Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission

Chemical Research in Toxicology

Volumn 14, Issue 1, 2001, Pages 62-70

  Kassahun, Kelem ^a   Pearson, Paul G ^a   Tang, Wei ^a   McIntosh, Ian ^a   Leung, Kwan ^a   Elmore, Charles ^a   Dean, Dennis ^a   Wang, Regina ^a   Doss, George ^a   Baillie, Thomas A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOCHROME P450 3A; CYTOCHROME P450 ISOENZYME; GLUTATHIONE; QUINONE DERIVATIVE; THIAZOLIDINE DERIVATIVE; TROGLITAZONE;

ANIMAL EXPERIMENT; ARTICLE; DRUG METABOLISM; DRUG OXIDATION; DRUG TRANSFORMATION; ENZYME INDUCTION; HUMAN; HUMAN CELL; LIVER MICROSOME; LIVER TOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATIVE STRESS; RAT;

ANIMALS; BILE; BIOTRANSFORMATION; CATALYSIS; CHROMANS; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; GLUTATHIONE; HUMANS; HYPOGLYCEMIC AGENTS; ISOENZYMES; KETOCONAZOLE; KINETICS; MASS SPECTROMETRY; MICROSOMES, LIVER; NADP; RATS; STEROID HYDROXYLASES; THIAZOLES; THIAZOLIDINEDIONES;

EID: 17744394481     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000180q     Document Type: Article

References (6)

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3. Neuschwander-Tetri, B. A., Isley, W. L., Oki, J. C., Ramrakhiani, S., Quiason, S. G., Phillips, N. J., and Brunt, E. M. (1998) Troglitazone-induced hepatic failure leading to liver transplantation. Ann. Intern. Med. 129, 36-38.
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5. European Patent EP 0 441 605 A2 (1991).
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