The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9

Drug Metabolism and Disposition

Volumn 30, Issue 6, 2002, Pages 709-715

  Kent, Ute M ^a   Aviram, Michael ^b   Rosenblat, Mira ^b   Hollenberg, Paul F ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b RAMBAM MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIMETHYLGABRIDIN; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYTOCHROME P450 2B6; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; GLABRIDIN; HEME DERIVATIVE; HERBACEOUS AGENT; ISOFLAVAN DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; DOSE TIME EFFECT RELATION; DRUG METABOLISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INACTIVATION; ENZYME INHIBITION; FOOD DRUG INTERACTION; GLYCYRRHIZA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PLANT ROOT; PRIORITY JOURNAL; PROTEIN ANALYSIS; SPECTROSCOPY;

ARYL HYDROCARBON HYDROXYLASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME ACTIVATION; ENZYME INHIBITORS; GLYCYRRHIZA; HUMANS; MIXED FUNCTION OXYGENASES; OXIDOREDUCTASES, N-DEMETHYLATING; PHENOLS; PLANT EXTRACTS; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES;

GLYCYRRHIZA; LIGUSTICUM;

EID: 0036259952     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.6.709     Document Type: Article

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