Aristolochic acid as a probable human cancer hazard in herbal remedies: A review

Mutagenesis

Volumn 17, Issue 4, 2002, Pages 265-277

  Arlt, Volker M ^a   Stiborova, Marie ^b   Schmeiser, Heinz H ^c  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b CHARLES UNIVERSITY   (Czech Republic)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOPURINE; 7 (DEOXYADENOSIN N YL)ARISTOLACTAM 1; ADENINE; ARISTOLOCHIC ACID; ARISTOLOCHIC ACID 1; ARISTOLOCHIC ACID 2; CARBOXYLIC ACID DERIVATIVE; DEOXYADENOSINE; MUTAGENIC AGENT; PLANT EXTRACT; PROTEIN P53; THYMINE; UNCLASSIFIED DRUG; ARISTOLOCHIC ACID I; CARCINOGEN; HERBACEOUS AGENT; OCHRATOXIN;

ARISTOLOCHIA; CANCER; CARCINOGENESIS; CARCINOGENICITY; CODON; CONTROLLED STUDY; DNA ADDUCT; DNA BINDING; DNA DAMAGE; EXPERIMENTAL ANIMAL; GENOTOXICITY; HEALTH HAZARD; HERBAL MEDICINE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KIDNEY DISEASE; KIDNEY FIBROSIS; LATENT PERIOD; MAMMAL; MEDICINAL PLANT; METABOLIC ACTIVATION; NEPHROTOXICITY; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; ONCOGENE H RAS; PRIORITY JOURNAL; REDUCTION; REVIEW; RODENT; UROGENITAL TRACT CANCER; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; INTERSTITIAL NEPHRITIS; KIDNEY; METABOLISM; NEOPLASM; PATHOLOGY;

ANIMALIA; ARISTOLOCHIA; MAMMALIA; RODENTIA;

ANIMALS; ARISTOLOCHIC ACIDS; BALKAN NEPHROPATHY; CARCINOGENS; DNA ADDUCTS; DRUGS, CHINESE HERBAL; HUMANS; KIDNEY; MEDICINE, HERBAL; MUTAGENS; NEOPLASMS; NEPHRITIS, INTERSTITIAL; OCHRATOXINS; RODENTIA;

EID: 0036020624     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/17.4.265     Document Type: Review

References (124)

1. Induction of structural chromosome aberrations and sister chromatid exchanges in human lymphocytes in-vitro by aristolochic acid
2. Using polymerase arrest to detect DNA binding specificity of aristolochic acid in the mouse H-ras gene
3. Analyses of DNA adducts formed by ochratoxin A and aristolochic acid in patients with Chinese herbs nephropathy
4. Sequence-specific detection of aristolochic acid-DNA adducts in the human p53 gene by terminal transferase-dependent PCR
5. Oncogene, activation in chemical carcinogenesis
6. 32P-post-labelling analysis of DNA adducts formed by aristolochic acid in tissues from patients with Chinese herbs nephropathy
7. Translesional synthesis on DNA templates containing site-specifically placed deoxyadenosine and deoxyguanosine adducts formed by the plant carcinogen aristolochic acid
8. Effect of site-specifically located aristolochic acid DNA adducts on in vitro DNA syntheses by human DNA polymerase α
9. Rapidly progressive interstitial fibrosis associated with Chinese herbal medications
10. The clinical and pathological manifestations of aristolochic acid nephropathy-The report of 58 cases
11. Role of serotonin in the development of Chinese herbs nephropathy?
12. Urothelial malignancy in nephropathy due to Chinese herbs
13. Chinese herbs nephropathy: A clue to Balkan endemic nephropathy?
14. Chinese herbs nephropathy-associated slimming regimen induces tumors in the forestomach but no interstitial nephropathy in rats
15. Urothelial lesions in Chinese-herb nephropathy
16. Chronic aristolochic acid toxicity in rabbits: A model of Chinese herbs nephropathy?
17. Aristolochic acid as a causative factor in a case of Chinese herbal nephropathy
18. Aristolochic acid induce chronic renal failure with interstitial fibrosis in salt-depleted rats
19. On a nephrotoxic and carcinogenic slimming regimen
20. Analgesic nephropathy
21. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in p53
22. Pathologic aspects of newly described nephropathy related to the prolonged use of Chinese herbs
23. DNA adducts of chemical carcinogens
24. 32P-postlabelling in target and non-target organs of rats treated with aristolochic acid I
25. Aristolochic acid is mutagenic and recombinogenic in Drosophila genotoxicity tests
26. Induction of unscheduled DNA synthesis in rat stomach mucosa by glandular stomach carcinogens
27. Aristolochic acid nephropathy in a Chinese patient: Time to abandon the term 'Chinese herbs nephropathy'?
28. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
29. Mutagenicity of aristolochic acids (I, II) and aristolic acid I in new YG strains in Salmonella typhimurium highly sensitive to certain mutagenic nitroarenes
30. Die Osterluzei - Aristolochia clematitis - eine alte Medizinal-Pflanze
31. Aristolochic acids and aristolactams from Aristolochia auricularia
32. Molecular epidemiology of human cancer: Contribution of mutation spectra studies of tumor suppressor genes
33. The problem of etiology of endemic nephropathy
34. Aristolochic acid (NSC-50413): Phase I clinical study
35. NAD(P)H-quinone oxidoreductase(1) (DT-diaphorase)-expression, regulation and role in cancer
36. Low molecular weight proteinuria in Chinese herbs nephropathy
37. SOS induction of selected naturally occuring substances in Escherichia coli (SOS chromotest)
38. Micronucleus formation in human lymphocytes and in the metabolically competent human hepatoma cell line Hep-G2: Results with 15 naturally occurring substances
39. Doppelblindstudie zur Beeinflussung der Phagocytosefähigkeit von Granulocyten durch Aristolochiasäure
40. Mutagenicity of aristolochic acid in the lambdallacZ transgenic mouse (Muta™Mouse)
41. Studies on the metabolism of aristolochic acids I and II
42. Reversible Fanconi syndrome after ingestion of a Chinese herbal 'remedy' containing aristolochic acid
43. Tumor inhibitors. I. Aristolochic acid, the active principle of Aristolochia indica
44. Aristolochic acid impedes endocytosis and induces DNA adducts in proximal tubule cells
45. An analysis of the clinical and pathological characteristics of mu-tong (a Chinese herb) induced tubulointerstitial nephropathy
46. Nephropathy caused by Chinese herbs in the UK
47. Urothelial malignancy and Chinese herbal nephropathy
48. Aristolochic acid induces 6-thioguanine-resistant mutants in an extrahepatic tissue in rats after oral application
49. Low oxygen tension as found in tissues in vivo, alters the mutagenic activity of aristolochic acid I and II
50. Chinese herb nephropathy is not a (dex)fenfluramine nephropathy but a serotonin nephropathy
51. Progression rate of Chinese herb nephropathy: Impact of Aristolochia fangchi ingested dose
52. Chinese herb: Risk, side effects and poisoning: The case for objective reporting and analysis reveals serious misrepresentation
53. On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid
54. Acute toxicity of aristolochic acid in rodents
55. Tumor induction in mice following exposure to aristolochic acid
56. Genotoxic effects of aristolochic acid in the mouse micronucleus test
57. Renal toxicity of aristolochic acid in rats as an example of nephrotoxicity testing in routine toxicology
58. The carcinogenic action of aristolochic acid in rats
59. Chinese herb nephropathy
60. The aristolochic acids and aristolactams
61. Weitere Untersuchungen über die Wirkung der Aristolochiasäure
62. Weitere Studien über Aristolochiasäure
63. Progressive interstitial renal fibrosis due to Chinese herbs in a patient with Calcinosis Raynaud Esophageal Sclerodactyly Telangiectasia (CREST) syndrome
64. Proximal tubular injury in Chinese herbs nephropathy: Monitoring by neutral endopeptidase enzymuria
65. Urothelial carcinoma associated with the use of Chinese herbs (Aristolochia species)
66. Zur Konstitution der Aristolochiasäuren
67. Rapidly progressive interstitial renal fibrosis due to chronic intake of a herb (Aristolochia pistolochia) infusion
68. Environment and cancer: Who are susceptible?
69. Evaluation of the mutagenic and cytostatic potential of aristolochic acid (3,4-methylenedioxy-8-methoxy-10-nitrophenanthrene-1-carboxylic acid) and several of its derivatives
70. 32P-postlabelling analysis of the DNA adducts formed by aristolochic acid I and II
71. Aristolochic acid binds covalently to the exocyclic amino group of purine nucleotides in DNA
72. 6-adenyl arylation of DNA by aristolochic acid II and a synthetic model for the putative proximate carcinogen
73. Ochratoxin A related DNA adducts in urinary tract tumours of Bulgarian subjects
74. Néphropathie associée à des herbes chinoises 2 cas
75. Minor aristolochic acids from Aristolochia argentina and mass spectral analysis of aristolochic acids
76. Genetic polymorphisms in human drug-metabolizing enzymes: Potential uses of reverse genetics to identify genes of toxicological relevance
77. Mutagenicity of nitroaromatic compounds
78. 32P-postlabeling analysis of DNA adducts persisting for up to 42 weeks in the skin, epidermis and dermis of mice treated topically with 7,12-dimethylbenz[a]anthracene
79. Chinese herbs nephropathy presentation, natural history and fate after transplantation
80. Aristolochic acid is a direct mutagen in Salmonella typhimurium
81. Zur Kenntnis der Aristolochiasäure
82. Induction of hepatic nodules in rat by aristolochic acid
83. Aristolochic acids from Aristolochia manshuriensis
84. Mutagenicity of the two main components of commercially available carcinogenic aristolochic acid in Salmonella typhimurium
85. Identification and mutagenicity of metabolites of aristolochic acid formed by rat liver
86. DNA adduct formation of aristolochic acid I and II in vitro and in vivo
87. Aristolochic acid activates ras genes in rat tumors at deoxyadenosine residues
88. Activating mutations at codon 61 of the c-Ha-ras gene in thin-tissue sections of tumors induced by aristolochic acid in rats and mice
89. Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy
90. 32P-post-labelling: Evidence for reductive activation by peroxidases
91. From the Food and Drug Administration
92. Chinese herbs and urothelial carcinoma
93. Site-specific mutagenesis: Retrospective and prospective
94. Is 'Chinese Herbs Nephropathy' a prejudical term?
95. End-stage renal insufficiency associated with Chinese herbal consumption in France
96. 32P-postlabelling analysis using different chromatographic procedures
97. Cytochrome P-450 and peroxidase oxidize detoxication products of carcinogenic aristolochic acids (aristolactams) to reactive metabolites binding to DNA in vitro
98. 32P-postlabeling: A sensitive technique for the detection of DNA adducts
99. Aristolactam I a metabolite of aristolochic acid I upon activation forms an adduct found in DNA of patients with Chinese herbs nephropathy
100. Isolation of DT-diaphorase [NAD(P)H dehydrogenase (quinone)] from rat liver cytosol: Identification of new enzyme substrates, carcinogenic aristolochic acids
101. Human cytochrome P450 enzymes involved in the metabolic activation of carcinogenic aristolochic acids: Evidence for reductive activation by CYP1A1 and CYP1A2
102. Carcinogenic and nephrotoxic aristolochic acids upon activation by NADPH: Cytochrome P450 reductase form adducts found in DNA of patients with Chinese herbs nephropathy
103. 32P-postlabeling analysis of DNA adduct formation
104. Carcinogenic aristolochic acid upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy
105. Traditional remedy-induced Chinese herbs nephropathy showing rapid deterioration of renal function
106. Chinese herbs nephropathy in the Kansai area: A warning report
107. Chinese herb nephropathy in Japan presents adult-onset Fanconi syndrome: Could different components of aristolochic acids cause a different type of Chinese herb nephropathy?
108. Outbreak of Chinese herbs nephropathy in Japan: Are there any differences from Belgium?
109. The etiology of Balkan endemic nephropathy: Still more questions than answers
110. A case of Chinese herbs-induced renal interstitial fibrosis associated with fibrosis of salivary glands
111. Identification of aristolochic acid in Chinese herbs
112. Association of valvular heart disease with Chinese-herb nephropathy
113. Misuse of herbal remedies: The case of an outbreak of terminal renal failure in Belgium (Chinese herbs nephropathy)
114. Rapidly progressive interstitial renal fibrosis in young women: Association with slimming regimen including Chinese herbs
115. Chinese herbs nephropathy and renal pelvic carcinomas
116. Effects of steroids on the progression of renal failure in chronic interstitial renal fibrosis: A pilot study in Chinese herbs nephropathy
117. Valvular heart disease and Chinese-herb nephropathy
118. Valvular heart disease and Chinese-herb nephropathy
119. The tragic paradigm of Chinese herbs nephropathy
120. Belgian (Chinese herb) nephropathy: Why?
121. 2 from Vipera russelli with aristolochic acid
122. Rapidly progressive interstitial nephritis associated with Chinese herbal drugs
123. Aristolochic acid-induced Fanconi's syndrome and nephropathy presenting as hypokalemic paralysis
124. Establishment of model of aristolochic acid-induced chronic renal interstitial fibrosis in rats