pharmacol , vol.69 , pp. 193-9
    • Fang, Z.Z.1    Zhang, Y.Y.2    Ge, G.B.3
  • 34
    • 77955926982 scopus 로고    scopus 로고
    • Clinically significant CYP2C inhibition by noscapine but not by Glucosamine
    • Rosenborg S, Stenberg M, Otto S, et al. Clinically significant CYP2C inhibition by noscapine but not by Glucosamine. Clin Pharmacol Ther 2010;88:343-6
    • (2010) Clin Pharmacol Ther , vol.88 , pp. 343-6
    • Rosenborg, S.1    Stenberg, M.2    Otto, S.3
  • 35
    • 20444458671 scopus 로고    scopus 로고
    • Meta-analysis of the efficacy of the acetonic kava-kava extract WS®1490 in patients with non-psychotic anxiety disorders
    • DOI 10.1002/ptr.1609
    • Witte S, Loew D, Gaus W. Meta-analysis of the efficacy of the acetonic kava-kava extract WS1490 in patients with non-psychotic anxiety disorders. Phytother Res 2005;19:183-8 (Pubitemid 40827638)
    • (2005) Phytotherapy Research , vol.19 , Issue.3 , pp. 183-188
    • Witte, S.1    Loew, D.2    Gaus, W.3
  • 36
    • 1842479653 scopus 로고    scopus 로고
    • Kava kava: Examining new reports of toxicity
    • DOI 10.1016/j.toxlet.2003.07.005, PII S0378427404000402
    • Clouatre DL. Kava kava: examining new reports of toxicology. Toxicol Lett 2004;150:85-96 (Pubitemid 38447238)
    • (2004) Toxicology Letters , vol.150 , Issue.1 , pp. 85-96
    • Clouatre, D.L.1
  • 37
    • 0037532579 scopus 로고    scopus 로고
    • Kava extracts: Safety and risks including rare hepatotoxicity
    • DOI 10.1078/0944-7113-00314
    • Teschke R, Gaus W, Loew D. Kava extracts: safety and risks including rare hepatotoxicity. Phytomedicine 2003;10:440-6 (Pubitemid 36745169)
    • (2003) Phytomedicine , vol.10 , Issue.5 , pp. 440-446
    • Teschke, R.1    Gaus, W.2    Loew, D.3
  • 39
    • 0036842023 scopus 로고    scopus 로고
    • Inhibition of human cytochrome P450 activities by kava extract and kavalactones
    • DOI 10.1124/dmd.30.11.1153
    • Mathews JM, Etheridge AS, Black SR. Inhibition of human cytochrome P450 activities by kava extracts and kavalactones. Drug Metab Dispos 2002;30:1153-7 (Pubitemid 35265819)
    • (2002) Drug Metabolism and Disposition , vol.30 , Issue.11 , pp. 1153-1157
    • Mathews, J.M.1    Etheridge, A.S.2    Black, S.R.3
  • 40
    • 79551670426 scopus 로고    scopus 로고
    • Identification of cytochrome P450 (CYP) isoforms involved in the metabolism of corynoline and assessment of its herb-drug interactions
    • Fang ZZ, Zhang YY, Ge GB, et al. Identification of cytochrome P450 (CYP) isoforms involved in the metabolism of corynoline and assessment of its herb-drug interactions. Phytother Res 2011;25:256-63
    • (2011) Phytother Res , vol.25 , pp. 256-63
    • Fang, Z.Z.1    Zhang, Y.Y.2    Ge, G.B.3
  • 41
    • 9444257635 scopus 로고    scopus 로고
    • Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract
    • DOI 10.1124/dmd.104.000646
    • Iwata H, Tezuka Y, Kadota S, et al. Identification and characterization of potent CYP3A4 inhibitors in Schisandra Fruit extract. Drug Metab Dispos 2004;32:1351-8 (Pubitemid 39564554)
    • (2004) Drug Metabolism and Disposition , vol.32 , Issue.12 , pp. 1351-1358
    • Iwata, H.1    Tezuka, Y.2    Kadota, S.3    Hiratsuka, A.4    Watabe, T.5
  • 42
    • 0142181023 scopus 로고    scopus 로고
    • Human cytochrome P450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components
    • DOI 10.1124/dmd.31.11.1391
    • Chatterjee P, Franklin MR. Human cytochrome P450 inhibition and metabolic- intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7 (Pubitemid 37310329)
    • (2003) Drug Metabolism and Disposition , vol.31 , Issue.11 , pp. 1391-1397
    • Chatterjee, P.1    Franklin, M.R.2
  • 43
    • 0017086593 scopus 로고
    • Microsomal metabolism of furosemide evidence for nature of reactive intermediate involved in covalent binding
    • Wirth PJ, Bettis CJ, Nelson WL. Microsomal metabolism of furosemide evidence for nature of reactive intermediate involved in covalent binding. Mol Pharmacol 1976;12:759-68
    • (1976) Mol Pharmacol , vol.12 , pp. 759-68
    • Wirth, P.J.1    Bettis, C.J.2    Nelson, W.L.3
  • 44
    • 0027949161 scopus 로고
    • Hepatotoxicity of germander (Teucrium chamaedrys L.) and one of its constituent neoclerodane diterpenes teucrin A in the mouse
    • DOI 10.1021/tx00042a020
    • Kouzi SA, McMurtry RJ, Nelson SD. Hepatotoxicity of germander (Teucrium chamaedrys L.) and one of its constituent neoclerodane diterpenes teucrin A in the mouse. Chem Res Toxicol 1994;7:850-6 (Pubitemid 24370245)
    • (1994) Chemical Research in Toxicology , vol.7 , Issue.6 , pp. 850-856
    • Kouzi, S.A.1    McMurtry, R.J.2    Nelson, S.D.3
  • 46
    • 0033860137 scopus 로고    scopus 로고
    • Human microsomal epoxide hydrolase is the target of germander-induced autoantibodies on the surface of human hepatocytes
    • De Berardinis V, Moulis C, Maurice M, et al. Human microsomal epoxide hydrolase is the target of germander-induced autoantibodies on the surface of human hepatocytes. Mol Pharmacol 2000;58:542-51
    • (2000) Mol Pharmacol , vol.58 , pp. 542-51
    • De Berardinis, V.1    Moulis, C.2    Maurice, M.3
  • 47
    • 0029994146 scopus 로고    scopus 로고
    • Hepatotoxicity of the herbal medicine germander: Metabolic activation of its furano diterpenoids by cytochrome P450 3A depletes cytoskeleton- associated protein thiols and forms plasma membrane blebs in rat hepatocytes
    • DOI 10.1053/jhep.1996.v24.pm0008707265
    • Lekehal M, Pessayre D, Lereau JM, et al. Hepatotoxicity of the herbal medicine germander: Metabolic activation of its furano diterpenoids by cytochrome P450 3A depletes cytoskeleton-associated protein thiols and forms plasma membrane blebs in rat hepatocytes. Hepatology 1996;24:212-18 (Pubitemid 26249436)
    • (1996) Hepatology , vol.24 , Issue.1 , pp. 212-218
    • Lekehal, M.1    Pessayre, D.2    Lereau, J.M.3    Moulis, C.4    Fouraste, I.5    Fau, D.6
  • 48
    • 33750216760 scopus 로고    scopus 로고
    • Characterization of the amino acid adducts of the enedial derivative of teucrin A
    • DOI 10.1021/tx060143k
    • Druckova A, Marnett LJ. Characterization of the amino acid adducts of the enedial derivative of teucrin A. Chem Res Toxicol 2006;19:1330-40 (Pubitemid 44607319)
    • (2006) Chemical Research in Toxicology , vol.19 , Issue.10 , pp. 1330-1340
    • Druckova, A.1    Marnett, L.J.2
  • 50
    • 22944469767 scopus 로고    scopus 로고
    • Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes
    • DOI 10.1124/dmd.104.003475
    • Lim HK, Duczak N Jr, Brougham L, et al. Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes. Drug Metab Dispos 2005;33:1211-19 (Pubitemid 41043765)
    • (2005) Drug Metabolism and Disposition , vol.33 , Issue.8 , pp. 1211-1219
    • Lim, H.-K.1    Duczak Jr., N.2    Brougham, L.3    Elliot, M.4    Patel, K.5    Chan, K.6
  • 51
    • 18844433876 scopus 로고    scopus 로고
    • The naturally occurring cytochrome P450 (P450) 2B6 K262R mutant of P450 2B6 exhibits alterations in substrate metabolism and inactivation
    • DOI 10.1124/dmd.105.003749
    • Bumpus NN, Sridar C, Kent UM, et al. The naturally occurring cytochrome P450 (P450) 2B6 K262R mutant of P4502B6 exhibits alterations in substrate metabolism and inactivation. Drug Metab Dispos 2005;33:795-802 (Pubitemid 40686633)
    • (2005) Drug Metabolism and Disposition , vol.33 , Issue.6 , pp. 795-802
    • Bumpus, N.N.1    Sridar, C.2    Kent, U.M.3    Hollenberg, P.F.4
  • 52
    • 15744405556 scopus 로고    scopus 로고
    • The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: Evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5
    • DOI 10.1124/jpet.104.079608
    • Lin HL, Kent UM, Hollenberg PF. The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5. J Pharmacol Exp Ther 2005;313:154-64 (Pubitemid 40411339)
    • (2005) Journal of Pharmacology and Experimental Therapeutics , vol.313 , Issue.1 , pp. 154-164
    • Lin, H.-L.1    Kent, U.M.2    Hollenberg, P.F.3
  • 55
    • 0032558386 scopus 로고    scopus 로고
    • Mechanism-based inactivation of cytochrome P450 2B1 by 8- methoxypsoralen and several other furanocoumarins
    • DOI 10.1021/bi981198r
    • Koenigs LL, Trager WF. Mechanism-based inactivation of cytochrome P450 2B1 by 8-Methoxypsoralen and several other furanocoumarins. Biochemistry 1998;37:13184-93 (Pubitemid 28449562)
    • (1998) Biochemistry , vol.37 , Issue.38 , pp. 13184-13193
    • Koenigs, L.L.1    Trager, W.F.2
  • 56
    • 0032516469 scopus 로고    scopus 로고
    • Mechanism-based inactivation of P450 2A6 by furanocoumarins
    • DOI 10.1021/bi980003c
    • Koenigs LL, Trager WF. Mechanism-based inactivation of P450 2A6 by Furanocoumarins. Biochemistry 1998;37:10047-61 (Pubitemid 28366359)
    • (1998) Biochemistry , vol.37 , Issue.28 , pp. 10047-10061
    • Koenigs, L.L.1    Trager, W.F.2
  • 57
    • 24144432308 scopus 로고    scopus 로고
    • Mechanism-based inactivation of human liver microsomal CYP3A4 by rutaecarpine and limonin from Evodia fruit extract
    • Iwata H, Tezuka Y, Kadota S, et al. Mechanism-based inactivation of human liver microsomal CYP3A4 by rutaecarpine and limonin from Evodia fruit extract. Drug Metab Pharmacokinet 2005;20:34-45
    • (2005) Drug Metab Pharmacokinet , vol.20 , pp. 34-45
    • Iwata, H.1    Tezuka, Y.2    Kadota, S.3
  • 58
    • 0032960136 scopus 로고    scopus 로고
    • Metabolism of (R)-(+)-pulegone and (R)-(+)-menthofuran by human liver cytochrome P-450s: Evidence for formation of a furan epoxide
    • Khojasteh-Bakht SC, Chen W, Koenigs LL, et al. Metabolism of (R)-(+)-pulegone and (R)-(+)- menthofuran by human liver cytochrome P450s: evidence for formation of a furan epoxide. Drug Metab Dispos 1999;27:574-80 (Pubitemid 29214468)
    • (1999) Drug Metabolism and Disposition , vol.27 , Issue.5 , pp. 574-580
    • Khojasteh-Bakht, S.C.1    Chen, W.2    Koenigs, L.L.3    Peter, R.M.4    Nelson, S.D.5
  • 59
    • 0026510560 scopus 로고
    • Reactive intermediates in the oxidation of menthofuran by cytochromes P450
    • Thomassen D, Knebel N, Slattery JT, et al. Reactive intermediates in the oxidation of menthofuran by cytochromes P450. Chem Res Toxicol 1992;5:123-30
    • (1992) Chem Res Toxicol , vol.5 , pp. 123-30
    • Thomassen, D.1    Knebel, N.2    Slattery, J.T.3
  • 60
    • 0018828516 scopus 로고
    • Determination of a urinary epoxide metabolite of alclofenac in man
    • Slack JA, Fordhutchinson AW. Determination of a urinary epoxide metabolite of alclofenac in man. Drug Metab Dispos 1980;8:84-6 (Pubitemid 10122802)
    • (1980) Drug Metabolism and Disposition , vol.8 , Issue.2 , pp. 84-86
    • Slack, J.A.1    Ford-Hutchinson, A.W.2
  • 61
    • 0019519508 scopus 로고
    • Some biochemical and pharmacological properties of an epoxide metabolite of alclofenac
    • DOI 10.1016/0009-2797(81)90094-6
    • Slack JA, Fordhutchinson AW, Richold M, et al. Some biochemical and pharmacological properties of an epoxide metabolite of alclofenac. Chem Biol Interact 1981;34:95-107 (Pubitemid 11138539)
    • (1981) Chemico-Biological Interactions , vol.34 , Issue.1 , pp. 95-107
    • Slack, J.A.1    Ford-Hutchinson, A.W.2    Richold, M.3    Choi, B.C.K.4
  • 63
    • 0021054404 scopus 로고
    • Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1'-sulfooxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1'-hydroxysafrole in mouse liver
    • Boberg EW, Miller EC, Miller JA, et al. Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1′-sulfooxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1′- hydroxysafrole in mouce liver. Cancer Res 1983;43:5163-73 (Pubitemid 14227494)
    • (1983) Cancer Research , vol.43 , Issue.11 , pp. 5163-5173
    • Boberg, E.W.1    Miller, E.C.2    Miller, J.A.3
  • 65
    • 0031410088 scopus 로고    scopus 로고
    • Cytochrome P450 mediated bioactivation of methyleugenol to 1'-hydroxymethyleugenol in Fischer 344 rat and human liver microsomes
    • DOI 10.1093/carcin/18.9.1775
    • Gardner I, Wakazono H, Bergin P, et al. Cytochrome P450 mediated bioactivation of methylglyoxal to 1′-hydroxymethyleugenol in Fischer 344 rat and human liver microsomes. Carcinogenesis 1997;18:1775-83 (Pubitemid 28134685)
    • (1997) Carcinogenesis , vol.18 , Issue.9 , pp. 1775-1783
    • Gardner, I.1    Wakazono, H.2    Bergin, P.3    De Waziers, I.4    Beaune, P.5    Kenna, J.G.6    Caldwell, J.7
  • 66
    • 0025872079 scopus 로고
    • Inhibition of cytochrome P450 2E1 by diallyl sulfide and its metabolites
    • Brady JF, Ishizaki H, Fukuto JM, et al. Inhibition of Cytochrome P450 2E1 by Diallyl Sulfide and its metabolites. Chem Res Toxicol 1991;4:642-7
    • (1991) Chem Res Toxicol , vol.4 , pp. 642-7
    • Brady, J.F.1    Ishizaki, H.2    Fukuto, J.M.3
  • 67
    • 0030992920 scopus 로고    scopus 로고
    • Metabolism of the chemoprotective agent diallyl sulfide to glutathione conjugates in rats
    • DOI 10.1021/tx9601768
    • Jin L, Baillie TA. Metabolism of the chemoprotective agent diallyl sulfide to glutathione conjugates in rats. Chem Res Toxicol 1997;10:318-27 (Pubitemid 27137143)
    • (1997) Chemical Research in Toxicology , vol.10 , Issue.3 , pp. 318-327
    • Jin, L.1    Baillie, T.A.2
  • 70
    • 17744394481 scopus 로고    scopus 로고
    • Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission
    • DOI 10.1021/tx000180q
    • Kassahun K, Pearson PG, Tang W, et al. Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission. Chem Res Toxicol 2001;14:62-70 (Pubitemid 32064376)
    • (2001) Chemical Research in Toxicology , vol.14 , Issue.1 , pp. 62-70
    • Kassahun, K.1    Pearson, P.G.2    Tang, W.3    McIntosh, I.4    Leung, K.5    Elmore, C.6    Dean, D.7    Wang, R.8    Doss, G.9    Baillie, T.A.10
  • 71
    • 0032881830 scopus 로고    scopus 로고
    • Metabolism of trimethoprim to a reactive iminoquinone methide by activated human neutrophils and hepatic microsomes
    • Lai WG, Zahid N, Uetrecht JP. Metabolism of trimethoprim to a reactive iminoquinone methide by activated human neutrophils and hepatic microsomes. J Pharmacol Exp Ther 1999;291:292-9 (Pubitemid 29451602)
    • (1999) Journal of Pharmacology and Experimental Therapeutics , vol.291 , Issue.1 , pp. 292-299
    • Lai, W.G.1    Zahid, N.2    Uetrecht, J.P.3
  • 73
    • 67650002130 scopus 로고    scopus 로고
    • Identification of quinone methide metabolites of dauricine in human liver microsomes and in rat bile
    • Wang Y, Zhong D, Chen X, et al. Identification of quinone methide metabolites of dauricine in human liver microsomes and in rat bile. Chem Res Toxicol 2009;22:824-34
    • (2009) Chem Res Toxicol , vol.22 , pp. 824-34
    • Wang, Y.1    Zhong, D.2    Chen, X.3
  • 74
    • 77249154241 scopus 로고    scopus 로고
    • Pulmonary toxicity and metabolic activation of dauricine in CD-1 Mice
    • Jin H, Dai J, Chen X, et al. Pulmonary toxicity and metabolic activation of dauricine in CD-1 Mice. J Pharmacol Exp Ther 2010;332:738-46
    • (2010) J Pharmacol Exp Ther , vol.332 , pp. 738-46
    • Jin, H.1    Dai, J.2    Chen, X.3
  • 75
    • 0036158062 scopus 로고    scopus 로고
    • The possible implication of trans-Resveratrol in the cardioprotective effects of long-term moderate wine consumption
    • DOI 10.1124/mol.61.2.294
    • Orallo F, Alvarez E, Camina M, et al. The possible implication of trans-resveratrol in the cardioprotective effects of Long-Term moderate wine consumption. Mol Pharmacol 2002;61:294-302 (Pubitemid 34112803)
    • (2002) Molecular Pharmacology , vol.61 , Issue.2 , pp. 294-302
    • Orallo, F.1    Alvarez, E.2    Camina, M.3    Leiro, J.M.4    Gomez, E.5    Fernandez, P.6
  • 76
    • 0034909129 scopus 로고    scopus 로고
    • A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol
    • Gusman J, Malonne H, Atassi G. A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol. Carcinogenesis 2001;22:1111-17 (Pubitemid 32737324)
    • (2001) Carcinogenesis , vol.22 , Issue.8 , pp. 1111-1117
    • Gusman, J.1    Malonne, H.2    Atassi, G.3
  • 77
    • 0000023835 scopus 로고    scopus 로고
    • Mechanism-based inactivation of human cytochrome P450 3A4 by grapefruit juice and red wine
    • Chan WK, Nguyen LT, Miller VP, et al. Mechanism-based inactivation of human cytochrome P450 3A4 by grapefruit juice and red wine. Life Sci 1998;62:135-42
    • (1998) Life Sci , vol.62 , pp. 135-42
    • Chan, W.K.1    Nguyen, L.T.2    Miller, V.P.3
  • 78
    • 0034634252 scopus 로고    scopus 로고
    • Resveratrol, a red wine constituent, is a mechanism-based inactivator of cytochrome P450 3A4
    • Chan WK, Delucchi AB. Resveratrol, a red wine constituent, is a mechanism-based inactivator of cytochrome P450 3A4. Life Sci 2000;67:3103-12
    • (2000) Life Sci , vol.67 , pp. 3103-12
    • Chan, W.K.1    Delucchi, A.B.2
  • 79
    • 0035064593 scopus 로고    scopus 로고
    • Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigenin
    • Chun YJ, Ryu SY, Jeong TC, et al. Mechanism-based inhibition of human cytochrome P450 1A1 by Rhapontigenin. Drug Metab Dispos 2001;29:389-93 (Pubitemid 32275551)
    • (2001) Drug Metabolism and Disposition , vol.29 , Issue.4 , pp. 389-393
    • Chun, Y.J.1    Ryu, S.Y.2    Jeong, T.C.3    Kim, M.Y.4
  • 80
    • 0030775534 scopus 로고    scopus 로고
    • Absorption, metabolism and health effects of dietary flavonoids in man
    • DOI 10.1016/S0753-3322(97)88045-6
    • Hollman PCH, Katan MB. Absorption, metabolism and health effects of dietary flavonoids in man. Biomed Pharmacother 1997;51:305-10 (Pubitemid 27423753)
    • (1997) Biomedicine and Pharmacotherapy , vol.51 , Issue.8 , pp. 305-310
    • Hollman, P.C.H.1    Katan, M.B.2
  • 81
    • 78049420487 scopus 로고    scopus 로고
    • Reversible inhibition of three important human liver cytochrome P450 enzymes by tiliroside
    • Sun DX, Lu CJ, Fang ZZ, et al. Reversible inhibition of three important human liver cytochrome P450 enzymes by tiliroside. Phytother Res 2010;24:1670-5
    • (2010) Phytother Res , vol.24 , pp. 1670-5
    • Sun, D.X.1    Lu, C.J.2    Fang, Z.Z.3
  • 82
    • 0025874589 scopus 로고
    • Study on the mutagenic activity of 13 bioflavonoids with the Salmonella Ara test
    • Jurado J, Alejandre-Duran E, Alonso-Moraga A, et al. Study on the mutagenic activity of 13 bioflavonoids with the Salmonella Ara test. Mutagenesis 1991;6:289-95
    • (1991) Mutagenesis , vol.6 , pp. 289-95
    • Jurado, J.1    Alejandre-Duran, E.2    Alonso-Moraga, A.3
  • 84
    • 34548812546 scopus 로고    scopus 로고
    • A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties
    • DOI 10.1016/j.fct.2007.05.015, PII S0278691507001780
    • Harwood M, Danielewska-Nikiel B, Borzelleca JF, et al. A critical review of the data related to the safety of quercetin and lack of evidence of genotoxic/carcinogenic properties. Food Chem Toxicol 2007;45:2179-205 (Pubitemid 47451573)
    • (2007) Food and Chemical Toxicology , vol.45 , Issue.11 , pp. 2179-2205
    • Harwood, M.1    Danielewska-Nikiel, B.2    Borzelleca, J.F.3    Flamm, G.W.4    Williams, G.M.5    Lines, T.C.6
  • 85
    • 0036259952 scopus 로고    scopus 로고
    • The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9
    • DOI 10.1124/dmd.30.6.709
    • Kent UM, Aviram M, Rosenblat M, et al. The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450s 3A4, 2B6 and 2C9. Drug Metab Dispos 2002;30:709-15 (Pubitemid 34579106)
    • (2002) Drug Metabolism and Disposition , vol.30 , Issue.6 , pp. 709-715
    • Kent, U.M.1    Aviram, M.2    Rosenblat, M.3    Hollenberg, P.F.4
  • 86
    • 2442649042 scopus 로고    scopus 로고
    • Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases
    • DOI 10.1124/dmd.32.6.587
    • Sridar C, Goosen TC, Kent UM, et al. Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases. Drug Metab Dispos 2004;32:587-94 (Pubitemid 38668150)
    • (2004) Drug Metabolism and Disposition , vol.32 , Issue.6 , pp. 587-594
    • Sridar, C.1    Goosen, T.C.2    Kent, U.M.3    Williams, J.A.4    Hollenberg, P.F.5
  • 87
    • 0029926719 scopus 로고    scopus 로고
    • Bioactivation of carbamazepine in the rat in vivo: Evidence for the formation of reactive arene oxide(s)
    • Madden S, Maggs JL, Park BK. Bioactivation of carbamazepine in the rat in vivo-evidence for the formation of reactive arene oxides. Drug Metab Dispos 1996;24:469-79 (Pubitemid 26119942)
    • (1996) Drug Metabolism and Disposition , vol.24 , Issue.4 , pp. 469-479
    • Madden, S.1    Maggs, J.L.2    Park, B.K.3
  • 88
    • 0033058630 scopus 로고    scopus 로고
    • Biotransformation of coumarin by rodent and human cytochromes P-450: Metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice
    • Zhuo XL, Gu J, Zhang QY, et al. Biotransformation of coumarin by rodent and human cytochromes P450: metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice. J Pharmacol Exp Ther 1999;288:463-71 (Pubitemid 29119652)
    • (1999) Journal of Pharmacology and Experimental Therapeutics , vol.288 , Issue.2 , pp. 463-471
    • Zhuo, X.1    Gu, J.2    Zhang, Q.-Y.3    Spink, D.C.4    Kaminsky, L.S.5    Ding, X.6
  • 89
    • 0036236050 scopus 로고    scopus 로고
    • Identification of the cytochromes P450 that catalyze coumarin 3,4-epoxidation and 3-hydroxylation
    • DOI 10.1124/dmd.30.5.483
    • Born SL, Caudill D, Fliter KL, et al. Identification of the cytochromes P450 that catalyze coumarin 3,4-epoxidation and 3-hydroxylation. Drug Metab Dispos 2002;30:483-7 (Pubitemid 34456966)
    • (2002) Drug Metabolism and Disposition , vol.30 , Issue.5 , pp. 483-487
    • Born, S.L.1    Caudill, D.2    Fliter, K.L.3    Purdon, M.P.4
  • 91
    • 33644867949 scopus 로고    scopus 로고
    • A safety assessment of coumarin taking into account species-specificity of toxicokinetics
    • DOI 10.1016/j.fct.2005.08.019, PII S0278691505002620
    • Felter SP, Vassallo JD, Carlton BD, et al. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75 (Pubitemid 43375122)
    • (2006) Food and Chemical Toxicology , vol.44 , Issue.4 , pp. 462-475
    • Felter, S.P.1    Vassallo, J.D.2    Carlton, B.D.3    Daston, G.P.4
  • 92
    • 0032767738 scopus 로고    scopus 로고
    • Coumarin metabolism, toxicity and carcinogenicity: Relevance for human risk assessment
    • DOI 10.1016/S0278-6915(99)00010-1, PII S0278691599000101
    • Lake BG. Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment. Food Chem Toxicol 1999;37:423-53 (Pubitemid 29335767)
    • (1999) Food and Chemical Toxicology , vol.37 , Issue.4 , pp. 423-453
    • Lake, B.G.1
  • 93
    • 68849100390 scopus 로고    scopus 로고
    • Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts
    • Zhuo XL, Zhao WP, Zheng JN, et al. Bioactivation of coumarin in rat olfactory mucosal microsomes: detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts. Chem Biol Interact 2009;181:227-35
    • (2009) Chem Biol Interact , vol.181 , pp. 227-35
    • Zhuo, X.L.1    Zhao, W.P.2    Zheng, J.N.3
  • 94
    • 0031844523 scopus 로고    scopus 로고
    • Oxidation of a metabolite of indomethacin (desmethyldeschlorobenzoylindomethacin) to reactive intermediates by activated neutrophils, hypochlorous acid, and the myeloperoxidase system
    • Ju C, Uetrecht JP. Oxidation of a metabolite of indomethacin to reactive intermediates by activated neutrophils, hypochlorous acid, and the myeloperoxidase system. Drug Metab Dispos 1998;26:676-80 (Pubitemid 28345851)
    • (1998) Drug Metabolism and Disposition , vol.26 , Issue.7 , pp. 676-680
    • Ju, C.1    Uetrecht, J.P.2
  • 95
    • 0028798219 scopus 로고
    • Medicinal plants in Europe containing pyrrolizidine alkaloids
    • Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98
    • (1995) Pharmazie , vol.50 , pp. 83-98
    • Roeder, E.1
  • 96
    • 0033788020 scopus 로고    scopus 로고
    • Medicinal plants in China containing pyrrolizidine alkaloids
    • Roeder E. Medicinal plants in China containing pyrrolizidine alkaloids. Pharmazie 2000;55:711-26
    • (2000) Pharmazie , vol.55 , pp. 711-26
    • Roeder, E.1
  • 98
    • 0032921958 scopus 로고    scopus 로고
    • Hepatotoxicity associated with pyrrolizidine alkaloid (Crotalaria spp) ingestion in a horse on Easter Island
    • Arzt J, Mount ME. Hepatotoxicity associated with pyrrolizidine alkaloid (Crotalaria spp) ingestion in a house on Easter Island. Vet Hum Toxicol 1999;41:96-9 (Pubitemid 29156117)
    • (1999) Veterinary and Human Toxicology , vol.41 , Issue.2 , pp. 96-99
    • Arzt, J.1    Mount, M.E.2
  • 99
    • 0028234389 scopus 로고
    • Hepatotoxic pyrrolizidine alkaloids in the Mexican medicinal plant Packera candidissima (Asteraceae: Senecioneae)
    • DOI 10.1016/0378-8741(94)90112-0
    • Bah M, Bye R, Pereda-Miranda R. Hepatotoxic pyrrolizidine alkaloids in the Mexican medicinal plant Packera candidissima (Asteraceae: Senecioneae). J Ethnopharmacol 1994;43:19-30 (Pubitemid 24186506)
    • (1994) Journal of Ethnopharmacology , vol.43 , Issue.1 , pp. 19-30
    • Bah, M.1    Bye, R.2    Pereda-Miranda, R.3
  • 100
    • 1642323484 scopus 로고    scopus 로고
    • Pyrrolizidine Alkaloids - Genotoxicity, Metabolism Enzymes, Metabolic Activation, and Mechanisms
    • DOI 10.1081/DMR-120028426
    • Fu PP, Xia Q, Lin G, et al. Pyrrolizidine alkaloids-genotoxicity, metabolism enzymes, metabolic activation, and mechanisms. Drug Metab Rev 2004;36:1-55 (Pubitemid 38387834)
    • (2004) Drug Metabolism Reviews , vol.36 , Issue.1 , pp. 1-55
    • Fu, P.P.1    Xia, Q.2    Lin, G.3    Chou, M.W.4
  • 101
    • 2442667779 scopus 로고    scopus 로고
    • Workshop overview: Hepatotoxicity assessment for botanical dietary supplements
    • DOI 10.1093/toxsci/kfh075
    • Willett KL, Roth RA, Walker L. Workshop overview: hepatotoxicity assessment for botanical dietary supplements. Toxicol Sci 2004;79:4-9 (Pubitemid 38660241)
    • (2004) Toxicological Sciences , vol.79 , Issue.1 , pp. 4-9
    • Willett, K.L.1    Roth, R.A.2    Walker, L.3
  • 103
    • 42749087687 scopus 로고    scopus 로고
    • Basil extract inhibits the sulfotransferase mediated formation of DNA adducts of the procarcinogen 1′-hydroxyestragole by rat and human liver S9 homogenates and in HepG2 human hepatoma cells
    • Jeurissen SMF, Punt A, Delatour T, et al. Basil extract inhibits the sulfotransferase mediated formation of DNA adducts of the procarcinogen 1′-hydroxyestragole by rat and human liver S9 homogenates and in HepG2 human hepatoma cells. Food Chem Toxicol 2008;46:2296-302
    • (2008) Food Chem Toxicol , vol.46 , pp. 2296-302
    • Smf, J.1    Punt, A.2    Delatour, T.3
  • 104
    • 77952892062 scopus 로고    scopus 로고
    • Identification of nevadensin as an important herb-based constituent inhibiting estragole bioactivation and physiology-based biokinetic modeling of its possible in vivo effect
    • Alhusainy W, Paini A, Punt A, et al. Identification of nevadensin as an important herb-based constituent inhibiting estragole bioactivation and physiology-based biokinetic modeling of its possible in vivo effect. Toxicol Appl Pharmacol 2010;245:179-90
    • (2010) Toxicol Appl Pharmacol , vol.245 , pp. 179-90
    • Alhusainy, W.1    Paini, A.2    Punt, A.3
  • 105
    • 79960524334 scopus 로고    scopus 로고
    • Deoxyschizandrin could attenuate cytochrome P450 3A4-mediated bioactivation of gomisin A in human liver microsomes
    • Zhang YY, Yang L. Deoxyschizandrin could attenuate cytochrome P450 3A4-mediated bioactivation of gomisin A in human liver microsomes. Drug Metab Rev 2010;42:140-1
    • (2010) Drug Metab Rev , vol.42 , pp. 140-1
    • Zhang, Y.Y.1    Yang, L.2
  • 106
    • 0026529577 scopus 로고
    • Guinea pig and rat hepatic microsomal metabolism of monocrotaline
    • Dueker SR, Lame MW, Morin D, et al. Guinea pig and rat hepatic microsomal metabolism of monocrotaline. Drug Metab Dispos 1992;20:275-80
    • (1992) Drug Metab Dispos , vol.20 , pp. 275-80
    • Dueker, S.R.1    Lame, M.W.2    Morin, D.3
  • 109
    • 0035819912 scopus 로고    scopus 로고
    • Investigation of the role of the 2′,3′-epoxidation pathway in the bioactivation and genotoxicity of dietary allylbenzene analogs
    • DOI 10.1016/S0300-483X(00)00456-X, PII S0300483X0000456X
    • Guenthner TM, Luo G. Investigation of the role of the 2′,3′-epoxidation pathway in the bioactivation and genotoxicity of dietary allylbenzene analogs. Toxicology 2001;160:47-58 (Pubitemid 32200463)
    • (2001) Toxicology , vol.160 , Issue.1-3 , pp. 47-58
    • Guenthner, T.M.1    Luo, G.2
  • 111
    • 67650727414 scopus 로고    scopus 로고
    • Use of physiologically based biokinetic (PBBK) modeling to study estragole bioactivation and detoxification in humans as compared with male rats
    • Punt A, Paini A, Boersma MG, et al. Use of physiologically based biokinetic (PBBK) modeling to study estragole bioactivation and detoxification in humans as compared with male rats. Toxicol Sci 2009;110:255-69
    • (2009) Toxicol Sci , vol.110 , pp. 255-69
    • Punt, A.1    Paini, A.2    Boersma, M.G.3
  • 112
    • 30644456411 scopus 로고    scopus 로고
    • Dietary flavonoids: Effects on xenobiotic and carcinogen metabolism
    • DOI 10.1016/j.tiv.2005.06.048, PII S0887233305002080
    • Moon YJ, Wang X, Morris ME. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol Vitro 2006;20:187-210 (Pubitemid 43087702)
    • (2006) Toxicology in Vitro , vol.20 , Issue.2 , pp. 187-210
    • Moon, Y.J.1    Wang, X.2    Morris, M.E.3
  • 113
    • 0030899064 scopus 로고    scopus 로고
    • Effect of Glycyrrhiza glabra roots and glycyrrhizin on the glucuronidation in rats
    • Kim SK, Moon A. Effect of Glycyrrhiza glabra roots and glycyrrhizin on the glucuronidation in rats. Planta Med 1997;63:115-19 (Pubitemid 27196076)
    • (1997) Planta Medica , vol.63 , Issue.2 , pp. 115-119
    • Moon, A.1    Kim, S.H.2
  • 114
    • 70649087106 scopus 로고    scopus 로고
    • Drug-induced liver injury: Insights from genetic studies
    • Andrade RJ, Robles M, Ulzurrun E, et al. Drug-induced liver injury: insights from genetic studies. Pharmacogenomics 2009;10:1467-87
    • (2009) Pharmacogenomics , vol.10 , pp. 1467-87
    • Andrade, R.J.1    Robles, M.2    Ulzurrun, E.3
  • 115
    • 1942421701 scopus 로고    scopus 로고
    • Pharmacogenetics of cytochrome P450 and its applications in drug therapy: The past, present and future
    • DOI 10.1016/j.tips.2004.02.007, PII S0165614704000550
    • Ingelman-Sundberg M. Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future. Trends Pharmacol Sci 2004;25:193-200 (Pubitemid 38519910)
    • (2004) Trends in Pharmacological Sciences , vol.25 , Issue.4 , pp. 193-200
    • Ingelman-Sundberg, M.1
  • 116
    • 0032731634 scopus 로고    scopus 로고
    • Gender-related differences in pharmacokinetics and their clinical significance
    • DOI 10.1046/j.1365-2710.1999.00246.x
    • Tanaka E. Gender-related differences in pharmacokinetics and their clinical significance. J Clin Pharm Ther 1999;24:339-46 (Pubitemid 29520783)
    • (1999) Journal of Clinical Pharmacy and Therapeutics , vol.24 , Issue.5 , pp. 339-346
    • Tanaka, E.1
  • 117
    • 57049161412 scopus 로고    scopus 로고
    • Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction
    • Verbeeck RK. Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction. Eur J Clin Pharmacol 2008;64:1147-61
    • (2008) Eur J Clin Pharmacol , vol.64 , pp. 1147-61
    • Verbeeck, R.K.1
  • 118
    • 75249103572 scopus 로고    scopus 로고
    • Evaluation of human interindividual variation in bioactivation of estragole using physiologically based biokinetic modeling
    • Punt A, Jeurissen SM, Boersma MG, et al. Evaluation of human interindividual variation in bioactivation of estragole using physiologically based biokinetic modeling. Toxicol Sci 2010;113:337-48
    • (2010) Toxicol Sci , vol.113 , pp. 337-48
    • Punt, A.1    Jeurissen, S.M.2    Boersma, M.G.3
  • 119
    • 76749144742 scopus 로고    scopus 로고
    • In silico methods for physiologically based biokinetic models describing bioactivation and detoxification of coumarin and estragole: Implications for risk assessment
    • Rietjens IMCM, Punt A, Schilter B, et al. In silico methods for physiologically based biokinetic models describing bioactivation and detoxification of coumarin and estragole: implications for risk assessment. Mol Nutr Food Res 2010;54:195-207
    • (2010) Mol Nutr Food Res , vol.54 , pp. 195-207
    • Imcm, R.1    Punt, A.2    Schilter, B.3
  • 120
    • 0034007388 scopus 로고    scopus 로고
    • Phenotyping of drug-metabolizing enzymes in adults: A review of in-vivo cytochrome P450 phenotyping probes
    • Streetman DS, Bertino JS Jr, Nafziger AN. Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes. Pharmacogenetics 2000;10:187-216 (Pubitemid 30242736)
    • (2000) Pharmacogenetics , vol.10 , Issue.3 , pp. 187-216
    • Streetman, D.S.1    Bertino Jr., J.S.2    Nafziger, A.N.3
  • 121
    • 33845473315 scopus 로고    scopus 로고
    • Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction
    • DOI 10.1517/17425255.2.6.875
    • Martignoni M, Groothuis GMM, de Kanter R. Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert Opin Drug Metab Toxicol 2006;2:875-94 (Pubitemid 44911538)
    • (2006) Expert Opinion on Drug Metabolism and Toxicology , vol.2 , Issue.6 , pp. 875-894
    • Martignoni, M.1    Groothuis, G.M.M.2    De Kanter, R.3
  • 122
    • 79952843362 scopus 로고    scopus 로고
    • Comparative metabolism of cinobufagin in liver microsomes from mouse, rat, dog, minipig, monkey and human
    • published online 4 January 2011, doi: 10.1124/dmd.110.036830
    • Ma XC, Ning J, Ge GB, et al. Comparative metabolism of cinobufagin in liver microsomes from mouse, rat, dog, minipig, monkey and human. Drug Metab Dispos 2011;published online 4 January 2011, doi: 10.1124/dmd.110.036830
    • (2011) Drug Metab Dispos
    • Ma, X.C.1    Ning, J.2    Ge, G.B.3
  • 123
    • 77957018120 scopus 로고    scopus 로고
    • Determination of propofol UDP-glucurosyltrnasferase (UGT) activities in hepatic microsomes from different species by UFLC-ESI-MS
    • Liang SC, Ge GB, Liu HX, et al. Determination of propofol UDP-glucurosyltrnasferase (UGT) activities in hepatic microsomes from different species by UFLC-ESI-MS. J Pharm Biomed Anal 2011;54:236-41
    • (2011) J Pharm Biomed Anal , vol.54 , pp. 236-41
    • Liang, S.C.1    Ge, G.B.2    Liu, H.X.3
  • 124
    • 0034036571 scopus 로고    scopus 로고
    • Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms
    • Court MH, Greenblatt DJ. Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms. Pharmacogenetics 2000;10:355-69 (Pubitemid 30345183)
    • (2000) Pharmacogenetics , vol.10 , Issue.4 , pp. 355-369
    • Court, M.H.1    Greenblatt, D.J.2
  • 125
    • 0030855768 scopus 로고    scopus 로고
    • Cytosolic arylamine N-acetyltransferase (NAT) deficiency in the dog and other canids due to an absence of NAT genes
    • DOI 10.1016/S0006-2952(97)00140-8, PII S0006295297001408
    • Trepanier LA, Ray K, Winand NJ, et al. Cytosolic Arylamine N-acetyltransferase (NAT) deficiency in the dog and other canids due to an absence of NAT genes. Biochem Pharmacol 1997;54:73-80 (Pubitemid 27353223)
    • (1997) Biochemical Pharmacology , vol.54 , Issue.1 , pp. 73-80
    • Trepanier, L.A.1    Ray, K.2    Winand, N.J.3    Spielberg, S.P.4    Cribb, A.E.5
  • 126
    • 34547641946 scopus 로고    scopus 로고
    • 2-(trans-isoestragol- 3′-yl)-2′-deoxyguanosine as a strategy to study species differences in sulfotransferase conversion of the proximate carcinogen 1′- hydroxyestragole
    • DOI 10.1021/tx600298s
    • Punt A, Delatour T, Scholz G, et al. Tandem mass spectrometry analysis of N2-(trans-Isoestragole-3′-yl)-2′- deoxyguanosine as a strategy to study species differences in sulfotransferase conversion of the proximate carcinogen 1′-hydroxyestragole. Chem Res Toxicol 2007;20:991-8 (Pubitemid 47204812)
    • (2007) Chemical Research in Toxicology , vol.20 , Issue.7 , pp. 991-998
    • Punt, A.1    Delatour, T.2    Scholz, G.3    Schilter, B.4    Van Bladeren, P.J.5    Rietjens, I.M.C.M.6
  • 127
    • 0032444587 scopus 로고    scopus 로고
    • Species differences in the hepatic microsomal enzyme metabolism of the pyrrolizidine alkaloids
    • DOI 10.1016/S0378-4274(98)00152-0, PII S0378427498001520
    • Huan JY, Miranda CL, Buhler DR, et al. Species differences in the hepatic microsomal enzyme metabolism of the pyrrolizidine alkaloids. Toxicol Lett 1998;99:127-37 (Pubitemid 29027796)
    • (1998) Toxicology Letters , vol.99 , Issue.2 , pp. 127-137
    • Huan, J.-Y.1    Miranda, C.L.2    Buhler, D.R.3    Cheeke, P.R.4
  • 128
    • 77949362123 scopus 로고    scopus 로고
    • Glucuronidation, a new metabolic pathway for pyrrolizidine alkaloids
    • He YQ, Yang L, Liu HX, et al. Glucuronidation, a new metabolic pathway for pyrrolizidine alkaloids. Chem Res Toxicol 2010;23:591-9
    • (2010) Chem Res Toxicol , vol.23 , pp. 591-9
    • He, Y.Q.1    Yang, L.2    Liu, H.X.3
  • 129
    • 85033050877 scopus 로고    scopus 로고
    • Effects of coumarin following perinatal and chronic exposure in Sprague-Dawley rats and CD-1 mice
    • Carlton BD, Aubrun JC, Simon GS. Effects of coumarin following perinatal and chronic exposure in Sprague-Dawley rats and CD-1 mice. Fundam Appl Toxicol 1996;30:145-51
    • (1996) Fundam Appl Toxicol , vol.30 , pp. 145-51
    • Carlton, B.D.1    Aubrun, J.C.2    Simon, G.S.3
  • 130
    • 77954144994 scopus 로고    scopus 로고
    • Herbal interactions on absorption of drugs: Mechanisms of action and clinical risk assessment
    • Colalto C. Herbal interactions on absorption of drugs: mechanisms of action and clinical risk assessment. Pharmacol Res 2010;62:207-27
    • (2010) Pharmacol Res , vol.62 , pp. 207-27
    • Colalto, C.1
  • 131
    • 33947236216 scopus 로고    scopus 로고
    • Herbs for the nervous system: Ginkgo, kava, valerian, passionflower
    • Cass H. Herbs for the nervous system: ginkgo, kava, valerian, passionflower. Semin Integrat Med 2004;82-8
    • (2004) Semin Integrat Med , pp. 82-8
    • Cass, H.1
  • 132
    • 0034680792 scopus 로고    scopus 로고
    • Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine
    • Strassburg CP, Kneip S, Topp J, et al. Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine. J Biol Chem 2000;275:36164-71
    • (2000) J Biol Chem , vol.275 , pp. 36164-71
    • Strassburg, C.P.1    Kneip, S.2    Topp, J.3
  • 134
    • 11844301652 scopus 로고    scopus 로고
    • Effects of dietary chemopreventive phytochemicals on P-glycoprotein function
    • DOI 10.1016/j.bbrc.2004.12.081, PII S0006291X04028736
    • Nabekura T, Kamiyama S, Kitagawa S. Effects of dietary chemopreventive phytochemicals on P-glycoprotein function. Biochem Biophys Res Commun 2005;327:866-70 (Pubitemid 40092828)
    • (2005) Biochemical and Biophysical Research Communications , vol.327 , Issue.3 , pp. 866-870
    • Nabekura, T.1    Kamiyama, S.2    Kitagawa, S.3
  • 136
    • 49749143424 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals
    • Nabekura T, Yamaki T, Ueno K, et al. Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals. Cancer Chemother Pharmacol 2008;62:867-73
    • (2008) Cancer Chemother Pharmacol , vol.62 , pp. 867-73
    • Nabekura, T.1    Yamaki, T.2    Ueno, K.3
  • 138
    • 50849084986 scopus 로고    scopus 로고
    • The gastrointestinal microbiota as a site for the biotransformation of drugs
    • Sousa T, Paterson R, Moore V, et al. The gastrointestinal microbiota as a site for the biotransformation of drugs. Int J Pharm 2008;363:1-25
    • (2008) Int J Pharm , vol.363 , pp. 1-25
    • Sousa, T.1    Paterson, R.2    Moore, V.3
  • 139
    • 1942421701 scopus 로고    scopus 로고
    • Pharmacogenetics of cytochrome P450 and its applications in drug therapy: The past, present and future
    • DOI 10.1016/j.tips.2004.02.007, PII S0165614704000550
    • Ingelman-Sundberg M. Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present, and future. Trends Pharmacol Sci 2004;25:193-200 (Pubitemid 38519910)
    • (2004) Trends in Pharmacological Sciences , vol.25 , Issue.4 , pp. 193-200
    • Ingelman-Sundberg, M.1
  • 140
    • 72449137142 scopus 로고    scopus 로고
    • Small chemicals, bioactivation, and the immune system - A fragile balance of i-Tox and benefits?
    • Esser C, Jux B. Small chemicals, bioactivation, and the immune system-a fragile balance of i-Tox and benefits? Chem Biodivers 2009;6:2138-43
    • (2009) Chem Biodivers , vol.6 , pp. 2138-43
    • Esser, C.1    Jux, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.