Human cytochrome P450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components

Drug Metabolism and Disposition

Volumn 31, Issue 11, 2003, Pages 1391-1397

  Chatterjee, Parnali ^a   Franklin, Michael R ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BENZODIOXOLE DERIVATIVE; 1,3 DIOXOLANE DERIVATIVE; ALKALOID; BERBERINE; BUFURALOL; CARBENE; CYTOCHROME P450; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DICLOFENAC; DRUG DERIVATIVE; GOLDENSEAL EXTRACT; HYDRASTINE; ISOENZYME; METHANE; PLANT EXTRACT; TESTOSTERONE; UNCLASSIFIED DRUG;

ARTICLE; CHEMISTRY; COMPLEX FORMATION; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; ENZYME INHIBITION; HUMAN; HYDRASTIS; HYDROXYLATION; LIVER MICROSOME; METABOLISM; PLANT ROOT; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CYTOCHROME P-450 ENZYME SYSTEM; DIOXOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDRASTIS; HYDROCARBONS; ISOENZYMES; METHANE; MICROSOMES, LIVER; PLANT EXTRACTS; PLANT ROOTS;

HYDRASTIS; HYDRASTIS CANADENSIS;

EID: 0142181023     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.31.11.1391     Document Type: Article

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