Identification of nevadensin as an important herb-based constituent inhibiting estragole bioactivation and physiology-based biokinetic modeling of its possible in vivo effect

Toxicology and Applied Pharmacology

Volumn 245, Issue 2, 2010, Pages 179-190

  Alhusainy, W ^a,b,c,d   Paini, A ^a,d   Punt, A ^a   Louisse, J ^a   Spenkelink, A ^a   Vervoort, J ^a   Delatour, T ^d   Scholz, G ^d   Schilter, B ^d   Adams, T ^b   van Bladeren, P J ^a,d   Rietjens, I M C M ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b Flavor and Extract Manufacturers Association   (United States)

^c International Organization of Flavor Industries IOFI   (Switzerland)

^d NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

Basil; Estragole; Matrix; Nevadensin; PBBK; Sulfotransferase

Indexed keywords

1' HYDROXYESTRAGOLE; 1' SULFOOXYESTRAGOLE; CARCINOGEN; ESTRAGOLE; NEVADENSIN; SULFOTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER RISK; CONTROLLED STUDY; DETOXIFICATION; DNA ADDUCT; DRUG STRUCTURE; ENZYME INHIBITION; EXPOSURE; GLUCURONIDATION; HERB; HUMAN; HUMAN TISSUE; LIVER CELL; LIVER TUMOR; MALE; NONHUMAN; OXIDATION; RAT; TOXICITY; TOXICOKINETICS;

ACUTE TOXICITY TESTS; ANIMALS; ANISOLES; CARCINOGENS; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONES; GLUCURONIDES; HEPATOCYTES; HUMANS; MALE; MODELS, BIOLOGICAL; OCIMUM BASILICUM; OXIDATION-REDUCTION; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SULFOTRANSFERASES;

OCIMUM; OCIMUM BASILICUM; RATTUS; RODENTIA;

EID: 77952892062     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.02.017     Document Type: Article

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