Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract

Drug Metabolism and Disposition

Volumn 32, Issue 12, 2004, Pages 1351-1358

  Iwata, Hiroshi ^a,b   Tezuka, Yasuhiro ^a   Kadota, Shigetoshi ^a   Hiratsuka, Akira ^c   Watabe, Tadashi ^d  

^a UNIVERSITY OF TOYAMA   (Japan)

^b MITSUBISHI CHEMICAL CORPORATION   (Japan)

^c TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^d NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BENZODIOXOLE DERIVATIVE; ANTITUSSIVE AGENT; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 3A4 INHIBITOR; ENZYME INHIBITOR; ERYTHROMYCIN; ETHOXYRESORUFIN; GOMISIN; KAMPO; KETOCONAZOLE; RESORUFIN; SCHISANDRA CHINENSIS EXTRACT; SCHIZANDRIN; SCHIZANDRIN GAMMA; TESTOSTERONE; TOLBUTAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CHINESE MEDICINE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEMETHYLATION; DIALYSIS; DOSE TIME EFFECT RELATION; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; ENZYME INACTIVATION; ENZYME INHIBITION; FRUIT; HUMAN; HUMAN CELL; HUMAN TISSUE; INHIBITION KINETICS; JAPAN; LIVER FUNCTION; PRIORITY JOURNAL; SCHISANDRACEAE; SEDATION; SPECTRAL SENSITIVITY;

ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOCTANES; CYTOCHROME P-450 ENZYME SYSTEM; DIOXOLES; ENZYME INHIBITORS; ERYTHROMYCIN; FEMALE; HUMANS; KETOCONAZOLE; LIGNANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MICRODIALYSIS; MICROSOMES, LIVER; OPTICAL ROTATION; PLANT EXTRACTS; POLYCYCLIC COMPOUNDS; SCHISANDRA; SOLVENTS;

SCHISANDRA; SCHISANDRA CHINENSIS; SCHISANDRACEAE;

EID: 9444257635     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.104.000646     Document Type: Article

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