Pulmonary toxicity and metabolic activation of dauricine in CD-1 mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 332, Issue 3, 2010, Pages 738-746

  Jin, Hua ^a   Dai, Jieyu ^a   Chen, Xiaoyan ^b   Liu, Jia ^b   Zhong, Dafang ^b   Gu, Yansong ^c   Zheng, Jiang ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMINOTRANSFERASE; DAURICINE; ETHIDIUM; KETOCONAZOLE; LACTATE DEHYDROGENASE; QUINONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL DEATH; CELL MEMBRANE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; LUNG EDEMA; LUNG HEMORRHAGE; LUNG INJURY; LUNG LAVAGE; LUNG TOXICITY; MALE; METABOLIC ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STAINING;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BENZYLISOQUINOLINES; BIOTRANSFORMATION; BLOOD UREA NITROGEN; BRONCHOALVEOLAR LAVAGE FLUID; CELL LINE; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMORRHAGE; HUMANS; KETOCONAZOLE; L-LACTATE DEHYDROGENASE; LUNG; MALE; MICE; MICROSOMES; PULMONARY EDEMA; RECOMBINANT PROTEINS; TETRAHYDROISOQUINOLINES; TISSUE DISTRIBUTION;

EID: 77249154241     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.162297     Document Type: Article

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