Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy

Cancer Research

Volumn 56, Issue 9, 1996, Pages 2025-2028

  Schmeiser, Heinz H ^a   Bieler, Christian A ^a   Wiessler, Manfred ^a   Van Ypersele De Strihou, Charles ^b   Cosyns, Jean Pierre ^b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF LOUVAIN MEDICAL SCHOOL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ARISTOLOCHIC ACID;

ADULT; ARTICLE; CARCINOGENICITY; CHINESE MEDICINE; CLINICAL ARTICLE; DNA CLEAVAGE; DNA DETERMINATION; DRUG DNA BINDING; DRUG TOXICITY; FEMALE; GENE MUTATION; HERBAL MEDICINE; HUMAN; NEPHROTOXICITY; PRIORITY JOURNAL; WEIGHT REDUCTION;

ADULT; ARISTOLOCHIC ACIDS; DNA ADDUCTS; DRUGS, CHINESE HERBAL; FEMALE; HUMANS; KIDNEY; KIDNEY DISEASES; PHENANTHRENES;

EID: 0029983768     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Vanherweghem, J. L , Depierreux, M., Tielemans, C., Abramowicz, D , Dratwa, M., Jadoul, M., Richard, C., Vanderwelde, D., Verbeelen, D , Vanhaelen-Fastre, R , and Vanhaelen, M. Rapidly progressive interstitial renal fibrosis in young women: association with a slimming regimen including Chinese herbs. Lancet, 341: 387-391, 1993.
2. Vanhaelen, M., Vanhaelen-Fastre, R., But, P., and Vanherweghem, J L. Identification of aristolochic acid in Chinese herbs. Lancet, 343: 174, 1994.
3. Jackson, L., Kofman, S., Weiss, A., and Brodovsky, H Aristolochic acid (NSC-50413): Phase I clinical study, Cancer Chemother. Rep , 42: 35-37, 1964
4. Mengs, U., Lang, W., and Poch, J. A The carcinogenic action of aristolochic acid in rats. Arch. Toxicol. 61: 107-119, 1982.
5. Schmeiser, H. H., Janssen, J. W. G , Lyons, J., Scherf, H. R., Pfau, W., Buchmann, A , Bartram, C. R., and Wiessler, M. Aristolochic acid activates ras genes in rat tumors at deoxyadenosine residues. Cancer Res., 50: 5464-5469, 1990.
6. Broschard, T. H., Wiessler, M., von der Lieth, C. W , and Schmeiser, H H. Translesional synthesis on DNA templates containing site-specifically placed deoxyadenosine and deoxyguanosine adducts formed by the plant carcinogen aristolochic acid. Carcinogenesis (Lond.), 15. 2331-2340, 1994.
7. Schmeiser, H H., Schoepe, K. B., and Wiessler, M. DNA adduct formation of aristolochic acid I and II in vitro and in vivo. Carcinogenesis (Lond.), 9. 297-303, 1988
8. Pfau, W., Schmeiser, H. H., and Wiessler, M. Aristolochic acid binds covalently to the exocyclic amino group of purine nucleotides in DNA. Carcinogenesis (Lond.), 11: 313-319, 1990.
9. Cosyns, J P., Jadoul, M., Squifflet, J. P., De Plaen, J. F., and van Ypersele de Strihou, C. Chinese herbs nephropathy: a clue to Balkan endemic nephropathy? Kidney Int., 45: 1680-1688, 1994.
10. Cosyns, J. P., Jadoul, M., Squifflet, J. P., and van Ypersele de Strihou, C. Urothelial malignancy in nephropathy due to Chinese herbs. Lancet, 344: 188, 1994
11. Vanherweghem, J. L., Tielemans, C., Simon, J., and Depierreux, M. Chinese herbs nephropathy and renal pelvic carcinoma. Nephrol. Dial. Transplant., 10: 270-273, 1995
12. 32P-postlabelling analysis using different chromatographic procedures. Carcinogenesis (Lond.), 15: 1187-1192, 1994.
13. 32P-postlabelling test for structurally diverse DNA adducts. Carcinogenesis (Lond.), 7: 1543-1551, 1986.
14. 32P-labelling test for DNA damage. Proc. Natl. Acad. Sci USA, 78: 6126-6129, 1981.
15. van Ypersele de Strihou, C., and Vanherweghem, J. L. The tragic paradigm of Chinese herbs nephropathy. Nephrol. Dial. Transplant , 10: 157-160, 1995.
16. 32P-postlabelling in target and non-target organs of rats treated with aristolochic acid I. In: D. H. Phillips, M. Castegnaro, and H. Bartsch (eds.), Postlabeling Methods for Detection of DNA Adducts, pp 167-171. IARC Scientific Publ. No. 124, Lyon, France: IARC, 1993.
17. Moorthy, B., Chen, S., Li, D., and Randerath, K. 3-Methylcholanthrene-inducible liver cytochrome(s) P450 in female Sprague-Dawley rats: possible link between P450 turnover and formation of DNA adducts and I-compounds. Carcinogenesis (Lond.), 14: 879-886, 1993.
18. Phillips, D. H., Hewer, A., Malcolm, A. D. B., Ward, P., and Coleman, D. V. Smoking and DNA damage in cervical cells. Lancet, 335. 417, 1990.
19. Talaska, G., al Juburi, A. Z., and Kadlubar, F. F. Smoking related carcinogen-DNA adducts in biopsy samples of the urinary bladder identification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl as a major product. Proc. Natl. Acad. Sci USA, 88: 5350-5354, 1991.
20. Kee Chang Huang. The Pharmacology of Chinese Herbs. Boca Raton, FL: CRC Press, Inc., 1993.