Identification of cytochrome P450 (CYP) isoforms involved in the metabolism of corynoline, and assessment of its herb-drug interactions

Phytotherapy Research

Volumn 25, Issue 2, 2011, Pages 256-263

  Fang, Zhong Ze ^a,b   Zhang, Yan Yan ^a   Ge, Guang Bo ^a   Liang, Si Cheng ^a   Sun, Dong Xue ^c   Zhu, Liang Liang ^a   Dong, Pei Pei ^a   Cao, Yun Feng ^c   Yang, Ling ^a  

^a DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

corynoline; cytochrome P450 (CYP); drug herb interaction; time dependent inhibition (TDI)

Indexed keywords

1 AMINOBENZOTRIAZOLE; CLOMETHIAZOLE; CORYNOLIN; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; CYTOCHROME P450 ISOENZYME; FURAFYLLINE; ISOQUINOLINE ALKALOID; METHOXSALEN; MONTELUKAST; OMEPRAZOLE; QUINIDINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SULFAPHENAZOLE; TESTOSTERONE; THIOTEPA; UNCLASSIFIED DRUG;

ARTICLE; DRUG METABOLISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME KINETICS; HERB DRUG INTERACTION; HUMAN; HUMAN TISSUE; IC 50; LIVER MICROSOME METABOLISM;

ARYL HYDROCARBON HYDROXYLASES; BERBERINE ALKALOIDS; CYTOCHROME P-450 CYP3A; ENZYME INHIBITORS; HERB-DRUG INTERACTIONS; HUMANS; MICROSOMES, LIVER; TIME FACTORS;

CORYDALIS;

EID: 79551670426     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3255     Document Type: Article

References (21)

1. Choi SU, Baek NI, Kim SH, et al. 2007. Cytotoxic isoquinoline alkaloids from the aerial parts of Corydalis incisa. Arch Pharm Res 30: 151-154.
2. Emoto C, Murase S, Sawada Y, Iwasaki K,. 2005. In vitro inhibitory effect of aminobenzotriazole on drug oxidations in human liver microsomes: a comparison with SKF-525A. Drug Metab Pharmacokinet 20: 351-357.
3. Fang ZZ, Zhang YY, Ge GB, Huo H, Liang SC, Yang L,. 2010. Time-dependent inhibition of CYP3A4 and CYP2C9 by noscapine potentially explains clinical noscapine-warfarin interaction. Br J Clin Pharmacol 69: 193-199.
4. Goldman P., 2001. Herbal medicines today and the roots of modern pharmacology. Ann Intern Med 135: 594-600.
5. Guengerich FP., 2006. Cytochrome P450s and other enzymes in drug metabolism and toxicity. AAPS J 8: E101-E111.
6. Iwata H, Tezuka Y, Kadota S, Hiratsuka A, Watabe T,. 2004. Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract. Drug Metab Dispos 32: 1351-1358.
7. Kamigauchi M, Noda Y, Nishijo J, et al. 2005. Cell adhesion inhibitory activity of (d)-corynoline, a hexahydrobenzo[c] phenanthridine-type alkaloid, and its structure-activity relationship, studied by x-ray crystal structure analysis and molecular docking study. Bioorg Med Chem 13: 1867-1872.
8. Kim DK., 2002. Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Arch Pharm Res 25: 817-819.
9. Lin JH, Lu AYH,. 1997. Role of pharmacokinetics and metabolism in drug discovery and development. Pharmacol Rev 49: 403-449.
10. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ,. 1951. Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275.
11. Ma WG, Fukushi Y, Tahara S,. 1999. Fungitoxic alkaloids from Hokkaido Corydalis species. Fitoterapia 70: 258-265.
12. Mederski W, Osswald M, Dorsch D, et al. 1998. 2. Endothelin antagonists: Evaluation of 2,1,3-benzothiadiazole as a methylendioxyphenyl bioisoster. Bioorg Med Chem Lett 8: 17-22.
13. Murray M., 2000. Mechanisms of inhibitory and regulatory effects of methylenedioxyphenyl compounds on cytochrome P450-dependent drug oxidation. Curr Drug Metab 1: 67-84.
14. Omura T, Sato R,. 1964. Carbon monoxide-binding pigment of liver microsomes I. Evidence for its hemoprotein nature. J Biol Chem 239: 2370-2385.
15. Purnapatre K, Khattar SK, Sain KS,. 2008. Cytochrome P450s in the development of target-based anticancer drugs. Cancer Lett 259: 1-15.
16. Rae JM, Soukhova NV, Flockhart DA, Desta Z,. 2002. Triethylenethiophosphoramide is a specific inhibitor of cytochrome P4502B6: Implications for cyclophosphamide metabolism. Drug Metab Dispos 30: 525-530.
17. Tran A, Giraud C, Rey E, Vincent J, Treluyer J, Pons G,. 2005. Inhibitory effect of stiripentol on clobazam metabolism by cDNA-expressed human CYP. Clin Pharmacol Ther 77: P49-P49.
18. Walsky RL, Obach RS, Gaman EA, Gleeson JPR, Proctor WR,. 2005. Selective inhibition of human cytochrome P4502C8 by montelukast. Drug Metab Dispos 33: 413-418.
19. Zhang YY, Liu Y, Zhang JW, et al. 2009. Characterization of human cytochrome P450 isoforms involved in the metabolism of 7-epi-paclitaxel. Xenobiotica 39: 283-292.
20. Zhou SF, Chan SY, Goh BC, et al. 2005. Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs. Clin Pharmacokinet 44: 279-304.
21. Zhou SF, Zhou ZW, Li CG, et al. 2007. Identification of drugs that interact with herbs in drug development. Drug Discov Today 12: 664-673.