Biotransformation of coumarin by rodent and human cytochromes P-450: Metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 288, Issue 2, 1999, Pages 463-471

  Zhuo, Xiaoliang ^a   Gu, Jun ^a   Zhang, Qing Yu ^a   Spink, David C ^a   Kaminsky, Laurence S ^a   Ding, Xinxin ^a,b  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COUMARIN; CYTOCHROME P450;

ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; DRUG METABOLISM; DRUG TRANSFORMATION; ENZYME ANALYSIS; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; OLFACTORY EPITHELIUM; OTOTOXICITY; PRIORITY JOURNAL; RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARINS; CYTOCHROME P-450 ENZYME SYSTEM; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; MALE; MICE; MICE, INBRED C57BL; MICROSOMES; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; OLFACTORY MUCOSA; PHARMACEUTIC AIDS; RATS; RATS, WISTAR; STEROID HYDROXYLASES;

EID: 0033058630     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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