Metabolism of trimethoprim to a reactive iminoquinone methide by activated human neutrophils and hepatic microsomes

Journal of Pharmacology and Experimental Therapeutics

Volumn 291, Issue 1, 1999, Pages 292-299

  Lai, W George ^a   Zahid, Nasir ^a   Uetrecht, Jack P ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTIINFECTIVE AGENT; HYDROCHLORIC ACID; HYDROGEN PEROXIDE; MYELOPEROXIDASE; QUINONE DERIVATIVE; TRIMETHOPRIM;

AGRANULOCYTOSIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIASTEREOISOMER; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER MICROSOME; LIVER TOXICITY; MASS SPECTROMETRY; NEUTROPHIL; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ACETYLCYSTEINE; ANIMALS; DRUG INTERACTIONS; FREE RADICAL SCAVENGERS; HUMANS; HYPOCHLOROUS ACID; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICROSOMES, LIVER; NEUTROPHILS; OXIDATION-REDUCTION; PEROXIDASE; QUINONES; RATS; RATS, SPRAGUE-DAWLEY; TRIMETHOPRIM; TRITIUM;

EID: 0032881830     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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