Pyrrolizidine Alkaloids - Genotoxicity, Metabolism Enzymes, Metabolic Activation, and Mechanisms

Drug Metabolism Reviews

Volumn 36, Issue 1, 2004, Pages 1-55

  Fu, Peter P ^a,c   Xia, Qingsu ^a   Lin, Ge ^b   Chou, Ming W ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c HFT 110 ^*  (United States)

Author keywords

DNA adduct; Enzymes; Genotoxicity; Mechanism; Metabolic activation; Metabolism; Pyrrolizidine alkaloids

Indexed keywords

ALKALOID; ASPERUMINE; CLIVORINE; HELIOTRIDINE; HELIOTRINE; HYDROXYSENKIRKINE; INTERMEDINE; ISATIDINE; JACOBINE; LASIOCARPINE; LYCOPASAMINE; MONOCROTALINE; OTONECINE; PETASITENINE; PLANT EXTRACT; PLATYNECINE; PYRROLIZIDINE; PYRROLIZIDINE ALKALOID; RETRONECINE; RETRORSINE; RIDDELLINE; SENECIONINE; SENECIPHYLLINE; SENKIRKINE; SYMPHYTINE; TRACHELANTHATE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL MODEL; BLADDER TUMOR; BORAGINACEAE; BRAIN TUMOR; CARCINOGENICITY; CHEMICAL STRUCTURE; CHRONIC TOXICITY; CROSS LINKING; DETOXIFICATION; DNA ADDUCT; DNA PROTEIN COMPLEX; DOSE RESPONSE; ENZYME ACTIVITY; GENOTOXICITY; HEMANGIOENDOTHELIOSARCOMA; ISOTOPE LABELING; LEGUME; LIVER ADENOMA; LIVER CELL CARCINOMA; LUNG ADENOMA; METABOLITE; NONHUMAN; PANCREAS ISLET CELL TUMOR; PLANT; RAT; REVIEW; RHABDOMYOSARCOMA; SEX DIFFERENCE; SKIN CARCINOMA; SKIN TUMOR; SPECIES DIFFERENCE; SPINAL CORD TUMOR; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARCINOGENICITY TESTS; CLINICAL TRIALS; DNA ADDUCTS; FEMALE; HUMANS; LIVER; MALE; MUTAGENICITY TESTS; NEOPLASMS; PLANT POISONING; PYRROLIZIDINE ALKALOIDS; SEX FACTORS; SPECIES SPECIFICITY;

EID: 1642323484     PISSN: 03602532     EISSN: None     Source Type: Journal    
DOI: 10.1081/DMR-120028426     Document Type: Review

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